Detta arbete har gått ut på att spela in, producera och mixa en annan artists kommande singel på distans, till hennes debutalbum. Låten heter Springer Hem I Ösregn. Det utfördes och började med en färdig demo med alla instrument först gjorda i datorn och en slasksång insjungen av skribenten. Demon skickades till en trummis och basist som spelade in på distans. Sångerskan, Moa Silén, tog tåget till Arvika från Stockholm och spelade in all sång under en helg hemma hos mig. Gitarrer spelades in på egen hand i efterhand och låten producerade upp ytligare. Mixandet gjordes av mig och Anton Fagerberg. Mastern står även Anton för. Resultatet blev ett mer nytt och modernt sound än hennes tidigare singel. Vilket målet var redan från början och att kunna blanda akustiska instrument med digitala. Det uppstod problem då mycket gjordes på distans och även i mixnings-processen för att få bas och trummor att samarbeta, men med hjälp av Anton så löste det sig. I framtiden kommer detta projekt ske utan distans och med bättre arbetsförhållanden. Trots den långa resan blev resultatet av låten som förväntat. / This assignment has been about recording, producing and mixing another artist's upcoming single, remotely, for her debut EP. The song is called ”Springer Hem I Ösregn”. It was first created with a demo with all the instruments made in the computer and a demo-vocal sung by myself. The demo was sent to a drummer and bass-player who recorded it remotely. The singer, Moa Silén, took the train to Arvika from Stockholm and recorded all the vocals during a weekend at my place. Guitars were recorded on their own and the song produced more superficially afterwards. The mix was done by myself and Anton Fagerberg. The master was also done by Anton. The result was to get a more new and modern sound than her previous single. Which the goal was right from the start and to be able to mix acoustic instruments with digital instruments. There were problems cause a lot was done remotely and also during the mixing process to get the bass and drums to work together, but with some help from Anton it was solved. In the future, this project will be done without the distance and with better working-conditions. Despite the long journey, the result of the song was as expected.

Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

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Paper 1 - Consultation is a widely used model of practice amongst Educational Psychology Services (EPS) in the United Kingdom (UK) as evidenced in the amount of research carried out on this practice (Leadbetter, 2006, p. 246). This paper attempts to supplement the limited evidence on how and why consultation is used. This paper provides an account of Educational Psychologists (EPs) perceptions of using consultation in a Welsh Educational Psychology Service (EPS). The study uses a thematic analysis of interviews with EPs and 3 accounts of the practice of consultation are provided as examples of how consultation is used. Data analysis revealed that EPs’ practice is dominated by the influence of Wagner’s model of consultation, which is a result of both university, and service based training and not because they feel it is necessarily the best way of working and were vague about their reasons for using this approach. Evidence emerged to suggest EPs were only aware of one model of consultation, which is the Wagner model. Evidence also emerged to suggest that EPs confused service delivery models with models of consultation and that EPs are unclear about their unique skills and role when using consultation and feel that schools do not understand the work they are trying to achieve when working in this way. EPs also considered that schools want more time with them, but burdensome bureaucracy hinders this. These findings are discussed in more detail at the end of Paper 2 where the overall findings suggest there is a systemic problem in Pantysgawn EPS, where the dominance of the EP role to provide statutory assessments prevents EPs from working in a truly consultative way. The paper ends by discussing the key element of the EP’s role, whether a consistent and rigid adherence to one practice model is practicable or desirable, and the various ways that EP services can monitor outcomes to alleviate some of the bureaucratic processes. Paper 2 - Paper 1 of this study looked at EPs’ perceptions of using consultation. Very few studies have looked at service users experiences in consultation based EP services. Paper 2 therefore looks at schools’ perceptions of the EP service and considers the benefits and barriers to effective service delivery using a thematic analysis of interviews with staff from 5 primary and 3 secondary schools. Findings suggest that schools continue to regard the expertise of the EP as being a provider of individual assessments, but they also revealed an awareness of the wider systemic role that EPs can provide. This traditional view of the role of the EP is discussed in terms of a wider systemic pressure for schools to seek this kind of EP intervention due to the Local Authority’s (LA) focus on statutory assessments. Schools appreciated a greater continuity of EPS staff as this helped them to develop more productive working relationships and they wanted more time with the EP. The findings suggest that the level of bureaucracy and the statutory assessment requirements to gain access to targeted resources were a barrier to working more effectively with schools. The paper ends by integrating these findings with the paper 1 findings and discussing the key element of the EP’s role, whether a consistent and rigid adherence to one practice model is practicable or desirable, and the various ways that EP services can monitor outcomes to alleviate some of the bureaucratic processes.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Epilepsy is one of the most common neurologic disorders. It has been suggested that seizures may be facilitaded by inflammation. PGE2 is one of the most important inflammatory mediators, and facilitates pentylenetetrazol (PTZ)-induced seizures by stimulating EP1 and EP3 receptors. However, up to the present moment, no study has investigated whether EP1 and EP3 receptors blocking attenuate seizures induced by convulsants other than PTZ. It is also unknown whether Na+,K+-ATPase activity alterations are involved in such an effect. Therefore, in the current study we investigated whether EP1 and EP3 ligands (agonists and antagonists) modulate PTZ- and kainic acid (KA)-induced seizures, and whether alterations in Na+,K+-ATPase activity mediate such a protective effect, in mice. EP1 and EP3 antagonists (ONO-8713 and ONO-AE3-240, respectively, 10 Og/kg, s.c.) attenuated PTZ (60 mg/kg, i.p.)- and KA (20 mg/kg, i.p.)-induced seizures. The respective agonists (ONO-DI-004 and ONO-AE-248, 10 Og/kg, s.c.) facilitated seizures in both acute models, and at noneffective doses, prevented the protective effects of the antagonists. Animals injected with PTZ presented decreased Na+,K+-ATPase activity in the cerebral cortex and hippocampus. On the other hand, animals injected with KA presented increased Na+,K+-ATPase activity in the same cerebral structures at the end of the experiment. These divergent findings suggest that alterations in Na+,K+-ATPase activity in both acute models depends on the convulsant agent used and make difficult to establish a relationship between Na+,K+-ATPase activity and seizure development. Moreover, EP1 and EP3 antagonists administration abolished Na+,K+- ATPase activity alterations induced by PTZ and KA, in such a way that these alterations seem to be related more to the presence of ictal phenomenon itself than to the seizure induction mechanisms. Notwithstanding, the currrent results clearly show that EP1 and EP3 receptors might constitute novel targets for anticonvulsants development, since EP1 and EP3 decreased seizures, regardless of the convulsant agent used. / A epilepsia é uma das disfunções neurológicas mais comuns. Tem sido sugerido que as crises epilépticas podem ser facilitadas pela ocorrência de inflamação. A PGE2 é um dos mediadores inflamatórios mais importantes que, agindo por meio dos receptores EP1 e EP3, facilita as convulsões induzidas por pentilenotetrazol (PTZ). Contudo, até a presente data, nenhum estudo investigou, de maneira sistêmica, se a ativação ou bloqueio de receptores EP1 e EP3 facilitam as convulsões induzidas por outros agentes; tampouco se alterações na atividade da Na+,K+-ATPase estão envolvidas nesse efeito. Assim, no presente estudo, investigamos se ligantes (agonistas e antagonistas) de receptores EP1 e EP3 modificam as crises induzidas por PTZ e ácido caínico (KA), e se tais efeitos estão associados a alterações na atividade da enzima Na+,K+-ATPase, em camundongos. Os antagonistas EP1 e EP3 (ONO-8713 e ONO-AE3-240, respectivamente, 10 Og/Kg, s.c.) atenuaram as convulsões induzidas por PTZ (60 mg/Kg, i.p.) e KA (20 mg/Kg). Os seus respectivos agonistas (ONO-DI-004 e ONO-AE-248 de 10 Og/Kg, s.c.) facilitaram as convulsões em ambos modelos agudos de crises epilépticas e, em doses não efetivas para gerar crises, preveniram os efeitos dos antagonistas. Os animais submetidos à administração de PTZ apresentaram, ao final do experimento, a atividade Na+,K+-ATPásica diminuída no córtex cerebral e hipocampo. Por outro lado, animais tratados com KA apresentaram um aumento na atividade Na+,K+-ATPásica nestas mesmas estruturas, que se correlacionou positivamente com a vigência de status epilepticus no momento do sacrifício. Os achados divergentes no que diz respeito à alteração da atividade da Na+,K+-ATPase nos dois modelos de crises agudas sugere que tais alterações estejam relacionadas ao tipo de agente convulsivante utilizado, e dificultam estabelecer, de forma inequívoca, uma relação entre atividade desta ATPase e sensibilidade à crises agudas. Ademais, a administração de antagonistas EP1 e EP3 aboliu as alterações da atividade da Na+,K+-ATPase induzidas tanto por PTZ como por KA, de tal forma que estas parecem estar mais associadas com o fenômeno ictal em si, do que com os mecanismos de indução da crise. Contudo, os resultados mostram de forma clara que os receptores EP1 e EP3 podem se constituir possíveis novos alvos para o desenvolvimento de drogas antiepilépticas, pois antagonistas EP1 e EP3 diminuíram as crises, independente do agente convulsivante utilizado.

Valdeltagandet i EP-valet har historiskt sett varit betydligt lägre än valdeltagandet vid nationella val, både för medborgare i Europeiska unionen som hos de svenska medborgarna. I denna undersökning tittar vi närmare på de faktorer som potentiellt påverkar huruvida man deltar eller ej. Från den tidigare forskningen hämtar vi förklaringar som kön, ålder, utbildning etc och applicerar dessa på valdeltagandet. Vi ämnar undersöka i vilken utsträckning samma individer deltar i riksdagsvalet och EP-valet, samt att undersöka vilka faktorer, om några, som påverkar benägenheten hos individer att delta i riksdagsvalet och EP-valet. Vi undersöker om det är samma eller olika faktorer som påverkar deras deltagande i dessa val. Vi använder data inhämtat från Europaparlamentsvalundersökningen 2019 som genomfördes i samarbete mellan Statsvetenskapliga institutionen vid Göteborgs universitet och Statistiska centralbyrån (SCB) och med hjälp av en korstabell och logistisk regression kommer vi bland annat fram till att det finns ett statistiskt signifikant samband mellan utbildning och politisk kunskap och deltagande i EP-valet, vilket inte finns i riksdagsvalet. Vi ser även att det finns ett statistiskt signifikant samband mellan kön och deltagande i riksdagsvalet vilket inte finns i EP-valet. Faktorerna inkomst, politisk diskussion och konsumtion av politiska nyheter har ett starkare samband och påverkan i riksdagsvalet än vad det har i EP-valet. Medan politiskt intresse har ett starkare samband och påverkan i EP-valet än i riksdagsvalet. / The voter turnout in the elections to the European Parliament have historically been low among the citizens in the European Union, including Sweden. In this study, our aim is to further investigate which factors affect voter turnout. From the previous research, we derive explanations such as gender, age, education, etc. and apply these to voter turnout. We intend to investigate to what extent the same individuals participate in the parliamentary elections and the European Parliament elections, as well as to investigate which factors, if any, influence the propensity of individuals to participate in the parliamentary elections and the EP elections. We are interested in investigating whether similar or different factors influence their participation in these elections. We use data obtained from the European Parliament election survey 2019, which was carried out in collaboration between the Department of Political Science at the University of Gothenburg and Statistics Sweden and by using a cross table and logistic regression, we conclude that there is a statistically significant relationship between education and political knowledge and participation in the EP election, which is not found in the parliamentary election. Additionally we discover that there is a statistically significant relationship between gender and participation in the parliamentary election, which is not found in the EP election. The factors income, political discussion and consumption of political news have a stronger connection and influence in the parliamentary elections compared to the EP elections. Conversely, political interest demonstrates a stronger association and influence in the EP election than in the parliamentary election

I detta konstnärliga examensarbete undersöks huruvida det går att binda samman fyra låtar av olika karaktär med hjälp av övergångar bestående av olika musikaliska- och icke musikaliska element. Fyra olika metoder för övergångar har testats och utvärderats för att se vilken som fungerar bäst. Metoderna som testats är: körarrangemang, atonala övergångar, ledmotiv och narrativt tal. Tidigt i arbetet stod det klart att körarrangemang var svårt att få till estetiskt och att tiden för att få till det bra skulle bli för knapp. Att arbeta atonalt var däremot lättare då inga regler sattes upp förutom att övergången skulle börja på tonarten som varit och landa i tonarten som skulle komma. När ledmotivet skrevs tonalt var det svårt att få till men då ett vindljud fick agera återkommande ledmotiv tillförde det rymd och rum till övergångarna. För att hitta de narrativa stroferna som skulle sägas lästes de fyra låttexterna igenom för att hitta nyckelfraser som bäst beskrev känslan inför kommande låt. Som resultat visade det sig senare att kombinationen av atonala syntar, vindljudet som agerade ledmotiv samt de narrativa stroferna passade bäst när de kopplades samman och arbetade tillsammans. / This artistic degree project researches if it is possible to link four different songs of diverse genres onto one EP through the use of both musical and non-musical elements that arise as bridges between the songs. Four different methods have been tested and evaluated to see which one gives the best result. The tested methods are: arrangements for choir, atonal bridges, leitmotif and narrative phrases. Early on it became clear that the arrangements for choir were hard to complete in the limited time that existed for the project. To work with atonal bridges was easier since the only guide line used was that the bridge should start in the key last heard and end on the same key as the upcoming song. When the leitmotif was written tonally it was difficult to do but using the sound of wind as a non-musical leitmotif added a nice space to the bridges. When working with the narrative phrases the songs were analysed carefully to find the key phrases of the lyrics from the four songs to use in the narrative speech. The result of this project indicates that the best way to create these bridges is to combine the different methods, use the atonal synthesizers with the non-musical wind sounds as a leitmotif along with the narrative phrases. The only method not used was the arrangement for choir. / <p>Jag bifogar en mp3-fil med övergångarna mellan låtarna samt de 4 låtarna jag arbetat med. </p><p>Musiker, låtskrivare, producent och mixare: Frida Holmgren Övriga musiker:Martin Axelsson, Oscar Treitler, Emma Beskow, Jonna Inge, Caroline Waldemarsson, Olle Roberg, Karolin Engman</p>

Die Ausbildung und der Schweregrad einer Anaphylaxie kann durch verschiedene Co-Faktoren beeinflusst werden. Zu diesen zählen die nichtsteroidalen Antiphlogistika (NSAIDs), die ihre Wirkung über die Inhibition der COX entfalten. Wie NSAIDs den Schweregrad der Anaphylaxie beeinflussen, ist bisher nicht genau bekannt. Interessanterweise zeigen Anaphylaxie-Patienten mit einer NSAID-Hypersensibilität niedrige Konzentrationen des regulatorischen Prostaglandins E2 (PGE2). Zudem zeigen ASA-tolerante und –intolerante Asthma-Patienten variable anaphylaktische Sensitivitäten. Anhand der vorliegenden Arbeit sollte untersucht werden, ob sich eine PGE2-Dysregulation auf die Ausbildung und den Schweregrad der Anaphylaxie auswirkt und ob diese durch genetische Prädispositionen gefördert werden kann. Dazu wurden zunächst die PGE2 Konzentration im Serum von ANA-Patienten und gesunden Individuen gemessen. ANA-Patienten zeigten reduzierte PGE2 Level, die invers mit dem Schweregrad der ANA korrelierten. Unterstützend weisen zwei in der Allergieforschung häufig verwendete Mauslinien, Balb/c und C57BL/6, unterschiedliche PGE2 Level auf, die wiederum invers mit dem ANA-Schweregrad korrelierten. Eine Stabilisierung der PGE2 Konzentration mittels eines pharmakologischen Inhibitors der Hydroxyprostaglandin-Dehydrogenase (15-PGDH-I) in vivo führte zu einer Verbesserung des ANA Schweregrades. Um in diesem Zusammenhang den Einfluss von ASA und PGE2 besser zu verstehen, wurde das Model der systemisch passiven ANA im Mausmodel eingesetzt. ASA verschlimmerte den Schweregrad der ANA durch die Inhibition der COX1/2. PGE2 konnte diese Verschlimmerung über die EP Rezeptoren 2, 3 und 4 reduzieren. Um die zugrundeliegenden Mechanismen der Wirkweise von exogenem PGE2 und EP-Agonisten besser zu verstehen, wurden diese Zusammenhänge in murinen und humanen Mastzellen untersucht. PGE2 reduzierte die Schwere der ANA durch Inhibition der Mastzell-Aktivität in diesem System über die Rezeptoren EP2 und EP4. Anhand der vorliegenden Arbeit konnte gezeigt werden, dass bereits homöostatische PGE2 Konzentrationen die Aktivität der Mastzelle verändern und vor einer schweren ANA schützen. Zudem kann der Grad der ANA und der Einfluss des PGE2 auf die Mastzellantwort durch genetische Prädisposition beeinflusst werden. Die pharmakologische Stabilisierung des PGE2 könnte daher eine vielversprechende, therapeutische wie auch vorbeugende Strategie zur Behandlung risikoreicher ANA- Patienten sein. / The clinical outcome of anaphylaxis (ANA) can be affected by several co-factors. Non-steroidal anti-inflammatory drugs (NSAIDs) are well-known co-factors of ANA acting via COX-inhibition. The NSAIDs-mediated mechanisms altering the severity of ANA are not well-defined. It is reported that patients of ASA (NSAID)-hypersensitivity show low levels of the regulatory prostaglandin E2 (PGE2). Moreover, the effectiveness of PGE2 administration in such patients suggests a critical role of PGE2 in ASA hypersensitivity. In addition, patients of ASA-tolerant and ASA-intolerant asthma show variable ANA sensitivities suggesting a role of genetic variation in susceptibility. The aim of this thesis was to study whether and how PGE2 dysregulation predisposes to ANA and whether genetic pre-dispositions affect the PGE2 system and therefore ANA susceptibility. First, sera from ANA patients and healthy individuals were analyzed for PGE2 levels. ANA patients were characterized by reduced PGE2 levels which inversely correlated with the severity of ANA. This disparity was confirmed by differential PGE2 levels between Balb/c and BL/6 strains, two genetic mouse strains frequently employed in allergy research. PGE2 levels in these mice were again inversely related with the severity of ANA. Results were confirmed by in vivo PGE2 stabilization using 15-hydroxyprostaglandin dehydrogenase inhibitor (15-PGDH-I). Pharmacological PGE2 stabilization ameliorated ANA severity in mice. A passive systemic ANA (PSA) model was applied to study the impact of ASA on ANA severity and the role of PGE2 in this context. ASA aggravated ANA by inhibiting COX-1/COX-2, while PGE2 reduced the aggravation through EP receptors 2, 3 and 4. To delineate the underlying mechanisms, murine and human mast cells were used to study the impact of exogenous PGE2 and EP agonists. PGE2 attenuated ANA severity by inhibiting MC activation through EP2 and EP4 receptors and interfering with MC signaling. In summary, this thesis demonstrates that homeostatic levels of PGE2 modulate MC activation and protect against ANA severity. The impact of PGE2 on MC responses and ANA susceptibility is governed by genetic variation. Pharmacological stabilization of PGE2 may prove to be a therapeutic or preventive strategy in the management of high-risk ANA patients.

Depuis quelques décennies, le syndrome d'immunodéficience acquise a causé la mort de millions de personnes. La recherche des dernières années a permis de caractériser l'agent causal, le virus de l'immunodéficience humaine, d'identifier des cibles thérapeutiques ainsi que de développer des drogues permettant de contrôler la réplication de ce virus. Toutefois, nous constatons l'émergence de souches virales résistantes à un ou plusieurs des médicaments disponibles. De plus, bien qu'elle permette de bien contrôler la réplication du virus, la thérapie actuelle ne permet pas son éradication et il n'existe aucun vaccin efficace pour la prévention de l'infection. Le virus persiste ainsi dans certaines cellules infectées, lesquelles formeront un réservoir viral. Les monocytes représentent une population cellulaire favorable à la formation d'un tel réservoir viral. Leur dissémination et leur accumulation dans les ganglions lymphatiques constitueraient une étape critique dans la persistance du virus. Les mécanismes menant à la migration des monocytes vers les ganglions lymphatiques sont actuellement méconnus. Les travaux réalisés dans le cadre de cette thèse avaient pour objectif de mieux comprendre les évènements immunologiques et moléculaires contrôlant la migration des monocytes vers les ganglions lymphatiques. Dans un premier temps, nous avons démontré le rôle de la prostaglandine E[indice inférieur 2], une cytokine produite massivement au cours de l'infection, dans le contrôle de l'expression du récepteur de chimiokine CCR7 chez les monocytes. Ce récepteur est responsable de la migration des leucocytes vers les ganglions lymphatiques sous l'action chimiotactique des chimiokines CCL19 et CCL21. Nous avons démontré qu'une exposition des monocytes à la prostaglandine E[indice inférieur 2] entraînait une augmentation de leur migration vers ces chimiokines. Nous avons caractérisé les voies de signalisation intracellulaire activées par la prostaglandine E[indice inférieur 2] menant à l'expression de CCR7 chez les monocytes. Nous avons ainsi établi que la synthèse d'AMPc résultant de l'activation des récepteurs EP[indice inférieur 2] et EP[indice inférieur 4] entraînait l'expression de CCR7 chez les monocytes. Nous avons ensuite démontré l'implication des kinases PKA, ERK et p38 dans ce processus. Dans un second temps, nous avons vérifié l'effet de l'infection par le virus de l'immunodéficience humaine sur l'expression et la fonctionnalité du récepteur CCR7 chez les monocytes exposés à la prostaglandine E[indice inférieur 2]. Notre modèle expérimental démontre que l'exposition des monocytes au virus de l'immunodéficience humaine diminue le niveau de surface ainsi que la fonctionnalité du récepteur CCR7. Toutefois, la prostaglandine E[indice inférieur 2] augmente l'expression de CCR7 à la surface des monocytes exposés au virus, ce qui résulte en une augmentation de la sensibilité des monocytes pour la chimiokine CCL19. Nos résultats suggèrent que lors de la transmission mucosale du virus de l'immunodéficience humaine, l'exposition des monocytes au virus ainsi qu'à la prostaglandine E[indice inférieur 2] pourrait favoriser la dissémination du virus vers les ganglions lymphatiques. Une meilleure compréhension de la pathogenèse du virus ainsi que des mécanismes menant à la dissémination virale pourrait conduire à l'amélioration de l'approche thérapeutique actuelle.

Made available in DSpace on 2015-04-14T13:38:15Z (GMT). No. of bitstreams: 1 423913.pdf: 526562 bytes, checksum: ef02a11f81d42730060ccec260dc6a17 (MD5) Previous issue date: 2010-03-10 / Este estudo trata da ep?ntese consonantal do portugu?s brasileiro, que se manifesta em processos derivados e que j? est? consagrada na escrita. Os dados que comp?em o corpus foram captados atrav?s da ferramenta de pesquisa do dicion?rio eletr?nico Houaiss, restringindo-se aos sufixos -ada, -al e -eiro. Dentre os afixos listados nas gram?ticas, esses foram considerados os mais produtivos em temos de inser??o de consoante, motivo pelo qual foram escolhidos. A an?lise, que se fundamenta na Fonologia Lexical, parte do pressuposto de que /z/ ? a consoante epent?tica default no portugu?s brasileiro para as palavras-base acabadas em vogal do radical e de que /r/ ? default para as palavras-base terminadas em vogal tem?tica. Os resultados confirmaram essa pressuposi??o.