There is high variability in response to cancer chemotherapies among patients. Its sources are diverse: genetic, physiologic, comorbidities, concomitant medications, environment, compliance, etc. As the therapeutic window of anticancer drugs is usually narrow, such variability may have serious consequences: severe (even life-threatening) toxicities or lack of therapeutic effect. Therefore, various approaches to individually tailor treatments and dosing regimens have been developed: a priori (based on genetic information, body size, drug elimination functions, etc.) and a posteriori (that is using information of measurements of drug exposure and/or effects). Mixed-effects modelling of pharmacokinetics and pharmacodynamics (PK-PD), combined with Bayesian maximum a posteriori probability estimation of individual effects, is the method of choice for a posteriori adjustments of dosing regimens. In this thesis, a novel approach to adjust the doses on the basis of predictions, given by a model for ordered categorical observations of toxicity, was developed and investigated by computer simulations. More technical aspects concerning the estimation of individual parameters were analysed to determine the factors of good performance of the method. These works were based on the example of capecitabine-induced hand-and-foot syndrome in the treatment of colorectal cancer. Moreover, a review of pharmacodynamic models for discrete data (categorical, count, time-to-event) was performed. Finally, PK-PD analyses of hydroxyurea in the treatment of sickle cell anemia were performed and used to compare different dosing regimens and determine the optimal measures for monitoring the treatment

Few would disagree that the media landscape has undergone significant changes the last decade. From bulky computers and plain mobile phones to portable High-Definition computers and multi-functional smartphones. Other media, such as newspapers and music, have evolved and prospered in a digitalized environment. The constant urge to digitalize aspects and functions of our daily lives seems almost instinctive. Television has taken further steps into this environment as it is now accepted and featured via the Internet. This essay investigates in the ways the new platforms of television will affect the traditional one. More specifically, whether the Internet Streaming Media functions as an extension or as a replacement to the current form of television.  Furthermore, this essay explores age- and gender-related content-preferences in Streaming, as well as speculating on the subject of the consequences of Streaming consumption.  The method in acquiring the empirical data is through a quantitative one, in a survey.  The conclusions made are that the survey respondents, at this current time, are using Streaming as an extension to traditional TV, that there are, in some genres, significant gender-related content preferences when watching TV over the Internet (these include: Drama, reality and sports) and that there are age-related content preference when using Streaming; as the younger age-groups watch “entertainment-shows” more than the older age-groups but neither of the groups do so exclusively. When it then comes to the discussion concerning increased individualization it is, at this point in time, too early to speculate since the respondents mostly use Streaming as an extension to the traditional television.

Abstract   Authors:                           Emmy Davidsson and Fredrik Doohan Pehrman Title:                                  What’s on TV tonight? Swedish title:                  Vad är det på tv ikväll? Level:                                BA Thesis in Media and Communication Studies Language:                                             Swedish Number of pages:          53   Aim: The purpose of this study is to chart and explain Swedish high school students’ TV viewing and their attitude towards the TV medium. The aim is also to discuss the students’ views on news and citizenship. The purpose is also to, through the term habitus, explore how the background of a person reflects on their choice of TV content, in what way they watch television and on their purpose of TV viewing. What similarities and differences can we discover in different groups’ TV viewing and attitude towards the TV medium and how can these similarities and differences be explained? Method: The used method is a qualitative method of investigation, divided in three parts. The first part is a TV diary, in which the respondents document different aspects of their TV viewing during a week. The second part of the method is focus groups and the last part is a survey concerning the background environment of the respondents.   Main result: In our study we have determined that Swedish high school students still, in some aspects, watch television in a traditional manner. They mainly watch entertaining content, but the varieties of entertainment vary depending on habitus, especially gender. We have also discovered that TV viewing is fragmented, but also formalized depending on which level; general, group or individual level, we choose to study. The main aspect of habitus that influence the behavior concerning TV viewing is gender, but also other aspects of habitus, for example education and place to live. We have studied a rather homogenous group of students, which result in differences in attitude towards the TV medium, mostly based on gender. However, we have also discovered subtleties in attitude between the different groups of respondents depending on lifestyle and taste. The results concerning TV use and attitude towards television can not alone determine if Swedish high school students are enlightened members of society or not. However, through habitus and the influence of parenthood and schooling, the students gain opportunities to create habits and a behavior surrounding news consumption that will make them take their social responsibility later in life. Program:                          The Program for Information and Communication Studies Location:                          Linnaeus University, Växjö Period:                              March – May 2012 Assessor:                        Magnus Eriksson Examinor:                        Malin Hjorth   Keywords:                       media use · TV · TV viewing · habitus · capital · identity · taste ·                           lifestyle · social responsibility · individualization · fragmentation

The purpose of this study is to examine the view of knowledge and the view of learner which are prominent in the ministry memorandum Specific programs and access to vocational programs (U2009/5552/G) and thereby understand the potential impact of the new transformation of the current individual program and what it brings to the students who do not achieve the objectives in grade 9. We have used a qualitative text analysis method. The background to the study describes in particular today's individual program, view of knowledge and view of learner. The result shows that the most prominent in the memorandum is that knowledge is divided into theory and practice, that individualization is the focus and the text shows freedom for interpretation.

The aim of this thesis is to explore from a cultural diversity perspective, students 'views on teachers' leadership styles in the classroom and what style of management students prefer. The study uses a qualitative methodology to interviewed focus groups of students consisting of a total of twelve students at a secondary school in Botkyrka municipality. The corpus was divided into three different groups. Overall, results showed that students seem to prefer an intercultural situational leadership style. This is based on the students expressed need of wanting to be understood on the basis of their cultural background. That means that the teacher according to their background,  situation and knowledge should adapt leadership. Teachers should also be leaders who maintain balance, responsiveness and flexibility in teaching style in order to increase the motivation of students.

The terms”inclusion” and” a school for all” are closely connected. The question schools can ask themselves is how they choose to create inclusion and a school for all and also in what perspective. The purpose with this study was to find out how the headmasters and the teachers at “Blommans skola” reasoned about the definition “inclusion”. In order to fulfill the purpose I used the following questions: How do the teachers reason around the two definitions “inclusion” and “a school for all” and how does this school include children with special needs? I chose to work with a qualitative research method and I performed interviews based on an interview guide. The empirical material I gathered was divided into themes in order to analyze how the participants in the study had concluded the central definition inclusion to individualization, pupils with special needs, a school for all and interest and motivation.  The result of my research show that the informants define inclusion as having the same human value regardless and include everyone accordingly even the ones at the moment not present in the classroom. My material shows that it is the segregated integration that dominates the education situations and that the informants think that it is necessary in order to individualize learning. The informants think it is not excluding to have the pupil attend the school best fitted for the individual needs. My conclusion is that “a school for all” needs to be individually laid out, no matter what special needs are required, since all of us have a different way of learning.

<p>Läroplan för det obligatoriska skolväsendet, fritidshemmet och förskoleklassen, (Lpo94) är tydlig i sin definition att en individanpassad undervisning ska tillämpas i skolan och att undervisningen ska utgå från den enskilde elevens behov. Då forskning pekar på att definitionen och innebörden av begreppet behov inte är tydlig fann vi det intressant att undersöka hur lärare definierar innebörden av begreppet individanpassad undervisning i år 1 med särskilt fokus på aspekten elevers behov. För att studera verksamma lärares resonemang kring detta valdes en kvalitativ metod med intervjuer som hjälpmedel för att samla in data. Det insamlade materialet har analyserats och därefter diskuterats med referens till forskning inom området. Resultatet visar att individanpassad undervisning ses som en förutsättningsfråga. Identifieringen av enskilda elevers behov är det som uppfattas ligga till grund för hur undervisningen ska individanpassas. Svårigheten ligger i att det inte alltid är enkelt att identifiera behoven. Det framkom i resultatet att möjligheten att individanpassa grundar sig i tillgången på resurser samt skolämnets karaktär. Resultatet visar även att åldersintegrerade klasser är en fördel med tanke på tillgången på resurser, då samarbete i arbetslag lättare möjliggör en individanpassad undervisning.</p> / <p>Curriculum for the Compulsory School System, the Pre-School Class and the Leisure-time Centre (Lpo 94) is clear in its definition that individualized tuition shall be applied in the school and that the tuition shall come from the individual pupil’s needs. Since research emphasizes that the definition and meaning of the term needs is not clear we found it interesting to research how teachers define the meaning of the term individualized tuition in school year 1 with special focus on the aspect of pupils’ needs. In order to study active teachers’ reasoning and dictums regarding this we chose a qualitative method with interviews as aid to gather data. The collected material has been analyzed and subsequently discussed with reference to research within the area. The result shows that individualized tuition is regarded as a question of conditions. The identification of individual pupils’ needs is what is perceived to be the basis of how the education should be individualized. The difficulty lies in that it is not always easy to identify the needs. The result showed that the possibility to individualize bases itself in the access of resources and the school subject’s nature. The result also show that age integrated classes is an advantage considering the access of resources, since cooperation between coworkers makes it easier to enable individualized tuition.</p>

The purpose of this study has been to investigate the views of five teachers on their own leadership, and on the way they make it work in the classroom. The method was a qualitative investigation consisting of separate interviews with five elementary school teachers from three different schools in the southern part of Stockholm. The results showed that a good pedagogic leadership, successful with the pupils, can be characterised as at the same time democratic and "situation adjustable". This includes the ability to formulate the rules of conduct clearly, to take decisions and to create a good working atmosphere in the classroom, so that the pupils can feel secure, and be able to learn and develop. That however, cannot be accomplished if the teacher only maintains a negative communication, reminding the pupils of what is forbidden. A majority of the interviewed teachers emphasised the importance of positive feedback, and maintaining the work motivation of the pupils was seen as an important aspect of leadership in the classroom. A good leadership is furthermore characterised by the flexibility of the teacher in adapting to different situations and to the maturity of the pupil or group. Flexibility in adjusting the level of the lesson, and of the tasks given to the individual pupils or groups, is also an aspect of leadership. The results finally showed that the teacher should try to maintain a good personal relationship not just to the pupil but also with the parents. This makes it easier for the teacher to influence the pupils and engage them in a better performance in the classroom, scholastically as well as in terms of conduct.

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Läroplanen (Skolverket, 2011) och Skollagen (SFS 2010:800) anger att undervisningen ska individanpassas. Skolinspektionen (2011) fastställer att det finns brister i hur skolorna bedriver en sådan undervisning och även min erfarenhet var att detta inbegrep en del utmaningar. Med detta som bakgrund blev studiens syfte att beskriva, tolka och förstå innebörden i lärares upplevelser av att individanpassa den egna undervisningen samt eventuella relaterade utmaningar. För att undersöka detta användes en kvalitativ metod med intervjuer som datainsamlingsteknik, där fem verksamma lärare intervjuades. En hermeneutiskt-fenomenologisk ansats användes som utgångspunkt. Resultatet visade att individanpassa undervisningen inte är lätt att göra, då det är mycket upp till läraren att själv tolka och bedriva undervisningen med de svårigheter det innebär. Det är många faktorer som är med och påverkar undervisningen och i analysen av resultatet kunde det påvisas att dessa faktorer fungerar i en kombination med varandra och är vad som möjliggör individanpassad undervisning. / The curriculum (Skolverket, 2011) and Education Act (SFS 2010:800) indicates that education must be adapted to the students' abilities and needs. The National Agency for Education (2011) determines that there are deficiencies in how the schools practice such education and also my experience was that this included some challenges. Against this background, this study aim became to describe, interpret and understand the meaning of the teachers’ experiences of individualizes their own teaching and any related challenges. To investigate this, a qualitative method with interviews as a data collection technique was used, where five practicing teachers were interviewed. A hermeneutic - phenomenological approach was used as a base. The results showed that individualized education is not easy to do, as it's much up to the teacher to interpret and carry out the education with the difficulties it means. There are many factors that will affect the education and the analysis of the result show that these factors work in combination with each other and are what enables individualized education.