Background: Sleep disorders have been considered risk factors for cardiovascular disease, including coronary artery disease (CAD). Therefore, poor sleep quality should be frequent complaint in patients with coronary disease. However, in patients with CAD, the prevalence of poor sleepers and factors associated were not properly investigated. Objectives: To evaluate the frequency and the factors associated with poor sleepers in patients with chronic CAD. Method: We used validated questionnaires to examine sleep quality (Pittsburgh Sleep Quality Index; PSQI), high risk of obstructive sleep apnea (Berlin Questionnaire; BQ), excessive sleepiness (Epworth Sleepiness Scale; ESS), angina-related health status (Seattle Angina Questionnaire; SAQ) and quality of life (Medical Outcomes Study 36-item Short Form; SF-36) in 257 volunteers with stable CAD, mean age 62.5 ± 10.5 years. We categorized and compared good and poor sleepers, according to PSQI global score. Subsequently, adjusted analysis was performed to investigate the factors associated with poor sleepers and demographics, clinical characteristics, risk for obstructive sleep apnea, excessive sleepiness, angina-related health status and quality of life. Results: The majority of CAD patients (75.1%) were poor sleepers. The adjusted analysis indicated that older patients (OR 1.05, 95% CI 1.02 to 1.09; p = 0.004), women gender (OR 3.09, 95% CI 1.48 to 6.45; p = 0.003), lower ejection fraction (OR 1.04, 95% CI 1.01 to 1.06; p = 0.015), lower physical limitation (OR 1.03, 95% CI 1.00 to 1.05; p = 0.020), lower angina stability (OR 1.02, 95% CI 1.00 to 1.04; p = 0.027), worse angina-related quality of life (OR 1.03, 95% CI 1.01 to 1.05; p = 0.002) and lower vitality (OR 1.02, 95% CI 1.00 to 01.03; p = 0.042) were associated with poor sleepers. Conclusion: Poor sleepers were highly frequency in chronic CAD patients. Patients with chronic CAD and poor sleepers present higher age, women gender, lower ejection fraction, higher physical limitation, lower angina stability, lower angina-related quality of life and lower vitality. / Introdução: Distúrbios do sono têm sido considerados fatores de risco para doença cardiovascular, inclusive para doença arterial coronariana (DAC). Portanto, qualidade do sono ruim deve ser queixa frequente em portadores de doença coronariana. Entretanto, em portadores de DAC, a prevalência de qualidade do sono ruim e os fatores associados não foram devidamente investigados. Objetivos: Avaliar a prevalência e investigar os fatores associados à qualidade do sono ruim em pacientes portadores de DAC crônica. Métodos: Foram utilizados questionários validados para examinar a qualidade do sono (Índice de Qualidade de Sono de Pittsburgh; PSQI), o alto risco para apneia obstrutiva do sono (Questionário de Berlim; QB), a sonolência excessiva (Escala de Sonolência de Epworth; ESE), o status funcional relacionado à angina (Questionário de Seattle sobre Crise de Angina; QSA) e a qualidade de vida relacionada à saúde (Questionário de Qualidade de Vida SF-36; SF-36), em 257 voluntários com DAC crônica, com idade média de 62,5 ± 10,5 anos. Os pacientes foram categorizados em dois grupos, boa qualidade do sono e qualidade do sono ruim, de acordo com a pontuação global do PSQI. Posteriormente, foi realizada a análise multivariada para investigar a associação entre qualidade do sono ruim e fatores demográficos, características clínicas gerais, risco para apneia obstrutiva do sono, sonolência excessiva, status funcional relacionado à angina e qualidade de vida relacionada à saúde. Resultados: A maioria dos pacientes com DAC crônica (75,1%) apresentaram qualidade do sono ruim. A Análise multivariada indicou que pacientes com idade avançada (OR 1.05, IC 95% 1.02 - 1.09; p = 0,004), gênero feminino (OR 3.09, IC 95% 1.48 - 6.45; p = 0,003), menor fração de ejeção (OR 1.04, IC 95% 1.01 - 1.06; p = 0,015), maior limitação física (OR 1.03, IC 95% 1.00 - 1.05; p = 0,020), menor estabilidade da angina (OR 1.02, IC 95% 1.00 - 1.04; p = 0,027), pior qualidade de vida relacionada à angina (OR 1.03, IC 95% 1.01 - 1.05; p = 0,002) e menor vitalidade (OR 1.02, IC 95% 1.00 - 1.03; p = 0,042), foram associados à qualidade do sono ruim. Conclusão: Qualidade do sono ruim foi altamente frequente em pacientes com DAC crônica. Pacientes portadores de DAC crônica e pior qualidade do sono apresentam maior probabilidade de serem mais idosos, do gênero feminino, apresentarem menor fração de ejeção, maior limitação funcional, menor estabilidade da angina, pior qualidade de vida relacionada à angina e menor vitalidade.

本研究主要目的在探討高中生的睡眠型態與學業表現的關係，試圖分析睡眠時間量及睡眠的規律性與其課業表現以及睡眠相關現象(白天嗜睡程度及睡眠品質)的關係，並探討白天嗜睡及睡眠品質之中介效果及以日夜節律型態之調節效果。本研究以自填「青少年睡眠習慣問卷」，對台灣北區普通高中及綜合高中中學術學程的高中生進行調查，採群集抽樣的方式進行，共進行42個班級施測，發出1,650份問卷，取得有效問卷1,308份樣本分別以日夜節律型態類型及高低成就動機兩種分類方式進行分析，主要研究結果如下： 1.夜貓型高中生之週間週末規律性變項對於學業表現具有影響力。 2.白日型高中生之週間規律性變項對於學業表現具影響力。 3.以高低成就動機分組，兩組之睡眠型態變項對於學業影響力皆未達顯著性。 4.白天嗜睡及睡眠品質在兩種分類分析下，皆無中介效果。 本研究初步結果支持夜貓型高中生在維持週間週末某種程度睡眠規律性對於學業表現具有相當的影響性，而早晨型在週間內維持其規律性也是對於其學業表現是具有顯著影響性，也就是依其日夜節律型態在其睡眠型態維持自己生活作息的規律性，而不在時間點或睡眠量的多寡來作要求，也許對於正值課業壓力或生心理高度變化的青少年時期會是更合適的睡眠作息。 / The purposes of this study are to explore the relationship of the sleep pattern with academic performance, day time sleepiness and sleep quality in senior high school students. Data were collected by sleep pattern questionnaire of the adolescent. The participants included 1650 students form the 10th grade to 12th grade, recruited form senior high schools in Taipei. Using stratified cluster sampling method. There were 1308 of valid questionnaires obtained. The major results are as follow: (1) The variablity of the sleep-wake pattern between weekdays and weekends has significant influences on academic performace in the evening type students. (2) The variablity of the sleep-wake pattern during weekdays showed significant influences on academic performace in the morening type students. (3) In both the high and low achievement motivation groups, sleep pattern showed no significant associations with academic performance. (4) The mediation effect of daytime sleepiness and sleep quality were not proven in all the data analyses. In coclusion, the results indicate that in evening type students, maintaining regularity of sleep pattern between weekdays and weekends would be beneficial to their academic performance; and in the morning type students, keeping regular weekday sleep-wake schedules seem to be more important for better academic performance. Therefore, when considering the influences on academic performance, regularity of sleep seem to be more important than quantity of sleep in high schoolers.

Nearly all functional magnetic resonance imaging (fMRI) studies are conducted in the supine body posture, which has been discussed as a potential confounder of such examinations. The literature suggests that cognitive functions, such as problem solving or perception, differ between supine and upright postures. However, the effect of posture on many cognitive functions is still unknown. Therefore, the aim of the present study was to investigate the effects of body posture (supine vs. sitting) on one of the most frequently used paradigms in the cognitive sciences: the N-back working memory paradigm. Twenty-two subjects were investigated in a randomized within-subject design. Subjects performed the N-back task on two consecutive days in either the supine or the upright posture. Subjective sleep quality and chronic stress were recorded as covariates. Furthermore, changes in mood dimensions and heart rate variability (HRV) were assessed during the experiment. Results indicate that the quality of sleep strongly affects reaction times when subjects performed a working memory task in a supine posture. These effects, however, could not be observed in the sitting position. The findings can be explained by HRV parameters that indicated differences in autonomic regulation in the upright vs. the supine posture. The finding is of particular relevance for fMRI group comparisons when group differences in sleep quality cannot be ruled out.

L’objectif général de la thèse était d’élargir les connaissances scientifiques sur le sommeil des enfants. La thèse est composée de quatre articles empiriques. Le premier visait à estimer la validité de l’actigraphie comme mesure de sommeil chez les enfants d’âge préscolaire en la comparant à la polysomnographie, et à examiner si son emplacement influence sa validité. 12 enfants âgés de 2 à 5 ans ont porté simultanément un actigraphe à la cheville et un au poignet pendant une nuit d’enregistrement polysomnographique. Les résultats démontrent que l’actigraphie permet une bonne détection du sommeil, mais qu’elle détecte moins bien l’éveil. Cet article suggère également que les jeunes enfants nécessitent un algorithme adapté à leur niveau d’activité nocturne. Enfin, la validité de l'actigraphie semble similaire pour le poignet et la cheville. Le deuxième article visait à comparer trois mesures de sommeil souvent utilisées avec de jeunes enfants, soit les agendas de sommeil, l’échelle des problèmes de sommeil du Child Behavior Checklist (CBCL) et l’actigraphie, afin de déterminer leurs similarités et leurs divergences quant aux variables de sommeil qui en sont dérivées. 80 familles ont participé à cette étude lorsque les enfants étaient âgés de 2 ans. Les enfants ont porté un actigraphe durant 72 heures consécutives et les mères ont complété un agenda de sommeil durant cette même période. Les deux parents ont aussi rempli le CBCL. Les résultats démontrent que ces mesures de sommeil évaluent des aspects différents du sommeil de l’enfant, et suggèrent une concordance particulièrement faible entre les mesures subjectives et objectives. Le troisième article visait à évaluer l’apport unique de la sécurité d’attachement dans la prédiction du sommeil de l’enfant. 62 dyades mère-enfant ont été rencontrées à deux reprises. La sécurité d’attachement et la dépendance ont été évaluées par observation à l’aide du Q-Sort d’attachement lorsque l’enfant avait 15 mois. À l’âge de 2 ans, les enfants ont porté un actigraphe durant 3 jours consécutifs. Les résultats indiquent que la sécurité d'attachement a une contribution unique à la prédiction de la durée du sommeil nocturne et de l'efficacité du sommeil nocturne. Ainsi, cette étude suggère que plus les enfants ont un attachement sécurisant envers leur mère, plus grandes sont la durée et la qualité de leur sommeil quelques mois plus tard. Le quatrième article visait à examiner la relation entre le sommeil et les comportements extériorisés. 64 familles ont participé à cette étude. À l’âge de 2 ans, les enfants ont porté un actigraphe durant 72 heures consécutives et les parents ont complété le CBCL. Lorsque les enfants étaient âgés de 4 ans, les parents ainsi que l’éducateur(trice) de garderie ont rempli le CBCL. Les résultats démontrent que le sommeil de l’enfant est associé aux comportements extériorisés concomitants et à l’augmentation de ceux-ci à travers le temps. Par ailleurs, les relations entre la qualité de sommeil et les comportements extériorisés étaient modérées par le sexe de l’enfant, c’est-à-dire significatives seulement chez les garçons. Les résultats des quatre articles sont finalement intégrés dans la discussion générale. / The overall objective of the thesis was to contribute to the expansion of the current state of knowledge on young children’s sleep. The thesis consists of four empirical articles. The first article compared the validity of three algorithms for detecting sleep with actigraphy by comparing them to polysomnography in preschoolers. The putative influence of device location (wrist or ankle) was also examined. 12 children aged 2 to 5 years simultaneously wore an actigraph on an ankle and a wrist during a night of polysomnography recording at home. The results showed that actigraphy generally provides good detection of sleep, but weaker detection of wakefulness. The article also suggests that young children require an algorithm adapted to their level of nocturnal motor activity. Finally, sleep variables derived from the ankle and wrist were not statistically different, suggesting that the validity of the actigraphy is not influenced by the location of the monitor. The second article examined associations between actigraphy, maternal sleep diaries, and the parent-completed Child Behavior Checklist (CBCL) sleep items, which are instruments widely used by clinicians and researchers to assess sleep among young children. 80 middle-class families participated in this study when children were aged 2 years. Children wore an actigraph monitor for a 72-hour period and mothers completed a sleep diary during the same period. Both parents also completed the CBCL. The results show that these sleep measures assess different aspects of children’s sleep, and suggest a particularly low concordance between the subjective and objective sleep measures. The third article used objective measures of sleep and attachment to assess the longitudinal links between mother-child attachment security and subsequent sleep, while partialling out child dependency. 62 middle-class families were met twice. Security and dependency of attachment were assessed with the observer version of the Attachment Q-Sort when the child was 15 months. At the age of 2 years, children wore an actigraph monitor for a 72-hour period. Results indicated that children more securely attached to their mothers had higher nighttime sleep duration and efficiency, and these predictions were not confounded by child dependency. The aim of the fourth article was to investigate the concurrent and longitudinal relations between sleep and externalizing symptoms among young children. Sixty-four families were met twice. At the age of 2 years, children wore an actigraph monitor for a 72- hour period and both mothers and fathers completed the CBCL. When children were aged 4 years, both parents as well as the daycare educator filled the CBCL. The results show that child sleep is associated with concurrent externalizing symptoms and with an increase in externalizing symptoms over time. Associations between sleep efficiency and externalizing symptoms were moderated by child sex, such that links were only significant among boys. Finally, the results of the four articles are integrated into the general discussion.

Aims: The overall aim was to determine how lower urinary tract symptoms (LUTS) suggestive of benign prostatic obstruction (BPO) affect sleep, health related quality of life and disease specific quality of life, and how the men’s urinary symptoms affect their partners. Subjects and methods: In papers I–II, a descriptive design with a pre-test and post-test was used and in papers III-IV the design was descriptive and comparative. The method was self-administered questionnaires. In papers I- II: The questionnaires were translated in the ethnographic mode. In paper I the reliability of the questionnaire was tested in 122 patients with LUTS/ BPO. The disease specific quality of life was studied before and after intervention in 572 consecutive patients with BPO, aged 45-94 yrs. In paper II, the partner specific quality of life was studied in partners to men with BPO before and after TURP. The reliability and the responsiveness of the questionnaire were tested in two groups with 51 partners each. Papers III-IV: A study of 239 men with LUTS, aged 45-80 yrs, and their partners (n=126) who were compared to randomly selected men from the population (n=213) and their partners (n=131). The men had an extra control group, men with inguinal hernia (n=200). Sleep and health related quality of life was studied in both men and their partners. The partners’ specific quality of life was also studied and the men with LUTS answered questions about urinary symptoms and disease specific quality of life. Results: Papers I-II: All the tested questionnaires showed an acceptable reliability and responsiveness. I: Before and after intervention the prevalence of urinary incontinence was 46 % and 16 % respectively. II: Partners were affected by the patients’ BPO symptoms before and improved after the patients TURPs. III: Most sleep variables were significantly impaired in men with LUTS compared to one or both of the control groups. The men with LUTS had a significantly higher prevalence of insomnia (40 %) than both control groups and significantly lower sleep efficiency (49 %) than men with hernia. The men with LUTS were significantly impaired in most domains of the health related quality of life compared to men in the population. IV: There were no significant differences between the two partner groups regarding the quantity and quality of sleep or the health related quality of life. Conclusions: All tested questionnaires showed an acceptable reliability and responsiveness. The prevalence of urinary incontinence before and after intervention was higher than earlier reported. Men with LUTS had significantly poorer sleep quality, reduced sleep efficiency and a higher prevalence of insomnia than men in the population and men with inguinal hernia. The HRQOL is impaired in men with LUTS compared to men in the population and men with inguinal hernia. Partners are affected by the patients’ symptoms, and it is emotional rather than practical aspects that affect them most. Partners of men with LUTS did not differ significantly from partners in the population with regard to sleep and health related quality of life.

Nearly all functional magnetic resonance imaging (fMRI) studies are conducted in the supine body posture, which has been discussed as a potential confounder of such examinations. The literature suggests that cognitive functions, such as problem solving or perception, differ between supine and upright postures. However, the effect of posture on many cognitive functions is still unknown. Therefore, the aim of the present study was to investigate the effects of body posture (supine vs. sitting) on one of the most frequently used paradigms in the cognitive sciences: the N-back working memory paradigm. Twenty-two subjects were investigated in a randomized within-subject design. Subjects performed the N-back task on two consecutive days in either the supine or the upright posture. Subjective sleep quality and chronic stress were recorded as covariates. Furthermore, changes in mood dimensions and heart rate variability (HRV) were assessed during the experiment. Results indicate that the quality of sleep strongly affects reaction times when subjects performed a working memory task in a supine posture. These effects, however, could not be observed in the sitting position. The findings can be explained by HRV parameters that indicated differences in autonomic regulation in the upright vs. the supine posture. The finding is of particular relevance for fMRI group comparisons when group differences in sleep quality cannot be ruled out.

No description available.

No description available.

Well-being is associated with comfort and health, and it represents wellness and quality of life. Sleep quality is an important index when evaluating a person’s well-being. KTH Live-in-lab performs Human-building interaction studies to explore the growing potential of how built environments, measured by Schneider Electric (SE), can influence humans and their well-being in their everyday lives. This thesis works as an explorative study of using the OURA ring to evaluate sleep quality for tenants living in KTH LiL. Specifically, this project aims to assess the quality of the data collected from the ring and SE sensors by using Total Data Quality Management (TDQM) and propose a Multilayer perceptron (MLP) model for predicting sleep scores. Results first showed that the OURA ring is an appropriate tool for evaluating sleep quality. Its data passed 11 TDQM’s dimensions, including accuracy, objectivity, relevancy, interpretability and understandability. Second, the OURA was able to capture the relationship between sleep quality and building’s temperature and humidity through its sleep scores. Results showed that higher sleep scores situated more around the suggested ideal ranges of temperature and humidity. However, some low sleep scores were also situated around these ideal ranges which suggests that an additional study needs to be conducted. Such a study would take in tenants’ feedback in order to distinguish sleep scores heavily affected by psychological and/or other factors rather than built environments. Third, we were able to create an MLP model to predict sleep scores based on temperature and humidity values as well as user-related information, like activity rate and total burn. The model had validation and training losses converging at 1.90-2.50. Those low loss rates suggest that the building's temperature and humidity along with information about tenants from the ring can be used to improve the sleep scores. This model can be extended into a recommendation model where buildings’ operators and tenants can benefit from. Buildings’ operators would get information and recommendations on how to properly administer their buildings to achieve higher well-being for their tenants. Also, tenants would get recommendations on how to increase their sleep scores and, ultimately, their sleep qualities and well-being. / Välbefinnande är förknippat med komfort och hälsa, och det representerar livskvalitet. Sömnkvalitet är ett viktigt index när man utvärderar människors välbefinnande. KTH Live-in-lab utför interaktionsstudier mellan Människor-Byggnader interaktion för att utforska den växande potentialen för hur byggda miljöer, mätt av Schneider Electric (SE), kan påverka människor och deras välbefinnande i vardagslivet. Denna avhandling fungerar som en explorativ studie av att använda OURA-ringen för att utvärdera sömnkvaliteten för hyresgäster som bor i KTH LiL. Specifikt syftar detta projekt till att bedöma kvaliteten på de data som samlats in från ring- och SE-sensorerna genom att använda Total Data Quality Management (TDQM) och föreslå en Multilayer perceptron (MLP) - modell för att förutsäga sömn resultat. Resultaten visade först att OURA-ringen är ett lämpligt verktyg för att utvärdera sömnkvaliteten. Dess data passerade 11 TDQMs dimensioner, inklusive noggrannhet, objektivitet, relevans, tolkbarhet och förståbarhet. För det andra kunde OURA fånga förhållandet mellan sömnkvalitet och byggnadens temperatur och fuktighet genom sina sömnvärden. Resultaten visade att högre sömn värden ligger mer runt de föreslagna ideala temperatur- och luftfuktighet områdena. Några låga sömn resultat låg dock också runt dessa ideala intervall, vilket tyder på att ytterligare en studie måste genomföras. En sådan studie skulle ta hyresgästernas återkoppling för att urskilja sömn poäng som påverkas starkt av psykologiska och / eller andra faktorer förutom de byggda miljöer. För det tredje kunde vi skapa en MLP-modell för att förutsäga sömn värden baserat på temperatur- och luftfuktighets värden samt använda relaterad information, som aktivitetsgrad och totalt bränn. Modellen hade validering och näringsförluster som konvergerade vid 1,90-2,50. Dessa låga förlust nivåer antyder att byggnadens temperatur och luftfuktighet tillsammans med information om hyresgäster från ringen kan användas för att förbättra sömn värdena. Denna modell kan utvidgas till en rekommendation modell där byggnadens operatörer och hyresgäster kan dra nytta av. Byggnadens operatörer skulle få information och rekommendationer om hur de ska förvalta sina byggnader på rätt sätt för att uppnå högre välbefinnande för sina hyresgäster. Hyresgästerna skulle också få rekommendationer om hur man ökar sina sömn värden och i slutändan deras sömnkvaliteten och välbefinnande.

No description available.