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Elevers intresse för skolämnet kemi sjunker mellan mellanstadiet och högstadiet. En pedagogisk arbetsform som kan verka motivationshöjande för elever är att utgå från samhällsfrågor med naturvetenskapligt innehåll [SNI] i undervisningen. Syftet med studien är därför att undersöka hur fall av SNI skrivs fram i läroböcker för kemi riktade till mellanstadiet och högstadiet. Lärobokstexterna analyseras utifrån en tematisk innehållsanalys för att se hur SNI skiljer sig mellan de olika stadierna, samt formas av innehållet. Resultaten visar att båda läroböckerna lyfter flera samhällsfrågor med naturvetenskapligt innehåll i form av intressekonflikter om samhällets användning av naturresurser. Dock ser vi att det saknas ekonomiska och politiska perspektiv i boken för mellanstadiet vilket hindrar etiska och ekonomiska diskussioner. Det leder till att det är otydligt vem som egentligen bär eller bör bära ansvar i dessa frågor, och eftersom texterna presenterar olika vanor som enskilda individer kan förändra uppfattas ansvaret ligga på dem. Däremot inkluderas ekonomiska och etiska perspektiv i högre grad i boken för högstadiet. I båda böckerna introduceras frågorna efter ämnesinnehållet, vilket går emot principen för SNI-baserat arbetssätt eftersom det är samhällsfrågan som ska styra kunskapsinhämtningen. Likaså överensstämmer inte de frågor som efterfrågar ett rätt svar med principerna för SNI. Men det finns också exempel på flertalet frågor där eleverna tränas i kritiskt tänkande, vilket är i enlighet med SNI-baserat arbetssätt. Undersökningen bidrar till att lyfta diskussioner kring kritisk granskning av läromedel och de synsätt som läroböcker ger uttryck för.

“All countries are vulnerable to climate change and instability in weather patterns but the poorest countries and the poorest people within them are most vulnerable, being the most exposed and having the least means to adapt” (IMF and World Bank Development Committee, 2006). African cities, as other cities around the world, are prone to flooding within in urban areas. The increased flooding from climate change, could have seriously destabilising effects for Africa (Commission for Africa, 2005). Climate records shows that most of Africa warmed by approximately 0.7°C during the twentieth century (IPCC Working Group II, 2001). Future changes in rainfall will depend greatly on the influence of global warming. In addition, a United Nations World Water Report states that in the beginning of the twenty-first century, the Earth with its diverse and abundant life forms (including over six billion humans), is facing a serious water crisis. Water needs to be conserved in any way possible. (United Nations World Water Report, n.d.). This study aims to explore the role in which floodingin urban landscapes can be addressed, but simultaneously stored for future use. It argues that the negative element of flooding can rather be used, i.e the water could be conserved and used in the build environment, rather than inhibiting social, economic and ecological factors. The pilot project in this stage can at the same time, serve as an urban generator. An innovative solution (urban water park) is analysed and tested and serves as a possible outcome to address flooding problems within an African city (Maputo, Mozambique). Afrika, 2005). / Stede in Afrika, soos in ander in die wêreld, is onderhewe aan vloedrampe in stedelike areas. Die toenemende vloedegevalle, tesame met die impak van klimaatsverandering, kan uiterse destabilisering vir die Afrika kontinent inhou (Kommissie vir Afrika, 2005). ‘n Klimaatsrekord, bewys dat gedurende die twintigste eeu, ‘n groot deel van Afrika onderworpe was aan ‘n hittetoename van omtrent 0.7°C (IPPC Werksgroep II, 2011). Toekomstige veranderinge in reënval sal grootliks afhang van die invloed van aardsverwarming. Ter aanvoering van die argument word daar adisioneel toegevoeg dat die Verenigde Nasies se Wêreldswater Verslag die volgende aanlas: dat die aarde, met sy diverse en verskeidenheid van lewende wesens (wat oor die ses miljioen mense insluit), aan die begin van die een-en-twintigste eeu onderworpe sal wees aan ernstige watertekorte. Water moet dus in alle moontlike maniere gespaar word (Verenigde Nasies se Wêreldswater Verslag, geen datum). Die studie beoog om die rol van vloede in die verstedelike landskap te ondersoek en aan te spreek tot voordeel van die bouomgewing. Die ontwerp poog om die huidige negatiewe element van water eerder te bewaar en die gebruik daarvan te aan te moedig. Hierdeur word word die omswaai in sosiale, ekonomiese en ekologiese faktore inplekgestel. ‘n Projek sal dan terselfdertyd as verstedelike genereerder dien. ‘n Innoverende oplossing, ‘n stedelike water park, is geondersoek en getoets. Hierdie sal moontlik as die oplossing dien van die huidige vloedprobleme in hierdie Afrika stad (Maputo, Mosambiek). / Dissertation (ML(Prof))--University of Pretoria, 2011. / Architecture / unrestricted

À l’heure où l’intégration des enjeux environnementaux dans le développement de procédés éco-efficients joue un rôle essentiel dans le moteur de l’innovation responsable, la chimie verte est devenue l’un des sujets de préoccupation majeure. Ainsi, le développement de nouveaux procédés éco-respectueux pour la production d’ingrédients naturels issus de matières premières végétales renouvelables est devenu une démarche incontournable dans le modèle de recherche. L’objectif de cette thèse a consisté au développement d’une stratégie d’éco-valorisation innovante employant les fluides sub/supercritiques pour l’extraction, la caractérisation, la production et l’imprégnation sur support cosmétique de produits naturels d’origine végétale. Pour cela, nous avons utilisé comme modèle végétal : les graines oléagineuses de la plante Kniphofia uvaria, sélectionnée pour des applications cosmétiques grâce à ses propriétés bioactives antioxydantes et anti-âge. Dans un premier temps, le développement de méthodes complémentaires en SFC ainsi que le développement du couplage SFC-MS a été réalisé à l’aide de la source APCI afin d’identifier les molécules responsables des activités bioactives des graines de Kniphofia uvaria. Ainsi, le développement d’un système hybride (U)HPLC/SFC-HRMS a été réalisé afin de mettre en place ce couplage. Des optimisations en termes de proportion et nature de solvant make-up ainsi qu’un travail au niveau des paramètres SFC et MS ont été faits afin de d’améliorer la sensibilité et la spécificité des analyses lipidiques. Dans un second temps, nous nous sommes attachés au développement d’une stratégie d’enrichissement en composés bioactifs à l’aide des méthodes : SFE et CPC. Ainsi, en SFE, des optimisations en termes de température, pression, nature/proportions de co-solvant dans le fluide ont été réalisées alors qu’en CPC, des optimisations au niveau de l’injection ont été faites. Des conditions optimales pour le fractionnement sélectif des anthraquinones et des triglycérides ont été déterminées en SFE et CPC. Dans un dernier temps, ce travail a consisté à développer un couplage en-ligne pour extraire et imprégner sélectivement sur silice cosmétique : les anthraquinones. Le développement et l’optimisation de ce procédé en-ligne ont été réalisés à l’échelle du laboratoire et ont démontré la faisabilité de ce couplage ainsi qu’un intérêt certain pour l’obtention de produits naturels sous une première forme galénique, destinée à une future incorporation dans la formulation de cosmétiques. / Nowadays, green chemistry is a great challenge. It seeks innovation in the development of eco-efficient processes. The production of natural products from renewable materials by these new environmentally friendly processes is more and more used. The aim of this Ph.D thesis is to develop an eco-valuation strategy to extract, characterize, produce and impregnate natural products onto a cosmetic support using sub/supercritical fluids. Consequently, we used oleaginous plant seeds from Kniphofia uvaria as a plant model, which was selected for its interesting cosmetic properties such as antioxidant or anti-ageing. Firstly, the SFC-MS hyphenation with the APCI as an ionization source was developed to screen bioactive molecules; responsible of cosmetic properties. This coupling was performed by the hybrid combination of (U)HPLC/SFC-HRMS. Various optimizations in terms of the solvent make-up (nature and proportion), modulation with SFC and MS parameters were carried out in order to improve sensitivity and selectivity of lipid analysis. Secondly, an enrichment strategy to concentrate bioactive compounds in the final extract was developed by SFE and CPC. Thus, in SFE, experimental parameters (temperature, pressure, nature/proportion of the modifier in the CO2 fluid) were optimized while in CPC, the injection optimization was realized. Methods for the selective fractionation of anthraquinones and triglycerides were obtained in CPC and SFE. Finally, an on-line sub/supercritical extraction-impregnation process was developed to extract and for simultaneously impregnating anthraquinones onto a cosmetic silica. Development and optimization of this process was realized on a laboratory scale. Consequently, this study demonstrated the feasibility of this concept and it presents a great interest to provide natural products as a galenic form, which could be used in the cosmetic formulation.

The electronic identification regulation, eIDAS, and its trusted service providers are currently based on technologies that have been used for decades. The eIDAS and many others in the security industry have shown interest in newer technologies such as distributed ledgers and blockchain. This research looks into the current eIDAS regulation, its plans for future work, and how the current trusted systems could benefit from introducing blockchain into the solutions. Looking at new technologies is of importance to move forward but also making solutions more secure for the user with for example Self-Sovereign Identity solutions. The research was conducted through a literature review followed by interviews. A number of themes were identified to answer the research question. The findings were that blockchain is a viable technology to use but only if used in the right cases. A better understanding and knowledge of the technology is needed for new implementation to succeed and should not be rushed due to the hype of blockchain technology. / Se bif. fil

Bakgrund: Postoperativa sårinfektioner orsakar lidande för den drabbade patienten och kostnader för patienten, vården och samhället. Intraoperativ kontamination av operationsinstrumenten är en av källorna till dessa infektioner. Operationssjuksköterskan är ansvarig för aseptiken och operationsinstrumenten.   Syfte: Syftet med denna pilotstudie var att mäta graden av bakteriell kontamination över tid på operationsinstrument som används vid öppen neurokirurgi samt observera utvalda källor till kontamination under samma tid. Metod: Denna studie designades som en kvantitativ icke-experimentell observationsstudie. Datainsamlingen skedde under hösten 2015 och bestod av omhändertagandet av specifika instrument som använts av operatören under operationen efter förutbestämd åtgången knivtid. Bakterieodlingar på dessa instrument skedde sedan på laboratorium enligt en förutbestämd metod och graden av kontamination mättes genom observation av mängden colony forming units (CFU). Resultaten presenteras i form av förändringar av mängden CFU. Resultat: Fem operationer observerades och tio odlingar utfördes på tio instrument. Totalt tio CFU registrerades under samtliga observationer. Ingen signifikant ökning av antal CFU kunde observeras från en till två timmars knivtid (P=0,156). Antal dörröppningar ökade från 3,4 till 9,0 och antal personer på operationssalen ökade från 5,4 till 5,8. Slutsats: Trots det ringa antal observationer som ingick i denna studie tyder resultaten på god aseptik och minimal bakteriell kontamination på operationsinstrumenten under operationens två första timmar. Ytterligare forskning med längre observationer, fler observationer och observationer kring annan typ av kirurgi behövs. / Background: Post-operative surgical site infections (SSI) cause suffering for the afflicted patient and is a great cost for the patient, the health care system and society. Intra-operative contamination of surgical instruments is one of the sources of these infections. The operating room nurse is responsible for preventing infections. Purpose: The purpose of this pilot-study was to measure the degree of bacterial contamination over time on surgical instruments used in open neurosurgery as well as to observe specific sources of contamination during this time. Method: The design was a quantitative nonexperimental observational study. The data collection took place during autumn 2015 and consisted of the sampling of specific instruments used by the surgeon during surgery after preset elapsed operating times. Bacterial culturing on these instruments was then carried out at a laboratory according to a preset routine and the degree of contamination was measured by observing the amount of colony forming units (CFU). The results are presented as changes in CFU. Results: Five operations were observed and ten bacterial culturings were conducted on ten instruments. A total of ten CFU was registered during all observations. No significant increase in the number of CFU could be observed from one to two hours of elapsed surgery (P=0,156). The amount of door openings increased from 3,4 to 9,0 and the number of personnel in the operating room increased from 5,4 to 5,8. Conclusion: Despite the small number of observations included in this study the results indicate good aseptics and minimal bacterial contamination on the surgical instruments during the first two hours of surgery. Further research with longer observations, more observations and observations on other forms of surgery is needed.

基於生存權的保障，國家應提供人民生活扶助與醫療救助等給付。全民健保施行後，大法官釋字四七二號揭示對於無力繳納保費者，國家應予適當救助，不得逕行拒絕給付。遂開啟一連串對經濟弱勢者的保費協助措施，輔以相關醫療補助辦法的補助。惟我國領有醫療補助的人口比例甚低。 以美國醫療救助為例，自一九六五年建立Medicaid制度後，發展自今已有超過百分之十五的人口領有醫療救助，其制度強調實質醫療需求的內涵。在美國採開放式醫療市場的情況下，Medicaid對於貧者所提供的醫療服務更形重要。 相對於我國縣（市）醫療補助辦法對於社會救助法規定之過度限縮，是否有違母法，深值檢討。此外，我國亦應放寬對收入戶的認定，並修正醫療補助的資格與內容，以提供更多實質醫療需求者的醫療保障。

Cette thèse a pour objectif de répondre à la question suivante : Quel est le niveau de prise en compte de la Sécurité des Systèmes d’Information (SSI) par les collectivités territoriales françaises face aux risques numériques ? Ces dernières étant aujourd’hui confrontées à de nouveaux défis qui nécessitent un recours toujours plus important aux nouvelles technologies (administration électronique, e-démocratie, dématérialisation des appels d’offre…), le management de la sécurité des Systèmes d’Information (SI) territoriaux devient un enjeu majeur -bien qu’encore peu étudié- en matière de service public et de protection des données à caractère personnel. Etablie au travers de postures professionnelles successives et dans le cadre d’une approche naturaliste de la décision, notre modélisation théorique tend à mesurer le niveau réel de prise en compte du risque numérique en partant d’hypothèses fondées sur l’influence respective d’un ensemble de caractéristiques propres aux collectivités territoriales. Il se traduit par une enquête de terrain menée directement auprès de responsables territoriaux. Alors que cet enjeu nécessite une prise de conscience, par les décideurs locaux, de la nécessité de protéger les données qui leur sont confiés, il s’avère que ceux-ci n’ont, au mieux, qu’une connaissance très imparfaite des enjeux et des risques inhérents à la sécurisation d’un SI ainsi que de l’ensemble des menaces, directes ou indirectes, susceptibles de compromettre leur bonne utilisation. Une solution potentielle pourrait résider, simultanément à de la mise en place de procédures adaptées à l’échelon de chaque collectivité, par la définition d’une politique publique spécifique. / This doctoral thesis aims at answering a key question: what is the level of consideration given to Information Systems Security (ISS) by the French local authorities (LAs)? The latter are now facing new challenges that require an ever-increasing use of new technologies (e-government, e-democracy, dematerialization of call for tenders...). The under-researched territorial IT risk becomes a major issue in the sphere of public services and the protection of personal data. Theoretically based and constructed through successive professional positions, our theoretical model helps measure the actual level of inclusion of digital risk taking into account the respective influence of a set of characteristics of local authorities. A field survey was conducted with the close collaboration of representatives of LAs.While numerical risk requires a high level awareness by LA decision makers, it appears that they have a very imperfect knowledge of IT security related risks as well as of direct or indirect threats that may jeopardize their management systems. A potential solution lies with the definition of a specific public policy and with the implementation of appropriate procedures at the level of each community.

Cette thèse s'inscrit dans le cadre des systèmes radiocommunications numériques pour des récepteurs mobiles basés sur la modulation multi-porteuse OFDM. L'objectif est de proposer des algorithmes d'estimation de canal et de suppression d'IEP pour les <br />récepteurs OFDM à grande mobilité en liaison descendante. Notre démarche est d'estimer les paramètres de propagation du canal physique tels que les retards et les variations temporelles des gains complexes du canal à trajet multiples, au lieu du canal discret équivalent. Nous avons développé une approximation à base de polynôme pour l'évolution des gains complexes d'un canal multi-trajet de type Rayleigh avec un spectre de Jakes. En se basant sur cette modélisation polynomiale, nous avons présenté une étude théorique sur les Bornes de Cramér-Rao Bayésiennes (BCRBs) pour l'estimation des gains complexes du canal, en supposant les délais des trajets connus. Enfin, nous avons développé et analysé trois algorithmes itératifs d'estimation des variations temporelles des gains complexes (à l'intérieur d'un symbole OFDM) et de suppression d'IEP pour des récepteurs à grande mobilité. Les deux premiers sont basés sur l'interpolation (passe-bas ou polynomiale) des valeurs moyennes estimées et sur un égaliseur SSI. Ils ont montré de bonnes performances pour des récepteurs à vitesses modérées (i.e., fd.T <= 0.1). Le troisième algorithme est basé sur une modélisation AR et un filtre de Kalman pour estimer les coefficients polynomiaux des gains complexes, et sur un égaliseur QR. Il a fait preuve de bonnes performances pour des récepteurs à vitesses très élevées (i.e. , fd.T> 0.1).

The advances in computational and experimental modeling in the area of structural mechanics have stimulated research in a class of hybrid problems that require both of these modeling capabilities to be combined to achieve certain objectives. Real-time substructure (RTS) testing, structural system identification (SSI) and active control techniques fall in the category of hybrid problems that need efficient tools in both computational and experimental phases for their successful implementation. RTS is a hybrid testing method, which aims to overcome the scaling problems associated with the conventional dynamic testing methods (such as shake table test, effective force test and pseudo dynamic test) by testing the critical part of the structure experimentally with minimum compromise on spatio-temporal scaling, while modeling the remaining part numerically. The problem of SSI constitutes an important component within the broader framework of problems of structural health monitoring where, based on the in-situ measurements on the loading and a subset of critical responses of the structure, the system parameters are estimated with a view to detecting damage/degradation. Active control techniques are employed to maintain the functionality of important structures, especially under extreme dynamic loading. The work reported in the present thesis contributes to the areas of RTS, SSI and active control of nonlinear systems, the main focus being the computational aspects, i.e., in developing numerical strategies to address some of the unsolved issues, although limited efforts have also been made to undertake laboratory experimental investigations in the area of nonlinear SSI. The thesis is organized into seven chapters and five appendices. The first chapter contains an overview of the state of the art techniques in dynamic testing, SSI and structural control. The topics covered include effective force test, pseudo dynamic test, RTS test, time and frequency domain methods of nonlinear system identification, dynamic state estimation techniques with emphasis on particle filters, Rao-Blackwellization, structural control methods, control algorithms and active control of nonlinear systems. The review identifies a set of open problems that are subsequently addressed, to an extent, in the thesis. Chapter 2 focuses on the development of a time domain coupling technique, involving combined computational and experimental modeling, for vibration analysis of structures built-up of linear/nonlinear substructures. The numerical and experimental substructures are allowed to interact in real-time. The equation of motion of the numerical substructure is integrated using a step-by-step procedure that is formulated in the state space. For systems with nonlinear substructures, a multi-step transversal linearization method is used to integrate the equations of motion; and, a multi-step extrapolation scheme, based on the reproducing kernel particle method, is employed to handle the time delays that arise while accounting for the interaction between the substructures. Numerical illustrations on a few low dimensional vibrating structures are presented and these examples are fashioned after problems of seismic qualification testing of engineering structures using RTS testing techniques. The concept of substructuring is extended in Chapter 3 for implementing Rao-Blackwellization, a technique of combining particle filters with analytical computation through Kalman filters, for state and parameter estimations of a class of nonlinear dynamical systems with additive Gaussian process/observation noises. The strategy is based on decomposing the system to be estimated into mutually coupled linear and nonlinear substructures and then putting in place a rational framework to account for coupling between the substructures. While particle filters are applied to the nonlinear substructures, estimation of linear substructures proceeds using a bank of Kalman filters. Numerical illustrations for state/parameter estimations of a few linear and nonlinear oscillators with noise in both the process and measurements are provided to demonstrate the potential of the Rao-Blackwellized particle filter (RBPF) with substructuring. In Chapter 4, the concept of Rao-Blackwellization is extended to handle more general nonlinear systems, using two different schemes of linearization. A semi-analytical filter and a conditionally linearized filter, within the framework of Monte Carlo simulations, are proposed for state and parameter estimations of nonlinear dynamical systems with additively Gaussian process/observation noises. The first filter uses a local linearization of the nonlinear drift fields in the process/observation equations based on explicit Ito-Taylor expansions to transform the given nonlinear system into a family of locally linearized systems. Using the most recent observation, conditionally Gaussian posterior density functions of the linearized systems are analytically obtained through the Kalman filter. In the second filter, the marginalized posterior distribution of an appropriately chosen subset of the state vector is obtained using a particle filter. Samples of these marginalized states are then used to construct a family of conditionally linearized system of equations to obtain the posterior distribution of the states using a bank of Kalman filters. The potential of the proposed filters in state/parameter estimations is demonstrated through numerical illustrations on a few nonlinear oscillators. The problem of active control of nonlinear structural dynamical systems, in the presence of both process and measurement noises, is considered in Chapter 5. The focus of the study is on the exploitability of particle filters for state estimation in feedback control algorithms for nonlinear structures, when a limited number of noisy output measurements are available. The control design is done using the state dependent Riccati equation (SDRE) method. The Bayesian bootstrap filter and another based on sequential importance sampling are employed for state estimation. Numerical illustrations are provided for a few typically nonlinear oscillators of interest in structural engineering. The experimental validation of the RBPF using substructuring (developed in Chapter 3) and the conditionally linearized Monte Carlo filter (developed in Chapter 4), for parameter estimation, is reported in Chapter 6. Measured data available through laboratory experiments on simple building frame models subjected to harmonic base motions is processed using the proposed algorithms to identify the unknown parameters of the model. A brief summary of the contributions made in this thesis, together with a few suggestions for future research, are presented in Chapter 7. Appendix A provides an account of the multi-step transversal linearization method. The derivation of the reproducing kernel shape functions are presented in Appendix B. Appendix C provides the details of the stochastic Taylor expansion and derivation of the covariance structure of Gaussian MSI-s. The performance of a particle filtering algorithm (bootstrap filter) and Kalman filter in the state estimation of a linear system is provided in Appendix D and Appendix E contains the theoretical details of the Rao-Blackwellized particle filter.