PurposeThe purpose of this pilot study was to explore nutritional injury in the context of oral mucositis (OM). It was a beginning look at oral L-glutamine (L-Gln) treatment efficacy through investigation of three "Reaction-to-Nutritional Injury" hypotheses defining OM as a localized secondary nutritional disorder of deficiency (Van Itallie, 1977) resulting from absence of/limited nutritional collateral systems (Kight, 1994):(1) OM severity and human buccal epithelial cell glutamine synthetase (HBEC GS) abundance,(2) HBEC GS abundance and L-Gln treatment, and(3) OM severity and L-Gln treatment.Patients and MethodsThree female colorectal cancer (CRC) outpatients between 61 and 70 years of age receiving FOLFIRI chemotherapy regimen and diagnosed with grades 1 and 2 OM were followed daily throughout treatment cycles and randomly assigned into a two-week mouthwash regimen of 1.0 gm/m2 qid L-Gln or placebo. Treatment crossover occurred every two weeks without defined washout periods. Four controls were recruited as controls for single Western blot (WB) analyses.ResultsOral L-Gln effect on OM severity was statistically significant in all three study participants, although two of the relationships had positive direction. Treatment and OM severity were moderately correlated with a negative direction in one patient. Glutamine appeared to be most efficacious in severe grade 2 OM erythema. Western blot analysis demonstrated absence of HBEC GS activity in cancer patients receiving FOLFIRI treatment for colorectal cancer suggesting competitive inhibition of GS enzyme by chemotherapy. Higher WB bands observed at 55 and 66 kDa may be O-linked glycosylation posttranslational modifications, a possible explanation for the Gln-influenced mechanism of Hsp70 biosynthesis and apoptosis prevention. This may be suggestive of compression of the nutritional injury clinical horizon from stage 4 to stage 1 or 2 where adaptation to absence of/limited nutritional collateral systems theoretically begins after chemotherapy insult. An extended definition of nutritional injury may be the acquired loss of nutritional status at the biomolecular level by way of drug-induced disruption of normal, adaptive metabolic pathways resulting in absence of/limited HBEC GS abundance affecting Gln and Hsp70 availability. This may suggest the need for preemptive L-Gln treatment prior to initiation of a 5-fluorouracil-based chemotherapy regimen.

Ce travail se construit autour du mystère qui, comme un " nimbe permanent ", irradie l'œuvre romanesque jouvienne. Il s'appuie surtout sur les apports de la phénoménologie, qui replace le corps au centre de la connaissance, pour tenter de cerner les rapports entre mystère et sens. La première partie s'attache à établir une topologie du mystère. Chez Pierre Jean Jouve en effet, l'espace visible se double d'un invisible au statut ambigu : à la fois de l'ordre d'un sens, immanent au sensible, et d'une présence qui échappe au sens. La deuxième partie analyse les marques stylistiques fondant cette impression de mystère. Comme l'affirme Jean Paul Sartre, toute technique romanesque renvoie à la métaphysique de son romancier. Ainsi les divers procédés d'écriture reflètent-ils le regard particulier de Pierre Jean Jouve sur le monde et l'art de rendre compte d'un " nouveau réel ". La troisième partie se penche sur les diverses références mythiques en tant que voies d'accès au mystère du " continent intérieur " que constitue l'inconscient. Ces images, qui naissent dans le corps, sont issues d'une " structure archaïque " et agissent sur le mode de la révélation : elles offrent une figuration de l'irreprésentable et rendent compte du phénomène de visibilité. Elles nous éclairent sur les structures de l'imaginaire jouvien. Enfin, la quatrième et dernière partie de ce travail s'attache aux liens entre mystère et mystique. La mystique de Pierre Jean Jouve, qui réintègre le corps et les pulsions inconscientes, découle sur un art dans lequel toutes les hauteurs " agglutinées " convergent vers une figuration de l'absence.

This research aims to develop a process for eliciting expert knowledge and incorporating this knowledge as prior distributions for a Bayesian logistic regression model. This work was motivated by the need for less data reliant methods of modelling species habitat distributions. A comprehensive review of the research from both cognitive psychology and the statistical literature provided specific recommendations for the creation of an elicitation scheme. These were incorporated into the design of a Bayesian logistic regression model and accompanying elicitation scheme. This model and scheme were then implemented as interactive, graphical software called ELICITOR created within the BlackBox Component Pascal environment. This software was specifically written to be compatible with existing Bayesian analysis software, winBUGS as an odd-on component. The model, elicitation scheme and software were evaluated through five case studies of various fauna and flora species. For two of these there were sufficient data for a comparison of expert and data-driven models. The case studies confirmed that expert knowledge can be quantified and formally incorporated into a logistic regression model. Finally, they provide a basis for a thorough discussion of the model, scheme and software extensions and lead to recommendations for elicitation research.

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / Several are the transformations that the family has going through, situations that also implied in changes in the performance of parental roles. Whereas motherhood has many of its assumptions well naturalized, the paternity, supposedly, was the one what has most changed into the familiar scenery. In this context, the research from which originates the present dissertation had as the main goal to understand the meanings attributed to paternity by women heads of household in urban periphery. For this, an exploratory qualitative study was performed in a group of ten women, mothers, who constituted a monoparental family and that lived in an urban periphery from a countryside city located in Rio Grande do Sul State, Brazil. The number of participants followed the definition of the saturation criterion. The data collection instruments used were the semi-structured interviews and the focus group, with the data obtained processed by the analysis of thematic content. The results of this research are presented and discussed in three articles that compose this dissertation. Thus, the results of the first article pointed out to the existence of traditional and contemporary conceptions regarding to the structure of the family, as well as the role that the father has within the family. The second article, on the other hand, referred to a discussion about the importance of the pregnancy being part of project shared by the couple, especially by highlighting that many relationships end, even before the birth of the child, a situation which contributes to the difficulty of many fathers in establish their affective position toward these children. The results of the third article showed the existence of a number of crossings situations that pervade the coparental relationship after the couple's separation. Furthermore, it was noticed that the participant´s understanding regarding to the parental roles seem to have been permeated by the belief that the mother is naturally better prepared to take care of the children, while the father was delegated to a peripheral function. The issue which appeared with more emphasis in this study was the coexistence of traditional and modern meanings regarding to the paternity. While the mothers reported that the father is the "foundation" of the house, the head of the family, many of them asserted their wish of a more attentive and affective former partner with their children, showing signs of what is called "contemporary father", in the speech of women heads of households in urban periphery. / Diversas são as transformações pelas quais a família tem passado, o que tem implicado também em mudanças no desempenho dos papéis parentais. Considerando que a maternidade mantém muitos de seus pressupostos naturalizados, pode-se pensar que a paternidade é a que mais tem se modificado no cenário familiar. Partindo deste pressuposto, a pesquisa da qual se origina a presente dissertação teve como objetivo geral compreender os significados atribuídos à paternidade por mulheres chefes de família de periferia urbana. Com este intuito, realizou-se um estudo qualitativo de caráter exploratório com dez mulheres, mães, que compunham uma família monoparental e que residiam em uma periferia urbana do interior do Rio Grande do Sul. O número de participantes respeitou a definição do critério de saturação. Os instrumentos de coleta de dados utilizados foram a entrevista semiestruturada e o grupo focal, tendo sido os dados analisados por meio da análise de conteúdo temática. Os resultados da presente pesquisa são apresentados e discutidos nos três artigos que compõe esta dissertação. Os resultados do primeiro artigo apontaram para a existência de concepções tradicionais e contemporâneas no que tange à configuração familiar e ao papel que o pai possui dentro da família. O segundo artigo, por sua vez, remeteu a uma reflexão a respeito da importância da gestação fazer parte de um projeto compartilhado pelo casal, em especial por se evidenciar que muitos relacionamentos terminam antes mesmo do nascimento da criança, o que acaba contribuindo para que muitos pais tenham dificuldades em se posicionar afetivamente frente a estes filhos. Os resultados do terceiro artigo apontaram para a existência de uma série de atravessamentos que perpassam o relacionamento coparental após a separação do casal. Ademais, foi possível perceber que o entendimento das participantes a respeito dos papéis parentais parecem terem sido permeados pela crença de que a mãe é naturalmente a mais bem preparada para cuidar dos filhos enquanto ao pai foi delegada uma função periférica. A questão que apareceu com mais ênfase neste estudo foi a coexistência de significados tradicionais e modernos no que diz respeito à paternidade. Ao mesmo tempo em que as mães referiram que o pai é o alicerce da casa, o chefe da família, muitas delas asseveraram seu desejo de que o ex-companheiro fosse mais atencioso e afetivo com os filhos, evidenciando indícios do que se denomina de pai contemporâneo no discurso de mulheres chefes de família de periferia urbana.

Made available in DSpace on 2016-08-03T16:34:49Z (GMT). No. of bitstreams: 1 Mariana Campos.pdf: 357625 bytes, checksum: 78f7cb4567b9a080a787cae974a72886 (MD5) Previous issue date: 2010-02-26 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This study aimed at a) investigating the effects of father absence on child development, b) describing the intrapsychic content of children with present parents and children with absent fathers in their homes. Therefore, three cases of school-age children who attended a non-governmental organization in the city of Santos were studied and the tools of semi-structured interviews were utilized with the mothers and The Drawing-Story with Theme with the children. Application was made as follows the participant was asked to design a child and then tell a story about the drawing. Thereafter, the child was asked to draw the father of this child and tell a story about this same design. We decided also to apply the The Raven's Coloured Progressive Matrices with the children. Although each case had its peculiarities, the results showed indications of disturbances of sexual identity, helplessness, insecurity, depressive tendencies, and the association between father absence, cognitive deficit and / or intellectual inhibition. It was also observed in one case, the mother's difficulty in allowing the father to fulfill his role as "father". It was concluded that father absence was perceived by the child not only as the absence of the father in the home, but by its omission: adding to the fact that the internalization of the father figure did not seem determined by the biological connection, but by the possibility of offering the child identification and affection. It would appear from this study that healthy psychological development can be facilitated by the introjection of good mother / father figures for the child. Thus, studies devoted to the theme of fatherhood are as important to be explored today as the ones intended to motherhood through the history of developmental psychology and psychoanalysis.(AU) / O presente estudo teve por objetivos a) investigar as repercussões da ausência paterna sobre o desenvolvimento da criança; b) descrever o conteúdo intrapsíquico de crianças com pais presentes e de crianças com pais ausentes no lar. Para tanto foram estudados três casos de crianças em idade escolar que freqüentavam uma instituição não governamental da cidade de Santos e utilizou-se dos instrumentos entrevista semi-estruturada com as mães e Procedimento de Desenho-Estória com Tema com as crianças. A aplicação foi feita nos seguintes termos, pediu-se ao participante que desenhasse uma criança e, em seguida que contasse uma estória sobre o desenho. Após, foi solicitado à criança que desenhasse o pai dessa criança e que contasse uma estória sobre esse mesmo desenho. Optamos também por aplicar o Teste das Matrizes Coloridas de Raven - Escala Especial com as crianças. Embora cada caso tivesse revelado suas peculiaridades, os resultados mostraram indicativos de distúrbios da identidade sexual, desamparo, insegurança, tendências depressivas, além de associação entre a ausência paterna, déficit cognitivo e/ou inibição intelectual. Foi também observado em um dos casos, dificuldades da mãe em permitir que o pai paternasse . Concluiu-se que a ausência paterna foi percebida pela criança não somente como a falta da pessoa do pai no lar, mas sim por sua omissão; somando-se ao fato de que a internalização da figura paterna não pareceu determinada pelo laço biológico, mas sim pela possibilidade de oferecimento à criança de identificação e afeto. Entendeu-se com esse estudo que o desenvolvimento psíquico saudável pode ser facilitado pela introjeção das boas figuras materno/paternas pela criança. Sendo assim, estudos dedicados ao tema da paternidade são tão importantes de serem explorados na atualidade quanto o foram aqueles destinados à maternidade ao longo da história da psicologia do desenvolvimento e da psicanálise. (AU)

[pt] A pesquisa objetiva refletir sobre as possibilidades de uma pretensa relação entre a revelação divina e a vulnerabilidade humana, propondo, para isso, caminhos para uma hermenêutica da revelação que se compreenda a partir do movimento dialético entre a presença e a ausência. Discute, portanto, se essa revelação diz respeito apenas ao divino e se tal vulnerabilidade é característica apenas do humano. Para tanto, parte-se do pressuposto de que a tradição ocidental, em grande medida, se constrói sobre pressupostos metafísicos que delineiam o horizonte a partir do qual se conceberá a revelação durante a maior parte do tempo. A Modernidade, que se ergue sobre essa lógica metafísica, altamente comprometida com o desnudamento do mundo, verá a revelação apenas como um processo por meio do qual aquilo que estava oculto se manifesta absoluta, plena e substanciamente, ou seja, assumirá a revelação apenas em seu caráter manifestacional, tornando-se, nesse sentido, refratária a qualquer interpretação que se conceba sob o signo do mistério . Verifica-se, portanto, uma inflação da presença e do sentido que se materializa historicamente na cultura ocidental moderna, em geral, e no cristianismo, em particular. O cristianismo sob o influxo dessa saturação se organizará em torno da presença divina, metafisicamente concebida, e a partir de um discurso altamente apologético. Mas, ao longo do percurso aqui proposto constatou-se, também, uma crítica exacerbada ao modo metafísico de se conceber o mundo e o surgimento de uma nova tradição que se insinua cada vez mais pós-metafísica, mediante a qual se considerará o tema aqui proposto. Resgata-se esse horizonte teórico a partir de importantes mudanças históricas ocorridas nos campos da linguagem, da hermenêutica e da pragmática (Linguistic Turn). Essa mudança de paradigmas repercutiu em diversas áreas das ciências humanas, inclusive na própria teologia. Destaca-se aqui a dialética inferida de Martin Heidegger e a hermenêutica kenótica proposta por Gianni Vattimo, importantes pensadores no contexto das mudanças que estabelecerão o pensamento pós-metafísico. Além deles, e na esperança de se consolidar o referencial teórico desta pesquisa, ressaltam-se três teólogos cujas reflexões serão significativamente influenciadas pela crítica ao pensamento metafísico: Karl Rahner, Edward Skillebeekx e Andrés Torres Queiruga. Finalmente, mediante uma hermenêutica da presença-ausência , a pesquisa propõe caminhos para a construção de uma teologia da revelação que se faça a partir da vulnerabilidade humana. Assume, nesse sentido, a recepção enquanto critério hermenêutico-teológico, ao sugerir uma teologia de textos escritos — amparada no pressuposto de que está circunscrita aos limites da linguagem —, bem como uma teologia de textos vivos — consciente de que há experiências humanas que extrapolam esses limites. Em ambos os casos pressupõe-se uma epistemologia frágil , que proporcione lidar com esse caráter abscôndito e manifesto do divino ao modo de um pastoreio . Ou seja, propõe-se que o processo através do qual somos interpelados por esse Deus que se expressa na dialética da presença-ausência, que aqui se nomeia de revelação, seja alvo do cuidado humano. Pastorear o divino; pastorear os meios através dos quais o compreendemos; pastorear o produto final desse processo, que se transforma em teologia; pastorear o próprio pastoreio; enfim, pastorear a revelação — eis aí o desafio proposto pela pesquisa. / [en] This research seeks for possible relations between divine revelation and human vulnerability. To that purpose it proposes ways to a hermeneutics of revelation on the basis of the dialectic movement between presence and absence. It discusses the question whether revelation concerns only the divine and whether vulnerability is only a human characteristic. We assume that Western tradition is based on metaphysical presuppositions that frame the horizon in which revelation will generally be conceived. Since Modern Age builds upon this metaphysical logic, which is highly responsible for the denudation of the world, it sees revelation only as a process through which the hidden becomes totally, substantially and absolutely manifest. It conceives revelation only as manifestation and will, thus, become refractory to every kind of interpretation of revelation as mystery . As a result we can observe an inflation of the presence and the sense which materializes historically in modern Western culture and particularly in Christianity. Under the effect of this saturation , Christianity organizes itself around the metaphysical divine presence and with a highly apologetic discourse. During the course of the research we also detected a harsh critique of this metaphysical way to understand the world as well as the emerging of a new tradition, which tends to be more and more post- metaphysical and which helps us to deal with the research subject. This theoretical horizon emerges from important historical changes that happened in the fields of language, hermeneutics and pragmatics (Linguistic Turn). This change of paradigms echoed in several areas of Humanities, including Theology. We might mention here the inferred dialectic of Martin Heidegger and the kenotic hermeneutics proposed by Gianni Vattimo, two important scholars involved in the changes which will solidify the post-metaphysical thought. With the hope to consolidate the theoretical frame of this research, we should also mention three theologians whose thinking has been influenced by the critique of the metaphysical thought: Karl Rahner, Edward Schillebeeckx and Andrés Torres Queiruga. Finally, by means of a presence-absence hermeneutics , this research points out ways to conceive a theology of revelation that can be done on the basis of human vulnerability. In this sense, it adopts the reception as a hermeneutical-theological criterion, as it proposes a theology of written texts - upon the supposition that it is circumscribed to the limits of language – as well as a theology of living texts – conscious that there are human experiences that go beyond these limits. In both cases, we assume a fragile epistemology which helps us to deal with the hidden and manifest character of the divine in the way of shepherding . So, we propose that the process through which God speaks to us and which finds its expression in the presence-absence dialectic – here called revelation – be the object of human care. Shepherding the divine; shepherding the means through which we understand him; shepherding the final product of this process which ends up in theology; shepherding the act of shepherding itself; in summary, shepherding the revelation – that is the challenge posed by this research.

Le présent travail a pour objectif de disserter sur la garantie constitutionnelle de la motivation des sentences judiciaires, norme qui impose aux juges le devoir de présenter les motifs qui les ont conduits à la décision prise. Se caractérisant comme vrai compte rendu judiciare, la motivation de la sentence a aussi une grande importance comme instrument de réalisation d’autres garanties du procès assurées aux citoyens, ansi que de l’impartialité du juge, de la juste audition des litigants et même de la contradiction. En partent de la notion de la motivation de la sentence et d’une analyse historique, la dissertation analyse le rapport de cette garantie avec les autres principes, garanties et instituts du procès, pour à la fin discuter les conséquences des vices de motivation ou de l’absence de la motivation ellemême. / O presente trabalho tem por objetivo discorrer a respeito da garantia constitucional de motivação da sentença, norma que impõe aos juízes o dever de apresentar os motivos que os conduzem à decisão tomada. Por se caracterizar como verdadeira prestação de contas judicial, a motivação da sentença tem grande relevância também como instrumento de realização de outras garantias processuais asseguradas aos cidadãos, tais como, por exemplo, a de imparcialidade do julgador, a de justa audição dos litigantes e mesmo a do contraditório. Partindo da noção de motivação da sentença e de uma análise histórica, a dissertação enfrenta a relação desta garantia com outros princípios, garantias e institutos processuais, para ao final enfrentar as conseqüências dos vícios de motivação ou de sua ausência.

This study focuses on the way in which learners living with epilepsy, who attend mainstream schools in the rural areas of the Limpopo Province, experience epilepsy. The results of the study indicate that the needs of learners with epilepsy are not well-catered for in mainstream schools. They often experience fear, anxiety, humiliation, ostracisation, name-calling, scape-goating, blaming and suspicion. Recommendations were made regarding the measures which should be taken to address the needs of rural children living with epilepsy. These recommendations could be used by teachers and the Department of Education. / Educational Studies / M.Ed. (Guidance and Councelling)

In today’s working life both the physical and the psychosocial aspects has to be considered when examining the work environment. The psychosocial working environment is of great relevance because it illuminates the individual's perception and experience of relationships and phenomena at work. This essay aims to investigate, describe and analyze the obligation an employer has to pursue in order to tackle high short- term sickness absence and at the same time manage the psychosocial work environment at the workplace. Furthermore, the purpose of this study is to acknowledge the European legislation on this subject matter in order to broaden the understanding of the comprehensiveness of the term psychosocial work environment and how applicable laws and guidelines apply in working life. The legal methodology has been used in order to answer the questions of this essay. The social perspective worked as a complement to the legal method in order to observe new problems and conduct more information in how to confront this issue at small scale enterprises. In conclusion this study deals with a complex situation where every case is unique. It is not possible to prevent all short-term sickness absence, but with the right preconditions and external assistance, employers can handle it without neglecting the psychosocial work environment. By securing a good psychosocial work environment even the smallest enterprises might be able to handle short- term sickness absence.

As the literature on work–family conflict grows and absenteeism increasingly comes into the spotlight, one cannot help but ask the question: “What is an acceptable absenteeism rate and how can an organisation control and manage absenteeism?” With current absenteeism rates as high as 12% and with an estimated R12 million lost per annum because of absenteeism, the idea of an on-site employer-sponsored childcare facility seems viable. The purpose of this study is to examine the relationship between absenteeism and on-site employer- sponsored childcare. The following dimensions of absenteeism will be examined over a period of a year: absence frequency, absence intensity, attitudinal absence and medical absence. The results of two companies, one with a facility and one without, will then be compared in order to establish the relationship between absenteeism and an on-site facility. To date, evidence remains mixed and the ongoing challenge of establishing real return on equity remains a major barrier to the support of on-site employer-sponsored childcare. / Industrial and Organisational Psychology / M. A. (Industrial and Organisational Psychology)