Le travail de recherche réalisé au cours de cette thèse s'intéresse à la nature des représentations spatiales formées par le cortex entorhinal médian (CEM). Tout d'abord, nous montrons que le CEM code spécifiquement une information de distance, l'une des composantes nécessaires pour que l'animal puisse réaliser un type de navigation reposant sur les informations idiothétiques, appelé intégration des trajets. Puis, nous observons que le système vestibulaire, une source importante d'informations idiothétiques, influence l'activité thêta du CEM et permet la modulation de ce rythme thêta par la vitesse de déplacement des animaux. Ensuite, nous montrons que l'activité du CEM est nécessaire à la stabilité de l'activité des cellules de lieu. Parallèlement, nous observons que l'activité des cellules grilles du CEM est modifiée par les informations contenues dans l'environnement (allothétiques).Dans leur ensemble, nos résultats montrent que le CEM traite et intègre des informations idiothétiques mais aussi des informations allothétiques. Ces données suggèrent que la carte spatiale du CEM ne fournit pas une métrique universelle reposant sur les informations idiothétiques, mais possède un certain degré de flexibilité en réponse aux changements environnementaux. De plus, cette carte spatiale entorhinale n'est pas requise pour la formation de l'activité spatiale des cellules de lieu, contrairement à ce que suggère l'hypothèse dominante. / The work conducted during my PhD thesis was aimed at understanding the nature of the spatial representation formed by the the medial entorhinal cortex (MEC). First, we show that the MEC codes specifically distance information which is necessary for a type of navigation based on idiothetic cues, called path integration. Then, we observe that the vestibular system, an important source of idiothetic information in the brain, influences the MEC theta rhythm and its modulation by the animal velocity. In addition, we show that MEC activity is necessary for the stability of place cells activity. Finally, we observe that entorhinal grid cells activity is modified by the information available in the environment (allothetic information).Together, our results show that the MEC processes and integrates idiothetic information as well as allothetic information. These data suggest that the entorhinal map is not a universal metric based on idiothetic information, but is flexible and dependant on the information present in the environment. In addition, the entorhinal map is not required for the generation of place cells activity, contrary to the dominant hypothesis.

Made available in DSpace on 2016-04-27T19:32:48Z (GMT). No. of bitstreams: 1 Jussaramar da Silva.pdf: 2477923 bytes, checksum: 2614632b7c9c8440973ccdeb6c695ac2 (MD5) Previous issue date: 2010-06-17 / Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This dissertation objective to discuss the role assumed for the Special Assessorship of Security and Informations of Itaipu Hydroeletric (AESI s), enter the years 1973 up to 1988. These Assessorships had consisted as an arm of the repression in Brazil and Paraguay, as well as of the Condor Operation. During the analyzed period, they had had the role to spy on and to emit reports on the workers of Itaipu, as well as of any people who were considered suspicion in the region of the Tríplice Border. For the understanding of the object in analysis, we launch hand of the expedient to understand the construction of the hydroelectric as form to objectify the model of development of the Brazilian and Paraguayan State, which discharged in the States of National Security, transforming all into internal enemy potentials / Essa dissertação objetiva discutir o papel assumido pelas Assessorias Especiais de Segurança e Informações da Hidrelétrica de Itaipu (AESI s), entre os anos de 1973 até 1988. Essas Assessorias constituíram-se como um braço da repressão no Brasil e no Paraguai, bem como da Operação Condor. Durante o período analisado, elas tiveram o papel de espionar e emitir relatórios sobre os trabalhadores de Itaipu, bem como de quaisquer pessoas que fossem consideradas suspeitas na região da Tríplice Fronteira. Para a compreensão do objeto em análise, lançamos mão do expediente de compreender a construção da hidrelétrica como forma de objetivar o modelo de desenvolvimento do Estado brasileiro e paraguaio, que desembocou nos Estados de Segurança Nacional, transformando todos em potenciais inimigos internos

The main focus of this disertation are relationships of Jan Neruda. They are explained from two different points of view: historical and didactic. The historical part is about the facts, for which the evidence can be found. Those that don't have any evidence in the historical sources are separated. In this part there were also discussed some novels, which portray Jan Neruda. The didactic part contains of the analysis of the textbooks, there was studied, how the information about Neruda's relationships were explained to the students. The last chapter is about websites, where the information about this topic can be found. This topic was there also assessed from the historical and didactic point of view.

This paper deals with the consensus problem under communication network inducing delays. It is well-known that introducing a delay leads in general to a reduction of the performance or to instability due to the fact that timedelay systems are infinite dimensional. For instance, the set of initial conditions of a time-delay system is not a vector but a function taken in an interval. Therefore, investigating the effect of time-delays in the consensus problem is an important issue. In the present paper, we assume that each agent receives instantaneously its own state information but receives the state information from its neighbors after a constant delay. Two stability criteria are provided based on the frequency approach and on Lyapunov-Krasovskii techniques given in terms of LMI. An analytic expression of the consensus equilibrium which depends on the delay and on the initial conditions taken in an interval is derived. The efficiency of the method is tested for different network communication schemes. / <p>QC 20110120</p>

My thesis addresses a systematic approach to stochastic models in population genetics; in particular, the Wright-Fisher models affected only by the random genetic drift. I used various mathematical methods such as Probability, PDE, and Geometry to answer an important question: \"How do genetic change factors (random genetic drift, selection, mutation, migration, random environment, etc.) affect the behavior of gene frequencies or genotype frequencies in generations?”. In a Hardy-Weinberg model, the Mendelian population model of a very large number of individuals without genetic change factors, the answer is simple by the Hardy-Weinberg principle: gene frequencies remain unchanged from generation to generation, and genotype frequencies from the second generation onward remain also unchanged from generation to generation. With directional genetic change factors (selection, mutation, migration), we will have a deterministic dynamics of gene frequencies, which has been studied rather in detail. With non-directional genetic change factors (random genetic drift, random environment), we will have a stochastic dynamics of gene frequencies, which has been studied with much more interests. A combination of these factors has also been considered. We consider a monoecious diploid population of fixed size N with n + 1 possible alleles at a given locus A, and assume that the evolution of population was only affected by the random genetic drift. The question is that what the behavior of the distribution of relative frequencies of alleles in time and its stochastic quantities are. When N is large enough, we can approximate this discrete Markov chain to a continuous Markov with the same characteristics. In 1931, Kolmogorov first introduced a nice relation between a continuous Markov process and diffusion equations. These equations called the (backward/forward) Kolmogorov equations which have been first applied in population genetics in 1945 by Wright. Note that these equations are singular parabolic equations (diffusion coefficients vanish on boundary). To solve them, we use generalized hypergeometric functions. To know more about what will happen after the first exit time, or more general, the behavior of whole process, in joint work with J. Hofrichter, we define the global solution by moment conditions; calculate the component solutions by boundary flux method and combinatorics method. One interesting property is that some statistical quantities of interest are solutions of a singular elliptic second order linear equation with discontinuous (or incomplete) boundary values. A lot of papers, textbooks have used this property to find those quantities. However, the uniqueness of these problems has not been proved. Littler, in his PhD thesis in 1975, took up the uniqueness problem but his proof, in my view, is not rigorous. In joint work with J. Hofrichter, we showed two different ways to prove the uniqueness rigorously. The first way is the approximation method. The second way is the blow-up method which is conducted by J. Hofrichter. By applying the Information Geometry, which was first introduced by Amari in 1985, we see that the local state space is an Einstein space, and also a dually flat manifold with the Fisher metric; the differential operator of the Kolmogorov equation is the affine Laplacian which can be represented in various coordinates and on various spaces. Dynamics on the whole state space explains some biological phenomena.

The production and consumption of information and communication technology (ICT) products and services continue to grow worldwide. This trend is accompanied by a corresponding increase in electricity use by ICT, as well as direct environmental impacts of the technology. Yet a more complicated picture of ICT’s effects is emerging. Positive indirect effects on environmental sustainability can be seen in substitution and optimization (enabling effects), and negative indirect effects can be seen in additional demand due to efficiency improvements (rebound effects). A variety of methods can be employed to model and assess these direct and indirect effects of ICT on environmental sustainability. This doctoral thesis explores methods of modeling and assessing environmental effects of ICT, including electronic media. In a series of five studies, three methods were at times applied in case studies and at others analyzed theoretically. These methods include life cycle assessment (LCA) and complex systems modeling approaches, including System Dynamics (SD) and agent-based (AB) modeling. The first two studies employ the LCA approach in a case study of an ICT application, namely, the tablet edition of a Swedish design magazine. The use of tablets has skyrocketed in recent years, and this phenomenon has been little studied to date. Potential environmental impacts of the magazine’s tablet edition were assessed and compared with those of the print edition. The tablet edition’s emerging version (which is marked by a low number of readers and low reading time per copy) resulted in higher potential environmental impacts per reader than did the print edition. However, the mature tablet edition (with a higher number of readers and greater reading time per copy) yielded lower impacts per reader in half the ten impact categories assessed. While previous studies of electronic media have reported that the main life-cycle contributor to environmental impacts is the use phase (which includes operational electricity use as well as the manufacture of the electronic device), the present study did not support those findings in all scenarios studied in this thesis. Rather, this study found that the number of readers played an important role in determining which life-cycle phase had the greatest impacts. For the emerging version, with few readers, content production was the leading driver of environmental impacts. For the mature version, with a higher number of readers, electronic storage and distribution were the major contributors to environmental impacts. Only when there were many readers but low overall use of the tablet device was the use phase the main contributor to environmental impacts of the tablet edition of the magazine. The third study goes beyond direct effects at product- and service-level LCAs, revisiting an SD simulation study originally conducted in 2002 to model indirect environmental effects of ICT in 15 European countries for the period 2000-2020. In the current study, three scenarios of the 2002 study were validated in light of new empirical data from the period 2000–2012. A new scenario was developed to revisit the quantitative and qualitative results of the original study. The results showed, inter alia, that ICT has a stimulating influence on total passenger transport, for it makes it more cost- and time-efficient (rebound effects). The modeling mechanism used to represent this rebound effect is further investigated in the fourth study, which discusses the feedback loops used to model two types of rebound effects in passenger transport (direct economic rebound and time rebound). Finally, the role of systems thinking and modeling in conceptualizing and communicating the dynamics of rebound effects is examined. The aim of the fifth study was to explore the power of systems modeling and simulation to represent nonlinearities of the complex and dynamic systems examined elsewhere in this thesis. That study reviews previous studies that have compared the SD and AB approaches and models, summarizing their purpose, methodology, and results, based on certain criteria for choosing between SD and AB approaches. The transformation procedure used to develop an AB model for purposes of comparison with an SD model is also explored. In conclusion, first-order or direct environmental effects of ICT production, use, and disposal can be assessed employing an LCA method. This method can also be used to assess second-order or enabling effects by comparing ICT applications with conventional alternatives. However, the assessment of enabling effects can benefit from systems modeling methods, which are able to formally describe the drivers of change, as well as the dynamics of complex social, technical, and environmental systems associated with ICT applications. Such systems methods can also be used to model third-order or rebound effects of efficiency improvements by ICT. / Den ökande produktionen och konsumtionen av produkter och tjänster inom informations- och kommunikationsteknik (IKT) leder till en ökning av den globala elanvändningen samt direkta miljökonsekvenser kopplade till IKT. Men IKT har även indirekta miljömässiga effekter. Dessa kan vara positiva till exempel genom substitutions- och optimeringseffekter eller negativa genom att till exempel ge upphov till ytterligare efterfrågan på grund av effektivisering (så kallade reboundeffekter). Olika metoder kan användas för att modellera och bedöma både direkta och indirekta effekter av IKT. Syftet med denna avhandling är att undersöka metoder för modellering samt att studera miljöeffekter av IKT och elektronisk media med hjälp av livscykelanalys (LCA) och även modellering av komplexa och dynamiska system, samt simuleringsteknik, så som System Dynamics (SD) och agentbaserad (AB) modellering. Avhandlingen omfattar fem artiklar (artikel I-V). Artikel I &amp; II beskriver resultaten från en fallstudie där miljöeffekter kopplade till en svensk tidskrift studeras med LCA. Tidskriftens version för surfplatta samt motsvarande tryckta version studeras och jämförs. Artikel III går ett steg vidare från produktnivåns LCA. Artikeln återkopplar till en SD simuleringsstudie som ursprungligen genomfördes under 2002. Simuleringsstudien gällde framtida miljöeffekter av IKT i 15 europeiska länder med tidspespektivet 2000-2020. I artikeln valideras tre scenarier från simuleringsstudien med hjälp av nya empiriska data från 2000-2012 och ett nytt scenario modelleras. Kvantitativa och kvalitativa resultat från den ursprungliga studien diskuteras. Till exempel visar artikel III att IKT har en stimulerande effekt på den totala persontrafiken genom att göra den mer kostnads- och tidseffektiv (reboundeffekt). Modelleringsmekanismen som används för att representera denna reboundeffekt diskuteras vidare i artikel IV. Artikeln belyser och diskuterar den återkopplingsslinga (feedback-loop) som används för att modellera två typer av reboundeffekter kopplade till persontrafik (direkt ekonomisk rebound och tidsrelaterad rebound) samt jämför med en tidigare studie. Artikel IV behandlar också den roll systemtänkande och modellering kan spela i konceptualisering och kommunikation av reboundeffekters dynamik. För att ytterligare undersöka systemmodelleringens och simuleringens möjligheter att representera icke-linjära komplexa och dynamiska system (exempel på sådana diskuteras i artikel III och IV), sammanställer artikel V tidigare studier som jämför SD och AB-metoder och -modeller.  Studiernas mål och metod summeras och resultaten med avseende på vilka kriterier som presenteras för att välja mellan SD och AB sammanställs. Även processen för att omvandla en befintlig SD-modell till en AB-modell beskrivs. Avhandlingens slutsats är att LCA och systemmodelleringsmetoder kan vara användbara för att studera IKTs direkta effekter så väl som indirekta effekter på miljön. / <p>QC 20150813</p>

Mémoire numérisé par la Division de la gestion de documents et des archives de l'Université de Montréal

Les intérêts théoriques, cliniques et économiques, de l'informatisation des prescriptions au sein des établissements de santé sont nombreux : diminution du nombre de prescriptions, amélioration de leur pertinence clinique, diminution des erreurs médicales... Ces béné ces restent théoriques car l'informatisation des prescriptions est, en pratique, confrontée à de nombreux problèmes, parmi lesquels les problèmes d'interopérabilité et d'utilisabilité des solutions logicielles. L'utilisation de terminologies d'interface au sein de ux de terminologies permettrait de dépasser ces problèmes. L'objectif principal de ce travail était de modéliser et développer ces ux de terminologies pour la production d'examens de biologie et d'imagerie médicale puis d'en évaluer les béné ces en termes d'interopérabilité et d'utilisabilité. Des techniques d'analyse des processus ont permis d'aboutir à une modélisation des ux de terminologies qui semble commune à de nombreux domaines. La création des ux proprement dits repose sur des terminologies d'interface, éditées pour l'occasion, et des référentiels nationaux ou internationaux reconnus. Pour l'évaluation, des méthodes spéci- ques mises au point lors du travail d'intégration d'une terminologie d'interface iconique au sein d'un moteur de recherche de recommandations médicales et d'un dossier médical, ont été appliquées. Les ux de terminologies créés induisaient d'importantes pertes d'information entre les di érents systèmes d'information. En imagerie, la terminologie d'interface de prescription était signi cativement plus simple à utiliser que les autres terminologies, une telle di érence n'a pas été mise en évidence dans le domaine de la biologie. Si les ux de terminologies ne sont pas encore fonctionnels, les terminologies d'interface, elles, sont disponibles pour tout établissement de santé ou éditeur de logiciels et devraient faciliter la mise en place de logiciels d'aide à la prescription.

Förmåga att använda informations- och kommunikationsteknik framhålls numeraofta som en förutsättning för delaktighet på lika villkor i samhällslivet. Näraförknippat med detta är de insatser som görs för att överbrygga digitala klyftor isamhället. IKT har gjort deltagandet i samhällslivet mer möjligt för personer medsynnedsättning. Tillgång till teknik innebär dock inte alltid att den kan användas ivardagen. I denna avhandling analyseras den förmedlingsprocess som sker när barnmed grav synnedsättning, genom förskrivning på syncentraler, får tillgång tilldatortekniska hjälpmedel, samt hur barnen därefter tillägnar sig tekniken genom att,med olika stödpersoners hjälp, använda den i skolan och hemmet. Åtta barn (mellan7-18 år) från två syncentralers upptagningsområden deltog i studien, tillika medderas föräldrar, stödpersoner i skolan samt personal (datortekniker och anpassningslärare)från syncentralerna. Undersökningsmaterialet har samlats in genom intervjuer,samtal och observationer. Barnen har skrivit aktivitetsrelaterade dagböcker. Förmedlingsprocessen involverar många personer från flera organisationer och ärutsträckt i tid och rum. Olika rationaliteter ställs mot varandra när professionelltverksamma från syncentral och skola, tillsammans med föräldrar ska möjliggöra förbarnen att ta tekniken i bruk. Med utgångspunkt från datorn som hjälpmedel diskuterastre projekt vars mål är viktiga för barnet att nå: att lära sig, att bli socialtdelaktig och att bli självständig. Dessa projekt står ofta i konflikt med varandra, tillexempel barnens önskan att träna på datorn samtidigt som de vill leka med sinakamrater. Med en tidsgeografisk ansats analyseras situationer där konflikter uppstår,samt vilka avvägningar och försök till samordning som görs av de inblandadeparterna. Skolan utgör ett område där den övergripande samhälleliga ambitionen omett liv på lika villkor ska konkretiseras. Analysen pekar på att uppmärksamhet börriktas såväl mot den individcentrerade kompensatoriska användningen av tekniskahjälpmedel, som mot skolans uppläggning av undervisningen (strukturell förändring förtillgänglighet). Ett helhetsperspektiv på förmedlingsprocessen möjliggör långsiktigplanering där tidsrumsliga dimensioner betraktas och dess fragmentering minskas. / The ability to use information and communication technology is regarded today as acondition for participation in society. Closely associated with this are measurestaken to reduce the digital divide in society. Computer technology is accepted asmaking it possible for people with disabilities to manage most things on their ownthat previously required some help of others. However, access to technology doesnot necessarily equal usability. This thesis explores and analyses the mediationprocess that occurs when children with visual impairment, access assistive computertechnologies, and how these, by the help of support persons, are used in home and atschool. Eight children (between seven and eighteen years of age) were included inthe study, as well as their parents, support persons in school and professionals fromthe Low Vision Clinics. Research data have been collected through interviews,conversations, observations and activity oriented diaries. The mediation processinvolves a number of persons and organisations and is both organisationally complexand extended in time and space. Different rationalities are set against eachother, when professionally active persons from the Low Vision Clinics and schools,together with parents make it possible for the children to use the assistive devices.From the standpoint of the computer as an aid, three projects are discussed whosegoals are important for the child to achieve to be able to, in the short and long run,live life to the full. These projects are ‘learning’, ‘becoming socially involved’ and‘becoming independent’. The projects can often be in conflict with each other; forexample the children’s desire to practice on the computer against their wanting toplay with their friends at the same time. With a time-geographic approach,situations in which conflicts and trade-offs arise, as well as the coordination effortsmade by those involved, are analysed. The school constitutes an area in which theoverreaching societal ambition of a life on equal terms is realised. This studydiscusses how compensation for the individual as well as structural change foraccessibility manifests itself in organisation, structures and supportive efforts.

The purpose of this project has been to redesign an already existing cook-book. The title of the book (directly translated), “Season in food – the year around with herbs and spices”, contains what the headline imposes: spices, herbs and food. But when the author tries to entwine these parts and communicate it to the reader it is not working all to well due to a poor and inconsistent graphic design. I have followed the theories and values of information design when I redesigned the book layout with the intent to simplify the communication between author and reader. In the progress to make a complete dummie of the book I did multiple literature studies, book analysis, tests and a vast number of drafts. In this report I will describe the whole process from start to finish. It is impossible to explain every aspect of every theory and still make it interesting to read. Instead I try to explain the processes in a more comprehensive way. But details are inevitable and at those times it helps to use the appendix. / Mitt examensarbete har inneburit att göra en redesign på en redan befintlig kokbok. På bokensomslag står det: ”Kryddan i maten – året om med örter och kryddor” och den handlar om just detrubriken antyder: örter, kryddor och mat. Tyvärr har författarens syfte, att knyta samman dessa tvåbitar, gått förlorad i bokens inlaga. Detta beror på en inkonsekvent och ostrukturerad formgivning. Mitt arbete har varit att med hjälp av informationsdesignens regler och teorier göra om och styraupp bokens layout på ett sånt sätt så att informationen på nytt blir lättillgänglig för användaren. Föratt lyckas med det har jag förutom ett gediget skissarbete även utfört utprovningar, litteraturstudiersamt bokanalyser.I denna rapport avhandlar jag hur hela arbetsprocessen sett ut– från bakgrund till färdigt resultat. Rapporten har omöjligt kunnat behandla alla de frågor och tankegångar jag ställts inför utanbehandlar processen på ett mer övergripande sätt. Ibland beskrivs vissa moment detaljerat för attläsaren skall förstå, men genom bilagorna går det att snabbare få en förståelse för vad som menas.