O presente trabalho avalia e compara os resultados da tenacidade à fratura da zona termicamente afetada (ZTA) de soldas múltiplos passes por meio de ensaios de CTOD. Para este estudo, foi utilizado um aço alta resistência e baixa liga (ARBL) resistente à corrosão ambiental. As soldas foram realizadas com insumo de calor de 30 e 50 kJ/cm em um chanfro 1/2 K. Os resultados dos ensaios de CTOD mostraram que a solda produzida com maior insumo de calor apresenta tenacidade à fratura mais elevada. A análise microestrutural revelou que as microestruturas de elevada dureza e baixa tenacidade, formadas na ZTA de granulação grosseira, para a condição de 30 kJ/cm, deram lugar às microestruturas de tenacidade mais elevada, para o insumo de calor de 50 kJ/cm. / In this work the fracture toughness results of the heat affected zone (HAZ) in a multiple pass welds using a crack tip opening displacement (CTOD) concept were evaluated and compared. It was used an ambiental resistent high strengh low alloy steel. The welds were carried out using a heat input of 30 and 50 kJ/cm in a bevel preparation 1/2 K. The results of CTOD testing showed that increasing heat input, caused an improvement in the weldments fracture toughness. Microstructural analysis revealed that the high hardness and low toughness microstructures formed at coarse grain HAZ, near fusion line, for welding condition 30 kJ/cm were changed to higher toughness microstructure using a heat input of 50 kJ/cm.

O presente trabalho visa avaliar a microestrutura em chapas de um aço de alta resistência e baixa liga após soldagem por centelhamento e quantificar a resistência ao crescimento de trincas por fadiga ao longo do cordão de solda e da zona termicamente afetada, comparando-a ao comportamento do material base. O aço em estudo, recentemente desenvolvido pela Companhia Siderúrgica Nacional sob a designação RD480, foi fornecido na forma de chapas com 5,0 mm de espessura e soldado pelo processo de centelhamento na divisão de rodas e chassis da IOCHPE-MAXION. A avaliação microestrutural do aço após o processo de soldagem por centelhamento foi realizada nas regiões do metal de base, zona termicamente afetada e metal de solda, utilizando microscopia ótica com diferentes ataques químicos e microscopia eletrônica de varredura. A caracterização mecânica foi realiza com ensaio de tração, teste de dureza Vickers e ensaio de propagação de trincas por fadiga. Para este último foram adotados corpos-de-prova do tipo compacto C(T) e carregamento senoidal de amplitude constante com frequencia 10 Hz e razão de tensão R= 0,1 e as curvas obtidas deste ensaio foram avaliadas em relação a dois modelos matemáticos, o de Paris-Erdogan e o exponencial. Após o ensaio de propagação de trincas por fadiga, as superfícies dos corpos-de-prova foram avaliadas por microscopia eletrônica de varredura. Os resultados encontrados permitiram correlacionar a resistência mecânica e a taxa de crescimento da trinca com as características microestruturais resultantes do processo de soldagem. / This study aims to evaluate the microstructure of a high strength, low alloy (HSLA) steel after flash welding and to quantify the resistance to fatigue crack growth along the weld and heat affected zone, comparing it to the behavior of the base material. The steel under study, recently developed by the Companhia Siderúrgica Nacional under the designation RD480, was provided in the form of plates with 5.0 mm in thickness and welded by IOCHPE-MAXION, division of wheels and chassis. The microstructural evaluation of the steel after the flash welding process was performed at the base metal, heat affected zone and weld metal, using optical microscopy with different chemical attacks and scanning electron microscopy (SEM). The mechanical characterization was performed by means of tensile test, Vickers hardness measurement and fatigue crack growth (FCG) test. Compact Tension C(T) specimens were chosen for the fatigue tests, and the loading was sinusoidal with constant amplitude, frequency of 10 Hz and stress ratio R = 0.1. The crack propagation test results were summarized in terms of FCG rate (da/dN) versus stress intensity factor range (?K) curves. In order to describe the FCG behavior, two models were tested: the conventional Paris equation and a new exponential equation developed for materials showing non-linear FCG behavior. The fracture surfaces of the fatigued specimens were examined via SEM in the secondary electrons regime. The results allowed correlating the mechanical strength and crack growth rate with the microestrutural characteristics resulting from the welding process.

Novas demandas de aplicação tem sido a principal motivação para a produção de materiais estruturais associando boas propriedades mecânicas e baixo custo de fabricação. A indústria aeroespacial vem desenvolvendo estudos com titânio e suas ligas, devido, a sua elevada resistência mecânica e baixa massa específica. Alguns estudos afirmam que, em temperaturas acima de 500°C as ligas de titânio possuem baixa resistência à oxidação restringindo a sua aplicabilidade. Localizada na parte inferior das turbinas em aviões comerciais, a liga Ti ?-21S tem mostrado bom desempenho em até 700°C com grande potencial para substituir alguns componentes, diminuindo os gastos com manutenção e aumentando a autonomia das turbinas a gás. Diante desse cenário, o objetivo deste trabalho foi desenvolvimento de revestimentos visando o aumento da resistência a oxidação na liga Ti ?-21S mantendo as suas características iniciais. O processo de revestimento foi feito em diferentes condições de temperatura × tempo via HAPC (CVD in situ). A faixa de temperatura analisada foi de 560 à 760°C entre 1 à 25h. A microestrutura de todos os coupons (não revestidos, revestidos e oxidados) foram caracterizados por difração de raios X (DRX) e microscopia eletrônica de varredura (MEV). A cinética de crescimento aparente da camada de revestimento foi feita medindo a espessura de revestimento nas condições analisadas e a cinética de oxidação foi feita através da variação de massa superficial dos coupons. Os resultados do DRX e MEV mostraram que os revestimentos produzidos foram monofásicos com composição química TiAl3. A cinética de crescimento entre 660 à 760°C apresentou energia de ativação de 108 kJ/mol e constante pré-exponencial de 1,21 × 10-3 cm²/s, esses resultados sugerem que a cinética de crescimento é controlada pela difusão dos átomos de alumínio no volume da liga Ti ?-21S formando a camada de TiAl3. Os coupons revestidos foram oxidados à 750 e 850°C por 100, 200 e 300h, os resultados da caracterização microestrutural mostrou que nos coupons revestidos foi formada uma camada de Al2O3 e a variação de massa superficial após 300h à 850°C foi de 0,60 mg/cm². Portanto, após a oxidação dos coupons revestidos, foi observado que o revestimento promoveu a formação de óxidos protetores como Al2O3 aumentando a resistência a oxidação da liga Ti ?-21S revestida. / New application demands have been the main motivation for the production of structural materials associating good mechanical properties and low manufacturing cost. The aerospace industry has been developing studies with titanium and its alloys, due to its high mechanical strength and low specific mass. Some studies report that, at temperatures above 500°C, titanium alloys have low oxidation resistance, restricting their applicability. Located at the bottom of turbines in commercial aircraft, the Ti ?-21S alloy has shown good performance up to 700°C with great potential to replace some components, reducing maintenance costs and increasing the autonomy of gas turbines. In view of this scenario, the objective of this work was the development of coatings aiming at increasing the resistance to oxidation in the Ti ?-21S alloy while maintaining its initial characteristics. The coating process was done at different temperature × time conditions via Pack Cementation (CVD in situ). The temperature range analyzed was 560 - 760°C between 1 - 25h. The microstructure of all coupons (uncoated, coated and oxidized) were characterized by XRD and SEM. The kinetics of apparent growth of the coating layer were made by measuring the coating thickness under the analyzed conditions and the oxidation kinetics was done by varying the surface mass of the coupons. The results of the DRX and MEV showed that the coatings produced were monophasic with TiAl3 chemical composition. The kinetics of growth between 660 - 760°C showed activation energy of 108 kJ/mol and pre-exponential constant of 1.21 × 10-3 cm²/s, these results suggest that the kinetics of growth is controlled by the diffusion of atoms of aluminum in the volume of the Ti ?-21S alloy forming the TiAl3 layer. The coated coupons were oxidized at 750 and 850°C for 100, 200 and 300h, the results of the microstructural characterization showed that in the coated coupons an Al2O3 layer was formed and the surface mass variation after 300h at 850°C was 0.60 mg/cm². Therefore, after oxidation of the coated coupons, it was observed that the coating promoted the formation of protective oxides like Al2O3 increasing the oxidation resistance of the coated Ti ?-21S alloy.

[pt] Os materiais nanoestruturados têm se destacado nas pesquisas científicas relacionadas aos novos materiais por propriedades particulares, muitas vezes não presentes no mesmo material com constituição não nanométrica. O presente trabalho apresenta uma rota alternativa para síntese de liga de cobalto e níquel nanoestruturada. Esta rota tem como ponto de partida a obtenção de óxidos dos metais a partir da dissociação de seus respectivos nitratos e, subseqüente redução dos óxidos por hidrogênio. Os óxidos foram obtidos separadamente e também associados (co-formados) a partir da dissociação da mistura de seus nitratos à 400oC por três horas. Difração de raio-x foi utilizada para confirmar a formação de Co3O4 e NiO. Análises em MET (Microscópio Eletrônico de Transmissão) mostraram que, tanto o Co quanto o Ni, apresentavam partículas de dimensões nanométricas, com cerca de 20nm no caso do NiO e na faixa de 20-50nm no caso do Co3O4. As partículas de óxidos co-formados observadas apresentaram dimensões na faixa de 10nm a 50nm. Redução por H2 foi utilizada para obtenção dos metais Ni e Co e da liga. Estudos termodinâmicos preliminares foram realizados para confirmar a viabilidade do processo. As variáveis de processo analisadas foram temperatura (faixa de 200oC-500oC) e pressão parcial de H2 (0,4- 1,0atm). A redução do NiO mostrou um comportamento autocatalítico com Ea = 28,7kJ/mol, enquanto as reduções de Co3O4 e NiO+Co3O4 co- formados sugeriram modelo topoquímico, com Ea = 33,7kJ/mol e 29,7kJ/mol, respectivamente. Para a redução dos óxidos NiO+Co3O4 co-formados (obtenção da liga), a reação mostrou ser de 1a. ordem. Análises estruturais da liga realizadas em MET revelaram tamanhos médios de 20nm. / [en] It has been clear the increasing importance of nanostructured materials in the present scientific and technological developments due to their unique properties. It is also well established that properties of materials can be severely altered by making them to reach a nanostructured condition. The present work presents an alternative route for obtain nanoestructured nickelcobalt alloy. The methodology is based on the dissociation of the metal nitrates in a very small oxides particles, even nanometric ones, and subsequent hydrogen reduction of the obtained oxides. Thermodynamic studies have been developed to support the feasibility of the reactions carried out to obtain nickel and cobalt oxides as well as the metals particles. Nickel and cobalt oxides were produced, either isolated or co-formed, by dehydrating a water dissolved homogeneous solution of Ni (NO3)2 or/and Co(NO3)2 at 400oC for about three hours. X-ray diffraction has been carried out to confirmed the Co3O4 and NiO formation. Transmission Electron Microscopy (TEM) studies have shown nanoscale structures with different morphology and size distribution. Hydrogen reduction was applied to obtain Ni, Co and Ni0.5- Co0.5 alloy. The temperature and hydrogen partial pressure range studied were, respectively, 200oC-500oC and 0,4-1,0atm. The NiO reduction showed an autocatalytic behavior with Ea = 28,7kJ/mol while the isolated Co3O4 and the co-formed oxides reductions followed topochemical reaction model, with Ea = 33,7kJ/mol and 29,7kJ/mol, respectively. The Ni-Co alloy synthesis reaction showed a first order behavior. The TEM studies have revealed a Ni-Co alloy constituted by nanoscale single crystals of about 20nm in size.

INTRODUCTION Insomnia became an object of concern in Aristotelian times, when he wrote a monograph on sleep disorders (350 BC). Although community of science and medicine has been interested in sleep disorders for almost 2000 years, however, there are not much information about the prevalence of insomnia, especially among citizens of developing countries. Epidemiological information about prevalence of insomnia and sleep complaints varies in different countries [Roth et.al., 1996], because of diversity of methodology for data collection. According to data of research carried out in the United States of America, Europe and Australia, 10–49% of population are not satisfied with their sleep quality. [Walsh, Ustun, 1999]. According to data of lifestyle research in Lithuania (1996), insomnia was a problem for 22.5% of male (from 20 to 64 years old) and 29.3% of female [Grabauskas, Klumbienė, 1998]. Sleep complaints among Lithuanian citizens have not been researched up to now, although, as foreign scientists maintain, sleep disorder can accelerate development of many somatic as well as mental diseases, besides, after a few sleepless nights, follows irritability, decrease of efficiency, it is difficult to concentrate, considerably increases risk of traffic accidents or accidents at work [Balter, Uhlenhuth, 1992]. Supposedly, there is a connection among heart and vascular diseases, sleep disorders and depression [Mahowald et.al., 1989]. Research that was carried out abroad proved... [to full text]

Svarbią vietą psichikos sveikatos priežiūroje, keldamos rimtą grėsmę modernios valstybės vizijai ir sėkmingai ekonominei bei socialinei plėtrai, užima priklausomybės ligos. Lietuvai įsitvirtinant Vakarų erdvėje, valstybė turi nukreipti Lietuvos ekonomiką laiduoti prieinamą, laiku suteikiamą, saugią bei veiksmingą sveikatos, tame tarpe ir psichikos sveikatos, priežiūrą, nes šalies žmonių sveikata priklauso nuo socialinių ir ekonominių sąlygų, o nuo žmonių sveikatos priklauso valstybės ekonominis klestėjimas. Plečiantis teikiamų priklausomybės ligų gydymo bei prevencijos paslaugų tinklui būtina pasirūpinti valstybiniu reguliavimu, kurio paskirtis optimalus šios sveikatos priežiūros paslaugų dalies sistemos efektyvumas. Šio darbo tikslas – įvertinti administraciniu teisiniu požiūriu priklausomybių ligų bei su jomis susijusių procesų valstybinio reguliavimo mechanizmą ir pateikti šio mechanizmo sėkmingo veikimo reglamentavimo problemas. Nagrinėjant pasirinktą temą, buvo atlikta teisės aktų, reglamentuojančių priklausomybės ligas bei su jomis susijusius procesus, analizė; panaudojant anketinį metodą, buvo apklausti ekspertai, dirbantys priklausomybės ligų gydymo bei prevencijos paslaugų teikimo srityse, siekiant ištirti jų patirtį/požiūrį į priklausomybių ligų bei su jomis susijusių procesų valstybinį reguliavimą, funkcijų pasiskirstymą tarp šių procesų valdymo subjektų. Susisteminus gautus duomenis, juos įvertinus, suformuluotos išvados bei siūlymai. / The objective of this work is to evaluate the mechanism of state regulation of addictive disorders and processes related thereto from the administrative legal point of view and to present the problems of regulation of the successful mechanism operation. Analysing the chosen topic, the study of legal acts regulating addictive disorders and processes related thereto was made; using a questionnaire method, experts working in the field of addictive disorders treatment and the provision of prevention services were surveyed in order to find out about their experience/attitude towards the state regulation of addictive disorders and processes related thereto as well as the distribution of functions among parties managing these processes. / Abhängigkeitskrankheiten nehmen in der Pflege der psychischen Gesundheit einen wichtigen Platz ein, indem sie für die Vision eines modernen Staates und die erfolgreiche wirtschaftliche sowie soziale Entwicklung eine erhebliche Gefahr darstellen. Während sich Litauen in dem westeuropäischen Raum einbürgert, muss der Staat die Wirtschaft Litauens in die Richtung lenken, einen rechtzeitigen, sicheren und effektiven Zugang zur Gesundheitspflege, darunter auch zur Pflege der psychischen Gesundheit, zu leisten, weil die Gesundheit der Bürger direkt von den sozialen und wirtschaftlichen Bedingungen und das wirtschaftliche Wachstum des Staates von der Gesundheit der Menschen abhängt. Das Netz der zu erweisenden Dienstleistungen zur Vorbeugung sowie Behandlung von Abhängigkeitskrankheiten wird immer größer, deswegen muss eine staatliche Regulierung geschaffen werden, welche das Ziel verfolgen würde, eine optimale Systemeffizienz in diesem Teil der Dienstleistungen zur Gesundheitspflege zu erreichen. Das Ziel der vorliegenden Arbeit ist es, den Mechanismus der staatlichen Regulierung von Abhängigkeitskrankheiten und damit verbundener Prozesse unter dem verwaltungsrechtlichen Standpunkt einzuschätzen und die Reglamentierungsprobleme der wirkungsvollen Anwendung von diesem Mechanismus darzustellen. Bei der Analyse des gewählten Themas wurden Rechtsakte, die die Abhängigkeitskrankheiten und damit verbundene Prozesse reglamentieren, untersucht. Durch die Anwendung der Fragebogen-Methode... [der volle Text, siehe weiter]

Tyrimo tikslas – nustatyti galimas sąsajas tarp kiekvieno asmenybės stiliaus aukštesnio išreikštumo ir ligos suvokimo ypatumų, lyginant su kiekvieno asmenybės stiliaus žemesnio išreikštumo grupės ligos suvokimo ypatumais. Tyrime dalyvavo 190 VšĮ Ukmergės ligoninės Fizinės medicinos ir reabilitacijos skyriuje besigydančių pacientų (vyrų ir moterų). Siekiant įvertinti tiriamųjų asmenybės stiliaus išreikštumo bei ligos suvokimo sąsajas, tiriamiesiems išdalinti klausimynai, kuriuos jie pildė namuose ir grąžino tyrėjui. Tyrime naudoti du klausimynai: Ligos suvokimo klausimyno (Illness Perception Questionare, IPQ; Weinman ir kt., 1996) atnaujinta versija (IPQ-R) ir pagal DSM-IV-R klasifikaciją sudarytas klausimynas asmenybės stilių išreikštumui nustatyti. Tyrimo rezultatai parodė, kad aukštesnio išreikštumo vengiančiam, priklausomam, šizoidiniam, paranoidiniam, histrioniniam, ribiniam asmenybės stiliams būdingas didesnis tapatinimasis su liga, lyginant su žemesnio išreikštumo asmenybės stilių tapatinimusi su liga; aukštesnio išreikštumo vengiančio, priklausomo, paranoidinio, histrioninio, obsesinio-kompulsinio asmenybės stilių požiūris į ligą negatyvesnis, lyginant su žemesnio išreikštumo asmenybės stilių požiūriu į ligą; aukštesnio išreikštumo vengiantis, priklausomas, paranoidinis, histrioninis, ribinis, obsesinis-kompulsinis asmenybės stiliai patiria daugiau nuo ligos suvokimo skirtumų priklausančių neigiamų emocijų, kurios turi įtakos su sveikata susijusio elgesio... [toliau žr. visą tekstą] / The aim of the study was to examine the relations between every highly expressed personality style and illness perception peculiarity comparing with lower expressed personality style and illness perception peculiarity. 190 patients from Ukmerge Hospitals Physical Medicine and Rehabilitation centre were examined in this experiment (both men and women). In order to examine relations between expressed personality style and illness perception, every patient had to complete the questionnaire at home and bring it back researcher. Two questionnaires were used in this experiment: Illness Perception Questionnaire, IPQ (Weinman ir kt., 1996) new version IPQ – R and questionnaire to identify expressed personality style which was created based on DSM – IV – R. The results showed that: patients with higher expressed personality style (avoiding, depending, paranoid, schizoid, borderline personalities) have higher identification with illness, comparing with lower expressed personality style patients; patients with higher expressed personality style (avoiding, depending, paranoid, histrionic, anancastic personalities) have more negative attitude towards illness, comparing with lower expressed personality style patients; patients with higher expressed personality style (avoiding, depending, paranoid, histrionic, borderline and anancastic personalities) experience more negative emotions related to illness perception which influence health related behavior, comparing with lower expressed... [to full text]

Širdies ir kraujagyslių ligos, tame tarpe ir išeminės širdies ligos, laikomos pagrindine naujojo amžiaus sveikatos problema - tai ligos, kurių daugėja vykstant progresui ir kylant pragyvenimo lygiui. Darbe buvo nagrinėti vieni iš svarbiausių psichologinių IŠL rizikos veiksnių: nerimastingumas, pablogėjusi nuotaika ir tipo A elgsena, taip pat IŠL sergančiųjų sveikatai palankus elgesys, išskirtinį dėmesį skiriant IŠL sergančiųjų nerimastingumui ir pablogėjusiai nuotaikai bei jų kitimams stacionarinio gydymo metu. Šio Tyrimo tikslas – nustatyti išemine širdies liga sergančiųjų nerimastingumo ir pablogėjusios nuotaikos kitimus gydantis stacionare. Tyrime dalyvavo 178 28 – 74 metų (53,52 ± 9,03) respondentai. Iš jų 107 29 – 74 metų (53,91 ± 9,14) asmenys, sergantys IŠL ir 71 28 – 73 metų (52,94 ± 8,89) nesergantys IŠL (lyginamoji grupė). Pablogėjusiai nuotaikai ir nerimastingumui nustatyti naudota A.S. Zigmondo ir R.P.Snaitho ligoninės nerimo ir depresijos skalė (HAD – angl. Hospital Anxiety and Depression Scale). Elgsenos aktyvumui (A tipui) nustatyti naudotas sutrumpintas D. Dženkinso klausimyno (Jenkins Activity Survey – JAS) variantas, kurį sudarė trylika klausimų bei Framinghamo 10 klausimų skalė tipo A elgsenai nustatyti. Besigydančių stacionare IŠL sergančių pacientų nerimastingumas ir pablogėjusi nuotaika sumažėja stacionarinio gydymo pabaigoje. Tačiau nerimastingumas sumažėjo vyrų, sergančių IŠL, grupėje, o pablogėjusi nuotaika sumažėjo moterų, sergančių IŠL, grupėje... [toliau žr. visą tekstą] / Heart and blood vessels diseases including ischemic heart diseases are considered a major issue of health care in the modern age as these are the diseases which are growing in numbers in the times of progress and increasing level of subsistence. The thesis explores some major psychological ischemic heart disease risk factors: anxiety, worsening mood and type A behaviour as well as health-favouring behaviour of ischemic heart disease patients, essentially concentrating upon ischemic heart disease patients’ anxiety and worsening mood and its alterations in the process of hospital treatment. The aim of this analysis is to explore alterations of ischemic heart disease patients’ anxiety and worsening mood at the time of hospital treatment. The analysis covered 178 individuals aged 28 to 74 (53.52±9.03) including 107 ischemic heart disease patients aged 29 to 74 (53.91±9.14) and 71 members of the control group aged 28 to 73 (52.94±8.89) who are not ischemic heart disease patients. In order to assess worsening mood and anxiety, A.S. Zigmond and R.P. Snaith’s Hospital Anxiety and Depression Scale was employed. The assessment of the activeness of behaviour was performed by the brief variant of Jenkins Activity Survey containing thirteen questions and 10 questions scale by Framingham for the identification of type A behaviour. Anxiety and worsening mood of ischemic heart disease patients treated in hospital improve in the final stages of hospital treatment. However, anxiety decreased... [to full text]

The aim of the thesis – to investigate the role of the inflammatory bowel disease associated genetic variants in a subset of Crohn’s disease and ulcerative colitis patients from Lithuania and Latvia and to test the relation of genetic markers to disease phenotype. The following objectives were accomplished: the associations of the inflammatory bowel disease associated single nucleotide polymorphisms in the subset of Crohn’s disease and ulcerative colitis patients were determined; the associations of the single nucleotide polymorphisms with the phenotype of the inflammatory bowel disease were evaluated; the interactions of single nucleotide polymorphisms (SNP-SNP) and their association with inflammatory bowel disease were determined; the significance of the combinations of disease associated single nucleotide polymorphisms for diagnosis of inflammatory bowel disease was evaluated. TaqMan and SNPlex genotyping methods were used in this work. The statistical data analysis consisted of: statistical study power and data quality evaluations; single marker case-control association analysis using χ2 or Fisher's exact tests, Breslow-Day test, Cochran-Mantel-Haenzsel test and post-hoc Bonferroni correction; genotype–phenotype association analysis using χ2 test and post-hoc Bonferroni correction; SNP-SNP epistasis for case-control sample using logistic regression test and post-hoc Bonferroni correction; In sicilo prediction of gene interactive network; genetic risk profile construction... [to full text] / Disertacijos tikslas – ištirti su uždegiminėmis žarnyno ligomis siejamų ge¬netinių žymenų reikšmę Krono liga bei opiniu kolitu sergantiems Lietuvos ir Latvijos ligoniams bei nustatyti žymenų ryšį su ligos fenotipu. Tikslui pasiekti, įgyvendinti šie uždaviniai: ištirta su uždegiminėmis žarnyno ligomis siejamų vieno nukleotido polimorfizmų sąsaja su Krono liga bei opiniu kolitu; nustatyta vieno nukleotido polimorfizmų sąsaja su uždegiminių žarny¬no ligų fenotipu; ištirtos vieno nukleotido polimorfizmų tarpusavio epistazinės sąvei¬kos (VNP-VNP) bei jų ryšys su uždegiminėmis žarnyno ligomis; nustatytas su liga siejamų vieno nukleotido polimorfizmų derinių reikšmingumas uždegiminių žarnyno ligų diagnostikai. Darbe taikyti SNPlex ir TaqMan genotipavimo metodai. Statistinę duomenų analizę sudarė: studijos galios bei duomenų kokybės įvertinimas; atvejo-kontrolės genų sąsajos tyrimas, taikant χ2 arba Fišerio kriterijus, Breslow-Day testą, Cochran-Mantel-Haenzsel testą bei post-hoc Bonferroni kriterijų; genų sąsajų su Krono ligos ir opinio kolito fenotipu tyrimai, naudojant χ2 bei post-hoc Bonferroni kriterijų; VNP-VNP epistazinės sąveikos įvertinimas, taikant logistinės regresijos testą bei post-hoc Bonferroni kriterijų; genų tarpusavio sąveikos tinklo in silico tyrimas; genetinės rizikos profilio sudarymas, naudojant logistinę regresinę analizę.

Psychosocial factors affect the occurrence of coronary artery disease (CAD) disease and development of complications. People with depression or anxiety symptoms have the activate hypothalamic-pituitary-adrenal axis. Thyroid hormone changes are also found in patients with CAD. Fatigue and health-related quality of life (HRQoL) depends not only on good physical health, but also on psychoemotional state, especially on the presence of depression and anxiety disorders. Therefore, it is important to evaluate complex of hormonal markers and behavioral factors (depression, anxiety and fatigue) interaction on patients with CAD for quality of life, disease course and outcome. The aim of this study was examine relationship of cortisol and thyroid axis hormones concentrations with NT-pro B type natriuretic peptide (NT-proBNP) concentrations and with patient oriented outcomes such as depressive symptoms, fatigue and HRQoL in CAD patients. Study demonstrates relationship between thyroid axis hormones and cortisol concentrations with depression, anxiety symptoms, fatigue and HRQoL in CAD patients. Low T3, free T4 and higher RT3 concentrations are associated with higher NT-proBNP levels, depression symptoms, higher fatigue and worse HRQoL. Higher morning cortisol concentrations are associated with depression symptoms in women. The data obtained can be used in patients with coronary artery disease and depressive anxiety disorder, disease progression, and prognosis and quality of life... [to full text] / Psichosocialiniai veiksniai turi įtakos išeminės širdies ligos (IŠL) vystymuisi ir komplikacijų atsiradimui. Depresijos ir nerimo patogenezėje dalyvauja pagumburio-hipofizės-antinksčių ašis. Skydliaukės hormonų pokyčiai taip pat dažnai randami sergantiesiems IŠL bei depresija. Nuovargis ir su sveikata susijusi gyvenimo kokybė priklauso ne tik nuo geros fizinės sveikatos, bet ir nuo psichoemocinės būklės, todėl svarbu kompleksiškai įvertinti hormoninių žymenų ir elgesio veiksnių (depresijos, nerimo ir nuovargio) sąveikos įtaką sergančiųjų IŠL gyvenimo kokybei, ligos eigai bei baigtims. Šio tyrimo tikslas buvo išnagrinėti kortizolio ir skydliaukės ašies hormonų koncentracijų ryšį sergantiesiems IŠL su N-galinio smegenų tipo natriuretinio propeptido (NT-proBNP) koncentracija bei subjektyviomis sveikatos būklėmis: depresijos, nerimo simptomais, nuovargiu ir su sveikata susijusia gyvenimo kokybe. Tyrimas parodė skydliaukės hormonų ir kortizolio koncentracijų reikšmingą ryšį su subjektyviu sveikatos vertinimu sergantiesiems IŠL. Mažesnė bendrojo T3, laisvojo T4 ir didesnė reversinio T3 koncentracija susijusi su didesne NT-proBNP koncentracija, depresijos simptomų pasireiškimu, didesniu nuovargiu ir blogesniu su sveikata susijusios gyvenimo kokybės vertinimu. Didesnė rytinio kortizolio koncentracija susijusi su depresijos simptomų pasireiškimu moterims. Gauti duomenys gali būti panaudoti sergančiųjų IŠL depresijos bei nerimo simptomams, ligos eigai, prognozei ir gyvenimo kokybei... [toliau žr. visą tekstą]