Nesta dissertação apresenta-se uma reflexão acerca do Espaço Pessoal, Espaço Parcial, Espaço Total, Espaço Social, Espaço Cênico e a espacialidade Ma, Tendo como bases a extensa bibliografia e a também extensa experiência artística e pedagógica da autora como atriz-dançarina, professora, pesquisadora, diretora e coreógrafa. A dissertação visa servir de ponto de partida para que alunos e professores em Artes Cênicas pensem a abordagem do corpo cênico em sala de aulas e em criações artísticas. No início há definições de conceitos a respeito do corpo, assim como o estudo sobre abordagens teóricas significativas, tais como a teoria do Corpomídia e a Teoria do Corpo Sem Órgãos, para que sirvam como referência compartilhada com a autora, a fim de que se possa seguir para a reflexão acerca dos espaços propostos. A seguir há a apresentação de cada espaço. Ao se referir à espacialidade Ma, pela sua complexidade, já que se trata de um conceito da cultura japonesa de difícil compreensão pelos ocidentais, dadas as diferenças que existem entre as culturas ocidental e oriental, a autora se dedica ao estudo detalhado da tese de Doutorado de Michiko Okano, Ma: Entre-espaço da Comunicação no Japão Um estudo acerca dos diálogos entre Ocidente e Oriente, relacionandoa com as Artes Cênicas para, ao final, se esforçar em apontar espacialidades Ma nas montagens cênicas O Olho do Tamanduá, com direção de Takao Kusuno, e Lucíola cena 1, com direção da própria autora, sendo que em ambas ela participa como atrizdançarina- criadora. São mencionados especificamente os trabalhos de Rudolf Laban, Michiko Okano, Patrícia Stokoe, Eugênio Barba, Takao Kusuno, Antonin Artaud, Hideki Matsuka, Akira Kasai, Ko Murobushi, Gilles Deleuze, Felix Gattari, Helena Katz, Christine Greiner, Cassiano Quilice. / This dissertation presents a reflection on the Personal Space, Partial Space, Total Space, Social Space, Scenic Space and the Ma spatiality, having as basis the extensive bibliography and the extensive artistic and pedagogical experience of the author as an actress-dancer, teacher, researcher, director and choreographer. The dissertation aims to function as a starting point for Performing Arts pupils and teachers to think bodys scenic approach in classroom and in artistic creation. At the beginning there are definitions of concepts about the body and the study of major theoretical approaches, such as the Corpomedia and Body Without Organs theories, which serve as a shared reference to both author and reader and define a way of reflection about the spaces mentioned. Then we have the presentation of each space. As it concerns Ma Spatiality, because of its complexity and also because of the fact that it is a Japanese cultural concept of difficult understanding (concerning the differences between Western and Eastern cultures) the author engaged herself in the detailed study of the doctoral thesis of Michiko Okano, Ma: an inter-space of communication in Japan - a study on the dialogues between East and West. At the end, the author links it to Performing Arts and focuses on appointing the presence of Ma spatiality on Takao Kusunos work O Olho do Tamanduá, in which she has participated as an actress-dancer-creator, and Lucíola cena 1, directed and performed by the author herself. The work of Rudolf Laban, Michiko Okano, Patricia Stokoe, Eugenio Barba, Antonin Artaud, Kusuno Takao, Hideki Matsuka, Akira Kasai, Ko Murobushi, Gilles Deleuze, Felix Gattari, Helena Katz, Christine Greiner and Cassiano Quillice are specifically mentioned.

La Risala al-adhawiya fi al-ma`ad d’Avicenne, portant sur la question du Retour à la vie une fois la mort survenue, présente un certain nombre de thèses originales par rapport aux autres écrits de ce philosophe. Le Retour ne peut concerner les corps : il est en effet réserver aux âmes dans la mesure où l’essence de l’homme réside dans son âme. Les corps se corrompent définitivement au moment de la mort. Le Coran n’a rien d’un texte démonstratif, il s’agit d’un texte rhétorique visant à susciter chez ses lecteurs le comportement moral approprié. On ne peut donc déduire de l’affirmation coranique répétée selon laquelle les corps reviendront à la vie que les corps seront effectivement ressuscités. Par ailleurs, si dans le monde physique il existe une pluralité d’âmes, c’est uniquement en raison de la multiplicité de la matière corporelle qui les accueille. Si les âmes doivent survivre indépendamment des corps qui assurent leur individuation, comment pourraient-elles exister individuellement ? Il n’y aura pas d’existence individuelle des âmes après la mort, mais un Retour de ces âmes au Principe (l’Intellect Agent, ou, en dernière instance, le Principe Premier, Dieu) dont elles émanent : les âmes se résorbent donc dans leur origine et n’ont plus d’existence séparée. Le Retour est absolu. / Avicenna’s Risala al-adhawiya fi al-ma`ad, dealing with the question of Return to life once death has occurred, comes up with various original theses that do not appear in Avicenna’s other writings. The Return cannot affect the body : it is indeed dedicated to souls inasmuch as the essence of man lies in his soul. Bodies get corrupted once and for all when death occurs. The Quran has nothing to do with a demonstrative text, it is a rhetorical text that aims at provoking in its readers the appropriate moral behaviour. It is therefore impossible to deduce from the repeated coranic assertion saying that bodies will come back to life that bodies will effectively resurrect. If in the physical world there is a plurality of souls, it is only because of the multiplicity of the corporeal matter that receives them. If souls have to survive independently from bodies that allow their individuation, how then could they individually exist ? There will not be any individual existence of souls in the hereafter, but a Return of these souls to the Principle (the Agent Intellect, or, at last, the First Principle, God) from which they emanate : therefore souls resorb in their origin and do not have any separate existence. It is an absolute Return.

Pharmacometrics is widely used in drug development. Models are developed to describe pharmacological measurements with data gathered from a clinical trial. The information can then be applied to, for instance, safely establish dose-response relationships of a substance. Glycated hemoglobin (HbA1c) is a common biomarker used by models within antihyperglycemic drug development, as it reflects the average plasma glucose level over the previous 8-12 weeks. There are five different nonlinear mixed-effects models that describes HbA1c-formation. They use different biomarkers such as mean plasma glucose (MPG), fasting plasma glucose (FPG), fasting plasma insulin (FPI) or a combination of those. The aim of this study was to compare their performances on a population and an individual level using model averaging (MA) and to explore if reduced trial durations and different treatment could affect the outcome. Multiple weighting methods were applied to the MA workflow, such as the Akaike information criterion (AIC), cross-validation (CV) and a bootstrap model averaging method. Results show that in general, models that use MPG to describe HbA1c-formation on a population level could potentially outperform models using other biomarkers, however, models have shown similar performance on individual level. Further studies on the relationship between biomarkers and model performances must be conducted, since it could potentially lay the ground for better individual HbA1c-predictions. It can then be applied in antihyperglycemic drug development and to possibly reduce sample sizes in a clinical trial. With this project, we have illustrated how to perform MA on the aforementioned models, using different biomarkers as well as the difference between model weights on a population and individual level.

Cette thèse porte sur l'utilisation du BLASSO, un problème d'optimisation convexe en dimension infinie généralisant le LASSO aux mesures, pour la super-résolution de sources ponctuelles. Nous montrons d'abord que la stabilité du support des solutions, pour N sources se regroupant, est contrôlée par un objet appelé pré-certificat aux 2N-1 dérivées nulles. Quand ce pré-certificat est non dégénéré, dans un régime de petit bruit dont la taille est contrôlée par la distance minimale séparant les sources, le BLASSO reconstruit exactement le support de la mesure initiale. Nous proposons ensuite l'algorithme Sliding Frank-Wolfe, une variante de l'algorithme de Frank-Wolfe avec déplacement continu des amplitudes et des positions, qui résout le BLASSO. Sous de faibles hypothèses, cet algorithme converge en un nombre fini d'itérations. Nous utilisons cet algorithme pour un problème 3D de microscopie par fluorescence en comparant trois modèles construits à partir des techniques PALM/STORM. / This thesis studies the noisy sparse spikes super-resolution problem for positive measures using the BLASSO, an infinite dimensional convex optimization problem generalizing the LASSO to measures. First, we show that the support stability of the BLASSO for N clustered spikes is governed by an object called the (2N-1)-vanishing derivatives pre-certificate. When it is non-degenerate, solving the BLASSO leads to exact support recovery of the initial measure, in a low noise regime whose size is controlled by the minimal separation distance of the spikes. In a second part, we propose the Sliding Frank-Wolfe algorithm, based on the Frank-Wolfe algorithm with an added step moving continuously the amplitudes and positions of the spikes, that solves the BLASSO. We show that, under mild assumptions, it converges in a finite number of iterations. We apply this algorithm to the 3D fluorescent microscopy problem by comparing three models based on the PALM/STORM technics.

No description available.

No description available.

Es werden verschiedene Stetigkeitskonzepte, die in der statistischen Theorie und Methodik eine Rolle spielen, erläutert.

University of Macau / Faculty of Arts and Humanities. / Department of Chinese

Submitted by Cássio da Cruz Nogueira (cassionogueirakk@gmail.com) on 2017-10-18T12:31:26Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AspectosEpidemiologicosInfeccao.pdf: 1136672 bytes, checksum: 146a2db45dd644aba08d6543349e7e8f (MD5) / Approved for entry into archive by Irvana Coutinho (irvana@ufpa.br) on 2017-11-03T16:35:30Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AspectosEpidemiologicosInfeccao.pdf: 1136672 bytes, checksum: 146a2db45dd644aba08d6543349e7e8f (MD5) / Made available in DSpace on 2017-11-03T16:35:30Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AspectosEpidemiologicosInfeccao.pdf: 1136672 bytes, checksum: 146a2db45dd644aba08d6543349e7e8f (MD5) Previous issue date: 2012 / O câncer cervical uterino é o segundo câncer mais comum entre as mulheres no mundo e tem se associado à infecção pelo Papilomavírus humano (HPV), cujo diagnóstico de suspeita é feito através do teste de Papanicolaou. De modo geral, alguns fatores de risco estão envolvidos nessa relação, entretanto, esses fatores não são bem conhecidos em grupos especiais de mulheres, como as ribeirinhas. Este estudo teve como objetivo conhecer a magnitude da prevalência do HPV e os fatores de riscos associados, em mulheres residentes às margens do rio Tocantins, no município de Imperatriz – MA. Participaram 107 mulheres cadastradas na Unidade Básica de Saúde Beira Rio onde foram submetidas ao exame colpocitológico pela técnica de Papanicolaou e à pesquisa de DNA-HPV. Dados sócios demográficos e epidemiológicos relacionados à infecção pelo HPV foram obtidos através do formulário padrão do PPCCU do Ministério da Saúde e por entrevista. As mulheres participantes do estudo tinham em média 36 anos de idade, sendo 88,8% mulheres não brancas, a maioria com ensino fundamental, e vivendo com renda na faixa de um a três salários mínimos (57,9%). A prevalência de HPV foi 16,8%, e os fatores de riscos de maior importância neste grupo foram o início precoce da atividade sexual, múltiplos parceiros sexuais e baixo nível de escolaridade. O estudo revelou ainda, que o conhecimento sobre HPV era incipiente, embora as mulheres reconhecessem a necessidade de maiores esclarecimentos sobre a prevenção, os riscos para a saúde. Conclui-se que as atividades de educação em saúde sobre o HPV desenvolvido nos Serviços de Saúde Pública de Imperatriz do Maranhão voltado para grupos especiais, em particular, aqueles socialmente desfavorecidos, ainda são insuficientes para causar impacto na redução dos índices de morbidade causados pelo vírus, havendo necessidade de estudos em estratégias de abordagem para essas ações dentro do Programa de Prevenção do Câncer do Colo Uterino. / The cervical cancer is the second most common cancer among women worldwide and has been associated with infection by human papillomavirus (HPV) whose diagnosis of suspicion is done through the Pap test. In general, some factors are involved in this relationship, such as early onset of sexual activity, number of sexual partners, promiscuity, however, these factors are not well known in special groups of women, such as the riverside. This study aimed to understand the magnitude of the prevalence of human papillomavirus - HPV and associated risk factors among women living on the river Tocantins, in the municipality of Empress - MA. Participants 107 women enrolled in Basic Health Unit Riverside where they were subjected to a smear test by the Papanicolaou technique. Sociodemographic and epidemiological data related to HPV infection were obtained through the standard form of the Ministry of Health PPCCU Women Study participants averaged 36 years of age, and 88.8% non-white women, most with elementary school, and living with income in the range of 1 to 3 minimum wages (57.9%). Among the risk factors there was a mean age of 16.6 years at first intercourse, an average of 3.1 sexual partners in history, parity of 3 children, high smoking prevalence 24.2%, contraceptive use by 52, 3% of women and the frequent use of condoms by 62.6% of women. Conducting annual preventive examination of cervical cancer of 43.9%. However, there was no association of any of the risk factors studied with HPV infection. The study also revealed that women's knowledge about HPV was having incipient awareness that there was need for further clarification on prevention, health risks and treatment. We conclude that the activities of health education about HPV developed in the Public Health Services of Empress of Maranhão facing special groups, particularly those socially disadvantaged, are still insufficient to make an impact in reducing morbidity by cancer lap, and requires studies on strategies to approach these actions within the Programme for Prevention of Cervical Cancer.

Submitted by Cássio da Cruz Nogueira (cassionogueirakk@gmail.com) on 2017-10-18T12:26:03Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AspectosCliniciosEpidemiologicos.pdf: 543146 bytes, checksum: e965eaba384b2b007f5adbc905550893 (MD5) / Approved for entry into archive by Irvana Coutinho (irvana@ufpa.br) on 2017-11-06T12:21:08Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AspectosCliniciosEpidemiologicos.pdf: 543146 bytes, checksum: e965eaba384b2b007f5adbc905550893 (MD5) / Made available in DSpace on 2017-11-06T12:21:08Z (GMT). No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_AspectosCliniciosEpidemiologicos.pdf: 543146 bytes, checksum: e965eaba384b2b007f5adbc905550893 (MD5) Previous issue date: 2012 / CNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico / Sabe-se que a infecção pelo Papilomavírus humano (HPV) apresenta ampla distribuição na população, sendo considerada a doença sexualmente transmissível (DST) mais frequente mundialmente. Sua transmissão ocorre por exposição sexual em cerca de 98% dos casos e seu pico de positividade é observado entre mulheres na idade reprodutiva, principalmente nos primeiros anos de atividade sexual. Em geral, a infecção é limitada pela ação do sistema imunológico, o qual elimina o vírus no prazo de até 2 anos. Alterações que interfiram na ação do sistema imunológico podem interferir no curso da infecção pelo HPV, como em indivíduos com AIDS. Durante a gravidez ocorrem alterações fisiológicas que modificam a resposta imunológica para a não rejeição do feto semi-alogênico. Isso poderia interferir na evolução da infecção pelo HPV, porém, isto ainda é controverso. Este estudo teve como objetivo analisar a prevalência da infecção pelo HPV em mulheres grávidas no município de Imperatriz, MA e investigar as possíveis associações existentes entre a infecção genital pelo HPV e fatores sociodemográficos, comportamentais, sexuais, contraceptivos, reprodutivos e clínico - ginecológicos selecionados.Foi realizado um estudo transversal, com 168 mulheres grávidas no município de Imperatriz- MA. As pacientes selecionadas responderam a um questionário sobre os dados sócio demográficos, comportamentais e reprodutivos. Foi realizada coleta de material cervicovaginal para citologia convencional e escovado cervical para detecção de DNA-HPV por técnica da reação em cadeia de polimerase (PCR). A associação da infecção por HPV e fatores de risco selecionados foi avaliada por meio do teste do Qui-quadrado (2) e/ou exato de Fisher, todos com um nível alfa de significância de 0,05. Foram estudadas 200 amostras de material do colo do útero foi coletado para realização do exame Citopatológico e para identificação do DNA-HPV através por PCR. A prevalência da infecção genital pelo HPV em gestante na cidade de Imperatriz foi de 17,6%, sendo que a maior prevalência ocorreu na faixa etária entre 18 a 25 anos, a qual foi de 21,5%. Em relação à situação marital, nota-se que as gestantes solteiras apresentaram maior risco de adquirir a infecção pelo HPV que as casadas (OR= 4,03; p= 0,0046). Quanto às características reprodutivas, verifica-se as gestantes que afirmaram serem primigestas apresentaram maior prevalência da infecção pelo HPV, com 29%, sendo estatisticamente significantes (p=0,001), tendo 4 vezes mais chances de adquirir a infecção pelo HPV em relação às mulheres que engravidaram 2 ou mais vezes. Interessantemente, as mulheres que estavam realizando o primeiro PCCU na ocasião, apresentaram maior prevalência da infecção pelo HPV (25%) em relação àquelas que já haviam realizado este exame anteriormente.Os resultados mostraram uma elevada prevalência de HPV em Gestantes jovens com idade menor que 25 anos, em primigestas e entre as que realizaram PCCU pela primeira vez, portanto observa-se a necessidade de medidas para promoção e prevenção de saúde com esse alvo de gestante específico dentro da rotina de serviço Hospitalar . Desta forma, acredita-se que esses dados possam ser muito úteis no planejamento de programas, incluindo o controle de Doenças sexualmente transmissíveis, principalmente o HPV. / It is known that infection with human papillomavirus (HPV) is widely distributed in the population, and is considered a sexually transmitted disease (STD) more frequent worldwide. Its transmission occurs through sexual exposure in about 98% of cases and its positive peak is observed among women of reproductive age, especially in the first years of sexual activity. In general, the infection is limited by the action of the immune system, which eliminates the virus within 2 years. Changes that interfere with the action of the immune system can influence the course of HPV infection, such as people with AIDS. During pregnancy, physiological changes occur that alter the immune response to non-rejection of semi- allogeneic fetus. This could interfere with the evolution of HPV infection, but this is still controversial. This study aimed to analyze the prevalence of HPV infection in pregnant women in the city of Imperatriz, MA and investigate possible associations between genital HPV infection and sociodemographic, behavioral, sexual, contraceptive and reproductive clinic - gynecological selected. We conducted a cross-sectional study of 168 pregnant women in the city of Empress-MA. The selected patients answered a questionnaire on socio demographic, behavioral and reproductive. Material was collected cervicovaginal cytology and conventional cervical brushed to detect HPV DNA by the technique of polymerase chain reaction (PCR). The association of HPV infection and selected risk factors was evaluated using the chi-square (x²) and/or Fisher exact test, all with an alpha level of 0.05. We studied 200 samples of cervical material was collected for Pap smear testing and identification of HPV DNA by PCR. The prevalence of genital HPV infection in pregnant women in the city of Empress was 17.6%, with the highest prevalence was in the age group between 18 to 25 years, which was 21.5%. Regarding marital status, note that unmarried pregnant women had a higher risk of acquiring HPV infection than married women (OR = 4.03, p = 0.0046). As for reproductive traits, there is the women who reported being primigravidae had higher prevalence of HPV infection, with 29%, which was statistically significant (p = 0.001), and 4 times more likely to acquire HPV infection than women who became pregnant two or more times. Interestingly, women who were taking the first PCCU on occasion, had a higher prevalence of HPV infection (25%) compared to those who had performed this test anteriormente.Os results showed a high prevalence of HPV in young pregnant women aged less than 25 years in primigravidae and among those who underwent PCCU first, so there is a need for measures to promote prevention and health of pregnant women with this specific target within the service routine Hospital. Thus, it is believed that such data can be very useful in planning programs, including the control of STDs, especially HPV.