Syftet med studien är att beskriva hur specialpedagoger och klasslärare uppfattar kunskapskraven när det kommer till svagt teoretiskt begåvade elever som inte har rätt till anpassad grundskola (IK inom området 70-85). Syftet är också att beskriva hur specialpedagoger och klasslärare arbetar med dessa elever för att de ska ges möjlighet att uppnå kunskapskraven på lågstadiet. Avsikten är att försöka tydliggöra vilka upplevda konsekvenser kunskapskraven har i verkligheten för elever med svag teoretisk begåvning, med fokus på lågstadiet, och utgå från följande frågeställningar:● Hur uppfattar specialpedagoger och klasslärare kunskapskraven i anslutning till elever med svag teoretisk begåvning?● Vilka för- och nackdelar med kunskapskraven i skolan uttrycks av specialpedagoger och klasslärare i anslutning till elever med svag teoretisk begåvning?● Hur beskrivs specialpedagogers och klasslärares arbete för att svagt teoretiskt begåvade elever ska få möjligheten att uppnå kunskapskraven?Förhoppningen är att denna studie ska bidra till en bättre förståelse för skolsituationen för elever med svag teoretisk begåvning och öka kunskap om kunskapskravens tillämpning i verkligheten. Den teoretiska utgångspunkten för studien är läroplansteori med fokus på Lindes tre arenor om läroplanens påverkan på undervisningen, Läroplansteori kommer även att kompletteras med de specialpedagogiska perspektiven, dilemmaperspektivet och bristperspektivet. Studien är kvalitativ, med en induktiv ansats och har ett tydligt fokus mot tolkning av andra människors upplevelser. Metoden är semistrukturerade intervjuer som har analyserats utifrån en tematisk innehållsanalys med inspiration från Ritchies ”framework”. Resultatet i studien visar att specialpedagoger och klasslärare främst upplever kunskapskraven som något som begränsar elever med svag teoretisk begåvning, men att kraven samtidigt ses som en guide för lärarna. Det framgår också att det kräver mycket kunskap och engagemang från lärarna och specialpedagogerna för att tillämpa kunskapskraven i undervisningen vilket också kräver samarbete mellan specialpedagogen och klassläraren genom till exempel handledarsamtal och kontinuerliga uppföljningar av eleven.

Density Functional Theory is used in order to shed light on the reaction mechanisms and the origins of stereoselectivity in enantioselective organocatalytic reactions. The reactions investigated are the dipeptide-catalyzed aldol reaction, the cinchona thiourea-catalyzed nitroaldol reaction and the prolinol derivative-catalyzed hydrophosphination reaction. We can justify the stereoselectivity in the reactions from the energies arising from different interactions in the transition states. The major contributions to the energy differences are found to be hydrogen bond-type attractions and steric repulsions. This knowledge will be useful in the design of improved catalysts as well as general understanding of the basis of selection in other reactions. / QC 20101111

Polymer electrolyte fuel cells (PEFC) convert the chemically bound energy in a fuel, e.g. hydrogen, directly into electricity by an electrochemical process. Examples of future applications are energy conversion such as combined heat and power generation (CHP), zero emission vehicles (ZEV) and consumer electronics. One of the key components in the PEFC is the membrane / electrode assembly (MEA). Both the membrane and the electrodes consist of proton conducting polymers (ionomers). In the membrane, properties such as gas permeability, high proton conductivity and sufficient mechanical and chemical stability are of crucial importance. In the electrodes, the morphology and electrochemical characteristics are strongly affected by the ionomer content. The primary purpose of the present thesis was to develop experimental techniques and to use them to characterise proton conducting polymers and membranes for PEFC applications electrochemically at, or close to, fuel cell operating conditions. The work presented ranges from polymer synthesis to electrochemical characterisation of the MEA performance. The use of a sulfonated dendritic polymer as the acidic component in proton conducting membranes was demonstrated. Proton conducting membranes were prepared by chemical cross-linking or in conjunction with a basic functionalised polymer, PSU-pyridine, to produce acid-base blend membranes. In order to study gas permeability a new in-situ method based on cylindrical microelectrodes was developed. An advantage of this method is that the measurements can be carried out at close to real fuel cell operating conditions, at elevated temperature and a wide range of relative humidities. The durability testing of membranes for use in a polymer electrolyte fuel cell (PEFC) has been studied in situ by a combination of galvanostatic steady-state and electrochemical impedance measurements (EIS). Long-term experiments have been compared to fast ex situ testing in 3 % H2O2 solution. For the direct assessment of membrane degradation, micro-Raman spectroscopy and determination of ion exchange capacity (IEC) have been used. PVDF-based membranes, radiation grafted with styrene and sulfonated, were used as model membranes. The influence of ionomer content on the structure and electrochemical characteristics of Nafion-based PEFC cathodes was also demonstrated. The electrodes were thoroughly investigated using various materials and electrochemical characterisation techniques. Electrodes having medium Nafion contents (35<x<45 wt %) showed the best performance. The mass-transport limitation was essentially due to O2 diffusion in the agglomerates. The performance of cathodes with low Nafion content (<30 wt %) is limited by poor kinetics owing to incomplete wetting of platinum (Pt) by Nafion, by proton migration throughout the cathode as well as by O2 diffusion in the agglomerates. At large Nafion content (>45 wt %), the cathode becomes limited by diffusion of O2 both in the agglomerates and throughout the cathode. Furthermore, models for the membrane coupled with kinetics for the hydrogen electrode, including water concentration dependence, were developed. The models were experimentally validated using a new reference electrode approach. The membrane, as well as the hydrogen anode and cathode characteristics, was studied experimentally using steady-state measurements, current interrupt and EIS. Data obtained with the experiments were in good agreement with the modelled results. / QC 20101014

<p>Polymer electrolyte fuel cells (PEFC) convert the chemically bound energy in a fuel, e.g. hydrogen, directly into electricity by an electrochemical process. Examples of future applications are energy conversion such as combined heat and power generation (CHP), zero emission vehicles (ZEV) and consumer electronics. One of the key components in the PEFC is the membrane / electrode assembly (MEA). Both the membrane and the electrodes consist of proton conducting polymers (ionomers). In the membrane, properties such as gas permeability, high proton conductivity and sufficient mechanical and chemical stability are of crucial importance. In the electrodes, the morphology and electrochemical characteristics are strongly affected by the ionomer content. The primary purpose of the present thesis was to develop experimental techniques and to use them to characterise proton conducting polymers and membranes for PEFC applications electrochemically at, or close to, fuel cell operating conditions. The work presented ranges from polymer synthesis to electrochemical characterisation of the MEA performance.</p><p>The use of a sulfonated dendritic polymer as the acidic component in proton conducting membranes was demonstrated. Proton conducting membranes were prepared by chemical cross-linking or in conjunction with a basic functionalised polymer, PSU-pyridine, to produce acid-base blend membranes. In order to study gas permeability a new in-situ method based on cylindrical microelectrodes was developed. An advantage of this method is that the measurements can be carried out at close to real fuel cell operating conditions, at elevated temperature and a wide range of relative humidities. The durability testing of membranes for use in a polymer electrolyte fuel cell (PEFC) has been studied in situ by a combination of galvanostatic steady-state and electrochemical impedance measurements (EIS). Long-term experiments have been compared to fast ex situ testing in 3 % H2O2 solution. For the direct assessment of membrane degradation, micro-Raman spectroscopy and determination of ion exchange capacity (IEC) have been used. PVDF-based membranes, radiation grafted with styrene and sulfonated, were used as model membranes. The influence of ionomer content on the structure and electrochemical characteristics of Nafion-based PEFC cathodes was also demonstrated. The electrodes were thoroughly investigated using various materials and electrochemical characterisation techniques. Electrodes having medium Nafion contents (35<x<45 wt %) showed the best performance. The mass-transport limitation was essentially due to O2 diffusion in the agglomerates. The performance of cathodes with low Nafion content (<30 wt %) is limited by poor kinetics owing to incomplete wetting of platinum (Pt) by Nafion, by proton migration throughout the cathode as well as by O2 diffusion in the agglomerates. At large Nafion content (>45 wt %), the cathode becomes limited by diffusion of O2 both in the agglomerates and throughout the cathode. Furthermore, models for the membrane coupled with kinetics for the hydrogen electrode, including water concentration dependence, were developed. The models were experimentally validated using a new reference electrode approach. The membrane, as well as the hydrogen anode and cathode characteristics, was studied experimentally using steady-state measurements, current interrupt and EIS. Data obtained with the experiments were in good agreement with the modelled results. Keywords: polymer electrolyte fuel cell, proton conducting membrane, porous electrode, gas permeability, degradation, water transport</p>

Multivariate regression of several different quantum chemical descriptors was used to build a model for the reactivity of nucleophilic aromatic substitution reactions, i.e. SNAr reactions, through predictingthe molecular reaction site’s Gibb’s free activation energy (ΔG‡). The datasets used for training provided data of ΔG‡ for several differing halide leaving groups including chloride, bromide, and fluoride. A set of descriptors were tested for the different leaving groups revealing that dissimilar leaving groups are more dependent on certain descriptors than others, meaning each model has to be tailored for the specific leaving groups. Excellent correlations (R2 = 0.93) were achieved between the predicted ΔG‡ and the experimental ΔG‡.The ability of the model to predict regioselectivity in aromatic compounds with multiple leaving groups was tested and successfully predicted the correct regioselectivity through the calculation of ΔΔG‡ in each case tested. However, the model’s validity outside of the training dataset was put into doubt through low R2 values when the model was tested with several external datasets. An unknown factor arose which is speculated to be because of how differing nucleophiles and solvents affect the ΔG‡. One of these tests yielded excellent correlations (R2 = 0.9525) which could be because of similarities between solvents and nucleophiles between the training dataset but a similar factor between predicted ΔG‡ and the experimental ΔG‡ could still be observed.

<p>The study aims to explain the role of external causes in René Descartes’s (1594–1650) and Benedictus de Spinoza’s (1632–1677) accounts of the mastery of the passions. It consists in three parts: the mind-body union, the passions and their classification, and the mastery of the passions. </p><p>In the first part I argue that Descartes’s conception of the mind-body union consists in two elements: mind-body interaction and the experience of being one with the body. Spinoza rejects the first element because there cannot be psychophysical laws. He accepts the second element, but goes beyond Descartes, arguing that the mind and body are identical.</p><p>In the second part I discuss the classifications of the passions in the <i>Passions of the Soul</i> and the <i>Ethics</i> and compare them with the one Spinoza presents in the <i>Short Treatise</i>. I explain that <i>hilaritas</i> is an affect that expresses bodily equilibrium and makes it possible for the mind to be able think in a great many ways. Furthermore, I consider the principles of imagination that along with imitation and the striving to persevere provide a causal explanation for the necessary occurrence of the passions. </p><p>In the last part I argue that in Descartes the external conditions do not have a significant role in the mastery of the passions. For Spinoza, however, they are necessary. Commentators like Jonathan Bennett fail to see this. <i>Hilaritas</i> requires a diversity of sensual pleasures to occur. As Medea’s case shows, reason is not detached from Nature. Spinoza attempts to form a stronger human nature and to enable as many people as possible to think adequately. His recognition of the need for appropriate external conditions and a society in which ideas can be expressed freely allows him to present an ethics with a practical application, instead of another utopia or fiction.</p>

No description available.

<p>Individual proteins, and small collections of proteins, have been extensively studied for at least two hundred years. Today, more than 350 genomes have been completely sequenced and the proteomes of these genomes have been at least partially mapped. The inventory of protein coding genes is the first step toward understanding the cellular machinery. Recent studies have generated a comprehensive data set for the physical interactions between the proteins of <i>Saccharomyces cerevisiae</i>, in addition to some less extensive proteome interaction maps of higher eukaryotes. Hence, it is now becoming feasible to investigate important questions regarding the evolution of protein-protein networks. For instance, what is the evolutionary relationship between proteins that interact, directly or indirectly? Do interacting proteins co-evolve? Are they often derived from each other? In order to perform such proteome-wide investigations, a top-down view is necessary. This is provided by network (or graph) theory.</p><p>The proteins of the cell may be viewed as a community of individual molecules which together form a society of proteins (nodes), a network, where the proteins have various kinds of relationships (edges) to each other. There are several different types of protein networks, for instance the two networks studied here, namely metabolic networks and protein-protein interaction networks. The metabolic network is a representation of metabolism, which is defined as the sum of the reactions that take place inside the cell. These reactions often occur through the catalytic activity of enzymes, representing the nodes, connected to each other through substrate/product edges. The indirect interactions of metabolic enzymes are clearly different in nature from the direct physical interactions, which are fundamental to most biological processes, which constitute the edges in protein-protein interaction networks.</p><p>This thesis describes three investigations into the evolution of metabolic and protein-protein interaction networks. We present a comparative study of the importance of retrograde evolution, the scenario that pathways assemble backward compared to the direction of the pathway, and patchwork evolution, where enzymes evolve from a broad to narrow substrate specificity. Shifting focus toward network topology, a suggested mechanism for the evolution of biological networks, preferential attachment, is investigated in the context of metabolism. Early in the investigation of biological networks it seemed clear that the networks often display a particular, 'scale-free', topology. This topology is characterized by many nodes with few interaction partners and a few nodes (hubs) with a large number of interaction partners. While the second paper describes the evidence for preferential attachment in metabolic networks, the final paper describes the characteristics of the hubs in the physical interaction network of <i>S. cerevisiae</i>.</p>

Denna kvalitativa studie syftar till att bidra med kunskap om vilka faktorer som motiverar personalvetarstudenter på Uppsala universitet att kombinera heltidsstudier med deltidsarbete. Vi har preciserat syftet genom två frågeställningar: “Vilken betydelse får relationen mellan teoretisk och praktisk kunskap för studenternas motivation till att arbeta deltid?” och “Vilka inre och yttre faktorer påverkar studenternas motivation till att söka deltidsarbete?” Resultatet i studien har samlats in genom semistrukturerade intervjuer med åtta personalvetarstudenter. De teorier som studien utgår från är praktisk kunskap baserat på Deweys pragmatiska syn på lärande som handlar om att teori kombinerat med erfarenhet främjar lärande. Baserat på Decis self-determination theory används begreppen inre och yttre motivation. Är en person inre motiverad utför de en handling på grund av eget intresse, nöjet att utvecklas och lära sig nya saker. En person som är yttre motiverad motiveras av incitament som belöningar som kommer med att utföra en uppgift. Resultatet visar att respondenterna upplever en avsaknad av praktisk kunskap i utbildningen och att de ges större möjlighet att applicera sina teoretiska kunskaper i praktiken på deras deltidsarbeten. Vidare visar det sig att “utveckling och nyfikenhet”, “arbetslivserfarenhet och anställningsbarhet” och “beröm från arbetsgivare” var mer avgörande för valet att söka deltidsarbete än “lön” och “betyg från universitetet”. I studiens avslutande avsnitt diskuteras varför belöningar måste vara givande och meningsfulla på lång sikt och svårigheten med att kategorisera respondenternas motivation som antingen inre eller yttre motivation samt vikten av praktiska inslag i personalvetarutbildningen.

<p> In his book <em>Wittgenstein on Rules and Private Language </em>(1982)<em> </em>Saul Kripke claims that Wittgenstein argues for a certain form of scepticism in his book <em>Philosophical Investigations </em>(1953), namely a new form of philosophical scepticism, a result of Wittgenstein´s idea of language as language games. Nihilism, scepticism of meaning or of concept, constitutive scepticism are other commentators´<em> </em>different names of the same phenomenon. The philosophy of Wittgenstein accounts for how our words, including the words of mathematics, have no meaning and there are no a priori justified objective facts as to what I mean about a word. We follow the rules blindly and without justification. We are unable to find any facts against this proposal. Like a ´sceptic´ Wittgenstein denies the ´superlative fact,´ a fact supposed to give an a priori justification to our words. The consensus of a language community is enough to give meaning and assertions to what we in ordinary language call facts, but objective facts in logical meaning a priori, do not exist, a sceptical view in Kripke´s interpretation. Wittgenstein rejects explicit scepticism, but Kripke thinks Wittgenstein did not want to repudiate common belief as a common sense philosopher.</p><p>This paper ´Wittgenstein and Scepticism´ says that Wittgenstein certainly denies ´superlative fact´, but his reason was founded on conclusions from his investigation of grammar and language, which we use and misuse according to what we want, not to how it <em>is</em>. We demand that logic ought to be absolute, general and consistent, but there is no such logic a priori. Wittgenstein thinks we have to stick to reality and facts of experience. Facts a priori are very convincing facts, but they are not ´sublime´ in a logical metaphysic way. Logic is not rejected and the philosophy of logic uses the same words as common language. Logic has a normative function in our language. We learn words and rules in a certain context and use them in certain situations. How we use the word tells us the meaning of the word and the correct understanding. Our following the rules depends on how they work in real life.</p> / <p>I <em>Wittgenstein on Rules and Private Languages</em> (1982) hävdar Saul Kripke att Wittgensteins resonemang i <em>Filosofiska undersökningar </em>(1953) leder till en speciell  form av skepticism, en filosofisk skepticism, en konsekvens av Wittgensteins uppfattning om språket som språkspel. Nihilism, meningsskepticism, begreppsskepticism, konstitutiv skepticism är andra kommentatorers beteckningar. Wittgensteins filosofi visar att språkets ord, inklusive matematikens ord, saknar mening och inga rättfärdigade objektiva a priori fakta finns om vad jag menar med ett ord. Vi följer språkets regler blint och som det passar oss Argument saknas för att vederlägga  detta påstående. Som en skeptiker förnekar Wittgenstein filosofins "superlative fact", som förmodas ge en a priori grund för vad jag menar med ett ord. En språkgemenskaps konsensus ger dock orden mening och bekräftar vad som i vanligt språk kallas fakta, men objektiva fakta i logisk mening, fakta a priori saknas, d.v.s. en skeptisk uppfattning, enligt Kripkes tolkning Att Wittgenstein själv tar avstånd från skepticismen beror på att han inte vill bryta med den allmänna uppfattningen om fakta och  mening.</p><p>Uppsatsen "Wittgenstein och skepticismen" visar att visserligen överger Wittgenstein "superlative fact", men detta är ett resultat av hans grammatiska undersökning av språket, vilket vi brukar och missbrukar för våra syften, inte som det <em>är</em>. Vi önskar och fordrar att logiken ger oss ett absolut, generellt och beständigt svar, men ett  sådant svar kan inte logikens a priori ge. Wittgenstein menar att verkligheten och erfarenhetsfakta är vad vi har att hålla oss till. A priori fakta är enligt Wittgenstein mycket övertygande fakta, men inte i den "sublima" logikens metafysiska mening. Logiken förkastas inte, ty logikens filosofi talar inte om ord i någon annan mening än vi gör i det vanliga livet. Logiken har en styrfunktion i språket. Orden lärs in i ett sammanhang och används i ett sammanhang. Användningen av ordet visar om ordets mening är korrekt uppfattad. Vi följer regler efter hur de fungerar i en verklighet</p>