Global ETD Search

161	Undersökning och validering av lågprissystem för kraftmätning : Hur bra kan en Wii Balance Board bli med ny elektronik? / Analysis and validation of low-price system for force measurement : How good can a Wii Balance Board become with new electronics? Mustafa, Rahand January 2024 (has links) Behovet för kraftplattor idag växer inom idrotts- och sportsammanhang såväl som inom medicinska sektorn. Problemet med majoriteten av kraftplattorna på marknaden idag är att de är dyra, samt stora och tunga. På Kungliga tekniska högskolans skola för medicinteknik och hälsosystem utvecklades en kraftplatteprototyp med Wii Balance Board i hopp om att vara billigare och kunna användas i medicinskt, terapeutiskt och idrottssyfte. Enligt konstruktören och uppdragsgivaren finns det ett behov att göra om denna prototyp genom att undersöka möjligheten till att använda komponenter som är billiga, tillgängliga för allmänheten men samtidigt är noggrann och pålitlig i mätningarna. I detta arbete undersöks möjligheterna samt konstrueras två prototyper för jämförelse och analys för att säkerställa pålitlighet och noggrannhet. Två kraftplatteprototyper utvecklades, ena prototypen använde en HX711 som AD- omvandlare mellan lastcellerna på Wii Balance Boarden och ESP32 mikrokontrollern och den andra en AD7124-8 som AD-omvandlare mellan lastcellerna och ESP32 mikrokontrollern. Lastcellerna kopplades till dessa AD-omvandlare som sedan kopplades till en ESP32 mikrokontroller som tog emot datat och presenterade det i Arduino IDE samt i applikationen Blynk. Resultatet av arbetet visade att båda prototyperna är pålitliga och noggranna i viktmätningarna vid låga samplingsfrekvenser, men att AD7124-8 är betydligt mycket mer lämplig i idrott och medicinska syften på grund av dess höga samplingsfrekvens samt filtreringsalternativ för brus då det i dessa sammanhang är viktigt att kunna mäta snabba kraftförändringar. / The need for force plates is increasing today in the sports and medicine industry. The challenges with force plates are the price point and the immobility of them, they are often big and heavy. A force plate prototype with a Wii Balance Board was developed at Royal Institute of Technology’s school for biomedical engineering and health systems with the hope of achieving a cheaper solution that could be used in medical research and the sports industry. According to the constructor of the force plate prototype, there is a need to redo this prototype by doing research of using cheaper and more readily available components but at the same time be precise and trustworthy in measurements. The possibilities are evaluated in this work and two prototypes are constructed. Two force plate prototypes were constructed, one of them used a HX711 AD-converter between the load cells of the Wii Balance Board and the ESP32 microcontroller and the other prototype used a AD7124-8. The load cells connected to the AD-converters and then to the ESP32 which showed the output values in the serial monitor of Arduino IDE and in the Blynk app. The results of the tests conducted showed that both prototypes provided a reliable and precise measurement of weight at low sample rates. But that the AD7124-8 was considerably more suitable for medicine research and sports research due to its capability to sample at high frequencies and noise filtering options, which is crucial when wanting to detect rapid changes in force. Force plate Wii balance board analog-to-digital converter Arduino Wi-Fi load cell sports technology rehabilitation calibration validation ESP32 HX711 AD7124-8 Kraftplatta Wii balance board analog till digitalomvandlare Arduino Wi-Fi lastcell idrottsteknologi rehabilitering kalibrering validering ESP32 HX711 AD7124-8 Embedded Systems Inbäddad systemteknik
162	Development and validation of a LC-MS/MS method for analysis of perfluorooctanesulfonic acid and perfluorooctaonic acid in liver organoid media Heggebø Rolfsen, Sandra January 2024 (has links) Per- and polyfluoroalkyl substances (PFAS) are organic synthetic compounds used in several industries because of their unique properties and thermal and chemical stability. Perfluorooctanesulfonic acid (PFOS) and perfluorooctaonic acid (PFOA) are two of the most prominent PFAS that are undegradable and accumulate in nature. To study the impact of PFOS and PFOA on the liver in a controlled environment, organoids can be used. A sensitive and selective LC-MS/MS method for individual and simultaneous analysis of PFOS and PFOA in liver organoid media and equipment used in organoid analyses was developed. For detection of low concentrations, ability to analyse complex organoid samples, and limit background contamination, a solid phase extraction (SPE) column, automatic filter (AFFL) and a trap column was included. The AFFL-SPE-LC-MS/MS was optimised efficiently through Design of Experiment (DoE) regarding the loading phase in the LC and six MS parameters for PFOS and PFOA. Validation was controlled against Eurachem’s guideline showing high sensitivity, detecting LOD at 6 pg/mL. The method demonstrated high repeatability with an RSD below 8 % for most samples. Simultaneous analysis of PFOS and PFOA demonstrated high selectivity. Nevertheless, the method showed low intermediate precision and varying reliability, as well as persistent background contamination limiting detection of lower concentrations. The method was fit for purpose and allowed rapid analysis of PFOS and PFOA in organoid media and equipment used in organoid analyses. Result from studies of PFAS in liver organoids through analysis with this method can aid in understanding the connection between PFAS and metabolic diseases. / Populärvetenskaplig sammanfattning Per- och polyfluorerade alkylsubstanser (PFAS) är en grupp av människoskapta, syntetiska ämnen med unika egenskaper. Dessa egenskaper gör att de är olja- och vattenavvisande, och har många applikationsområden. De finns i textiler, livsmedelsförpackningar, brandsläckningsskum och andra industriprodukter. De är väldigt termiskt och kemisk stabila, vilket gör att de inte bryts ner och därmed ackumulerar i miljön. Flera studier har också visat koppling mellan PFAS och många kroniska sjukdomar, som hormonstörningar, cancer, immunsuppression och metabolt associerad fettlever (MAFLD, tidigare nonalkoholisk fettlever (NAFLD)). Kopplingen mellan MAFLD och PFAS har fått mycket uppmärksamhet då levern har visats sig vara ett målorgan för PFAS. Eftersom PFAS är ihärdiga, har ett komplicerat spridningsbeteende och ackumulerar i naturen är det svårt att studera kopplingen mellan MAFLD och PFAS i en kontrollerad miljö. För att studera effekten av PFAS kan man använda organoider, laboratorieodlade 3D modeller gjord från stamceller för att imitera ett äkta organ. Någon av de mest omtalade PFAS ämnen är perfluoroktansyra (PFOA) och perfluoroktansulfonat (PFOS), vilket är fokus för detta arbete. Leverorganoiderna kan utsättas för PFOS och PFOA, och mediet de ligger i kan extraheras och studeras med konventionella analytiska metoder för att få en bild av hur PFAS påverkar levern. I detta arbete vill analysen ske via vätskekromatografi med masspektrometri som detektion (LC-MS/MS). Med LC-MS/MS separeras den studerade molekylen, analyten från lösningen baserat på dess kemiska egenskaper. Analyten detekteras baserat på dess massa, mer bestämd massa/laddning-fördelningen (m/z). För att anpassa LC-MS metoden till injektion av komplexa organoidprover inkluderades ett automatiskt filter (AFFL) samt ett extra automatiskt separationssteg med en kolonn med fastfasextraktion (SPE). I övrigt ger SPE möjligheten att små mängder PFAS kan uppkoncentreras och fokuseras på kolonnen, vilket ger en sensitiv metod som kan detektera låga koncentrationer. SPE och AFFL implementerades båda för att bättre kunna separera och detektera PFOS och PFOA från andra ämnen, samt filtrera bort föroreningar och stora molekyler som kan skada LC-MS/MS instrumentet i längden. Då PFAS hopar upp sig i vår omgivning, visade det sig att kontamination av PFAS från systemet blev en utmaning under metodutvecklingen. Därför implementerades PFAS fritt utstyr, samt en extra kolonn för att fånga PFAS från systemet och på så sätt minska bakgrundskontaminationen som detekterades. AFFL-SPE-LC-MS/MS metoden optimerades via en maskininlärningsbaserad optimeringsmetod baserad på parametrar i LC och MS. Metoden baserar sig på att, med tre värden för varje parameter, uppger programmet ett antal experiment som måste utföras för att kunna beräkna ett optimalt värde för varje parameter. Med resultatet från experimenten kan modellen matematiskt, genom en Bayes baserat Gaussian modell, uppskatta optimala värden för metoden. På så sätt kunde metoden optimeras systematiskt och tidseffektivt. Innan rutinanvändning måste den optimerade metoden valideras. Validering blev gjord genom at följa Eurachem’s riktlinjer. Metoden visade hög repeterbarhet, selektivitet och riktighet. Den har hög sensitivitet, och kan detektera låga mängder, men bakgrundskontaminationen kunde inte elimineras totalt, och gör att man måste korrigera för detta i rutinanalyser. Komplexiteten av AFFL-SPE-LC-MS/MS med flera kolonner och filter gjorde att metoden visade låg robusthet och behövde justeras ofta. AFFL-SPE-LC-MS/MS metoden gör det möjligt att snabbt studera PFOS och PFOA i leverorganoider och utstyr använt i organoidanalyser, och kan bidra i forskningen för att bättre förstå hur PFAS påverkar levern. / Health Effects of Persistent Organic Pollutants PFAS PFOS PFOA LC-MS method development validation optimalisation experimental design DoE AFFL-SPE-LC-MS/MS on-line SPE column switching multidimensional LC organoid liver organoid organoid media MAFLD NAFLD PFAS exposure PFAS PFOS PFOA LC-MS metodutveckling validering optimering AFFL-SPE-LC-MS/MS tandem-MS experiment design DoE organoid 3D organmodel Analytical Chemistry Analytisk kemi
163	Adapting and validating the Strengths Use and Deficit Improvement Questionnaire for educators in Gauteng / Rachele Paver Paver, Rachele January 2014 (has links) Education is essential in providing future human capital that is much needed to build a sustainable, competitive economy. However, the importance of a quality education is often underestimated. In order to enhance working conditions of educators, it seems essential to investigate the role of the positive psychology paradigm by means of developing teachers’ areas of deficiencies and capitalising on their strengths in order for them to reach their full potential and flourish. The current study aimed to adapt and validate the recently developed Strengths Use and Deficit Improvement Questionnaire (SUDIQ) in an attempt to make it suitable for educators. The general objective of this research study was to establish the psychometric properties of the SUDIQ by means of confirmatory factor analysis (CFA), convergent, discriminant and empirical validity. A cross-sectional field survey design and a convenience sample of educators from several educational institutions in the Gauteng Province (N = 502) was utilised to gather the data. CFA was used to test the factorial validity of the adapted SUDIQ scale. In order to prove convergent and discriminant validity, the relationships between the SUDIQ dimensions and similar theoretical constructs (job resources, strengths use, psychological capital, proactive behaviour and person-job fit) as well as constructs postulated to be unrelated to the SUDIQ dimensions (age and education) were determined. Finally, the relationship between the SUDIQ dimensions with vigour, dedication, emotional exhaustion and depersonalisation was determined by using multiple regression analysis. The results confirmed that the SUDIQ comprised a four-factor structure. These four factors were perceived organisational support for strengths use, perceived organisational support for deficit improvement, proactive behaviour towards strengths use and proactive behaviour towards deficits improvement. These dimensions were positively related to the scales such as the strengths use scale, autonomy, supervisor and colleague support, psychological capital, proactive behaviour, and person-job fit. Anticipated perceived organisational support for deficit improvement and proactive behaviour towards strengths use and proactive behaviour towards deficit improvement were unrelated to age. The scales were also relatively weakly related to education. Furthermore, the results revealed that perceived organisational support for strengths use, proactive behaviour towards strengths use and proactive behaviour towards deficit improvement were significant predictors of both vigour and dedication. However, it was found that the only SUDIQ dimension that predicted emotional exhaustion and depersonalisation was proactive behaviour toward strengths use. Recommendations were made to be applied in practice, as well as for future research. / MCom (Industrial Psychology), North-West University, Potchefstroom Campus, 2014 Validation Gauteng educators Positive Psychology Validering Suid-Afrikaanse onderwysers Positiewe sielkunde
164	Adapting and validating the Strengths Use and Deficit Improvement Questionnaire for educators in Gauteng / Rachele Paver Paver, Rachele January 2014 (has links) Education is essential in providing future human capital that is much needed to build a sustainable, competitive economy. However, the importance of a quality education is often underestimated. In order to enhance working conditions of educators, it seems essential to investigate the role of the positive psychology paradigm by means of developing teachers’ areas of deficiencies and capitalising on their strengths in order for them to reach their full potential and flourish. The current study aimed to adapt and validate the recently developed Strengths Use and Deficit Improvement Questionnaire (SUDIQ) in an attempt to make it suitable for educators. The general objective of this research study was to establish the psychometric properties of the SUDIQ by means of confirmatory factor analysis (CFA), convergent, discriminant and empirical validity. A cross-sectional field survey design and a convenience sample of educators from several educational institutions in the Gauteng Province (N = 502) was utilised to gather the data. CFA was used to test the factorial validity of the adapted SUDIQ scale. In order to prove convergent and discriminant validity, the relationships between the SUDIQ dimensions and similar theoretical constructs (job resources, strengths use, psychological capital, proactive behaviour and person-job fit) as well as constructs postulated to be unrelated to the SUDIQ dimensions (age and education) were determined. Finally, the relationship between the SUDIQ dimensions with vigour, dedication, emotional exhaustion and depersonalisation was determined by using multiple regression analysis. The results confirmed that the SUDIQ comprised a four-factor structure. These four factors were perceived organisational support for strengths use, perceived organisational support for deficit improvement, proactive behaviour towards strengths use and proactive behaviour towards deficits improvement. These dimensions were positively related to the scales such as the strengths use scale, autonomy, supervisor and colleague support, psychological capital, proactive behaviour, and person-job fit. Anticipated perceived organisational support for deficit improvement and proactive behaviour towards strengths use and proactive behaviour towards deficit improvement were unrelated to age. The scales were also relatively weakly related to education. Furthermore, the results revealed that perceived organisational support for strengths use, proactive behaviour towards strengths use and proactive behaviour towards deficit improvement were significant predictors of both vigour and dedication. However, it was found that the only SUDIQ dimension that predicted emotional exhaustion and depersonalisation was proactive behaviour toward strengths use. Recommendations were made to be applied in practice, as well as for future research. / MCom (Industrial Psychology), North-West University, Potchefstroom Campus, 2014 Validation Gauteng educators Positive Psychology Validering Suid-Afrikaanse onderwysers Positiewe sielkunde
165	Streamlining Certification Management with Automation and Certification Retrieval : System development using ABP Framework, Angular, and MongoDB / Effektivisering av certifikathantering med automatisering och certifikathämtning : Systemutveckling med ABP Framework, Angular och MongoDB Hassan, Nour Al Dine January 2024 (has links) This thesis examines the certification management challenge faced by Integrity360. The decentralized approach, characterized by manual processes and disparate data sources, leads to inefficient tracking of certification status and study progress. The main objective of this project was to construct a system that automates data retrieval, ensures a complete audit, and increases security and privacy. Leveraging the ASP.NET Boilerplate (ABP) framework, Angular, and MongoDB, an efficient and scalable system was designed, developed, and built based on DDD (domain-driven design) principles for a modular and maintainable architecture. The implemented system automates data retrieval from the Credly API, tracks exam information, manages exam vouchers, and implements a credible authentication system with role-based access control. With the time limitations behind the full-scale implementation of all the planned features, such as a dashboard with aggregated charts and automatic report generation, the platform significantly increases the efficiency and precision of employee certification management. Future work will include these advanced functionalities and integrations with external platforms to improve the system and increase its impact on operations in Integrity360. Certification Management Automation Certification Retrieval ABP Framework Angular MongoDB Credly API Exam Information Exam Vouchers Authentication Role-Based Access Control Data Retrieval Audit Security Privacy Efficiency Accuracy Scalability Maintainability Domain-Driven Design Software Development User Interface Data Encryption HTTPS Input Validation Identity Management Audit Logging Cybersecurity Education Training Employee Certification Study Progress Centralized Platform Data Integration Consolidated View Graphs Bar Charts Manual Data Entry Information Silos Decision Making Compliance Industry Standards Partner Levels Financial Penalties Reputation Damage Business Opportunities NoSQL Database Unstructured Data Semi-structured Data Software Architecture Layered Architecture Presentation Layer Application Layer Domain Layer Entities Value Objects Aggregates Repositories Domain Services Data Transfer Objects (DTOs) Business Logic Domain Semantics Modern Web Applications User Authentication Authorization Audit Logging Dynamic Web Applications Component-Based TypeScript Type Safety Code Quality Maintainability Active Community Charts Graphs Secure Submission LeptonX Lite Responsive Design Navigation Sidebar Menu Bar Tabs Table Attributes Properties Buttons Modal Dialogs Profile Settings System Admin Panel Account Management Permissions System Settings Certifikathantering Automatisering Certifikathämtning ABP Framework Angular MongoDB Credly API Examinformation Examenvouchers Autentisering Rollbaserad åtkomstkontroll Datahämtning Granskning Säkerhet Integritet Effektivitet Noggrannhet Skalbarhet Underhållbarhet Domändriven design Programvaruutveckling Användargränssnitt Datakryptering HTTPS Indata validering Identitetshantering Granskningsloggning Cybersäkerhet Utbildning Träning Medarbetarcertifiering Studie Framsteg Centraliserad plattform Dataintegration Konsoliderad vy Grafer Stapeldiagram Manuell datainmatning Informationssilos Beslutsfattande Efterlevnad Branschstandarder Partnernivåer Ekonomiska påföljder Ryktesskada Affärsmöjligheter NoSQL-databas Ostrukturerad data Semistrukturerad data Programvaruarkitektur Skiktad arkitektur Presentationslager Applikationslager Domänlager Entiteter Värdeobjekt Aggregat Repositories Domäntjänster Dataöverföringsobjekt (DTO) Affärslogik Domänsemantik Moderna webbapplikationer Användarautentisering Auktorisering Granskningsloggning Dynamiska webbapplikationer Komponentbaserad TypeScript Typsäkerhet Kodkvalitet Underhållbarhet Aktiv gemenskap Diagram Grafer Säker inlämning LeptonX Lite Responsiv design Navigering Sidofält Menyrad Flikar Tabell Attribut Egenskaper Knappar Modala dialogrutor Profilinställningar Systemadministratörspanel Kontohantering Behörigheter Systeminställningar Software Engineering Programvaruteknik

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