5-HT2B receptor agonism causes cardiac valvulopathy, a condition characterized by thickening of the heart valves and as a result, regurgitation of blood within the heart. The anti-obesity drug fenfluramine, which was originally prescribed as an anorectic, was withdrawn from the market due to causing cardiac valvulopathy. Fenfluramine, after metabolism by N-dealkylation, produces the metabolite norfenfluramine, which acts as a more potent valvulopathogen. The same was seen with MDMA (ecstasy), a popular drug of abuse, which is metabolized by N-dealkylation to produce MDA, a more potent valvulopathogen. Glennon and co-workers. studied a series of 2,5-dimethoxy-4- substituted phenylisopropylamines (DOX type) hallucinogens and determined their affinities at the three types of 5-HT2 receptors. A high correlation was found between the affinities of these molecules at 5-HT2A and 5-HT2B receptors. Therefore, these hallucinogens have a high possibility of causing valvulopathy, which gives rise to a new class of valvulopathogens. Since certain hallucinogens have the common phenylisopropylamine structural scaffold as that of MDA and norfenfluramine, we conducted 3D-QSAR studies to identify the common structural features of these molecules that are responsible for their high affinities. We were unable to obtain a suitable CoMFA and CoMSIA model for 5-HT2B receptors, but we were able to obtain an internally and externally validated model for 5-HT2A receptor affinities which indicated the hydrophobicity of the substituent at the 4- position was essential for high affinity. Following up with this evidence, we conducted a correlation analysis for the hydrophobicity (π-value) of the 4-position substituent and found a positive correlation between the π-value and the affinity of the molecules. The same results were not observed for the volume of the substituents. We docked the molecules into the 5-HT2B receptor and successfully generated models of the putative interactions made by the DOX molecules and the receptor. In order to compare their binding modes with respect to known valvulopathogens, we also generated models for norfenfluramine and MDA. Our docking results revealed that DOX molecules bind in a more or less similar manner to valvulopathogens MDA and norfenfluramine. Ours is the first in silico model developed for the potent valvulopathogen MDA and the hallucinogenic DOX series of molecules.

Ce travail se propose d'interroger le problème des limites de la représentation du cinéma de l'âge classique (1920-1960) à partir de l'esthétique organique-pathétique conçue par Sergueï Eisenstein dans la Non-Indifférente Nature, qu'il nomme « formule de l'extase ». Après avoir montré l'existence d'une double nature de l'extase chez Eisenstein (en même temps eidétique et régressive), ce travail montre les analogies de cette formule avec la mise en forme de l'excès de pathos (thématique et formel) dans l’œuvre de trois cinéastes hollywoodiens, King Vidor, Josef von Sternberg et Orson Welles. / This piece of work aims to inquire the topic of the limits of representation in the cinema of classical era (1920-1960) on the basis of the organic-pathetic esthetics conceived by Sergei Eisenstein in The Nonindifferent nature, which he names “formula of ecstasy”. After having shown the existence of a double (that is, eidetic and regressive at the same time) nature of ecstasy in Eisenstein, this piece of work will focus on the analogies between this formula and the shaping of the excess of (thematic and formal) pathos in the works by three Hollywood filmmakers: King Vidor, Josef von Sternberg and Orson Welles.

Les raves sont des événements festifs dédiés à la musique techno et à la danse qui se distinguent des autres lieux de rassemblement tels que les bars et les discothèques notamment par le fait qu’ils se déroulent toute la nuit dans un lieu aménagé pour l’occasion et qu’il n’y a généralement pas de vente d’alcool. La consommation de drogues de synthèse telles que l’ecstasy et les speeds y est toutefois largement répandue. La tenue de ces rassemblements pose une série de problèmes du point de vue des autorités policières, tels que la présence de trafiquants de drogues ainsi que la sécurité des lieux où se déroulent les raves. Dans le contexte particulier de ces événements, les pratiques de contrôle social sont soumises à un certain nombre d’ambiguïtés. Le but général de l’étude est de permettre une compréhension de la façon dont se déterminent et s’appliquent les règles qui visent à encadrer la tenue de ce type de rassemblements. Trois objectifs spécifiques sont poursuivis, soit 1) de comprendre comment on a tenté de réguler ce type d’événements à Montréal, 2) de comprendre comment les différents acteurs responsables de l’organisation et du bon déroulement des événements établissent une série de règles, aussi bien formelles qu’informelles, et négocient leur application dans le cadre de leur pratique, et 3) de comprendre comment ces acteurs identifient certaines situations comme constituant un problème et éventuellement, y réagissent. La principale méthode de recueil des données a consisté à réaliser des entretiens semi-dirigés avec des promoteurs d’événements rave, des agents de sécurité ainsi que d’autres personnes impliquées dans le milieu telles que policier, pompier, artistes de la scène rave et intervenants. L’observation participante lors d’événements rave fut utilisée comme méthode complémentaire. L’étude démontre comment le service de police s’est vu confronté avec les raves à un vide juridique et comment l’encadrement de ce type d’événements s’est plutôt exercé par le service de prévention des incendies. Les autorités ont également tenté d’encadrer le phénomène par des modifications à certaines règlementations, dont celles sur les permis d’alcool. L’étude démontre également de quelle manière et en fonction de quoi les différents acteurs du milieu négocient les règles en cours d’action dans un contexte où la frontière entre le licite et l’illicite est floue. / Raves are festive events dedicated to dance and techno music, different from other places of gathering such as bars and discotheques by the fact that they take place in all night venues converted for the occasion and where there is generally no sale of alcohol. Synthetic drug consumption such as ecstasy and speed is largely widespread in these events. The existence of these gatherings poses a series of problems from the point of view of the police authorities, such as the presence of drug dealers as well as the safety of the venue where the raves are held. In the particular context of these events, social control practices are subjected to a certain number of ambiguities. The general goal of this study is to allow an understanding of the way the rules, that constitute the framework of this type of gathering, are determined and applied. Three specific objectives pursued in this study are 1) to understand how authorities tried to control these types of events in Montreal, 2) to understand how the various actors responsible for the organization of these events establish a series of rules, formal and informal, and negotiate their application within the framework of their practice, and 3) to understand how these actors identify certain situations as problematic and eventually react to them. The main data collection method consisted in carrying out semi-directed interviews with rave Producers, Security Agents, Police Officer, Fire Marshal, Artists of the rave scene and other parties involved. Participating observation in actual events was a complementary method. This study demonstrates how the police service faced a legal void regarding rave events and how the regulatory framework was rather introduced by the fire department. The authorities also tried to control the rave phenomenon by modifying certain regulations, such as those applicable to alcohol licence. The study also demonstrates how and why key stakeholders negotiate the rules in the course of action in this particular context where the frontier between the licit and the illicit is woolly.

Cette thèse pense la place des figures littéraires (le Cantique des cantiques, Kierkegaard, Hofmannsthal) et cinématographiques (Matador d'Almodóvar) de la séduction dans la relation entre le soi et l'autre. Elle interroge le rapport au sacré et à la transcendance que pose l'écriture de la séduction. Dans le premier chapitre, les frontières établies entre littérature et philosophie (personnage conceptuel, figure esthétique) sont interrogées à travers les figures de la séduction. À ces figures sont associées les figures de matadors, qui permettent de penser la violence extrême de la séduction et l'instant au cours duquel la conscience ne peut plus se dédoubler. Le deuxième chapitre est une réflexion, à partir des figures du maître et de l'esclave, sur le désir et la conscience de soi et de l'autre dans la séduction. Les figures tauromachiques exposent le sacrifice à l'œuvre dans la séduction. Le dialogue est ici pensé au sein de la séduction, pour saisir la place de celle-ci dans la formation de la pensée. Le troisième chapitre développe le rapport entre le soi, l'autre et le monde qu'établit la séduction. Le dandysme permet d'approcher la tension entre la matière et l'esprit que posent la séduction et son écriture. Le dialogue à l'œuvre dans la séduction est présenté comme un espace de formation. La séduction est envisagée comme séduction éthique, quête de la bonne distance, exercice spirituel. La syncope, le duende, l'extase sont décrits comme des états de conscience où la distance entre le soi et le monde, le soi et l'autre, l'esprit et la matière s'abolit. À partir de ces états, l'ouverture vers l'infini et vers la transcendance que peut poser la séduction est exposée. Dans le quatrième chapitre, la séduction est pensée comme le parfum du sacré, à travers une lecture du Cantique des cantiques. Par la séduction, l'importance du corps dans le sacré est soulignée. La place du secret et de la foi dans la séduction, dans le sacré et dans le littéraire est étudiée. La séduction permet une plongée érotique dans le monde et dans le réel, par les figures et par les images qu'elle déploie. Le savoir de la séduction est un parcours, savoir du corps et de l'esprit. / This thesis reflects on the place of literary (Kierkegaard, Hofmannsthal, The Song of Songs) and cinematic (Matador d'Almodóvar) figures of seduction in the relation between the self and the other. It explores the connection to transcendence and the sacred inscribed in writings on seduction. In the first chapter, the figures of seduction help us put into question the boundaries between literature and philosophy (conceptual persona and aesthetic figure). The figures of bullfighters, associated with the figures of seducers, present the extreme violence of seduction and the instant when consciousness can no longer be split in two. The second chapter is a reflexion, through the figures of the master and the slave, on desire, consciousness of the self and the other in the relationship of seduction. The figures of bullfighters manifest the sacrifice in seduction. Dialogue, considered at the heart of seduction itself, reveals the importance of seduction in the process of thinking. The third chapter develops the bond established by seduction between the self, the other and the world. In the writings of seduction, dandyism shows the tension between mind and matter. The dialogue at work in seduction opens a space of education. Seduction is viewed as an ethical process, the search for an appropriate distance, a spiritual exercise. Loss of consciousness, duende and ecstasy are described as states of consciousness that abolish the distance between self and world, self and other, and mind and matter. Through these states, seduction brings about an opening to the infinite and transcendence. Finally, seduction is defined as the perfume of the sacred through a reading of The Song of Songs. Through seduction, the importance of the body in the sacred is underscored. The place of secrecy and faith in seduction, the sacred and literature is examined. Seduction enables an erotic immersion in the world, in the real, through the figures and images of seduction. The knowledge of seduction is a process, a knowledge of body and mind.

Thesis (Ph. D. in Religion)--Vanderbilt University, Dec. 2008. / Title from title screen. Includes bibliographical references.

[pt] O objetivo desta dissertação é pesquisar o valor da dimensão extática da Igreja, fazendo um estudo teológico-pastoral sobre a Renovação Carismática Católica no Brasil. Com isso, começaremos a nossa pesquisa apresentando o desejo de Deus em se comunicar com o ser humano e, como consequência, este tem a necessidade de acolhê-Lo e de se comunicar com Ele. Esta ânsia de comunicação manifesta-se no arco da história das religiões de diversas formas, e uma delas é o êxtase. Investigaremos, então, a função que o êxtase tem na experiência religiosa cristã primitiva. Faremos um percurso histórico a respeito do êxtase no antigo Israel, como também na experiência religiosa de outros povos que tiveram contato com Israel, para podermos compreender a experiência extática tanto veterotestamentária como também neotestamentária. Mostraremos a dimensão extática na Igreja dos Atos do Apóstolos e na Igreja de Corinto. Veremos que por causa desta dimensão extática, os carismas transbordavam e milagres e prodígios aconteciam abundantemente. Com isso, a cada dia mais e mais pessoas se juntavam a eles, pois eram Igrejas inclusivas, onde ninguém passava necessidade. Em seguida, apresentaremos como, ao longo dos tempos, devido às dificuldades enfrentadas, surge a necessidade de sistematizar a Igreja, provocando o enfraquecimento da sua dimensão extática e dando preferência à defesa da fé pela razão. A doutrina passa a ser racional e o kerigma perde seu lugar para a filosofia moral, resultando no declínio da Igreja extática. Contudo, o Espírito Santo sopra, mais uma vez, sobre a Igreja, e o Concílio Ecumênico Vaticano II é convocado. Há, nesse momento da história, uma reviravolta na Igreja e o retorno dos carismas, propiciando assim o reavivamento da Igreja extática e dando início à Renovação Carismática Católica. Em seguida, mostraremos as críticas e controvérsias que a Renovação Carismática Católica teve que enfrentar, causando assim a necessidade de se sistematizar e hierarquizar. Finalizaremos a nossa pesquisa apresentando os riscos e as possibilidades pastorais atuais para a dimensão extática da Igreja. Mostraremos que, apesar de estarmos vivendo uma transição epocal, a proposta cristã permanece a mesma e, por essa razão, é preciso recuperarmos o projeto de Jesus Cristo e a dimensão extática de Sua Igreja, uma vez que a nossa intenção é mostrar que o êxtase é uma legítima expressão dentro de uma estrutura religiosa. / [en] The objective of this dissertation is to research the value of the ecstatic dimension of the Church. Fulfilling a theological-pastoral study on the Catholic Charismatic Renewal in Brazil. We will begin our research presenting God s desire in communicating with the human being; consequently, the human being has the need to accept God and to communicate with Him. This eagerness for communication will manifests, in the arc of the history of religions in various ways, one of which is ecstasy. We will investigate the role that ecstasy has in the early Christian religious experience. We will make a historic route about the ecstasy in ancient Israel, as well as in other people s religious experience who had contact with Israel. This will be done, so that we can understand the ecstasy experience in the Old Testament as well as in the New Testament. We will show the ecstatic dimension in the Church of the Acts of the Apostles and in the Church of Corinth. We will see that, because of this ecstatic dimension, the charisms overflowed, miracle and wonders happened, and every day more and more people joined them. That because they were an inclusive Churches and nobody was in need. We will show how throughout the years, due to the difficulties faced by the Church, there was a need to systematize the Church. This will weaken the ecstatic dimension of the Church and the doctrine will become rational. The kerigma loses its place for the moral philosophy; this will provoke the decline of the ecstatic Church. However, the Holy Spirit, once again, comes down over the Church and the Second Vatican Ecumenical Council is announced. At this point, a turnaround happens in the Church and the charisms returns, bringing the revival of the ecstatic Church, beginning the Catholic Charismatic Renewal. We will show the criticisms and controversies that the Catholic Charismatic Renewal had to face, causing the need to systematize and hierarchize. We will conclude our research by presenting the risk and pastoral possibilities for the ecstatic dimension of the Church. Although we are living in an epocal transition, the Christin proposal remains the same and for this reason, we must recover Jesus Christ project and the ecstatic dimension of His Church. We intend to show that ecstasy is a legitimate expression within a religious structure.

O primeiro objetivo do presente estudo, de cunho metodológico, foi verificar a viabilidade da realização de uma pesquisa com usuários de ecstasy via internet. A metodologia desenvolvida para o recrutamento e coleta de dados atingiu os objetivos propostos, demonstrando-se viável e profícua, além de apresentar grandes vantagens em relação à coleta de dados presencial. O segundo objetivo foi oferecer subsídio para futuras intervenções de Redução de Danos para o uso de ecstasy. O questionário on-line foi respondido por 1.140 pessoas, primordialmente jovens, com boa formação escolar, inseridos no mercado de trabalho e/ou estudantes, pertencentes às classes socioeconômicas A e B, e poliusuários de drogas. As respostas dos participantes foram descritas estatisticamente e os dados comparados através dos testes t ou chi-quadrado, e analisados por regressão categórica (CatReg) em que se relacionaram os comportamentos de risco associados ao uso de ecstasy com as variáveis independentes relevantes. Os resultados não fundamentam a elaboração de materiais preventivos com direcionamentos específicos, seja para gêneros, para opções sexuais ou para classes socioeconômicas. Indicam, porém, locais privilegiados para a distribuição de material preventivo: ambientes de lazer noturno, festas e eventos ligados à música eletrônica, eventos como paradas comunitárias, e universidades públicas e privadas. São discutidos os principais conteúdos a serem veiculados, tendo sempre como princípio básico a transmissão de informações cientificamente comprovadas. Os dados mostram ainda que é crescente a disponibilidade de ecstasy no Brasil indicando urgência na implantação de um primeiro programa preventivo brasileiro voltado para essa droga. A acolhida e as declarações de interesse dos participantes demonstraram que o projeto inspirou confiabilidade, que existe demanda por intervenções na área e que uma proposta de Redução de Danos teria grande receptividade dos usuários de ecstasy, embora sua implantação dependa do interesse das autoridades responsáveis pela política pública brasileira em relação às drogas ilegais. / One objective of this study was methodological investigating the feasibility of conducting a Web-based survey with ecstasy users. The method developed for participants recruitment and data collection attained the propose proving feasible and fruitful, as well as showing great advantages as compared to personal data collecting. The second objective was to provide subsidies for future Harm Reduction interventions on the use of ecstasy. Participants (N=1.140) were mostly youngsters, with high schooling levels, and currently employed or studying, of A and B social-economic classes, and polydrug users. The data were analyzed using chi-square or t tests and categorical regression (CatReg). The latter evaluated users’ risk behaviors and related them to relevant independent variables. The results do not set the grounds for the drafting of specially-oriented preventive materials, be it for genders, sexual orientation, or even social-economic classes. They do, however, indicate privileged places for the distribution of preventive materials: evening entertainment places, parties and events related to electronic music, events such as community Parades, and universities. The main contents to be conveyed are discussed, always keeping the communication of scientifically proven information as the basic principle. The data also show that there is increasing availability of ecstasy in Brazil, thus pointing to the urgent need of implementing a first Brazilian ecstasy preventive program. The buy-in and the interested statements from participants demonstrate that the project inspired reliability, that there is a demand for interventions in the area and that a Harm Reduction proposal would be highly accepted amongst ecstasy users, although its implementation depends on the interest of authorities responsible for the Brazilian public policy towards illegal drugs.

Ecstasy é o nome popular do 3,4-metilenodioximetanfetamina (MDMA), uma droga de abuso utilizada por adultos jovens. Diversos relatos têm mostrado existência de correlações positivas entre o abuso do Ecstasy e o aparecimento de doenças infecciosas. Muitos estudos em modelos animais mostram que o MDMA induz alterações de imunidade inata e adquirida; entretanto pouco se sabe sobre os mecanismos pelos quais estes efeitos ocorrem. Desta forma, buscamos neste trabalho os mecanismos neuroimunes pelos quais o MDMA diminui a atividade de neutrófilos e altera a distribuição de leucócitos nos diferentes compartimentos imunes. Além disso, avaliamos se os efeitos induzidos pelo MDMA afetam a resposta a uma infecção experimental induzida por Listeria monocytogenes. Nossos resultados mostram que 60 minutos após a administração de MDMA na dose 10mg/kg, houve 1) diminuição do burst oxidativo de neutrófilos induzido por SAPI e PMA e, também, da porcentagem e da intensidade da fagocitose dos neutrófilos sanguíneos; 2) diminuição da celularidade total da medula óssea e aumento da mesma no baço, além de diminuição do peso relativo do baço; 3) aumento na porcentagem de neutrófilos e diminuição na porcentagem de linfócitos sanguíneos; e 4) diminuição da expressão de NFB de neutrófilos sanguíneos. O tratamento com metirapona ou RU-486 prévio ao tratamento com MDMA foi capaz de inibir 5) os efeitos observados em todos os parâmetros avaliados na diminuição da atividade de neutrófilos; 6) as alterações das porcentagens de neutrófilos e linfócitos sanguíneos e 7) a diminuição da expressão de NFB. Observamos, ainda, que o tratamento com 6-OHDA ou ICI-118,551 prévio ao tratamento com MDMA 8) não foram capazes de inibir os efeitos induzidos pelo MDMA na atividade de neutrófilos e na contagem diferencial de leucócitos sanguíneos; no entanto, 9) preveniram as alterações de celularidade induzidas por MDMA na medula óssea e no baço, e 10) a diminuição do peso relativo do baço. Por fim, observamos em um modelo de infecção experimental por LM que o MDMA 11) induziu mielosupressão (diminuição do CFU na medula óssea e aumento no baço); 12) diminuiu o número de leucócitos sanguíneos e a celularidade da medula óssea; 13) aumentou a celularidade do baço; 14) diminuiu a produção de citocinas pró-inflamatórias (IL-12p70, TNF, IFN-, IL-6) e quimiocina (MCP-1) nas primeiras 24 h; e 15) aumentou a produção das mesmas citocinas e quimiocina após 72 h da indução da infecção. Desta forma, concluímos que os efeitos induzidos pelo MDMA sobre a atividade de neutrófilos foram provavelmente mediados pela diminuição da expressão de NFB induzido pela ação da corticosterona e que a corticosterona, também está envolvida com as alterações na contagem diferencial de neutrófilos e linfócitos. As catecolaminas periféricas responderam pelas alterações na distribuição de leucócitos entre baço e medula óssea, e diminuição do peso relativo do baço. Além disso, o MDMA pode ser considerado uma droga imunossupressora visto que diminuiu a resistência a uma infecção por LM por mecanismos neuroimunes / Ecstasy is the popular name of 3,4-metylendioxymetamphetamine (MDMA), a drug of abuse mainly used by young adults. Several reports have shown the existence of a positive correlation between Ecstasy abuse and increased susceptibility to infectious diseases. Some studies using animal models report that MDMA induces alterations in both innate and adaptive immunity, however little is known about the mechanisms that generate such alterations. Therefore, we sought for neuroimmune mechanisms that could be involved in the previously reported decreasing on neutrophil activity and alteration in the leukocyte distribution. Moreover, we analyzed the host resistance to Listeria monocytogenes after MDMA treatment. We show that MDMA (10 mg/kg), 60 min after administration: 1) decreases SAPI and PMA-induced oxidative burst and percentage/intensity of phagocytosis of circulating neutrophils; 2) decreases bone marrow cellularity while increases it in the spleen, and also decreases spleen relative weight; 3) increases neutrophil percentage while decreases lymphocyte percentage in the blood; and 4) decreases NFB expression on circulating neutrophils. Metyrapone or RU-486 prior to MDMA treatment abrogates 5) the MDMA effects previously reported on neutrophil activity; 6) alterations in the percentage of circulating neutrophils and lymphocytes, and 7) decreasing of NFB expression. We also show that 6-OHDA or ICI-118,551 prior to MDMA treatment were not able to 8) abrogated the MDMA effects previously reported on neutrophil activity and blood leukocyte differential counts; nevertheless, 9) they abrogated the previously reported alterations on bone marrow and spleen cellularity, and 10) reduction on spleen relative weight. Finally, in a model of host resistance to Listeria monocytogenes we show that MDMA: 11) induces myelosuppression by decreasing CFU on bone marrow while increasing it on spleen; 12) decreases circulating leukocytes and bone marrow cellularity; 13) increases spleen cellularity; 14) decreases pro-inflammatory cytokines production (IL-12p70, TNF, IFN-, IL-6) and chemokine (MCP-1) after 24h of the infection; and 15) increases the production of the pro-inflammatory cytokines and chemokines previously reported after 72h of the infection. Thus, we conclude that the MDMA effects on neutrophil activity were mediated by the reduction of NFB expression, and this effect was induced by corticosterone elevation in the serum. Corticosterone is also involved in the alterations on neutrophil and lymphocyte counts. Catecholamines were shown to be involved in the alterations on leukocyte distribution in the bone marrow and spleen, and in the reduction of relative weight of spleen. Additionally, MDMA reduced the host resistance to Listeria monocytogenes. Therefore, MDMA can be considered an immunosuppressive drug and those effects are mediated by neuroimmune mechanisms

In The Passion According to GH, Clarice Lispector novel, published in 1964, to verify how is the disintegration mimetic narrative, occurs an everyday and trite situation - a woman, identified only as G. H, kill a cockroach - but this fact in the story takes many dimensions and results an existential quest of character. This quest unleash changes in the psychology of GH, which are reviewed in the study, in the light of Freudian theory, especially the theory of drive, the element "strange" and the pleasure principle. We also verify the process of abjection, Kristeva, and their correspondence in the narrative. The analysis is done by inserting the reading in an attempt to show as getting rid of the referential illusion and the failure of the narrative, which finds its limits in silence. / Em A paixão segundo G. H., romance de Clarice Lispector, publicado em 1964, no qual se busca verificar como se dá a desintegração mimética na narrativa, ocorre uma situação cotidiana e banal uma mulher, identificada apenas como G. H, mata uma barata , mas esse fato adquire muitas dimensões na narração e origina uma busca existencial da personagem. Essa busca desencadeia transformações na psicologia de G. H., as quais são revistas, no estudo, à luz da teoria freudiana, principalmente, da teoria das pulsões, do elemento estranho e do princípio de prazer. Também se busca verificar o processo da abjeção de Kristeva, e suas correspondências na narrativa. A análise se faz pela inserção na leitura na tentativa de mostrar como acontece o desfazer-se da ilusão referencial e o fracasso da narrativa, que encontra seus limites no silêncio.

L’objet de cette thèse est de montrer, dans un corpus français compris entre 1601 et 1675, que l’extase est employée comme la condition du sens de ces discours. La première partie, qui porte sur la fin de l’extase mystique, vise à répondre aux besoins préliminaires d’une définition de l’extase au XVIIe siècle, afin de disposer des outils lexicaux, notionnels et historiques pour mener à bien la recherche poétique. Sont précisés le lexique de l’extase, les conséquences induites par la transformation d’un principe métaphysique en un phénomène humain, et la situation de l’extase face au discernement spirituel qui a abouti à sa faillite. La deuxième partie, qui est consacrée aux récits d’extases, permet de mesurer les conséquences poétiques des premières conclusions, en distinguant la poétique narrative de deux objets qui se trouvent à l’un et l’autre bout des mutations de l’extase au cours du siècle, à savoir l’extase visionnaire dans la Vie de Thérèse d’Avila et l’extase devenue invisible dans les relations spirituelles de Claudine Moine. Ces deux extases sont traitées comme des objets sémiotiques, dont les procédures narratives posent à la narration un problème d’ordre temporel qui a pour effet de faire échec au récit de sainteté que Thérèse d’Avila entend mener, et de rendre impossible dans les écrits de Claudine Moine la conjonction du sujet de l’histoire racontée avec le sujet de la narration. Enfin, la troisième partie traite de l’énonciation de l’extase dans un corpus principalement poétique. Elle isole les figures historiques employées pour représenter une telle énonciation, précise la façon dont l’affectivité extatique s’articule à la parole, et éclaire l’incidence de l’économie affective de sujet extasié sur les modes de figuration objective de l’extase. / This dissertation aims to show, through an analysis of a French corpus dating from 1601 to 1675, that ecstasy is used as the condition of the meaning of these speeches. The first part, which focuses on the end of mystical ecstasy, seeks to meet the primary needs of a definition of ecstasy in the 17th century, in order to gather the lexical, notional and historical tools for poetical research. It clarifies the lexicon of ecstasy, shows the results of the transformation of a metaphysical principle into a human phenomenon, and explains the situation of mystical ecstasy facing the discernment of spirits that led to its fall. The second part, which focuses on the narratives of ecstasy, allows to evaluate the poetical consequences of the previous conclusions. It distinguishes indeed between the narrative poetics of two objects located on both ends of the mutations of ecstasy during the century: the visionary ecstasy in the Life of Teresa of Avila, and the invisible ecstasy in the spiritual relations of Claudine Moine. These two kinds of ecstasies are considered as semiotic objects, whose procedures result in a temporal problem: ecstasy stymies the narrative of holiness that Teresa of Avila intends to tell, and hinders the identification between the subject of the story and the subject of the narration in Claudine Moine’s writings. Finally, the third part deals with the enunciation of ecstasy in a corpus that is mainly poetical. It isolates the historical figures that are used to represent this enunciation, specifies how the ecstatic emotions are linked to verbal expression, and determines the impact of the ecstatic subject’s emotional economy on the objective modes of figuration of ecstasy.