Global ETD Search

361	An evaluation of cognitive deficits in a rat-model of Huntington's disease García Aguirre, Ana I. January 2016 (has links) The purpose of this thesis was to develop methodology by which treatments for the cognitive impairments in Huntington's disease (HD) could be tested. As such, the thesis focused mainly on evaluating rats with quinolinic acid (QA) lesions of the striatum, as this manipulation mimics some aspects of the neural damage in Huntington's disease, to try to identify cognitive deficits of HD resulting from cell loss in the striatum. In the first part (Chapters 3-5), the role of the striatum in implicit memory was investigated. Chapter 3 compared the performance of rats and humans on a reaction time task that evaluated implicit memory by presenting visual stimuli with differing probabilities which change over time. Although rats made higher percentage of incorrect responses and late errors, both groups showed a similar pattern of reaction times. Chapter 4 investigated whether implicit memory (the computation of probabilities to predict the location of a stimulus) was affected by selective blockade of dopaminergic transmission at the D1 or D2 receptors by SCH-23390 and raclopride, respectively. Reaction times were slower with SCH-23390 and raclopride, but only SCH-23390 reduced errors to the least probable target location. Chapter 5 used the same task to evaluate implicit memory in rats with QA lesions of the dorsomedial striatum (DMS). Implicit memory was not affected by lesions of the DMS, which suggested that once a task that requires implicit memory has been learned, the DMS was not involved in sustaining the performance of the task. The second part of this thesis (Chapter 6), explored the contribution of the DMS in habit formation. DMS lesioned rats did not show habitual responding, and were not impaired in learning a new goal-directed behaviour. The third part (Chapters 7 and 8), investigated the role of the dorsal striatum in reversal learning, attentional set-formation, and set-shifting. Dorsal striatum lesioned rats were not impaired in reversal learning, but had a diminished shift-cost, which suggested that dorsal striatum lesions disrupted the formation of attentional sets. These results showed that although QA lesions of the dorsal striatum mimic some aspects of the neural damage in HD, they did not result in the same cognitive deficits observed in patients with HD, at least using the tasks presented in this thesis. However, other animal models of HD could be evaluated using the different tasks presented in this thesis to continue the search of a reliable animal model of HD in which treatments for the disease could be evaluated. 616.85
362	Working out with F.I.D.O. (Frequency, Intensity, Duration, & Outcomes) - a feasibility randomized controlled trial Lim, Kah Aeng Clarise 18 August 2017 (has links) Objective: Dog owners have been shown to walk more per week compared to non-dog owners; however, 60% of dog owners are still not walking their dogs at intensities sufficient to reap optimal health benefits. The aim of this study was to evaluate the feasibility, acceptability, and efficacy of a 9-week feasibility randomized controlled trial involving a program of six weekly scheduled instructor-led group dog walks supplemented with theory-based strategies to encourage increased dog walking among dog owners in Greater Victoria, BC. Methods: This study was based on the multi-process action control (M-PAC) framework and utilized an open parallel randomized controlled trial design involving experimental and waitlist-control group participants. Quantitative data was collected using pedometers and self-report measures. A program evaluation survey was administered upon the completion of the study. Primary outcomes examined the feasibility and acceptability of the program; secondary outcomes analyzed pedometry and self-report moderate-to-vigorous physical activity (MVPA) data; and tertiary outcomes observed changes in participants’ perceptions of M-PAC constructs. Percentage calculations were used to obtain primary outcomes, and analysis of covariance (ANCOVA; controlling for baseline) was performed to examine secondary and tertiary outcomes to explore the direction of effects and obtain a first estimate of expected effect sizes. Eligibility: Male and female adults aged 18+ living in Greater Victoria, BC, who owned at least one healthy and friendly dog aged six months and above, who were not meeting recommended guidelines of 150 minutes of MVPA per week, and who were medically cleared to participate. Results: Feasibility outcomes included 74 interested responses, 23% recruitment rate (n = 17), 94% retention rate (n = 16), and 94% adherence rate (n = 15). Program participants were overall (very) satisfied with the program – worksheets (62.5%), program instructor (100%), various program/group dog walks logistics (75% to 100%). Total weekly step counts and average daily step counts, MVPA dog walking, and MVPA with dog increased at the end of the program and at follow-up, resulting in large effect sizes when compared to the waitlist-control group. MVPA dog walking and total MVPA (with and without dog) exceeded recommended guidelines at follow-up. Positive changes across time were observed for dog responsibility and M-PAC constructs of affective judgments, opportunity, planning, identity, and habit, resulting in medium and large effect sizes when compared to the waitlist-control group. Conclusions: This six-week group dog walking program is overall feasible, acceptable, and efficacious in encouraging increased dog walking and MVPA among dog owners. Attendance at weekly scheduled instructor-led group dog walks and exposure to the M-PAC construct worksheets resulted in program participants’ adoption and maintenance of positive behavioral changes at the end of the program and at follow- up. Program participants reported enjoying the program and being (very) satisfied with it. It is recommended for future studies to refine/modify initial recruitment strategies and eligibility criteria, reimburse medical/veterinarian clearance costs to reduce cost-related barriers to participation, offer a variety of options for program delivery (e.g., different locations/schedules/seasons, online programs, multi-site study) to accommodate more participants, and apply the M-PAC framework to a larger sample. / Graduate dogs dog owners dog walking physical activity pedometers psychological outcomes behavior change behavioral medicine behavioral outcomes behavior regulation content analysis MVPA Multi-Process Action Control (M-PAC) feasibility study feasibility, acceptability, efficacy randomized controlled trial effect sizes exercise psychology self-report measures step counts objective measures health behavior program evaluation exercise identity exercise habit dog responsibility
363	Online News Habits: Related Motives, Context, and Behavior Hirsch, Christopher 19 June 2018 (has links) No description available. Communication Psychology Cognitive Psychology Journalism Mass Communications Mass Media Multimedia Communications Web Studies media habits media use online news habit strength social cognitive theory Internet behavior expected outcomes deficient self-regulation self-reactive incentives context stability behavioral antecedents of media use news quantitative survey
364	Le train de vie en droit privé / Standard of living in private law Martinez, Michaël 19 October 2016 (has links) Locution issue du langage courant, le « train de vie » a été importée dans la sphère juridique dès la fin des années 1930 pour lutter contre la fraude fiscale. Depuis les années 1960 et surtout 2000 elle est utilisée dans toutes les branches du droit privé. Elle n’a pourtant reçu aucune définition. Partant de ce constat, la première partie de cette thèse s’intéresse au contenu juridique de la notion de train de vie. Elle y est définie comme la jouissance, à titre habituel d’une certaine quantité de biens et de services, caractérisant à la fois un niveau de vie et une habitude de vie. Il ressort de cette définition que tant les biens que les services peuvent être le support du train de vie, que cette notion s’apprécie en jouissance et non en propriété et qu’une condition de durée doit être remplie. La seconde partie de cette thèse s’intéresse aux effets qui sont attachés au train de vie. Il est toujours utilisé en tant que point de référence mais n’est pas toujours invoqué par la même personne. Ainsi, le train de vie peut être soit opposé à son bénéficiaire par un tiers, soit opposé par son bénéficiaire à un tiers. Dans le premier cas, il est un point de référence permettant d’identifier une disproportion, à laquelle sont attachées des conséquences juridiques néfastes pour le bénéficiaire du train de vie. Dans le second cas, il sert de point de référence pour apprécier et traiter une situation de rupture patrimoniale. Caractérisant une situation économique habituelle, le train de vie est doté d’une certaine inertie,qui nécessite qu’il ne soit pas arrêté brutalement. Il est alors de nature à conférer des droits à son bénéficiaire. / An expression usually found in everyday language, the « train de vie », or standard of living, wasbrought into the legal sphere as early as the late 1930’s in a bid to fight fiscal fraud. Since the 1960’s, and evenmore so since the 2000’s, it is found in all branches of private law. It has, however, never been defined.Therefore, the first part of this thesis looks into the legal content of the idea of « train de vie ». It is definedhere as the enjoyment of a certain quantity of goods and services that has come to be the habitual, markingboth a standard of living and a life habit. This definition of the expression leads to the conclusion that as goodsand services can support of the « train de vie », this is a notion that is to be assessed in enjoyment and not inpropriety, and that a condition of length of time is to be fulfilled. The second part of this thesis focuses on theeffects attached to the « train de vie ». It is still used as a reference point but not always invoked by the sameperson. Therefore, the “train de vie” can either be set against it’s beneficiary by a third party, or by it’sbeneficiary against a third party. In the first case, it becomes a point of reference allowing to identify a lack ofproportion, unto which are attached legal consequences unfavorable to the beneficiary of the « train de vie ».In the second case, it serves as a point of reference to asses and deal with a situation of a patrimonial break.Charaterizing a habitual economic situation, le “train de vie” is endowed with a measure of inertia, whichrequires that it not by stopped suddenly. It is thusfore of a nature to create rights for it’s beneficiary. Niveau de vie Jouissance Habitude Ressources Dépenses Proportionnalité Disproportion Excès Fraude Apparence Assurance-vie Libéralités Facultés Fortune Obligations alimentaires Divorce Prestation compensatoire Cadre de vie Maintenance Conjoint survivant Droit fiscal Droit social Aide sociale Sécurité sociale Droit patrimonial Famille Mariage PACS Concubinage Dépendance économique Standard of living Possession Habit Means Spending Proportionality Disproportion Excess Fraud Appearance Life insurance Gifts Fortune Divorce Compensatory allowance Living environment Maintenance Child support Social support Surviving spouse Fiscal law Social law Social assistance Social security Social Security benefits Droit patrimonial Family Wedding PACS, Concubinage
365	Réexamen de la notion d'arbitraire linguistique. Définition et contribution à l'identification de sa problématique / Reconsideration of the notion of arbitrary linguistic. Definition and contribution to the identification of the problem / إعادة النظر في مفهوم الاعتباط اللغوي : تعريفه والإسهام في تشخيص إشكاليته Al-Hamdani, Hayja 30 March 2013 (has links) Cette thèse jette la lumière sur la notion d'arbitraire linguistique qui, depuis les premières réflexions sur la nature du langage, ne cesse d'être, plus ou moins, un objet de débat: l'origine du langage est-elle humaine ou divine? Son statut est-il conventionnel ou naturel? La dénomination des choses est-elle fondée sur l'arbitraire humain ou sur sa raison? Par conséquent, le signe linguistique est-il arbitraire ou motivé? Ce débat s'étend depuis l'Antiquité jusqu'à nos jours, dans une proportion d'intensité variable en temps et en lieu. Mais dans tout cela, qu'entendons-nous au juste par arbitraire? Et pourquoi représente-t-il toujours une problématique?Dans ce contexte, nous avons conduit un travail qui parcourt l'histoire, de l'Antiquité à la période actuelle, pour voir comment la question de l'arbitraire a été traitée chez les savants. La globalité de cette étude permet de construire une idée du point de divergence qui fait de l'arbitraire une question autant soutenue que débattue par les savants. Ainsi, cette étude est conçue pour réexaminer la notion de l'arbitraire afin de pouvoir la définir et identifier sa problématique.Conduite dans une méthode de travail qui repose sur l'analyse logique et philosophique des textes, cette étude montre en conclusion que le problème de l'arbitraire réside dans l'ambiguïté de sa notion. Celle-ci est due à la multiplicité des sens qu'il peut renfermer, donc à la multiplicité de sa conception chez les philosophes et linguistes, mais aussi à la multiplicité des points de vue pour déterminer la partie concernée par l'arbitraire dans la théorie du signe. Autrement dit, c'est en terme de l'arbitraire des idées, qu'on peut parler de l'arbitraire du langage.La thèse finit par présenter une position sur le langage et l'arbitraire, construite sur deux questions: i) le fait qu'il existe des lois dans le langage qui gèrent son fonctionnement selon un système propre; ii) le fait qu'il existe un lien pertinent entre la pensée du groupe et sa langue. / This thesis sheds light on the linguistic notion of arbitrariness, which, since the very first reflections on the nature of language, continues – to a greater or lesser extent – to be a subject of debate: is the origin of language human or divine? Is its status conventional or natural? Is the naming of things based on human arbitrariness or human reason? Consequently, is the linguistic sign arbitrary or motivated? This debate extends from antiquity to the present day, in a proportion of variable intensity in time and place. But in all this, what do we mean by arbitrary? And why has it always represented a problematic?In this context, we have conducted a survey which retraces the history of this notion from antiquity to the present day, to see how the question of arbitrariness has been treated by savants. The global nature of this study can enable the construction of an idea of the point of divergence which makes arbitrariness into a matter of such sustained and controversial debate among savants. Thus, this study was designed to review the concept of arbitrariness in order to identify and define the problem.This study has been conducted using a working method based on the logical and philosophical analysis of texts. It conclusively demonstrates that the problem of the arbitrary lies in the ambiguity of the concept. This is due to the multiplicity of meanings that it can contain, that is, the multiplicity of its conceptions among philosophers and linguists, but this is also due to the multiplicity of points of view applied to determining the part affected by the arbitrary within the theory of the sign. In other words, it is in terms of arbitrary ideas that we can speak of the arbitrariness of language.The thesis ends by presenting a position about language and arbitrariness, which has been constructed around two issues: i) the fact that there are laws in the language that manage its working according to an own system; ii) that there is a relevant connection between the thought of a group and its language. / تلقي هذه الأطروحة الضوء على مفهوم الاعتباط اللغوي الذي ما انفك يكون بشكل او بآخر موضوعا للجدل منذ البدايات الأولى للتفكير في طبيعة اللغة : فهل إن أصل اللغة إنسانيّ أم إلهي؟ وهل أنّ تشريعها جاء بشكل اتفاقي أم طبيعي؟ هل جرت التسمية على أساس اعتباطية الإنسان ام على عقلانيته؟ وبالنتيجة فهل ان الإشارة اللغوية اعتباطية ام معللة؟ امتد هذا الجدل منذ العصور القديمة وحتى يومنا هذا بنسب متفاوتة بالشدة في الزمان والمكان. ولكن في كل هذا ، ما الذي نعنيه بالضبط بالاعتباط؟ ولماذا يمثل دائما إشكالية؟في هذا السياق أجرينا بحثا طاف التاريخ برمته منذ العصر القديم حتى يومنا هذا كي نتعرف كيف تمت معالجة هذا الموضوع عند علماء اللغة. ان شمولية هذا العمل تسمح بتكوين فكرة حول نقطة الخلاف الذي جعل من الاعتباط موضوعا قابلا للتأييد والرفض على حد سواء بين العلماء. وعليه فقد صممت هذه الدراسة لإعادة النظر في مفهوم الاعتباط من اجل تعريفه وتحديد اشكاليته.تتألف الأطروحة من أربعة أجزاء فصلت في سياق زمني ، ولكن رتبت على وفق التوزيع ألموضوعاتي. يتناول الجزء الأول مكونات الاعتباط كعناصر تعريفية ، وأنواع الاعتباط ، ويبحث الجزء الثاني في إشكالية الاعتباط من خلال دراسة جذور فكره والحجج التي قدمت في هذا الطرح والطرح الذي عارضه ، الأمر الذي ترك المشكلة بلا حل، إضافة إلى المقترحات التي حاول من خلالها العلماء الخروج من المشكلة. وقد خصص الجزء الثالث حصرا حول ملامح الاعتباط عند سوسير ؛ في حين ناقش الجزء الرابع مفهوم الاعتباط في الفكر الحديث.أجريت هذه الدراسة على وفق منهج بحث استند على التحليل المنطقي والفلسفي للنصوص. وبينت بالنتيجة أن مشكلة الاعتباط تكمن في غموض مفهومه. ويعود ذلك إلى تعدد المعاني التي يمكن ان تحتويه المفردة، وبالتالي تعدد طريقة فهمه عند الفلاسفة وعلماء اللغة ، إضافة إلى تعدد وجهات النظر في تحديد الجانب المعني بالاعتباط في نظرية الإشارة اللغوية. وبعبارة أخرى، يمكننا القول إنّ اعتباطية اللغة تكمن في إطار اعتباطية الأفكار.تقدم الأطروحة في النهاية فكر المؤلف حول اللغة ومسألة الاعتباط اللغوي، وقد بناه على مسألتين: الأولى أن هناك قوانين في اللغة تدير حركته على وفق نظام خاص؛ والثانية أن هناك علاقة وثيقة بين فكر المجموعة ولغتها. Langue Arbitraire Conventionnel Naturel Artificiel Immotivé Imposé Nomination Platon Aristote Mots/choses Institution Caractères Usage Locke Choix Leibniz Condillac Saussure Signifiant/signifié Principe Système Valeur Contradictions Diversité des langues Lois du langage Language Signs Arbitrary Conventional Natural Artificial Symbol Imposed Unmotivated Hazard Name Nomination Plato Aristotle Words / things Institution Symbol Reality Analogy Characters Ideas Habit Usage Locke Freedom Choice Leibniz Condillac Saussure Signifier / signified Principle System Value Contradictions Proper noun Reference Diversity of languages Logic Laws Thought اللغة الإشارات الاعتباط اتفاقي طبيعي اصطناعي مفروض مفروض الصدفة الاسم التسمية أفلاطون أرسطو الكلمات الأشياء الرمز مؤسسة اتفاق الواقع القياس الحروف الأفكار التعود الاستخدام الفعل الإرادي الحرية الاختيار ليبنز لوك كوندياك سوسير الدال والمدلول المبدأ النظام القيمة التناقضات اسم العلم المرجع تنوع اللغات المنطق القوانين الفكر الثقافة

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