應屆畢業護生雖然經過多次臨床實習的學習過程，但對即將成為臨床護士的角色，感到壓力及焦慮。某技術學院基於增加護生能力及培育產業人才所須，實施臨床選習制度，但臨床選習壓力過大，會影響護生職涯抉擇，產生不當因應策略，有憂鬱與焦慮情緒。因此，本研究目的主要有二：（1）瞭解臨床選習壓力、因應策略、輔導需求的現況與關係；（2）設計及實施認知行為團體輔導方案，探討方案對護專學生臨床選習壓力、因應策略、輔導需求與壓力反應之成效，作為未來選習壓力輔導方案的參考。 於臨床選習結束後1週內，選取327位五專五年級護生，以自編「臨床選習壓力、因應策略、輔導需求等量表」進行資料蒐集，運用單因子多變量變異數分析、皮爾森積差相關、多元逐步迴歸分析等，結果顯示如下： 1、五專選習護生有輕度臨床選習壓力，以「專業知識與技能」壓力最高，「有時」會使用因應策略，以「情緒抒發或認知調適」頻率最多，「有些」需要臨床選習輔導需求，最需要「行政與專業技能協助」。 2、在「重急症與特殊單位」選習護生，在「實際護理病人」或「專業知識與技能」的壓力，比「一般內外科病房」及「產兒與精神科」單位高。 3、畢業前計畫為「不確定」的選習護生臨床選習壓力，高於計畫「工作」或「就學」者。 4、「問題逃避或轉移」因應策略運用愈多及「教師與作業協助」輔導需求愈高，「整體臨床選習壓力」愈高；「情緒抒發或認知調適」因應策略運用愈多，「整體臨床選習壓力」愈低。 5、「問題逃避或轉移」、「情緒抒發或認知調適」策略、「教師與作業協助」輔導需求能有效聯合預測「整體臨床選習壓力」，聯合預測力為32％（F(4, 322) = 40.92, p < .001），其中以「問題逃避或轉移」策略最具預測力，單獨解釋量為28％，故實施認知行為團體方案有助於改善臨床選習壓力，增加因應策略。 在驗證認知行為輔導方案成效上，採實驗研究法，分實驗與控制組兩班，各30位，於臨床選習前兩個月對五專五年級實驗組班級護生實施8次，每次90分鐘單元活動，以「臨床選習壓力、因應策略、輔導需求、貝克憂鬱、貝克焦慮等量表」來資料收集，進行GEE分析、成對樣本t檢定及 McNemar-Bowker test、獨立樣本T檢定等檢定分析差異，結果顯示如下： 1、臨床選習前護生呈現輕度憂鬱與焦慮，實施認知行為團體輔導方案後，實驗組護生整體憂鬱有越來越低趨勢，焦慮也下降。 2、實施認知行為團體輔導方案，可提升臨床選習護生對「護理工作的喜好程度」，不影響畢業規劃，無法改善臨床選習壓力及臨床選習輔導需求程度，但可增加「情緒抒發或認知調適」及「整體選習壓力因應策略」，具立即及延宕成效；可改善憂鬱情緒，具立即及延宕成效；可降低焦慮的「主觀感受」，具延宕成效。 根據上述的研究結果，提出相關的建議。 / Although the graduates of the nursing major have taken various clinical practicum courses along the five years during their college study, they still feel a huge amount of stress and anxiety when they are going to work as nurses. Due to the great stress from the preceptorship clinical practicum, the nursing students of one technical college have developed improper adjustment strategies which induce more anxiety and depression and, moreover, have impact upon their career choices. This study aims to (1) understand the relationship among the stress of the preceptorship clinical practicum, the adjustment strategies and the need for counseling; and (2) design and implement the cognitive-behavioral group counseling model to investigate its effectiveness for developing certain adjustment strategies and the need for counseling among the students facing the stress of the preceptorship clinical practicum. After the nursing students of the fifth grade from one five-year technical college finished the practicum, 327 were selected to fill out “the stress of the preceptorship clinical practicum, the adjustment strategies, the need for counseling questionnaire” within 1 weeks. Through One-way MANOVA, Pearson product-moment correlation and Multiple Step Regression, data analysis shows: 1. The subjects listed “the professional knowledge and skills” the highest stressful, “sometimes” adopted certain adjustment strategies among which “venting emotions and cognitive adjustment” were used most frequently. “Some” subjects expressed the need for counseling. “The administrative and the professional assistance” was most needed. 2. The subjects proceeding the practicum at the emergency or critical care units felt more stressful about “clinical nursing” and “professional knowledge and skills” than those at the medical, surgical, obstetrical, psychiatric units. 3. The subjects whose plans after graduation were uncertain showed higher stressful levels than those who planned to work or continue the formal education. 4. The more the coping strategies of “avoiding problems” were adopted and the need for “the instructor and the assignment assistance” was demanded, the higher the overall stress level of the preceptorship clinical practicum was. The more the coping strategies of “venting emotions and cognitive adjustment” were adopted, the lower the overall stress level of the preceptorship clinical practicum was. 5. “The avoiding problems strategies”, “the venting emotions and cognitive adjustment strategies” and “the need for the instructor and the assignment assistance” could be combined to predict the stress level of the preceptorship clinical practicum. The joint predictability is 32％（F(4, 322) = 40.92, p < .001）. “The avoiding problems strategies” had the most predictability. It is anticipated that the cognitive-behavioral intervention model would reduce the stress and promote the coping strategies. To prove the effectiveness of the cognitive-behavioral intervention model, the experiment group and the control group were composed of thirty nursing students separately. Before the experiment group students went to the preceptorship clinical practicum, they were requested to participate in a 90-minute activity section eight times. The data was evaluated through the preceptorship clinical practicum stress questionnaire, Beck depression inventory, Beck anxiety inventory, and was analyzed through Generalized Estimatig Equations, paired-samples T test, McNemar-Bowker test and Independent Sample t-test. The outcome was as following： 1. After the cognitive-behavioral intervention model was exercised, the anxiety level and depression level was reduced. 2. After the cognitive-behavioral intervention model was exercised, the interest in nursing is increased. Moreover, the immediate and delayed effectiveness of “venting emotions and cognitive adjustment” and “the coping strategies for the preceptorship clinical practicum”was increased. The depressive emotions were improved. The subjective feelings of anxiety were reduced.

Acute myocardial infarction (AMI), caused by ischaemic heart disease (IHD), is a leading cause of death in both men and women in the western society. Hypertension, diabetes, and smoking are examples of well-known risk factors of IHD, but also there are psychosocial factors, such as stress, vital exhaustion (unusual fatigue, irritability, and demoralization) and depression that have been associated with an increased risk in both genders. After an AMI, however, women are more likely than men to be psychosocially impaired resulting in suffering and a presumed increase in the risk of recurrent cardiac events. Psychosocial factors may be targeted in secondary prevention, complementary to drug treatment and conventional lifestyle advice. There is some evidence of beneficial effects on both psychosocial well-being and cardiac outcomes by psychosocial interventions in men. Far fewer women have been studied and the results have been inconsistent. It is not clear how psychosocial factors convey the increased risk of cardiac events, but many possible psychopathological mechanisms, including biochemical and physiological links, have been suggested. In the Women’s Hearts study we have, in a randomised controlled trial, evaluated a one-year cognitive-behavioural stress management programme designed specifically for women with IHD. We included 198 women with IHD, with a mean age of 61 years and from the county of Västerbotten in Northern Sweden, who were randomised to either conventional treatment and follow-up, or to stress management in addition to conventional care. Extensive questionnaires, blood samplings, and biomedical and physiologic data were obtained before randomisation, as well as at follow-ups approximately one and two years after randomisation. Two groups of healthy controls were included for comparisons with women with IHD. Compared to women without IHD, women with IHD reported more stress behaviour and vital exhaustion. Women with IHD also had a lower heart rate variability (HRV) than the healthy controls, possibly reflecting a dysfunctional autonomic nervous regulation of the heart. Reduced HRV has been shown to increase the risk of cardiac arrhythmias and sudden death. At the first follow-up, performed at the end of the one-year stress management programme, women who had participated in the programme had reduced the stress behaviour and vital exhaustion, compared to the women in the conventional care group. We could not find any evidence of a direct cause-effect relationship between stress management and biological cardiovascular risk indicators, or HRV; the intervention and control groups did not differ in insulin resistance, inflammatory, haemostatic and fibrinolytic factors, or HRV. At second follow-up one year later, several additional psychosocial domains were studied. The stress management programme had accelerated psychosocial recovery at the first follow-up over and above that observed in the control group. At the second follow-up, there was further marked improvement in the control group, so the differences in psychosocial variables between the intervention and control groups were no longer significant. In conclusion, a cognitive-behavioural stress management programme could accelerate psychosocial improvement in women with IHD, and thus reduce the amount of psychological and psychosocial suffering. We could not find any evidence that the stress management programme was associated with a concomitant improvement in biological cardiovascular risk indicators, or HRV. Our results suggest that the women with the greatest psychosocial burden should be identified and targeted in new clinical trials of cognitive-behavioural interventions in women with IHD. Future studies within the Women’s Hearts project will evaluate the psychosocial effects at a five-year follow-up, as well as investigations of other possible pathways by which psychosocial interventions might mediate beneficial effects on cardiac events.

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Au regard des restrictions à l’incarcération introduites par l’adoption de la Loi sur le système de justice pénale pour les adolescents (LSJPA), au Centre jeunesse de Montréal - Institut universitaire (CJM-IU), s’est amorcée en 2005 la mise sur pied du programme de suivis intensifs différenciés (SID) dans la communauté. Notre stage de maitrise en intervention clinique avait comme objectifs : de participer à la mise en œuvre transversale du programme SID, de contribuer à son intégrité, de supporter les intervenants y étant associés ainsi que de bonifier le processus de référence de ce programme en développant un outil d’évaluation. Suite à cette expérience, il nous semblait nécessaire d’entreprendre une réflexion sur la situation d’implantation du programme SID, plus précisément de faire une évaluation de type formatif et constructif du niveau de concordance entre son modèle théorique et son application au quotidien ainsi que des obstacles rencontrés. Une méthodologie qualitative est apparue appropriée pour produire le matériel. Deux techniques ont été utilisées, l’observation participante sur le terrain et l’analyse du contenu de documents écrits (procès-verbaux rédigés après certains comités). Pour structurer l’ensemble du présent rapport de stage, nous avons retenu le concept de plan d’action d’un programme proposé par Chen, dont les six composantes servent de grille à l’évaluation et aident à avoir une vue globale de son implantation, ainsi que le modèle de changement de programme de la TCU (pour Texas Christian University), qui inclut les principaux stades de changement et les facteurs, aux niveaux individuel, organisationnel et du programme en soi, favorisant ou entravant la mise en œuvre d’innovations avec succès. À la lumière de notre analyse, nous considérons qu’il serait possible de surmonter ce qui gêne l’application du programme SID et qu’il ne serait pas obligatoire de faire des changements majeurs à sa théorie. Nous nous sommes permis de suggérer des ajustements qui pourraient être apportés au processus d’implantation de ce programme. En conclusion, nous estimons que la mise en œuvre du programme SID pourrait être réussie seulement si les conditions propices étaient réunies. Toutefois, selon nous, il y aura toujours certaines contraintes avec lesquelles il faudra composer. / In 2005, in the wake of the adoption of the Youth Criminal Justice Act (YCJA) and its attendant restrictions on incarceration, the Centre jeunesse de Montréal - Institut universitaire (CJM-IU) [Montreal youth centre - University institute] launched a community-oriented intensive differential case management program (IDCMP). The clinical internship reported here had the following objectives: allow participation in the cross-sectional implementation of the program, improve the program’s robustness, support program specialists, and develop an assessment tool that would improve this program’s referral process. The results of this internship indicated the necessity of reviewing the IDCMP’s implementation process, specifically through constructive, pedagogical assessment of the congruence of the plan’s theoretical model and day-to-day application, as well of the obstacles encountered. A qualitative methodology appeared appropriate for these purposes. Two techniques were used: field participant observation, and content analysis of written documents (committee minutes). Chen's Program Action Model and the Texas Christian University (TCU) Program Change Model provided the conceptual framework for the internship report. The former’s six components were the basis for an assessment checklist and oriented the global overview of the implementation of the IDCMP, while the latter provided a model of the main stages of change and the individual, organizational, and program-specific factors that favour or hinder innovation. The results indicate that overcoming obstacles to the application of the IDCMP would not require any significant changes to the program’s underlying theoretical basis. Modifications of the program’s implementation process are presented. In conclusion, we consider that the successful implementation of the IDCMP is dependent on certain conditions, and will always be subject to constraints.

The thesis highlights the importance of the cross-cutting theme of ``Personal and social education.{\crqq} Various cross-cutting issues such as those included in the general curriculum of basic education are defined in the theoretical part of the work. However, closer attention is dedicated to the cross-cutting theme of "Personal and social education". Presented in the practical part of the thesis is the information from the survey conducted on the sample of schools. These schools have had a yearly experience in application of their School education programs, including Personal and social education, into their own education systems.

Advances in breast cancer detection and oncology treatment modalities have prolonged the survival time for the cancer population, which is officially the largest group of cancer survivors among women in the western world, including South Africa (Brem & Kumar, 2011; Fisher, Dolbeault, Sultan & Bredart, 2014; Herbst, 2011; Reyes-Gibby, et al., 2012). In the light of shocking statistics and ever rising numbers of cancer, especially breast cancer, the time is ripe for further research in the domain of psycho-oncology and has motivated the researcher, due to her interest and involvement in breast cancer, to make this her field of research. Despite the need for a bio-psycho-social approach when treating cancer patients there is little literature available on the psychological interventions in South Africa where the majority of research studies previously conducted in South Africa have generally focused on the bio-medical aspects of cancer (Albrecht, 2009; Venter, 2014). To comprehend the paradigm of psycho-oncology, which is the backbone of this study, a theoretical framework was attained from Engel’s humanistic or psychological model (caring) and Pasteur’s biomedical model (curing) (Borrel-Carrio, Suchman, & Epstein, 2004). The primary aim of this study was to explore the lived experiences of breast cancer patients concerning their diagnosis, treatment and survivorship and unique needs for psycho-oncological interventions through their own “voices”. The research was conducted within a qualitative framework with a case study method of inquiry employing open-ended style interviews and psychotherapeutic sessions with five purposely sampled breast cancer patients. Two qualitative questionnaires were also used for triangulation purposes. Transcripts of all the therapeutic sessions were analysed using interpretive analysis where categories and themes were developed and described in full. Findings indicated that in spite the extensive proof that breast cancer causes numerous sexual and psychological complications during active treatment and afterwards, patients still feel that they have no “platform” to express their emotions and sexual issues within the oncology framework, or that there is enough and sufficient assistance to attend to their needs. e The researcher hopes that this study will make a valuable contribution to research in the field of psycho-oncology in South Africa and to indicate new realities of the chronicity of breast cancer and treatment complications that demand psychotherapeutic interventions in cancer care and that the study will initiate new ways of understanding the role of psychology and the psychologist in the medical world of cancer. The researcher hopes that by offering an understanding of participants’ unique experiences of this process, practitioners will have insight when working therapeutically with this population and empower them to have a quality of life, even within the boundaries of their illness. / Psychology / D. Litt. et Phil. (Psychology)

Antalet sjukskrivningar till följd av stressrelaterade sjukdomar har ökat kraftigt för vårdpersonal. Därtill saknas det evidens för internetbaserade interventioner mot stressrelaterad ohälsa för vårdpersonal. Syftet var att undersöka och utvärdera en internetbaserad kognitiv beteendeterapi-intervention (iKBT) avseende graden av samvetsstress, arbetsrelaterad stress samt självmedkänsla hos vårdpersonal. Enkäter bestående av Stress of Conscience Questionnaire (SCQ), Copenhagen Psychosocial Questionnaire version II (COPSOQ II) och Self-Compassion Scale (SCS) besvarades av deltagarna (N = 8), samtliga var kvinnor mellan 27 – 53 år. Resultaten analyserades med PEM och RCI på individnivå och T-test på gruppnivå. RCI-analysen visade begränsade resultat för SCQ, blandade resultat för COPSOQ II och övervägande positiva resultat för SCS. Analysen på gruppnivå visade en signifikant minskning i Sömnbesvär (p = .032) och Self-Judgment (p = .021) samt signifikant ökning i Self-Kindness (p = .016). Studien behöver replikeras i framtida studier med ett större antal deltagare och en studiedesign som är metodologiskt robust. / The amount of sick leave due to stress-related illnesses has increased significantly for healthcare staff. In addition, there is a lack of evidence for internet-based interventions for stress-related illness for healthcare staff. The aim was to examine and evaluate an internet-based Cognitive Behavioral Therapy (iCBT) intervention regarding the degree of stress of conscience, work-related stress and self-compassion among healthcare staff. Questionnaires consisting of Stress of Conscience Questionnaire (SCQ), Copenhagen Psychosocial Questionnaire version II (COPSOQ II) and Self-Compassion Scale (SCS) were answered by the participants (N = 8), all were women between 27 - 53 years. The results were analyzed with PEM and RCI at the individual level and T-tests at group level. The RCI analysis showed limited results for SCQ, mixed results for COPSOQ II and predominantly positive results for SCS. The analysis at group level showed a significant decrease in Sleep Disorders (p = .032) and Self-Judgment (p = .021) as well as a significant increase in Self-Kindness (p = .016). The study needs to be replicated in future studies with a larger number of participants and a study design that is more methodologically robust.

La schizophrénie est considérée comme l'un des troubles psychiatriques les plus invalidants. L'une des principales raisons de ce fardeau élevé est qu'une grande partie des patients atteints de schizophrénie ne répondent pas adéquatement aux traitements pharmacologiques de première ligne et continueront de souffrir d’hallucinations auditives. La présence de celles-ci peut avoir un effet dévastateur sur le bien-être émotionnel des patients ainsi que sur leur qualité de vie. Les alternatives non-pharmacologiques (ex., Thérapie cognitivo-comportementale (TCC)) demeurent aussi limitées. Ainsi, pour plusieurs patients, les traitements actuellement recommandés ne sont pas suffisants. À cet égard, le traitement de la schizophrénie peut être perfectionné si, en plus du traitement des symptômes, l'accent thérapeutique est mis sur d’autres sphères importantes pour les patients (ex., améliorer l’estime de soi, réguler les émotions). Les efforts visant à accroître l'efficacité et les bénéfices des psychothérapies fondées sur des preuves ont mené à l'émergence d'interventions basées sur la réalité virtuelle (RV). Avec ces progrès technologiques, AVATAR Therapy et l’adaptation faite par notre équipe, la Thérapie assistée par la Réalité Virtuelle (TRV) (ou communément nommé la Thérapie Avatar (TA)), permettent aux patients d’entrer en dialogue en temps réel avec un avatar, animé entièrement par le thérapeute, qui représente leur voix la plus persécutrice. Cette approche, à la fois relationnelle et expérientielle, offre une occasion unique d’aider les patients à prendre le contrôle de leur voix. Cette thèse a pour objectif principal d’évaluer l’efficacité de cette psychothérapie basée sur la RV ainsi que les thèmes abordés durant et après la thérapie. Pour arriver à cette fin, divers objectifs ont été mis à l’avant : (i) résumer l'état des preuves sur l'efficacité des interventions basées sur la RV pour les troubles psychiatriques, (ii) évaluer l'efficacité de la TA/TRV par rapport à la TCC, (iii) illustrer l’efficacité de la thérapie à travers la perspective de patients ayant montré des effets bénéfiques, et (iv) explorer les thèmes émergeants ainsi que les processus thérapeutiques de la TA/TRV. Dans la première section, deux recensions des écritsdans diverses bases de données ont été effectuées pour examiner l’efficacité des psychothérapies basées sur la RV. Notre méta-revue (c’est-à-dire revue de méta-analyse) incluant 11 méta-analyses et 41 tailles d'effet a montré des résultats positifs de la RV dans le traitement des troubles psychiatriques, principalement des troubles anxieux. Les interventions basées sur la RV sont meilleures que le traitement usuel et montrent généralement des effets similaires par rapport aux approches fondées sur des preuves. Les résultats préliminaires suggèrent également que les effets de la RV se maintiennent dans le temps. Par contre, de nombreux symptômes et troubles psychiatriques qui peuvent être traités par des interventions utilisant RV n'ont pu être examinés par une analyse méta-analytique, en particulier les symptômes psychotiques (ex., hallucinations auditives) et les comportements liés à l'agressivité (ex., régulation émotionnelle). Ainsi, notre seconde revue a montré qu’il existe un nombre limité de paradigmes basés sur la RV pour traiter les individus atteints de troubles psychotiques et autres troubles mentaux à risque de comportements agressifs. Les études préliminaires dans des populations autres que la schizophrénie ont montré des réductions de la colère et de l'impulsivité, des améliorations des capacités de résolution des conflits ainsi que des niveaux d'empathie et des diminutions de l'agressivité. En ce qui a trait aux interventions basées sur la RV pour la schizophrénie, des réductions par rapport aux délires et aux hallucinations auditives ont été trouvées. Dans la seconde section, deux essais cliniques ont été menés pour évaluer l’efficacité de la TA/TRV seule en comparaison avec la TCC et en combinaison avec la TCC (TCC+TA/TRV). Notre essai randomisé comparant la TA/TRV à la TCC a compris 37 participants de plus de 18 ans entendant des voix persécutives et souffrant de schizophrénie résistante aux traitements dans chacun des groupes. Les résultats principaux ont montré que les deux interventions ont produit des améliorations significatives sur la sévérité des symptômes hallucinatoires avec des effets plus prononcés pour la TA/TRV. De plus, les résultats suggèrent une supériorité de la TA/TRV par rapport à la TCC sur les symptômes affectifs. La TA/TRV a également montré des effets positifs sur la qualité de vie. Les effets ont été maintenus à long terme, soit jusqu'à un an de suivi. Notre preuve de concept sur 10 patients ayant suivi la TCC de notre essai clinique comparatif qui souhaitaient continuer à obtenir des améliorations avec la TA/TRV a montré que les effets de la TCC+TA/TRV sur les symptômes dépressifs et les symptômes de la schizophrénie étaient plus larges que ceux trouvés pour l'une ou l'autre des interventions uniques. La troisième section a pour but de détailler les cas de 2 patients ayant suivi la TA/TRV. D’abord, nous avons décrit un partenariat entre un utilisateur de services en santé mentale et des chercheurs cliniciens en mettant en vedette M. X, le premier patient à suivre la thérapie. Nous avons ainsi montré l’apport de monsieur X quant à ses suggestions d’amélioration de la thérapie et ensuite en tant que notre pair aidant pour les futurs patients, dans son cheminement vers le rétablissement. Ensuite, nous avions rapporté le cas d'un patient atteint d’une schizophrénie ultra-résistante, soit M. Smith, qui n'a pas répondu à plusieurs traitements antipsychotiques, à la stimulation magnétique transcrânienne répétitive et à la thérapie par électrochocs avant de participer à notre essai. De plus, le patient a terminé notre TCC avant de se voir proposer notre TA/TRV. Cette dernière intervention a montré les effets les plus positifs. Or, ces deux cas ont montré que la thérapie a aidé non seulement à diminuer leurs symptômes, mais aussi à améliorer leur qualité de vie. La quatrième section a pour objectif d’explorer les thèmes émergents de la TA/TRV suite à des analyses de contenu. Ainsi, suite à une analyse qualitative découlant du discours spontané de 10 patients ayant bien répondu à la TA/TRV, quatre thèmes généraux ont émergé : impact de la thérapie sur les voix, relations interpersonnelles, bien-être psychologique et mode de vie. Cette analyse de contenu a permis d’identifier plusieurs sphères de vie qui sont davantage améliorées chez les patients ayant une schizophrénie résistante aux traitements à l’aide de la TA/TRV. Deux autres analyses qualitatives ont été conduites pour approfondir nos connaissances sur les processus thérapeutiques de la TA/TRV. Celles-ci ont permis de montrer que les patients répondent au propos de l’avatar en utilisant des mécanismes d'adaptation ou en exprimant des émotions, des croyances, des perceptions de soi ou des aspirations. Le discours de l'avatar a pu être catégorisé en techniques de confrontation (ex., provocation) et en techniques positives (ex., renforcement). Grâce à l'identification de changements mutuels dans l'interaction entre le patient et son avatar, un changement a été observé au fil des séances de la confrontation vers un dialogue constructif. L'affirmation de soi, les réponses émotionnelles et les stratégies de prévention semblaient être au cœur du processus thérapeutique, et celles-ci se produisent généralement en réponse à des techniques positives. Cette thèse contribue à la validation d’une nouvelle approche thérapeutique répondant à un besoin clinique fondamental. Ainsi, la TA/TRV met en lumière l'avenir des approches adaptées aux patients qui peuvent présenter des avantages par rapport aux traitements conventionnels. Ces types d’interventions holistiques utilisant la RV pourraient aussi présenter des avenues prometteuses dans plusieurs autres troubles psychiatriques. / Schizophrenia is considered one of the most debilitating psychiatric disorders. One of the main reasons for this high burden is that a large proportion of patients with schizophrenia do not respond adequately to first-line pharmacological treatments and will continue to suffer from auditory hallucinations. The presence of these symptoms can have a devastating effect on the emotional well-being of patients as well as their quality of life. Non-pharmacological alternatives (e.g., Cognitive Behavioral Therapy (CBT)) also remain limited. Thus, for many patients, the treatments currently recommended are not sufficient. In this regard, the treatment of schizophrenia may be improved if, in addition to the treatment of symptoms, therapeutic emphasis is placed on other areas of importance to patients (e.g., improving self-esteem, emotion regulation). Efforts to increase the effectiveness and benefits of evidence-based psychotherapies have led to the emergence of virtual reality (VR)-based interventions. With these technological advances, AVATAR Therapy and its related innovative form from our team, Virtual Reality Assisted Therapy (VRT) (or commonly Avatar Therapy (AT)), allow patients to enter a real-time dialogue with an avatar, animated entirely by the therapist, who represents their most persecutory voice. This approach, both relational and experiential, offers a unique opportunity to help patients take control of their voice. The main objective of this thesis is to evaluate the effectiveness of this psychotherapy based on VR as well as the themes addressed during and after the therapy. To achieve this end, various objectives have been put forward: (i) summarize the state of the evidence on the effectiveness of VR-based interventions for psychiatric disorders, (ii) assess the effectiveness of AT/VRT versus CBT, (iii) obtain the perspective of patients who have undergone AT/TRV, (iv) explore the therapeutic processes of AT/VRT. In the first section, two literature reviews in various databases were performed to examine the effectiveness of VR-based psychotherapies. Our meta-review including 11 meta-analyzes and 41 effect sizes showed positive results of VR in the treatment of psychiatric disorders, mainly anxiety disorders. VR-based interventions appear better than inactive controls and generally show similar effects compared to evidence-based approaches. Preliminary results also suggest that the effects of VR are sustained over time. On the other hand, many psychiatric symptoms and disorders that can be treated with interventions using VR have not been examined by a meta-analytical analysis, including psychotic symptoms (e.g., auditory hallucinations) and related behaviors. aggression (e.g., emotional regulation). Thus, our second review showed that there are a limited number of VR-based paradigms for treating individuals with psychotic disorders and other mental disorders at risk for aggressive behavior. Preliminary studies in populations other than schizophrenia have shown reductions in anger and impulsivity, improvements in conflict resolution skills as well as levels of empathy and decreases in aggression. Particularly related to VR interventions for schizophrenia, reductions in delusions and auditory hallucinations were found. In the second section, two clinical trials were conducted to evaluate the efficacy of AT/VRT alone in comparison with CBT and in combination with CBT (CBT+TA/VRT). Our randomized trial comparing AT/VRT to CBT included 37 participants over 18 years of age hearing persecutory voices and suffering from treatment-resistant schizophrenia in each group. The main results showed that the two interventions produced significant improvements in the severity of hallucinatory symptoms with more pronounced effects for AT/VRT. In addition, the results suggest that AT/VRT is superior to CBT on affective symptoms. AT/VRT has also shown positive effects on quality of life. The effects were maintained for up to one year of follow-up. Our proof of concept on 10 patients having followed CBT from our comparative clinical trial who wanted to continue to achieve improvements with AT/VRT showed that the effects of CBT+AT/VRT on depressive symptoms and symptoms of schizophrenia were broader than those found for either intervention alone. The third section details the cases of 2 patients who had followed AT/VRT. First, we described a partnership between a mental health service user and clinical researchers by featuring Mr. X, the first to follow therapy for his suggestions and our peer helper for future patients, on his journey to the recovery. Next, we reported the case of a patient with ultra-resistant schizophrenia, Mr. Smith, who failed to respond to multiple antipsychotic treatments, repetitive transcranial magnetic stimulation, and electroconvulsive therapy before participating in our trial. In addition, this patient completed our CBT before being offered AT/VRT. The latter intervention showed the most positive effects. These two cases showed that AT/VRT not only helped to decrease their symptoms, but also to improve their quality of life. The fourth section aimed to explore emerging themes of AT/VRT following content analyses. Thus, following a qualitative analysis resulting from the spontaneous speech of 10 patients who responded well to AT/VRT, four general themes emerged: impact of therapy on voices, interpersonal relationships, psychological well-being and lifestyle. This content analysis identified several areas of life that are further improved in patients with treatment resistant schizophrenia after having followed AT/VRT. Two other qualitative analyses were carried out to deepen our knowledge of the therapeutic processes of AT/VRT. These have shown that patients respond to the avatar's words by using a coping mechanism or by expressing emotions, beliefs, self-perceptions or aspirations. The avatar's discourse could be categorized into confrontational techniques (e.g., provocation) and positive techniques (e.g., reinforcement). With the identification of mutual changes in the interaction between the patient and their avatar, a shift was observed over therapy sessions from confrontation towards a constructive dialogue. Assertiveness, emotional responses, and prevention strategies seemed to be central to the therapeutic process, and these usually occurred in response to positive techniques. This thesis contributes to the validation of a new therapeutic approach responding to a fundamental clinical need. Thus, AT/VRT shines a light on the future of patient-oriented approaches that may have advantages over conventional treatments. These types of holistic interventions using VR may have notable applications in several other psychiatric disorders.

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