Master's thesis deals with the design of an antenna system for wireless sound transmission used mainly in professional sound reinforcement. The introductory part deals generally with wireless microphones, frequency bands used and proven antenna types. Next, this work deals with signal distribution that is realized using the antenna splitter. The antenna parts is focused on easy production and real usage, therefore were selected antennas with appropriate properties suitable for small series production. This thesis includes simulation of each device, their real construction design and measurements of built prototypes and final products. All three produced devices – the rack splitter, /4 antenna and Helix antenna are fully working, achieve good parameters and are ready for further manufacturing and easy modifications in case of frequency band change requirement. The conclusion includes an overall assessment of the results achieved.

The purpose of this work was to make a proposal for input parts of receiver for band 430 to 440 MHz. A model of chosen semiconductor triode BFP540 was created in simulation software. Possibilities how to decrease consumption of this semiconductor triode, keeping the profit, were investigated through the simulation.In compromise consumption, keeping the profit of the amplifier - an optimal operating point for this semiconductor triode UCE = 1,2 V and IC = 2 mA was found. It was tested through the testing wiring with noise microstrips conformity. Ascertained knowledge was used for construction of tuner for UHF receiver. An operating point of input amplifier of UHF receiver was owing to power supply amplifier forced for bigger effectiveness to UCE = 2,65 V and IC = 2,0 mA. Suppression of mirror frequency is provided with Helix filter of the third order, because of intermediate frequency 10,7 MHz. Mixing on intermediate frequency is made again by semiconductor triode BFP540. Selectivity of receiver is provided with intermediate frequency crystal filter 10,7 MHz with bandwidth 15 kHz. Designed input part enables reception of SSB, FM and digital types of modulation.Bandwidth intermediate frequency exit is adapted to this request To receive particular modulation , it is necessary to complete intermediate frequency signal way with appropriate intermediate frequency filter.

Cette thèse est consacrée à la synthèse et à l'étude structurale de peptides-beta/gamma, contenant en alternance des acides aminés-beta et -gamma, conçus pour mimer l'hélice-alpha (ou hélice-13), structure secondaire des protéines. Nous avons ainsi élaboré une stratégie de design « bottom-up » pour des peptides-beta/gamma devant se replier sous forme d'hélice-13. Ces peptides comportent un acide aminé-beta, le (1S,2S)-trans-2-aminocyclobutanecarboxylique, qui joue un rôle clé de brique constitutive en apportant des contraintes conformationnelles. Dans un premier temps, la synthèse énantiomériquement pure du trans-ACBC basée sur une étape clé de photocycloaddition [2+2] a été optimisée. Il a alors été possible de synthétiser des peptides-beta/gamma incorporant en alternance le trans-ACBC et le GABA, qui est un acide aminé-gamma dépourvu de toute contrainte. Des études expérimentales et théoriques fines de ces peptides-beta/gamma ont révélé une structuration inédite sous forme de rubban-9/8, en solution. Il a été démontré que ces nouveaux foldamères adoptent une forme plus ou moins courbe gouvernée par un code combinant configuration et conformation des acides aminés constitutifs de ces peptides. Dans un deuxième temps, des contraintes sur l'acide aminé-gamma ont été introduites par la préparation de peptides-beta/gamma alternant le trans-ACBC et des acides aminés-gamma4. Des études expérimentales et théoriques de ces peptides-beta/gamma en solution ont révélé une préférence conformationnelle sous forme d'hélice-13. La stabilité de cette structure hélicoïdale augmente avec la longueur de la chaîne peptidique. Ces hélices-13 sont en effet fortement stabilisées à partir de 5 liaisons hydrogènes inter-résidus. Enfin, des peptides-alpha/beta/gamma capables de mimer l'hélice-alpha du peptide p53(15-31) ont été conçus et synthétisés, afin de vérifier expérimentalement leur hélicité prédite par modélisation moléculaire. Une fois leur résistance à la dégradation protéolytique démontrée, ces peptides-alpha/beta/gamma ont été testés comme inhibiteur de l'interaction p53/hDM2. Un candidat a particulièrement été capable d'inhiber cette interaction en se liant au site naturel de fixation avec la protéine hDM2. Ce résultat illustre la réussite de notre stratégie de construction de mimes de l'hélice-alpha. / This thesis is devoted to the synthesis and the structural characterisation of beta/gamma-peptides, constructed from beta- and gamma-amino acids in alternation, designed to mimic the alpha-helix secondary structure which is present in many native proteins. The alpha-helix can be defined as a 13-helix and a bottom-up foldamer design strategy to target a 13-helical structure was examined, whereby beta/gamma-peptides were proposed in which (1S,2S)-trans-2-aminocyclobutanecarboxylic acid (trans-ACBC) was incorporated as a conformationally-restricted beta-amino acid component. The scalable synthesis of enantiomerically pure trans-ACBC using a [2+2] photocycloaddition strategy was successfully optimized. beta/gamma-Peptides incorporating trans-ACBC and GABA, the latter being the gamma-amino acid component devoid of any constraint, were then synthesised. Experimental and theoretical investigations of their solution-state folding behaviour revealed an unprecedented 9/8-ribbon foldamer structure that adopts curved shapes governed by a combined configuration-conformation code. Additional constraints on the gamma-amino acid component were then considered and beta/gamma-peptides incorporating trans-ACBC and gamma4-amino acids were synthesised. Experimental and theoretical investigations of these beta/gamma-peptides in solution unveiled a preference for 13-helix folding behaviour, which increased commensurately with the peptide chain length; robust 13-helices were stabilised by a minimum of five intramolecular hydrogen bonds. In the last part of this thesis, molecular modelling was used to design helical alpha/beta/gamma-peptides intended to reproduce as closely as possible the hot-spot residues of the known alpha-helical peptide sequence p53(15-31). These peptides were synthesised and their predicted helical folding was verified experimentally along with their resistance to proteolytic enzymes. The alpha/beta/gamma-peptides were tested as inhibitors of the p53/hDM2 interaction. One peptide was found to behave as potent inhibitor and to bind to the native peptide binding pocket of the hDM2 protein, providing a successful proof of concept of the alpha-helix mimetic design strategy.

There has been a growing call for change in the management of dental education programs, and, in response to this call, the faculty and staff at the University of the Pacific Arthur A. Dugoni School of Dentistry developed the Pacific Dental Helix Curriculum management model. The first major component of this curriculum was the development of the Integrated Clinical Science Strand of the Helix focused on multidisciplinary and case-based andragogies. The mixed method research design was used to identify common aspects of Case-Based Learning and multi-disciplinary teaching through a qualitative analysis of curricular materials and to analyze their impact on selected student outcomes of pre and post-change through statistical analysis. The outcomes chosen for the quantitative portion were surrogate measures of National Board Scores and grade point averages to represent knowledge and skills. The overall analysis of the quantitative data shows negligible impact on the outcomes being measured. We know from the literature that active learning models motivate and engage students at a higher level in their learning and better prepare them to solve problems creatively versus a traditional educational model, so it is significant to see that there were no decreases in performance with a move to a more engaging curriculum. This study offers foundational information for future curriculum design, pedagogy, and assessment.

No description available.

No description available.

No description available.

Abstract  Level: Master thesis in Innovation and design , 30 credits Institution: School of Innovation, Design and Technology, Mälardalen University Author: Cornelia Alenbring (98/05/24)   Title: In the search of the student's role in innovation ecosystems Supervisors: Anders Vikström, Erik Bjurström MDU examinator:Yvonne Eriksson Keywords: “ecosystems for innovation”, “eco systems for social innovation”, “social innovation ecosystems”, “quadruple helix” “students- innovation ecosystem” “students role in innovation ecosystems” Purpose: The purpose of this study is to explore the specific role of students in innovation ecosystems. By gaining a deeper understanding of their role, this research aims to contribute to a more nuanced micro-dynamic perspective on the role of students in innovation ecosystems. This thesis explores conceptualizations and metaphors of innovation ecosystems with the aim of exploring different theorizing in the field, related to the role of students within those.  Research question: What is the role of students in innovation ecosystems? Method: The study was based on a qualitative method. The empirical data was collected through semi-structured interviews and observations using focus groups with 5 actors within the public, academia, industry and civil society. Conclusion: The role of the student is at the heart of the innovation ecosystem metaphor - that of emergence and co-evolution. Rather, the empirical evidence of this thesis concurs that the roles available to students also depend on other actors taking them seriously, and that the reasons for less than optimal exchange between students and other actors deserves further investigation.  It is an interesting observation that students fall between the system perspective’s grand theorizing and pedagogics’ narrower focus on education: - So what is the point of pursuing a research approach where either students or ecosystems are not mentioned? There is an obvious gap in where the abstract level of the system perspective, whilst it can serve as an overview of the concept,  does not specify actors and misses to provide a micro perspective on what is occurring between actors, that could explain how it all happens. Are students rather representatives of the civil society, or of what Powell referred to ‘amphibians’, or representative of nothing but themselves as individuals-in-the-making, as a representative of becoming itself and emergence in itself – through their interaction on a campus which they don’t own, but inhabit? And what do companies really want when they want to be a campus? What is special about a campus and life on a campus? What is the very essence of it?

[ES] El presente estudio pretende establecer la importancia de la colaboración como un elemento integral para el desarrollo de la Red Chilena de Fab Labs y su vinculación con el ecosistema de innovación local. Esta noción se apoya en un marco teórico que valida la colaboración como un elemento clave al interior de la innovación abierta y su implementación en los espacios de innovación, en este caso específico, los Fab Labs. Junto con ello, surge el concepto de Cosmo-localismo, como un modelo integrador de la colaboración y la innovación, que busca el bienestar de los territorios y sus comunidades. Este se fundamenta en la cultura maker, la cual vincula el diseño abierto con las tecnologías de fabricación digital, para la generación de un nuevo conocimiento, siendo estos distribuidos globalmente. Es aquí donde los Fab Labs juegan un rol fundamental como espacios de articulación, buscando empoderar a sus comunidades mediante el acceso a herramientas, para generar un impacto positivo en lo social, económico y medioambiental. A partir de la importancia de vincular el entorno dentro de la innovación, surge la Quíntuple hélice como un elemento integrador en el proceso de innovación actual, reforzando la importancia del concepto de desarrollo sostenible. Bajo una investigación de enfoque mixto, se analizan los Fab Labs en Chile, caracterizándolos según su ubicación, modelo de trabajo, temáticas y disciplinas. A modo de identificar la vinculación de estos laboratorios con el ecosistema de innovación, se analiza el contexto chileno según el Modelo TE-SER, el cual establece sus características basadas en los roles de cada actor. De la misma forma, se establece para la Red Chilena de Fab Labs y los laboratorios que la componen. Como resultado de esta investigación se propone el diseño de un modelo de colaboración para el desarrollo de la Red Chilena de Fab Labs que promueva su vinculación con el ecosistema de innovación local para alcanzar el desarrollo sostenible de sus territorios, apoyándose en los principios del diseño abierto y la cultura maker. Los hallazgos identificados se basan en la importancia del ODS 17, "Alianza para cumplir todos los objetivos", al interior de la comunidad Fab Lab. Y también en el perfilamiento de los Fab Labs chilenos, el cual puede delinear los roles y actividades de los laboratorios al interior de la red y del ecosistema de innovación local. Además, a partir del modelo propuesto, se identifican actores claves para articular instancias de colaboración de forma eficiente, lo que desarrolla una estrategia de implementación basada en el Cosmo-localismo, promoviendo la Quíntuple hélice. / [CA] Aquest estudi pretén establir la importància de la col·laboració com un element integral per al desenvolupament de la Xarxa Xilena de Fab Labs i la vinculació amb l'ecosistema d'innovació local. Aquesta noció es recolza en un marc teòric que valida la col·laboració com un element clau a l'interior de la innovació oberta i la seva implementació als espais d'innovació, en aquest cas específic, els Fab Labs. Juntament amb això, sorgeix el concepte de Cosmo- localisme, com un model integrador de la col·laboració i la innovació, que cerca el benestar dels territoris i les seves comunitats. Aquest es fonamenta en la cultura maker, la qual vincula el disseny obert amb les tecnologies de fabricació digital, per a la generació d'un nou coneixement, i aquests es distribueixen globalment. És aquí on els Fab Labs juguen un rol fonamental com a espais d'articulació, buscant empoderar les seves comunitats mitjançant l'accés a eines, per generar un impacte positiu en allò social, econòmic i mediambiental. A partir de la importància de vincular l'entorn dins de la innovació, la Quíntuple hèlix sorgeix com un element integrador en el procés d'innovació actual, reforçant la importància del concepte de desenvolupament sostenible. Sota una investigació d'enfocament mixt, s'analitzen els Fab Labs a Xile, caracteritzant-los segons la ubicació, el model de treball, les temàtiques i les disciplines. Per identificar la vinculació d'aquests laboratoris amb l'ecosistema d'innovació, s'analitza el context xilè segons el Model TE-SER, el qual estableix les seves característiques basades en els rols de cada actor. De la mateixa manera, s'estableix per a la Xarxa Xilena de Fab Labs i els laboratoris que la componen. Com a resultat d'aquesta investigació es proposa el disseny d'un model de col·laboració per al desenvolupament de la Xarxa Xilena de Fab Labs que promogui la seva vinculació amb l'ecosistema d'innovació local per assolir el desenvolupament sostenible dels territoris, recolzant-se en els principis del disseny obert i la cultura maker. Les troballes identificades es basen en la importància de l'ODS 17, "Aliança per complir tots els objectius", a l'interior de la comunitat Fab Lab. I també en el perfilament dels Fab Labs xilens, el qual pot delinear els rols i activitats dels laboratoris dins de la xarxa i de l'ecosistema d'innovació local. A més, a partir del model proposat, s'identifiquen actors claus per articular instàncies de col·laboració de forma eficient, cosa que desenvolupa una estratègia d'implementació basada en el Cosmo-localisme, promovent la Quíntuple hèlix. / [EN] This study aims to establish the importance of collaboration as an integral element for the development of the Chilean Network of Fab Labs and its link with the local innovation ecosystem. This notion is supported by a theoretical framework that validates collaboration as a key element within open innovation and its implementation in innovation spaces, in this specific case, the Fab Labs. Along with this, the concept of Cosmo- localism, as an integrating model of collaboration and innovation, which seeks the well-being of the territories and their communities. This is based on the maker culture, which links open design with digital manufacturing technologies, for the generation of new knowledge, which is distributed globally. This is where the Fab Labs play a fundamental role as spaces for articulation, seeking to empower their communities through access to tools, to generate a positive social, economic and environmental impact. Based on the importance of linking the environment within innovation, the Quintuple Helix emerges as an integrating element in the current innovation process, reinforcing the importance of the concept of sustainable development. Under a mixed approach research, the Fab Labs in Chile are analyzed, characterizing them according to their location, work model, themes and disciplines. In order to identify the link between these laboratories and the innovation ecosystem, the Chilean context is analyzed according to the TE-SER Model, which establishes its characteristics based on the roles of each actor. In the same way, it is established for the Chilean Network of Fab Labs and the laboratories that comprise it. As a result of this research, the design of a collaborative model is proposed for the development of the Chilean Network of Fab Labs that promotes its link with the local innovation ecosystem to achieve the sustainable development of its territories, based on the principles of open design. and the maker culture. The identified findings are based on the importance of SDG 17, "Alliance to meet all objectives", within the Fab Lab community. And also, on the profiling of Chilean Fab Labs, which can outline the roles and activities of the Fab Labs. laboratories within the network and the local innovation ecosystem. In addition, based on the proposed model, key actors are identified to efficiently articulate instances of collaboration, which develops an implementation strategy based on Cosmo-localism, promoting the Fivefold Helix. / Valenzuela Zubiaur, MDP. (2022). Contribución de la Red Chilena de Fab Labs al ecosistema de innovación local para alcanzar el desarrollo sostenible [Tesis doctoral]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/183278

This study explores the basic social conditions for high-quality university research, and focuses on research in science and technology in Sweden. Swedish research policy has adopted more of a market perspective on academic research and its role in society. This has meant the promotion of competition between researchers, increased focus on efficiency at universities, and attempts to make academia harmonize more with industry and other actors. How do such policies affect the variety of perspectives within the academic system? How do they affect the positions and identities of individual academics? These issues are discussed through the concept of "relational tensions". Relational tensions refer to social strains arising when interacting actors have different perspectives. Relational tensions can stimulate creativity, but may also cause unproductive conflicts. The discussion is underpinned by interviews with university researchers and a case study of Uppsala BIO-X, a program to commercialize university research in biotechnology. Typical cases of relational tensions are identified. These concern both interpersonal relations and differences between organized science and industry. A notable observation concerns potential frustration of individual academics, as competition and efficiency tends to make their positions and identities more contested. Researchers cope with relational tensions in three identified ways: socialization, seclusion, and lateral authority. Socialization is natural and often necessary, but reduces the variety of perspectives. Seclusion serves to retain variety and independence, but reduces interaction with others. Lateral authority is to formally or informally lend a researcher more authority, which improves the chance of maintaining a variety of perspectives without reducing interaction. The sustained usefulness of academic research arguably depends on its ability to foster and communicate a variety of perspectives. Hence, (i) promoting lateral authority seems fruitful within academia and in relations between academia and industry, and (ii) encouraging competition and efficiency may to some extent be counterproductive. / Research Excellence and Science-Based Industrial Systems