The theme Point of View: David Lynch and intertextuality of this master thesis deals with the work of American film director David Lynch, which we view in terms of intertextuality. The aim is to show how David Lynch manipulates with intertextuality in his films Wild at Heart and Lost Highway and what other means he uses to achieve the specific atmosphere of his films. We say that it is impossible to unambiguously interpret Lynch's work and we will try to show that every of various points of view can be correct.

La inestabilidad de microatélites (MSI) está presente en diferentes tipos tumorales. Generalmente se explica por metilación del promotor de MLH1 o mutaciones germinales en los genes de reparación mismatch repair (MMR) del ADN, causando el conocido síndrome de Lynch. Recientemente, con el cribado universal se ha dado a conocer que un gran porcentaje de tumores con sospecha de síndrome de Lynch, no presentan estas mutaciones. Hasta la fecha, la hipótesis más aceptada para explicar este fenómeno conocido como síndrome Lynch-like, es la doble inactivación de estos genes a nivel somático. Aun así, estos pacientes presentan cáncer colorectal y otros tumores a edades tempranas y en muchos casos, se acompaña de una historia familiar de cáncer colorectal, que sugiere un origen hereditario. Objetivos: Elucitar las bases moleculares responsables de la pérdida de función del sistema MMR en casos de sospecha de Síndrome de Lycnh sin mutaciones germinales en estos genes. Estudio germinal: Identificar nuevas mutaciones germinales en genes reparadores del ADN que puedan estar implicadas en el desarrollo de inestabilidad de microsatélites. Estudio somático: Realizar una caracterización molecular de los tumores con MSI para identificar los eventos moleculares que pueden impactar el comportamiento tumoral y el manejo clínico. Materiales y métodos: Se analizó el exoma germinal de 100 muestras de pacientes Lynch-like y 30 Lynch. Adicionalmente se secuenciaron 37 tumores Lynch-like, 25 Lynch y se utilizó la información de 31 MSI/BRAF del TCGA. Las muestras fueron secuenciadas en Illumina HiSeq y analizadas en un High-performance computer siguiendo los estándares del Yale Center for Genome Analysis (YCGA). Resultados: Estudio germinal: Entre los Lynch-like encontramos 7 Lynch no identificados previamente. El 50% del MSI detectado en Lynch-like podía explicarse por dobles inactivación de los mismos a nivel somático. Además entre los Lynch-like encontramos 15 variantes germinales patogénicas que podían explicar la inestabilidad genética. Dos de ellas con inactivación del otro alelo a nivel somático. Además demostramos que la inactivación de un solo alelo es suficiente para tener un fenotipo deficiente. Estudio somático: no todos los tumores clasificados como MSI por MSI-PCR son presentan esta inestabilidad a nivel global. Al analizar diferentes tumores MSI descubrimos dos clústeres bien diferenciados en base a los perfiles mutacionales detectados. Buscamos mutaciones en genes reparadores y de predisposición al cáncer que pudieran estar marcando esas diferencias en las signatures. Discusión y conclusiones: Estudio germinal: Este estudio confirma el enriquecimiento existente en variantes germinales en los genes reparadores del ADN en pacientes con Síndrome Lynch-like. Variantes en estos genes, conferirían una deficiencia media heredada que promovería y podría inducir una inestabilidad genómica con el paso del tiempo. LA identificación de la variante en RECQL5 como potencial mutación asociada a un fenotipo de cáncer colorrectal familiar. Lynch-like es un grupo heterogéneo a nivel genético, con la característica común de ser MSI. Los tumores Lynch-like pueden ser causados por doble inactivación somática u otros defectos en otros genes reparadores. Además, el grupo incluye Lynch no identificados por los métodos de detección actuales. Estudio somático: Este estudio proporciona un valorable nueva perspectiva en los tumores con deficiencia en el sistema MMR. Muestra la correlación entre los diferentes niveles de MSI global y los perfiles mutacionales y clínicos, lo cual puede tener grandes implicaciones a nivel de diagnóstico y tratamiento de los pacientes.

Umeå är en växande stad som ligger längs norrlandskusten. Kommunen har starka mål och ambitioner för att staden ska växa de närmaste 25 åren. Kommunen planerar att komplettera ett område vid namn Berghem med 80-100 lägenheter. Ett helt nytt kvarter ska bildas på nuvarande naturmark i sluttande terräng. Kvarteret ligger nära Umeå centrum och bara ett stenkast ifrån Berghems eget centrum. Berghem är en av de dyraste stadsdelarna i Umeå att köpa en bostad på och kötiderna är bland de längsta för hyresrätter. Vid byggnation på denna plats behöver många faktorer beaktas. Att anpassa byggnaden efter platsen och dess terräng har varit arbetets stora utmaning och fokus har lagts på förstudiearbetet med en ingående platsanalys över planområdet och dess omgivning. Förstudiearbetet och platsanalysen består bland annat av resonemang kring hur solen påverkar byggnadernas placering, hur omkringliggande byggnader påverkar exploateringsgraden och hur markens terräng inverkar på utformningen. Detta arbete har som syfte att gestalta ett förslag för det nya kvarteret. Visionen har varit att skapa ett kvarter med stark anknytning till omkringliggande natur. / Umeå is a growing city that lies along the coast of Norrland. The municipality has strong goals and ambitions for the city to grow over the next 25 years. The municipality plans to complete an area named Berghem with 80-100 apartments. A new block shall be formed on current natural land on sloping ground. The area is near Umeå city center and just a stone throw away from Berghem’s own center. Berghem is one of the most expensive neighborhoods in Umeå to buy an apartment and queues for rental apartments are among the longest. Building on this area needs a lot of factors to take into account. To adapt the buildings to the area and its terrain has been the works greatest challenge, focus has been placed on the pilot study with a detailed site analysis of the area and its surroundings. Pilot study and site analysis consists among others on reasoning about how the sun affects the placement of the buildings, how the surrounding buildings affects on the rate of exploitation and how soil terrain affecting the composition. This work aims to design concept drawings for the new area. The vision was been to create a neighborhood with strong ties to the surrounding nature.

Lynch syndrome (LS), Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX) are different entities of familial cancer predisposition leading to an increased risk of colorectal cancer (CRC). The aim of this prospective study was to characterise and to compare the risks for adenoma and CRC in these three risk groups. Data was taken from the registry of the German Consortium for Familial Intestinal Cancer. Patients were prospectively followed up in an intensified colonoscopic surveillance programme that included annual examinations. Cumulative risks for adenoma and CRC were calculated separately for LS, LLS and FCCX, and then for males and females. Multivariate Cox regression was used to analyse the independent contributions of risk group, mismatch repair gene (within LS), sex and previous adenoma. The study population comprised 1448 individuals (103 FCCX, 481 LLS and 864 LS). The risks were similar for colorectal adenomas, but different for first and metachronous CRC between the three risk groups. CRC risk was highest in LS, followed by LLS and lowest in FCCX. Male sex and a prevalent adenoma in the index colonoscopy were associated with a higher risk for incident adenoma and CRC. In patients with LS, CRC risks were particularly higher in female MSH2 than MLH1 carriers. Our study may support the development of risk-adapted surveillance policies in LS, LLS and FCCX. What's new? While associations between colorectal cancer (CRC) risk and Lynch syndrome (LS) are well-described, less is known about CRC risks linked to the closely related Lynch-like syndrome (LLS) and familial colorectal cancer type X (FCCX). In this prospective follow-up study of patients with LS, LLS, and FCCX, risks were similar for colorectal adenomas but considerably different for first and metachronous CRCs. In addition, LS females who carried MSH2 mutations had notably higher CRC risks than female MLH1 mutation carriers. The identification of variations in carcinogenic pathways between LS, LLS, and FCCX could enable risk-adapted CRC surveillance for these syndromes.

A presente tese se ocupa de uma vertente da literatura e do cinema contemporâneos, especialmente do escritor Julio Cortázar e do cineasta David Lynch, que: busca um novo tratamento para a realidade, não esconde os artifícios discursivos das obras, joga com estratégias ilusionistas e antiilusionistas, debate a própria ficção por meio de recursos metaficcionais, que se utiliza da metáfora do teatro como espaço diferenciado e como palco de ilusões e que trabalha com a questão do fantástico (ou absurdo). Grande parte do trabalho é dedicada ao estudo da obra do escritor argentino Julio Cortázar. Estudo esse que se constrói a partir das correspondências entre as produções ficcionais e teóricas de Cortázar, além de suas próprias entrevistas. Cortázar é nosso foco principal e dele, acreditamos, brotou um veio dos mais significativos na narrativa contemporânea, que estabelece novos modos de se lidar com a representação e com as referências. É devido a esses aspectos, apontados anteriormente, que estabelecemos relações com outros autores, inclusive do cinema, como é o caso de David Lynch / This thesis deals with one aspect of literature and contemporary cinema, especially the writer Julio Cortázar and filmmaker David Lynch, that: a search for new treatment really does not hide the artifice of the discursive works, plays with illusionist and anti-illusionist strategies, debate the fiction itself through metaficcionais resources, which uses the metaphor of the theater as a space variable and to stage illusions and working with the issue of the fantastic (or nonsense). Much of the work is devoted to the study of the work of Argentine writer Julio Cortázar. Study which is constructed from the correspondence between the fictional and theoretical productions of Cortázar, and his own interviews. Cortázar is our main focus and goals, we came a shaft of the most significant in contemporary novels, establishing new ways of dealing with the representation and referrals. It is because of these issues, previously mentioned, we have established relationships with other authors, including the cinema, as is the case of David Lynch

Studiens syfte är att genom semiotisk analysmetod och fototeori, om fotografiet som medium, försöka tolka David Lynchs fotografiska bildspråk i en motivanalys av två fotografier ur The Factory Photographs. Om upplevelsen av dessa fotografier kan förändras genom resonemang hämtade från främst filosoferna Roland Barthes och Susan Sontag. Detta berör teoretiskt begrepp som punctum, men även riktningen surrealism inom konst. Resultatet ska utmynna i alternativa innebörder åt fotografierna vid sidan av dess dokumentära uttryck.

Guided by the feminist intention of reasserting the importance of neglected female writers, I have used this work to re-examine the lives and texts of eighteenth-century diarists Hester Thrale-Piozzi and Frances Burney. Adopting an interdisciplinary methodology, I draw on both literary and non-literary material to examine the effect of familial and social patriarchy in eighteenth-century England. Using the diaries, journals and letters of Hester and Frances, I ask why female conformity to masculine domination was expected, and how violence was used to extract subserviant behaviour from women. Beginning with gossip, and encompassing social, editorial and physical abuse, I use the medical profession's manipulation of female vulnerability to exemplify the way society legitimates violence to ensure female ductility. Moving beyond this physical aspect, I then examine the psychical, and question the existence of a ‘self’ which is vulnerable to external manipulation. By diverging from the influence of Freudian psychology, and developing a form of Jungian feminism, I propose the existence of an essential female Self which transcends the constraints of societal expectations and physical violence. In this work, both Hester and Frances emerge as physically and psychically strong entities who were forced to adopt socially conformist personae to survive.

Många individer är inte accepterade i samhället på grund av att de avviker. Detta är ett stort problem då de riskerar utanförskap och sämre livskvalitet. Vad jag därmed kommer att studera i denna uppsats är hur avvikande individer bemöts i samhället och hur de svarar på detta bemötande. De filmer som jag kommer att utgå ifrån i analysen är The Elephant Man (1980) av David Lynch och Mask (1985) av Peter Bogdanovich. Jag kommer sedan att använda mig av socialpsykologin som teori för att kunna analysera hur och varför detta sker. Då jag tolkar de scener jag valt ut kommer jag att använda mig av Hermeneutiken som vetenskaplig metod. I mitt arbete har jag kommit fram till att den avvikande individen bemöts olika i samhället beroende på de människor som bor där och vilken tid filmen skildrar. Vissa människor väljer att se individen utifrån kognitivt igenkännande, andra väljer genom socialt igenkännande. De kan se på den avvikande individen vara genom rädsla men också genom sympati, altruism. Dessa baseras i sin tur på de sociala normer som skapas i de samhällsgrupper som existerar. Den avvikande individens jag-identitet kan därmed påverkas negativt av andra människors handlingar. De väljer att svara på detta på olika sätt, antingen genom att försöka dölja sig, eller genom att stå emot och kämpa. De intar dock roller eller mimicry för att passa in.

Der Artikel untersucht einen Werbespot von David Lynch für die Playstation 2 und ordnet ihn in das Universum der Lynch’schen Texte, das Lynchville, ein. Zunächst werden dazu einige regelmäßig wiederkehrende Motive aus dem Werk Lynchs vorgestellt. Es folgt eine eingehende Analyse des Werbespots, in der zahlreiche Parallelen zu den bekannten Filmen des Œuvres aufgezeigt werden. Abschließend wird kurz der Frage nachgegangen, inwiefern der Begriff „auteur“ in dieser wohl kommerziellsten aller filmischen Ausdrucksformen überhaupt anwendbar ist. Der Artikel kommt zu dem Ergebnis, dass es Lynch in diesem Werbespot gelingt, eine persönliche Visiondurchscheinen zu lassen – und dass die Karte des Lynchville deshalb um einen neuen Ort ergänzt werden muss. / The article analyzes a television-commercial, which David Lynch shot for the launch of Playstation 2. It tries to introduce that commercial into the universe of well known Lynch-Movies, the Lynchville. At first, some of the recurrent motives in Lynch’s work will be discussed. Then the commercial will be analyzed, especially regarding any parallels to Lynch’s Œuvre. Finally, the question will shortly be discussed whether in this most commercial form of filmmaking the term “auteur” can still apply. The article comes to the conclusion, that Lynch succeeds in maintaining his personal vision – and that therefore the map of Lynchville has to be expanded.

In "Postmodernism, or, the Cultural Logic of Late Capitalism," Fredric Jameson describes the disappearance, within postmodernism, of an objective framework for mapping the social totality. In order to illustrate this concept, Jameson draws upon the ideas of urban planner Kevin Lynch as formulated in his seminal work, The Image of the City. For Lynch, the design of the postwar alienated city results in varying and fragmentary "cognitive maps" used by its inhabitants to negotiate urban space, a problem that can be rectified by "good" urban planning, which aims to create mappable public space through the implementation of external orientation markers. Utilizing this framework, this thesis suggests the existence of an aesthetic countertendency, within postwar literature, to Jameson's vision that is exemplified in William S. Burroughs's Naked Lunch and Samuel R. Delany's Dhalgren. These novels integrally deploy alienated urban environments as settings; however, rather than suggesting structural public spaces as solutions, they offer an alternative, opposite stratagem: the externalization of the intimate onto the public sphere through the integration of pornography. By using the sexual to map character space, they suggest an alternative to Michel Foucault's discursive formulation of sexuality, one that resonates with more recent theoretical work by Leo Bersani and Michael Warner. In order to examine the role of pornography within these works, this thesis integrates Frances Ferguson's account of the pornographic from her study, Pornography, the Theory, which looses pornography from prior "interpretive" models and recasts it as a distinct regime of representation that stresses objectivity and concretization, particularly in relation to the abstract notion of the "social body." While Delany's Dhalgren offers an image- based deployment of the pornographic experience, in which characters' viewing of the pornographic / sexual leads to full cognition and visual perception, Burroughs's Naked Lunch presents a more physical model, wherein subjective sexual experience (particularly in the rendering of the "mosaic orgasm") ultimately affords the subject with panoptic capabilities.