L'administration pénitentiaire française connaît, depuis plusieurs années, d'importantes mutations vis-à-vis de ses missions, qui tendent vers une externalisation et de son personnel. l'amélioration de la réinsertion des détenus est devenue un impératif majeur, surtout en ce qui concerne les mineurs incarcérés, en vue de réduire les risques de récidive. il s'agit d'expliquer et de qualifier ces changements correspondants à un besoins d'adaptation de cette administration envers l'évolution de la population carcérale, tout en améliorant ses relations avec les autres organismes publics (le ministère de l'education nationale notamment) afin de confirmer la politique de décloisonnement et de partenariat, suivie par l'administration pénitentiaire. cette étude tentera également de dresser un premier bilan concernant les efforts fournis par cette administration publique dans le cadre particulier des établissements pénitentiaires pour mineurs. / The correctional institution is experiencing a profound process of modernization under the influence of European and constitutional law, which tends to assign to it all the characteristics of a public service and significantly adds to the law of enforcement of sentences.This normative development, under the control of an administrative judge, has introduced the basis of a genuine legal status for minors as coerced users of this public service. Efforts carried out by the penitentiary administration in the aim of establishing detention rules that apply and are adjusted to the different categories of prison population, and particularly to minors, are changing the traditional/classic conception of the prison‟s missions.The specificity of detention rules, as confirmed by the creation of detention facilities for minors and the search for a legal status for the minor inmate, is endorsed by the opening up of the penitentiary administration and the building of partnerships with other institutional actors.The mobilization of new resources constitutes a fundamental axe in the preparation of the social rehabilitation of minors, in their own best interest and benefit. The issues around the correctional framing in the objective to define the administrative status of the minor inmate lead to double angled analysis: the fixing of the foundations of prison law applicable to minors, and the application of this law which illustrates the need for an adaptation of the penitentiary action when it comes to minors.

Le secret est une notion ancienne, ancrée dans notre législation, qui est généralement le fait des majeurs. Relier le mineur au secret suppose de préciser comment la minorité influe sur le droit au secret dont toute personne - y compris lorsqu’elle est mineure - est titulaire, qu'il s'agisse de l'étendue du droit au secret plutôt plus réduite que pour les majeurs, que de l'exercice de ce droit qui, comme tout droit du mineur est différent et plus complexe.Garder un savoir caché suppose un certain degré de capacité. Or, le statut particulier reconnu au mineur, sujet de droit vulnérable soumis à l’autorité parentale, créé un doute sur sa possibilité de se prévaloir d’un secret. La consécration d’un tel droit pour le mineur n’est pas si évidente et fait l’objet de controverses. Ainsi, le législateur y répond de manière éparse sans en établir une théorie générale applicable aux mineurs. Selon les hypothèses, le droit au secret du mineur passe en effet d’une inexistence à un droit lui consacrant une réelle autonomie.Si le secret est en général une protection, ce qui en fait un droit affaiblissant le pouvoir parental, il peut aussi exposer l’enfant à un réel danger et même l’empêcher d‘accéder à une information le concernant. La richesse de la notion du secret se traduit ainsi spécifiquement lorsque le mineur en est l’objet. Sa vulnérabilité et son incapacité imposant une protection accrue, justifie de réduire le secret ou au contraire de l’étendre. En réalité la mise en œuvre du secret du mineur est différente selon que ce dernier se situe dans une relation avec un tiers ou dans ses relations avec ses parents. / The secret is a former notion, anchored in our legislation, which is made generally adults. To bind the minor with the secret supposes to specify how the minority influence the right to secrecy every person of which - including when she is minor - is a holder, that it is about the extent of the right to secrecy rather more reduced than for the adults, that of the exercise of this right which, as any right of the minor is different and more complex.To keep a hidden knowledge supposes a certain degree of capacity. Yet, the particular status recognized by the minor, the subject of vulnerable right submitted to the parental authority, generates a doubt on its possibility to prevail of a secret. The consecration of such a right for the minor is not so obvious and is controversial. So, the legislator answers it in a scattered way without establishing a general theory applicable to the minors. According to the hypotheses, the right to secrecy of the minor indeed passes of a non-existence in a right dedicating him a real autonomy.If the secret is generally a protection, what makes it a right weakening the parental power, he can also expose the minor to a real danger and even prevent him from reaching an information concerning him. The richness of the notion of the secret is so specifically translated when the minor is the object. Its vulnerability and its incapacity imposing a superior protection, justify to reduce the secret or to spread it. In reality the implementation of the secret of the minor is different depending on whether this one is situated in a relation with a third party or in its relations with his parents.

No description available.

Bovine mastitis adversely affects the dairy industry around the world. This disease is caused by a diverse range of bacteria, broadly categorised as minor and major pathogens. In-line tools that help identify these bacterial groupings in the early stages of the disease are advantageous as timely decisions could be made before the cow develops any clinical symptoms. The first objective of this research was to identify the most informative milk parameters for the detection of minor and major bacterial pathogens. The second objective of this research was to evaluate the potential of supervised and unsupervised neural network learning paradigms for the detection of minor infected and major infected quarters in the early stages of the disease. The third objective was to evaluate the effects of different proportions of infected to non-infected cases in the training data set on the correct classification rate of the supervised neural network models as there are proportionately more non-infected cases in a herd than infected cases. A database developed at Lincoln University was used to achieve the research objectives. Starting at calving, quarter milk samples were collected weekly from 112 cows for a period of fourteen weeks, resulting in 4852 samples with complete records for somatic cell count (SCC), electrical resistance, protein percentage, fat percentage, and bacteriological status. To account for the effects of the stage of lactation on milk parameters with respect to days in milking, data was divided into three days in milk ranges. In addition, cow variation was accounted for by the sire family from which the cow originated and the lactation number of each cow. Data was pre-processed before the application of advanced analytical techniques. Somatic cell score (SCS) and electrical resistance index were derived from somatic cell count and electrical resistance, respectively. After pre-processing, the data was divided into training and validation sets for the unsupervised neural network modelling experiment and, for the supervised neural network modelling experiments, the data was divided into training, calibration and validation sets. Prior to any modelling experiments, the data was analysed using statistical and multivariate visualisation techniques. Correlations (p<0.05) were found between the infection status of a quarter and its somatic cell score (SCS, 0.86), electrical resistance index (ERI, -0.59) and protein percentage (PP, 0.33). The multivariate parallel visualisation analysis validated the correlation analysis. Due to significant multicolinearity [Correlations: SCS and ERI (-0.65: p<0.05); SCS and PP (0.32: p<0.05); ERI and PP (-0.35: p<0.05)], the original variables were decorrelated using principle component analysis. SCS and ERI were found to be the most informative variables for discriminating between non-infected, minor infected and major infected cases. Unsupervised neural network (USNN) model was trained using the training data set which was extracted from the database, containing approximately equal number of randomly selected records for each bacteriological status [not infected (NI), infected with a major pathogen (MJI) and infected with a minor pathogen (MNI)]. The USNN model was validated with the remaining data using the four principle components, days in milk (DIM), lactation number (LN), sire number, and bacteriological status (BS). The specificity of the USNN model in correctly identifying non infected cases was 97%. Sensitivities for correctly detecting minor and major infections were 89% and 80%, respectively. The supervised neural network (SNN) models were trained, calibrated and validated with several sets of training, calibration and validation data, which were randomly extracted from the database in such a way that each set has a different proportion of infected to non-infected cases ranging from 1:1 to 1:10. The overall accuracy of these models based on validation data sets gradually increased with increase in the number of non-infected cases in the data sets (80% for the 1:1, 84% for 1:2, 86% for 1:4 and 93% for 1:10). Specificities of the best models for correctly recognising non-infected cases for the four data sets were 82% for 1:1, 91% for 1:2, 94% for 1:4 and 98% for 1:10. Sensitivities for correctly recognising minor infected cases for the four data sets were 86% for 1:1, 76% for 1:2, 71% for 1:4 and 44% for 1:10. Sensitivities for correctly recognising major infected cases for the four data sets were 20% for 1:1, 20% for 1:2, 30% for 1:4 and 40% for 1:10. Overall, sensitivity for the minor infected cases decreased while that of major infected cases increased with increase in the number non-infected cases in the training data set. Due to the very low prevalence of MJI category in this particular herd, results for this category may be inconclusive. This research suggests that somatic cell score and electrical resistance index of milk were the most effective variables for detecting the infection status of a quarter followed by milk protein and fat percentage. The neural network models were able to differentiate milk containing minor and major bacterial pathogens based on milk parameters associated with mastitis. It is concluded that the neural network models can be developed and incorporated into milking machines to provide an efficient and effective method for the diagnosis of mastitis.

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Platonic Craft and Medical Ethics examines the Platonic theory of craft and shows its application to different ethical problems in medicine, both ancient and modern. I begin by elucidating the Platonic use of the term “craft” or “technē”, using especially the paradigmatic craft of medicine, and explicate a number of important principles inherent in his use of the term. I then show how Plato’s framework of crafts can be applied to two ancient debates. First, I show how Plato’s understanding of crafts is used in discussing the definition of medicine, and how he deals with the issue of “bivalence”, that medicine seems to be capable of generating disease as well as curing it. I follow this discussion into Aristotle, who, though he has a different interpretation of bivalence, has a solution in many ways similar to Plato’s. Second, I discuss the relevance of knowledge to persuasion and freedom. Rhetors like Gorgias challenge the traditional connections of persuasion to freedom and force to slavery by characterizing persuasion as a type of force. Plato addresses this be dividing persuasion between sorcerous and didactic persuasion, and sets knowledge as the new criterion for freedom. Finally, I discuss three modern issues in medical ethics using a Platonic understanding of crafts: paternalism, conclusions in meta-analyses and therapeutic misconceptions in research ethics. In discussing paternalism, I argue that tools with multiple excellences, like the body, should not be evaluated independently of the uses to which the patient intends to put them. In discussing meta-analyses, I show how the division of crafts into goal-oriented and causal parts in the Phaedrus exposes the confusion inherent in saying that practical conclusions can follow directly from statistical results. Finally, I argue that authors like Franklin G. Miller and Howard Brody fail to recognize the hierarchical relationship between medical research and medicine when they argue that medical research ethics should be autonomous from medical ethics per se.

La conservación del patrimonio cultural esta considerado como un principio fundamental en la vida cultural de las sociedades modernas. En los últimos años, se han realizado extensas investigaciones en torno a esta área, conduciendo a desarrollos en la inspección, ensayos no destructivos, monitorización y análisis estructural de monumentos.Por otra parte, el análisis de construcciones antiguas formula importantes desafíos dada la complejidad de su geometría, la variabilidad de las propiedades de los materiales tradicionales, las diferentes técnicas de construcción, la ausencia de conocimiento sobre los daños existentes, y de cómo afectan determinadas acciones a las construcciones a lo largo de su vida.Dichos desafíos suponen que las construcciones del patrimonio arquitectónico estén sometidas a una serie de dificultades de diagnóstico y restauración, que limitan la aplicación de las disposiciones normativas y las pautas vigentes en el ámbito general de la construcción. Y es por todo ello que la comprensión, el análisis y la reparación de construcciones históricas se establece como uno de los desafíos más importantes de los técnicos modernos.¿Sería razonable operar a un enfermo sin tener constancia objetiva del mal que adolece?, en ese caso ¿porqué intervenimos en nuestra herencia cultural sin tener conocimiento contrastado de las causas desencadenantes de sus procesos patológicos?Respondiendo a la cuestión formulada, las intervenciones en las construcciones antiguas, dada su fragilidad, requieren precisión, detalle y formación especial en el desarrollo de un estudio previo riguroso de diagnóstico que de soporte a las decisiones sobre las técnicas de intervención que deben adoptarse.En este proceso es fundamental la fase de reconocimiento - análisis, dado que es en esta etapa en la que se plantean hipótesis y se comprueban, de forma objetiva, a través de cálculos y ensayos. Dentro de la fase referida, debe prestarse especial atención al reconocimiento experimental, dado que dicha inspección además de contribuir a la obtención de parámetros de entrada de los modelos de análisis, tiene como misión el contribuir a calibrarlos mediante la comprobación experimental de los resultados obtenidos analíticamente en determinados puntos de control.Por su parte, es deseable que dicho reconocimiento experimental se realice de la forma menos intrusiva posible para con la construcción, sobremanera en el caso de bienes de carácter monumental.En línea con lo argumentado, la investigación que se presenta incide, dentro del proceso metodológico general de intervención en una construcción antigua, en la fase del reconocimiento experimental, in situ, ligeramente destructivo, y a su vez, dentro de éste, en las técnicas orientadas a obtener información útil desde un punto de vista de la caracterización mecánica de elementos estructurales de fábrica.En este sentido, se pretende contribuir a la puesta a punto, en España, de métodos para la evaluación in situ de la fiabilidad de los elementos estructurales existentes en construcciones históricas de obra de fábrica. Para ello, se van a focalizar los esfuerzos en el calibrado, en laboratorio, de las técnicas de gatos planos, hole drilling y mini-presurometría de fábricas, y posteriormente se aplicarán a casos reales in situ. / Cultural heritage conservation is considered as a fundamental principle of modern societies' cultural life. In recent years, extensive research has been done on this area, leading developments on inspection, non-destructive testing, monitoring and monument structural analysis.In other hand, old buildings analysis implies significant challenges due to the complexity of its geometry, variability of traditional materials properties, different construction techniques, lack of knowledge about existing damage, and how certain actions affect throughout their life to buildings.These challenges mean that architectural heritage buildings are subject to diagnosis and refurbishment difficulties, which limit the application of standards and construction guidelines. That is why the understanding, the analysis and the historic buildings' repair, are considered as one of the most important challenges of modern technicians.Would it be reasonable to operate a patient without objective evidence of the illness that suffers? In that case, why do we intervene in our cultural heritage without knowing the causes that have initiated its pathological processes?Answering to this question, interventions in old buildings, because of its fragility, require accuracy, detail and a special education in the development of a previous diagnostic study, in order to give support to decisions to be adopted on intervention techniques.In this process, it is essential the phase survey - analysis, because it is at this stage where the hypothesis are set out and verified with calculations and tests. Within this phase, it should pay special attention to experimental survey, since such inspection contributes to both obtaining input parameters of the model analysis, and contributes to calibrate it using the experimental verification of the results obtained analytically at certain checkpoints.Moreover, it is desirable that such experimental survey is performed of the least intrusive way as possible for the construction, greatly in the case of monumental constructions.Within the general process of intervention on old constructions, the research presented insists on the on-site experimental survey stage, slightly destructive, and within it, on the techniques aimed to obtain useful information for the mechanical characterization of masonry structural elements.In this sense, it aims to contribute to the development in Spain of methods for on-site evaluation of the structural elements' reliability in masonry historical buildings. For this, efforts will focus on the calibration, in laboratory, of the techniques of flat jacks, hole drilling and masonry mini-pressurometer, and then its application to real on-site cases.

The films of David Lynch are full of ambiguities that derive from his habitual distortion of time, inversion of characters, and creation of ironic, dreamlike worlds that are mired in crisis. While these ambiguities have been explored from numerous angles, scholars have only recently begun to closely examine music's role in Lynch's cinematic imagination. This dissertation explores the relationship between music and fantasy through the lens of Lacanian psychoanalysis where fantasy plays a crucial role in helping psychoanalytical subjects work through their psychical crises. In particular, I look at Blue Velvet (1986), Lost Highway (1996), and Mulholland Drive (2001), showing how Lynch employs music to manage and, in the case of Mulholland Drive, move beyond the particular crises of jouissance experienced by the Characters--and also the viewers. Before engaging in my analysis of Lynch's film music, however, I begin with an extended discussion of what Kevin Korsyn describes as the current crisis of music scholarship, examining how this crisis manifests itself in recent "postmodern" interpretations of Beethoven's Ninth Symphony. Few works are invested with as much cultural capital as this one and arguably the discourse around it exhibits the crisis more acutely than any other. Korsyn restricts his analysis to the fields of musicology and music theory, but I approach the crisis of music scholarship obliquely, through my Lacanian reading of Lynch's film music. This dissertation, then, has two goals. On one hand it attempts to examine music's role in Lynch's films, and on the other, it explores how Lynch's use of music might aid us in navigating and moving beyond the institutional crises of music scholarship. This Lynchian solution to our crisis provides a glimpse of what might lie beyond postmodernism, a new philosophical movement some are calling the "New Sincerity." This term covers several loosely related cultural or philosophical movements that have followed in the wake of postmodernism, the most notable being what Raoul Eshelman and Judith Butler refer to as "performatism." Finally, I return to Beethoven's Ninth to offer a second, performative reading, demonstrating how Lynch's use of music can be translated into current musical discourse. / text

Platonic Craft and Medical Ethics examines the Platonic theory of craft and shows its application to different ethical problems in medicine, both ancient and modern. I begin by elucidating the Platonic use of the term “craft” or “technē”, using especially the paradigmatic craft of medicine, and explicate a number of important principles inherent in his use of the term. I then show how Plato’s framework of crafts can be applied to two ancient debates. First, I show how Plato’s understanding of crafts is used in discussing the definition of medicine, and how he deals with the issue of “bivalence”, that medicine seems to be capable of generating disease as well as curing it. I follow this discussion into Aristotle, who, though he has a different interpretation of bivalence, has a solution in many ways similar to Plato’s. Second, I discuss the relevance of knowledge to persuasion and freedom. Rhetors like Gorgias challenge the traditional connections of persuasion to freedom and force to slavery by characterizing persuasion as a type of force. Plato addresses this be dividing persuasion between sorcerous and didactic persuasion, and sets knowledge as the new criterion for freedom. Finally, I discuss three modern issues in medical ethics using a Platonic understanding of crafts: paternalism, conclusions in meta-analyses and therapeutic misconceptions in research ethics. In discussing paternalism, I argue that tools with multiple excellences, like the body, should not be evaluated independently of the uses to which the patient intends to put them. In discussing meta-analyses, I show how the division of crafts into goal-oriented and causal parts in the Phaedrus exposes the confusion inherent in saying that practical conclusions can follow directly from statistical results. Finally, I argue that authors like Franklin G. Miller and Howard Brody fail to recognize the hierarchical relationship between medical research and medicine when they argue that medical research ethics should be autonomous from medical ethics per se.

Le système de différenciation entre le « soi » et le « non-soi » des vertébrés permet la détection et le rejet de pathogènes et de cellules allogéniques. Il requiert la surveillance de petits peptides présentés à la surface cellulaire par les molécules du complexe majeur d’histocompatibilité de classe I (CMH I). Les molécules du CMH I sont des hétérodimères composés par une chaîne lourde encodée par des gènes du CMH et une chaîne légère encodée par le gène β2-microglobuline. L’ensemble des peptides est appelé l’immunopeptidome du CMH I. Nous avons utilisé des approches en biologie de systèmes pour définir la composition et l’origine cellulaire de l’immunopeptidome du CMH I présenté par des cellules B lymphoblastoïdes dérivés de deux pairs de fratries avec un CMH I identique. Nous avons découvert que l’immunopeptidome du CMH I est spécifique à l’individu et au type cellulaire, qu’il dérive préférentiellement de transcrits abondants, est enrichi en transcrits possédant d’éléments de reconnaissance par les petits ARNs, mais qu’il ne montre aucun biais ni vers les régions génétiques invariables ni vers les régions polymorphiques. Nous avons également développé une nouvelle méthode qui combine la spectrométrie de masse, le séquençage de nouvelle génération et la bioinformatique pour l’identification à grand échelle de peptides du CMH I, dont ceux résultants de polymorphismes nucléotidiques simples non-synonymes (PNS-ns), appelés antigènes mineurs d’histocompatibilité (AMHs), qui sont les cibles de réponses allo-immunitaires. La comparaison de l’origine génomique de l’immunopeptidome de soeurs avec un CMH I identique a révélé que 0,5% des PNS-ns étaient représentés dans l’immunopeptidome et que 0,3% des peptides du CMH I seraient immunogéniques envers une des deux soeurs. En résumé, nous avons découvert des nouveaux facteurs qui modèlent l’immunopeptidome du CMH I et nous présentons une nouvelle stratégie pour l’indentification de ces peptides, laquelle pourrait accélérer énormément le développement d’immunothérapies ciblant les AMHs. / The self/nonself discrimination system of vertebrates allows detection and rejection of pathogens and allogeneic cells. It requires the surveillance of short peptides presented by major histocompatibility class I (MHC I) molecules on the cell surface. MHC I molecules are heterodimers that consist of a heavy chain produced by MHC genes and a light chain encoded by the β2-microglobulin gene. The peptides presented by MHC I molecules are collectively referred to as the MHC I immunopeptidome. We employed systems biology approaches to define the composition and cellular origin of the self MHC I immunopeptidome presented by B lymphoblastoid cells derived from two pairs of MHC-identical siblings. We found that the MHC I immunopeptidome is subject- and cell-specific, derives preferentially from abundant transcripts, is enriched in transcripts bearing microRNA response elements and shows no bias toward invariant vs. polymorphic genomic sequences. We also developed a novel personalized approach combining mass-spectrometry, next-generation sequencing and bioinformatics for high-throughput identification of MHC I peptides including those caused by nonsynonymous single nucleotide polymorphisms (ns-SNPs), termed minor histocompatibility antigens (MiHAs), which are the targets of allo-immune responses. Comparison of the genomic landscape of the immunopeptidome of MHC-identical siblings revealed that 0.5% of ns-SNPs were represented in the immunopeptidome and that 0.3% of the MHC I-peptide repertoire would be immunogenic for one of the siblings. We discovered new factors that shape the self MHC I immunopeptidome and present a novel strategy for the identification of MHC I-associated peptides that could greatly accelerate the development of MiHA-targeted immunotherapy.