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Florence Price (1887–1953) was one of the most important African American woman composers of the early twentieth century. Price's music is known for combining techniques of Western art music with elements of the African American musical heritage. Although Price composed many works for piano, from large virtuoso pieces to characteristic miniatures, this study will address only her Piano Sonata in E minor. The purpose of this study is to analyze this sonata and discuss her compositional techniques and musical style as a combination of African American elements and Classical European procedures, combined and coordinated yet remaining in tension. Traditional European harmony, tonality, and form are successfully combined with African American characteristics: pentatonic scale, spirituals, syncopations, repetition, and dance rhythms. Indeed, Price's work is a considerable achievement, and she is one of the important African American women composers who should be better recognized today.

Increasing the access to post-secondary education is a top priority around the world, but still many graduates experience serious challenges in entering the labor market. In Tanzania the issue is prominent and partly associated with the skills mismatch, but also with the imbalance of the number of jobs available in relation to the number of graduates seeking for a job. Skills development is acritical element of all efforts in this challenging area, and therefore a number of organizations has emerged to focus on this, especially in Tanzania. The area has been explored in the literature, but mainly quantitatively on a macro-level. Hence, there is a need of more qualitative research regarding the best practices of organizations focusing on skills development. This thesis therefore aims to investigate how skills development organizations can support graduates in entering the labor market in Tanzania. The thesis is a Minor Field Study, implying that semi-structured interviews with graduates and skillsdevelopment organizations were conducted on-site in Tanzania. Further, hypotheses, regarding challenges that graduates experience when entering the labor market, were formulated and tested through qualitative and quantitative data. The findings imply that the challenges graduates experience can be categorized into three groups: structural, skills and attitude. Skills development organizations can therefore support graduates in entering the labor market by addressing these challenges and adopt measures in three different operations: the planning, the execution and the evaluation of skills development activities. Except for specific actions within each operation, the findings accentuate the importance of incorporating both the graduate and employer perspective, as well as viewing the support as a long-term process, from the first years of studies to obtaining employment. / Att öka tillgången till eftergymnasial utbildning har hög prioritet runt om i världen, men trots att fler utbildas är arbetslösheten bland unga fortfarande ett stort problem. I Tanzania är detta särskilt påtagligt och delvis förknippat med kompetens- och kunskapsbrist, men också med obalansen mellan antalet lediga jobb och antalet utexaminerade som söker jobb. Hur organisationer kan stötta unga i övergången från utbildning till arbetsmarknaden har undersökts tidigare, men då främst genom kvantitativ forskning på makronivå. Därför behövs fler kvalitativa studier om hur organisationer effektivt kan stötta unga personer in på arbetsmarknaden, vilket detta arbete syftar till. Studien har utförts som en mindre fältstudie på plats i Tanzania. Den empiriska data som har använts i studien har samlats in genom intervjuer med studenter och organisationer samt genom ett frågeformulär. De empiriska resultaten kombinerades sedan med litteratur för att besvara forskningsfrågorna. Resultaten visar att utmaningar som utexaminerade studenter upplever kan delas in i tre kategorier; strukturella-, kompetens- och attitydutmaningar. Organisationer kan därför stödja utexaminerade studenter att komma in på arbetsmarknaden genom att möta dessa utmaningar och vidta åtgärder inom tre olika områden: planering, genomförande och utvärdering av aktiviteter för kompetensutveckling. Förutom specifika åtgärder inom vardera områden, betonar resultaten vikten av att införa både student- och arbetsgivarperspektivet, samt att se stödet som en långsiktig process, från de första studieåren till anställning eller självanställning

This study examines how the new temporary law (SFS 2016:752) guarantees the child’s right to mental health; focusing on the asylum-seeking unaccompanied minor. This subject is examined since the Swedish law that regulates migration got reduced to the minimum standards that can be found in the EU and in international conventions when Sweden received 163 000 asylum seekers during 2015. 35 400 of them were unaccompanied minors. This leads to the question if the new regulations jeopardize the child’s right to mental health. To answer that, this study’s theoretical ground that will be used is legal positivism. By practicing a legal-judicial method and law-based sociological method the study follows three questions; 1. What is Sweden bound to guarantee according to the Convention on the Right’s of the child, associated with the mental health of children and the provisions of the temporary law? 2. Does the temporary law constitute grounds for existential uncertainty, and is it thereby violating the child’s right to mental health? 3. What does the situation look like, related to the mental health of asylum-seeking unaccompanied minors? In relation to the Convention on the Right’s of the Child this temporary law, and the impact of it, is examined. In the discussion it is clear that not only article 24 (the child’s right to health) is fundamental to the question of mental health, but several other articles. The result of this study has shown that the temporary law clearly violates the asylum-seeking unaccompanied child’s right to mental health.

Previous research has reported that inequalities exist in uptake of NHS sight tests in relation to socio-economic status, and that community optometric services have potential to improve system efficiency. The current research found inequalities in sight test outcome related to socio-economic status and the type of practice that a patient visits (multiple, or independent). Patients attending multiples were more likely to receive a ‘new or changed prescription’ relative to ‘no prescription’ compared to patients that attended independent opticians (36-71% more likely). Those living in the least deprived areas were also less likely to receive a new prescription (1-12%) and those aged <16 years were less likely to be referred (9%). The study examining the need for a Minor Eye Condition Service in Leeds and Bradford found it would produce theoretical cost savings, whilst maintaining high patient satisfaction. Subsequently, a MECS was commissioned in Bradford. The study attempting to collect data from MECS across all areas of England found that data is not routinely collected, or shared. The limited data available typically showed that 73-83% of patients were retained in optometric practice with 12-18% receiving a hospital referral. A prospective evaluation of a COVID urgent eye care service found that teleconsultations frequently did not resolve patients’ eye problems (27%). These telephone consultations failed to detect some serious conditions such as scleritis, wet macular degeneration, retinal detachment. The results from the thesis support the view that the current method of delivering eye care in England is contrary to the public health interest.

As global inequality reaches unprecedented levels, social entrepreneurship has emerged as a promising tool for addressing this and fighting some of the most challenging social issues of our time. This thesis seeks to dive into the specific challenges that social entrepreneurs encounter in low-income settings by conducting a case study in the favelas in Brazil, one of the world’s most widely recognized low-income areas. By conducting a comprehensive literature review, the thesis establishes a conceptual framework for the challenges facing social entrepreneurs in low-income settings. This is used to guide the analysis for the data collection in a deductive manner. Data is collected using semi-structured interviews with seven social entrepreneurs operating within the favelas. The findings reveal that the interviewed social entrepreneurs in the favelas face significant obstacles across five main areas: financial capital, legal and regulatory environment, infrastructure, human capital, and social capital. These challenges are consistent with the conceptual framework of challenges facing social entrepreneurs in low-income settings. / I takt med att den globala ojämlikheten når rekordnivåer har socialt entreprenörskap vuxit fram som ett lovande verktyg för att tackla några av vår tids mest utmanande samhällsfrågor. Denna avhandling syftar till att undersöka de specifika utmaningar som sociala entreprenörer möter i låginkomstmiljöer genom att genomföra en fältstudie i favelorna i Brasilien, ett av världens mest kända låginkomstområden. Genom att göra en omfattande litteraturgenomgång etablerar avhandlingen först ett konceptuellt ramverk för de utmaningar som sociala entreprenörer i låginkomstmiljöer står inför. Denna används senare för att vägleda analysen av datainsamlingen på ett deduktivt sätt. Data samlas in med hjälp av semistrukturerade intervjuer med sju sociala entreprenörer verksamma inom dessa områden. Resultaten visar att de intervjuade sociala entreprenörerna möter betydande hinder inom fem huvudområden: finansiellt kapital, lagar och regler, infrastruktur, humankapital och socialt kapital. Dessa utmaningar är i linje med det konceptuella ramverket för utmaningar som sociala entreprenörer står inför i låginkomstområden.

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Increasing the access to post-secondary education is a top priority around the world, but still many graduates experience serious challenges in entering the labor market. In Tanzania the issue is prominent and partly associated with the skills mismatch, but also with the imbalance of the number of jobs available in relation to the number of graduates seeking for a job. Skills development is a critical element of all efforts in this challenging area, and therefore a number of organizations has emerged to focus on this, especially in Tanzania. The area has been explored in the literature, but mainly quantitatively on a macro-level. Hence, there is a need of more qualitative research regarding the best practices of organizations focusing on skills development. This thesis therefore aims to investigate how skills development organizations can support graduates in entering the labor market in Tanzania. The thesis is a Minor Field Study, implying that semi-structured interviews with graduates and skills development organizations were conducted on-site in Tanzania. Further, hypotheses, regarding challenges that graduates experience when entering the labor market, were formulated and tested through qualitative and quantitative data. The findings imply that the challenges graduates experience can be categorized into three groups: structural, skills and attitude. Skills development organizations can therefore support graduates in entering the labor market by addressing these challenges and adopt measures in three different operations: the planning, the execution and the evaluation of skills development activities. Except for specific actions within each operation, the findings accentuate the importance of incorporating both the graduate and employer perspective, as well as viewing the support as a long-term process, from the first years of studies to obtaining employment. / Att öka tillgången till eftergymnasial utbildning har hög prioritet runt om i världen, men trots att fler utbildas är arbetslösheten bland unga fortfarande ett stort problem. I Tanzania är detta särskilt påtagligt och delvis förknippat med kompetens- och kunskapsbrist, men också med obalansen mellan antalet lediga jobb och antalet utexaminerade som söker jobb. Hur organisationer kan stötta unga i övergången från utbildning till arbetsmarknaden har undersökts tidigare, men då främst genom kvantitativ forskning på makronivå. Därför behövs fler kvalitativa studier om hur organisationer effektivt kan stötta unga personer in på arbetsmarknaden, vilket detta arbete syftar till. Studien har utförts som en mindre fältstudie på plats i Tanzania. Den empiriska data som har använts i studien har samlats in genom intervjuer med studenter och organisationer samt genom ett frågeformulär. De empiriska resultaten kombinerades sedan med litteratur för att besvara forskningsfrågorna. Resultaten visar att utmaningar som utexaminerade studenter upplever kan delas in i tre kategorier; strukturella-, kompetens- och attitydutmaningar. Organisationer kan därför stödja utexaminerade studenter att komma in på arbetsmarknaden genom att möta dessa utmaningar och vidta åtgärder inom tre olika områden: planering, genomförande och utvärdering av aktiviteter för kompetensutveckling. Förutom specifika åtgärder inom vardera områden, betonar resultaten vikten av att införa både student- och arbetsgivarperspektivet, samt att se stödet som en långsiktig process, från de första studieåren till anställning eller självanställning

No / PURPOSE: This phase I dose-escalation study was undertaken to establish the maximum tolerated dose of the sequence-selective minor groove DNA binding agent SJG-136 in patients with advanced solid tumors. The study also investigated antitumor activity and provided pharmacokinetic and pharmacodynamic data. EXPERIMENTAL DESIGN: Sixteen patients were assigned sequentially to escalating doses of SJG-136 (15-240 microg/m(2)) given as a 10-minute i.v. infusion every 21 days. The dose was subsequently reduced in incremental steps to 45 microg/m(2) due to unexpected toxicity. RESULTS: The maximum tolerated dose of SJG-136 was 45 microg/m(2). The main drug-related adverse event was vascular leak syndrome (VLS) characterized by hypoalbuminemia, pleural effusions, ascites, and peripheral edema. Other unexpected adverse events included elevated liver function tests and fatigue. The VLS and liver toxicity had delayed onset and increased in severity with subsequent cycles. Disease stabilization was achieved for >6 weeks in 10 patients; in 2 patients this was maintained for >12 weeks. There was no evidence of DNA interstrand cross-linking in human blood lymphocytes with the use of the comet assay. Evidence of DNA interaction in lymphocytes and tumor cells was shown through a sensitive gamma-H2AX assay. SJG-136 had linear pharmacokinetics across the dose range tested. CONCLUSIONS: SJG-136 was associated with dose-limiting VLS and hepatotoxicity when administered by short injection every 21 days. DNA damage was noted, at all dose levels studied, in circulating lymphocytes. The etiology of the observed toxicities is unclear and is the subject of further preclinical research. Alternative clinical dosing strategies are being evaluated.

The aim of this compilation thesis is to explore variations in bilingualism with the help of everyday specific situations at a Spanish-Swedish early childhood institution in Sweden, and by means of a ‘material-semiotic theorizing’. This means that material and semiotic elements are treated equally and entwined. Through studying a bilingual preschool practice, theory and politics as three interwoven practices, the thesis produces knowledge on language and literacy as socially and materially divergent, transformative occurrences. The research process is a commitment with Deleuzio-Guattarian philosophy, theory and politics, and is defined as a becoming in and of the three practices (education, theory, politics). Ethical and methodological undertakings are described as results of the interaction of these practices. Processes of data production include a yearlong fieldwork with all year groups (1-5) at a bilingual preschool in Sweden with a Spanish-Swedish language policy. The materials of data (approx. 59 hours of video-recordings and additional field-notes of everyday activities) are extended and developed upon in interaction with theoretical concepts and political concerns in terms of an analytical process that ‘puts theory to work’. The results are phrased as three temporal suggestions: 1) Bilingualism is a plural, collectively produced, both transitory and specific phenomenon 2) Bilingualism emerges with different, simultaneous dimensions of language and literacy (language as both code and material intensities) 3) Bilingualism is shared and public but also private and inconclusive. The thesis also shows the interconnectedness and continuity between different constructions of bilingualism (i.e. separate – flexible, public - private) as well as the productivity of the unknown and of what is labelled as (il)literate expertise. The impact that these suggestions may have in working with bilingualism in early childhood education is discussed. At the same time the discussion inspires to thinking towards a minor bilingualism also in more general terms. / Syftet i denna sammanläggningsavhandling är att utforska variationer i tvåspråkighet med hjälp av alldagligt specifika situationer vid en spansk-svensk förskola i Sverige, samt genom ett ’material-semiotiskt teoretiserande’. Det betyder att materiella och semiotiska aspekter behandlas jämbördigt, sammanlänkat och icke-hierarkiskt. Genom att studera en tvåspråkig förskolepraktik, teori och politik som sammanvävda praktiker producerar avhandlingen kunskap om språk och litteracitet som socialt och materiellt divergenta, transformativa fenomen. Forskningsprocessen är en förlovning med DeleuzioGuattariansk filosofi, teori och politik och definieras som ett tillblivande i och med de tre praktikerna (utbildning, teori, politik). Etiska och metodologiska göranden beskrivs som resultat av interaktionen mellan dessa tre praktiker. Processer av dataproduktion inkluderar ett årslångt fältarbete med alla åldersgrupper (1-5) på en tvåspråkig förskola i Sverige med en spansk-svensk språkpolicy. Datamaterialen (59 timmars videoinspelningar och fältanteckningar från vardagliga aktiviteter) förlängs och utvecklas i avhandlingen i interaktion med teoretiska begrepp och politiska angelägenheter i termer av en analytisk process som ‘sätter teori i arbete’. Resultaten formuleras som tre temporära förslag. 1) Tvåspråkighet är ett pluralt, kollektivt producerat, både flyktigt och specifikt fenomen 2) Tvåspråkighet uppträder med olika, samtidiga språkliga dimensioner (språk som både kod och materiella intensiteter) 3) Tvåspråkighet är delat och publikt men också privat och odeciderat. Avhandlingens resultat visar också på länkar och kontinuitet mellan olika konstruktioner av tvåspråkighet (till exempel separat – flexibel, publik – privat) samt produktiviteten i det okända och vad som kan benämnas (il)litterat expertis. Betydelsen som avhandlingens förslag kan ha i arbete med tvåspråkighet i utbildningspraktiker med små barn diskuteras. Samtidigt inspirerar diskussionen till att tänka i riktningar mot en mindre tvåspråkighet också i mer generella termer.