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Выпускная квалификационная работа состоит из введения, трех частей, заключения, библиографического списка и приложений. В теоретической части представлены смежные понятия управления эффективностью, процесс управления эффективностью, инструменты исследования, методы исследования. Практическая часть: характеристика компании Z как объекта управления, структура человеческих ресурсов компании Z, оценка по системе PM компании Z, проблемы и причины в системе PM компании Z. На основе полученных данных разработаны предложения: Цели и принципы оптимизации, Основы построения схемы оптимизации, Мероприятия по оптимизации. В заключении подводятся итоги в соответствии с поставленными задачами. / The final qualifying work consists of an introduction, three parts, a conclusion, a bibliographic list, and appendixes. The theoretical part presents related concepts of performance management, process of performance management, research tools, research methods. The practical part characteristics of Company Z as an object of management, human resource structure of Company Z, appraisal on the PM system of Company Z, problems and causes in the company Z’s PM system. Based on the data obtained, proposals have been developed Objectives and principles of optimization, Optimization scheme design framework, Optimization measures. In conclusion, the results are summed up in accordance with the tasks set.

In this thesis, we present a new existence result for Lévy-type processes. Lévy-type processes behave locally like a Lévy process, but the Lévy triplet may depend on the current position of the process. They can be characterized by their so-called symbol; this is the analogue of the characteristic exponent in the Lévy case. Using a parametrix construction, we prove the existence of Lévy-type processes with a given symbol under weak regularity assumptions on the regularity of the symbol. Applications range from existence results for stable-like processes and mixed processes to uniqueness results for Lévy-driven stochastic differential equations. Moreover, we discuss sufficient conditions for the existence of moments of Lévy-type processes and derive estimates for fractional moments.

La sentence internationale est communément réputée obligatoire et non exécutoire et l’exécution est conçue comme une phase « post-adjudicative » relevant de l’imperium de l’Etat. L’étude des mécanismes de surveillance de l’exécution des arrêts et décisions des Cours européenne et interaméricaine des droits de l’homme permet un renversement de ces postulats. Alors que les articles 46§2 de la CEDH et 65 de la CADH prévoient des surveillances de nature politique de l’exécution desdits arrêts et décisions, la pratique a été toute autre. Il s’avère que les procédures de surveillance en question sont respectivement quasi juridictionnelle et juridictionnelle et continuent autrement le procès. Elles sont aussi contentieuses, car les organes de surveillance tranchent des différends relatifs à l’exécution des arrêts et décisions, selon les principes directeurs du procès. Les contentieux de l’exécution européen et interaméricain permettent alors une redéfinition du procès en droit international et attestent que la notion de phase « post-adjudicative » n’existe pas. Ces procédures de surveillance ont en outre une double finalité. La première s’attache au contrôle de deux types de comportements étatiques, des comportements imposés et escomptés. Ces contrôles révélant que l’Etat n’est pas libre de ses moyens d’exécution, visent à aboutir au résultat de l’exécution effective de l’arrêt ou de la décision juridictionnelle telle que cette exécution est conçue par les organes de surveillance. La seconde finalité consiste en des suivis d’actes rendus au cours des surveillances et desquels résulte une chose à exécuter. D’un point de vue procédural, les suivis de cette chose qui émerge des précisions apportées à la chose jugée et aux comportements étatiques, révèlent l’existence de nouveaux types de recours dans le contentieux international. D’un point de vue substantiel, les suivis de la chose sont une contrainte formelle pour l’Etat qui n’est libéré des procédures de surveillance que s’il exécute l’arrêt ou la décision conformément à la chose à exécuter. Ces suivis sont donc des voies d’exécution et attestent alors de la force exécutoire interne des arrêts et décisions des Cours européenne et interaméricaine des droits de l’homme, que les organes de surveillance garantissent. / In the absence of enforcement mechanisms, an international decision is deemed binding and non-enforceable, and execution is generally perceived as a “post-adjudicative” phase, belonging to the State’s imperium. Study of the supervision of execution of the judgments and decisions of the European and Inter-american Courts of Human Rights reveals that these basic assumptions can be challenged. Whereas articles 46§2 of the ECHR and 65 of the ACHR provide for political modes of supervision of execution of the judgments and decisions of the European and Inter-american Courts of Human Rights, the practice has been completely different. It appears that the said supervision procedures are respectively quasi judicial and judicial and arise in the continuation of the trial. They are also contentious, given that the supervision authorities resolve disputes relating to the execution of judgments and decisions in accordance with due process principles. These procedures contribute to redefining the concept of trial in international law and illustrate that the notion of “post-adjudicative” phase does not exist. They also serve a double purpose. First, they allow control of two types of the State conduct, imposed and expected conduct. Illustrating that the State is not free in choosing its means of execution, such control aspires to achieve the effective execution of the judgment or judicial decision. The second purpose consists in following up on the resolutions and/or orders made in the course of supervision and which result in a res executiva. This res executiva, which would have emerged on the basis of clarifications made to res judicata and State conduct, in turn becomes the subject of the follow-up procedures. The consequences of such follow-up are twofold : from the procedural point of view, it creates new forms of appeals; from the substantive point of view, it formally constraints the State and achieves enforceability of judgments and decisions, guaranteed by the supervision authorities.

Introdução: O linfoma difuso de grandes células B é o mais freqüente grupo de linfoma não- Hodgkin, perfazendo quase 50% dos casos no serviço de hematologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo e Instituto do Câncer do Estado de São Paulo. Possui heterogeneidade clínica e biológica traduzida em mais de vinte subtipos na Organização Mundial da Saúde. Sua terapêutica se baseia na associação do anticorpo monoclonal anti-CD20 e quimioterapia com antracíclico, esquema que resulta em 43,5% de sobrevida global em 10 anos. Determinantes de prognóstico clínico como o Índice Internacional de Prognóstico e o Índice Internacional de Prognóstico Revisado carecem de acurácia, pois até 20% dos pacientes de baixo risco falecerão da doença e 60% dos pacientes de alto risco estarão vivos em quatro anos. Essas discrepâncias podem, em parte, ser atribuídas a fatores genéticos. A assinatura gênica do linfoma difuso de grandes células B tipo centro germinativo apresenta sobrevida global superior ao tipo células B ativadas (76% versus 16%, p=0,01), contudo o perfil de expressão gênica por microarray ainda não está disponível na prática clínica. Entretanto, o escore preditivo de mortalidade para linfoma difuso de grandes células B baseado no valor prognóstico da expressão dos genes BCL2, BCL6, CCND2, FN1, LMO2 e SCYA3 por PCR em tempo real quantitativa mostrou-se independente do Índice Internacional de Prognóstico na era pré-rituximabe. Mas não foi significante em pacientes de alto risco clínico tratados com R-CHOP. Os genes BCL2, CCND2 e SCYA3 integram a assinatura de células B ativadas, BCL6 e LMO2 a do centro germinativo e FN1 a linfonodal. Objetivo: Avaliar o impacto da expressão absoluta dos genes BCL2, BCL6, CCND2, FN1, LMO2 e SCYA3 em população brasileira com linfoma difuso de grandes células B tratada com R-CHOP em relação à resposta global, sobrevida livre de doença, sobrevida livre de progressão e sobrevida global. Métodos: A expressão gênica foi analisada por PCR em tempo real quantitativa de RNA extraído de amostras parafinadas de 63 pacientes, porém foi avaliável em 42. Seus valores foram normatizados pelo gene endógeno ABL e transformados em escala logarítmica na base 2 para posterior correlação com variáveis clínicas e de desfecho. Resultados: Com mediana de seguimento de 29 meses, as sobrevidas global, livre de doença e livre de progressão foram, respectivamente, 82,8%, 97,14% e 87,53%, enquanto a resposta completa foi 82,5%. A expressão de LMO2>3logs e BCL6>3,5logs definiu um grupo de maior sobrevida global (91% versus 64,3%, p=0,040) e sobrevida livre de doença (95,5% versus 70,7%, p=0,03), independentemente do Índice Internacional de Prognóstico (p=0,010 e p=0,042) e com significativa hiperexpressão do SCYA3 (p=0,046). Não se observou associação entre escore preditivo de mortalidade baseado nos seis genes e prognóstico. Assim, foi criado novo escore genético prognóstico baseado no poder da expressão concomitante de LMO2 e CCND2, definindo-se grupos de baixo risco (<2,5) e alto risco (>=2,5) com distintas sobrevidas global (92,4% versus 57,1%, p=0,011) e livre de progressão (96,2% versus 66,7%, p=0,013), independentes do IPI. Conclusão: Em pacientes com linfoma difuso de grandes células B tratados com R-CHOP, a hiperexpressão de BCL6, LMO2 e SCYA3 correlacionou-se com melhor prognóstico. O novo escore genético prognóstico definido por LMO2 e CCND2 estratificou grupos de risco de prognósticos distintos independentes do Índice Internacional de Prognóstico / Introduction: Diffuse large B-cell lymphoma is the most common type of non-Hodgkin lymphoma; which accounts for almost 50% of the cases at the Hematology Department of Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo and Instituto do Câncer do Estado de São Paulo. Its clinical and biological heterogeneity results in more than twenty subtypes according to the World Health Organization classification. Its treatment is based on a combination of anti-CD20 monoclonal antibody and antracycline-based chemotherapy, with a 10-year overall survival of 43.5%. Clinical prognostic determinants such as the International Prognostic Index and the Revised International Prognostic Index lack accuracy, since up to 20% of low-risk patients will die from the disease and up to 60% of high-risk patients will be alive within four years. Such discrepancies can partially be attributed to genetic factors. Diffuse large B-cell lymphoma germinal center gene signature shows superior overall survival compared to activated B-cell signature (76% versus 16%, p=0.01), however microarray gene expression profile is not yet available in clinical practice. Nonetheless, the Mortality Predictor Score for diffuse large B-cell lymphoma based on the prognostic value of BCL2, BCL6, CCND2, FN1, LMO2 and SCYA3 gene expression by quantitative real-time PCR has proved to be independent from the International Prognostic Index in the pre-rituximab era. But it was not significant in high clinical risk patients treated with R-CHOP. The genes BCL2, CCND2 and SCYA3 compose activated B-cell signature, whereas BCL6 and LMO2 compose the germinal center signature and FN1 the lymph-node signature. Objective: Evaluate the impact of BCL2, BCL6, CCND2, FN1, LMO2 and SCYA3 absolute gene expression in Brazilian population diagnosed with diffuse large B-cell lymphoma and treated with R-CHOP, with respect to overall response, disease free survival, progression free survival and overall survival. Methods: Gene expression was analyzed by quantitative real-time PCR of RNA extracted from paraffin-embedded samples of 63 patients, although evaluable in 42. Their values were normalized by endogenous gene ABL and log- transformed on a base 2 scale for subsequent correlation with clinical and outcome variables. Results: With a median follow-up of 29 months, overall survival, disease free survival and progression free survival accounted for 82.8%, 97.14% and 87.53% respectively, while complete response was 82.5%. The expression of LMO2>3logs and BCL6>3.5logs defined a group with higher overall survival (91% versus 64.3%, p=0.040) and progression free survival (95.5% versus 70.7%, p=0.03), independent of International Prognostic Index (p=0.010 and p=0.042) and with significant overexpression of SCYA3 (p=0.046). It was not identified any association between six gene Mortality Predictor Score and prognosis. As a result, we developed the New Genetic Prognostic Score based on the power of concomitant expression of LMO2 and CCND2, defining low-risk (<2.5) and high-risk (>=2.5) groups with distinct overall survival (92.4% versus 57.1%, p=0.011) and progression free survival (96.2% versus 66.7%, p=0.013), independent of International Prognostic Index. Conclusion: In patients with diffuse large B-cell lymphoma treated with R-CHOP, hyperexpression of BCL6, LMO2 and SCYA3 was correlated with a better prognosis. The New Genetic Prognostic Score, defined by LMO2 and CCND2, stratified risk groups with different prognosis, independent of International Prognostic Index

Varumärkesrätten innefattar en bred definition av vilka kännetecken som kan konstituera ett varumärke, vilken inkluderar formen på en vara. När kännetecknet består av en varuform utgör således varan i sig kännetecknet och därmed varumärket. Vid en varumärkesregistrering ska bedömningen av olika kategorier av kännetecken inte skilja sig åt, men för varuformer finns ytterligare hinder vid registrering jämfört med andra typer av kännetecken. Ett sådant registreringshinder avser specifikt funktionella former. Många former tenderar att vara funktionella till viss grad, vilket aktualiserar art. 7.1 e) ii) VmF. Artikeln föreskriver ett absolut registreringshinder mot att registerna former som endast består av ”en varas form eller annan egenskap hos varan som krävs för att uppnå ett tekniskt resultat”. Om en varuform hindras registrering enligt artikeln, är uteslutningen från registrering permanent. Det innebär att registreringshindret inte kan övervinnas även om formen förvärvar särskiljningsförmåga på marknaden. EUD har uttalat att det inte vore skäligt att neka registrering av varuformer endast på grund av att de innehar några funktionella element. För att ett kännetecken ska falla inom ramen för artikeln behöver således en forms alla väsentliga särdrag falla inom ramen för bestämmelsen. Detta medför viss problematik när det kommer till hybridkännetecken vilka innehar vissa element som är funktionella, men även andra element som är icke-funktionella. Enligt gällande rätt kan hybridkännetecken registreras som varumärken om de innehar icke-funktionella särdrag som anses vara väsentliga. Hela formen av ett hybridkännetecken kan således registreras som ett varumärke under förutsättning att endast några av de väsentliga särdragen krävs för att uppnå den tekniska funktionen. Genom en undersökning av rättspraxis konstateras att EUD utför en fri och långtgående undersökning vid bedömning av vad som utgör en forms väsentliga särdrag och dessa särdrags eventuella funktion. EUD är inte bunden till vad som anges i varumärkesansökan, utan undersöker även den faktiska varan på marknaden för vilket kännetecknet är ämnat att användas. EUD verkar generellt vara restriktiv med att låta tredimensionella former registreras, inte minst när de innehåller funktionella element. Möjligen beror den negativa inställningen till att registrera hybridkännetecken på bristen av effektiva lösningar att tydligt undanta de funktionella elementen från registrering. Vid en registrering av hybridkännetecken uppstår även intressanta aspekter ur intrångssynpunkt eftersom formen är registrerad som en helhet, även om vissa väsentliga särdrag inte är ämnade att omfattas av ensamrätten. Vid analoga tillämpningar av rättspraxis framstår det som att dessa element, utan att det explicit framgår av exempelvis en disclaimer, ska vara undantagna från den ensamrätt som erhålls varumärkesinnehavaren. / The trade mark law includes a very broad definition of signs that can constitute a trade mark, which includes the shape of a product. When a sign consists of the shape of a product, the product itself becomes the sign and thus the trade mark. In the case of a trade mark registration, the assessment should not differ between different categories of signs. However, when it comes to registration for signs consisting of the shape of a product, there are further obstacles to overcome before protection can be granted compared to other types of signs. Many shapes tend to be functional to some extent, which brings relevance to the absolute ground for refusal found in art. 7.1 e) ii) EUTMR. The article prohibits registration of signs which consist exclusively of “the shape, or another characteristic, of goods which is necessary to obtain a technical result”. If the registration of a sign is prohibited by the article, the exclusion from registration is permanent. This means that the ground for refusal cannot be overcome even if the sign acquires distinctiveness on the market. The CJEU has stated that it would not be reasonable to deny a shape registration only on the sole ground that it has some functional elements. Therefore, in order for a sign to fall within the scope of the article, all the essential characteristics of a shape must fall within the scope of the provision. This causes certain difficulties when it comes to hybrid signs, which possess some elements that are functional, but also other elements that are non-functional. Under current law, hybrid signs can be registered as trade marks if the non-functional elements are considered as essential. The entire form of a hybrid sign can thus be registered as a trade mark only if some, but not all, essential characteristics are required to achieve the technical function. By examining case law, it can be stated that the CJEU carry out a free and extensive examination when assessing what constitutes the essential characteristics of a shape and the possible function of these elements. The CJEU is not bound to the trade mark application but also examines the actual goods for which the sign is intended to be used. The CJEU generally seems to be restrictive in allowing registration for three-dimensional shapes, especially in regard to those incorporating functional elements. This might be the case since there is no good way to clearly exclude the functional elements from the registration. However, when registering a hybrid sign, interesting aspects also arise from the infringement point of view since the shape is registered as a whole but contains certain essential features, which are not intended to be covered by the exclusive right granted. In analogous applications of case law, it appears that these elements, without being explicitly stated in e.g. a disclaimer, must be excluded from the exclusive right granted to the proprietor.

No presente estudo, 30 pacientes, do sexo masculino com idade mediana de 29 anos, portadores de hérnias inguinais / inguino-escrotais, unilaterais, indiretas e primárias, sem encarceramento ou estrangulamento, foram submetidos à hernioplastia inguinal, por meio de inguinotomia, sob raqui-anestesia em regime de internação hospitalar. A técnica de correção utilizada foi a de Bassini modificada, sendo que estas modificações repousam no tipo da incisão, abordagem da fáscia transversalis e no reforço da parede posterior do canal inguinal. Os objetivos foram os de avaliar os resultados do pós-operatório mediato quanto aos eventos: intensidade e duração da dor pós-operatória e o tempo de retorno às atividades normais, estabelecendo assim a duração maior ou menor do período de convalescença. Das hérnias operadas 33,33% e 66,67% foram classificadas no intra-operatório como tipos I e II de Nyhus, respectivamente. A duração da cirurgia variou entre 45 e 85 minutos, com média de 66,46 minutos e mediana de 66,5 minutos. A permanência hospitalar foi menor que 24 horas. O índice de mortalidade foi nulo e o seguimento foi feito no 10º e 30° dias de pós-operatório. A intensidade média da dor pós-operatória atingiu seu pico máximo no 1º dia, alcançando 2,93 na escala analógica decimal, sendo que a partir do 5° dia de pós-operatório se tornou insignificante. O retorno às atividades habituais e sociais se deu em um período médio de 5,34 dias. O tempo de retorno ao trabalho alcançou a média de 11,23 dias e mediana de 5 dias. Observou-se complicação leve em dois pacientes (6,67%), que apresentaram edema de bolsa escrotal de rápida resolução. Não se observou complicações infecciosas apesar do não uso de antimicrobianos. A análise dos dados obtidos permite concluir que o procedimento é exeqüível, com boa aceitação por parte dos pacientes, apresentando resultados comparáveis aos obtidos na literatura / In the present study, 30 patients, of the male sex, with an average age of 29, victims of inguinal hernias/ inguino-scrotum, unilateral, indirect and primaries, without confinement or strangulation, were submitted to inguinal hernioplasty, thru inguinotomy, under rachianesthesia on a regimen as hospital in--patients. The correction technique used was the modified- Bassini, since these modifications lie in the kind of incision, approaching of the fascia transversalis and in the reinforcement of the posterior wall of the inguinal duct. The purposes were of evaluating the mediate post-operative results as to the events: intensity and duration of the post-operative pain in the period of time of return to the normal activities, thus determining the longer or shorter duration of the recovery period. Among the operated hernias 33.33% and 66.67% they were classified in the intra-operative as types I and II of Nyhus, respectively. The duration of the surgery varied between 45 and 85 minutes, with an average of 66.46 minutes and median of 66.5 minutes. The in-patients stay in the hospital was less than 24 hours. The mortality rate was null and the follow up was made on the 10th and 30th days of the post operative. The average intensity of the post-operative pain reached its appex on the 1st day, reaching 2.93 in the decimal analogical scale, and as of the 5th day of the post-operative it became insignificant. The return both to the usual and social activities happened in an average period of time of 5.34 days. The period of time of returning to work reached an average of 11.23 days and a median of 5 days. A slight complication was observed in two patients (6.67%), who had edema in the scrotum pouch of fast solution. No infectious complications were detected in spite of not using any anti-microbians. The analysis of the data obtained allow to conclude that the procedure is feasible, with good approval on the part of the patients, presenting results comparable to the ones obtained in the literature

Le transporteur est tenu d’une obligation de résultat, dont l’inexécution engage automatiquement sa responsabilité, dès lors qu’il en découle un préjudice. Mais il peut se libérer de sa responsabilité en prouvant l’existence d’une cause d’exonération. Considérée comme un obstacle à l’indemnisation, l’exonération sera appréciée avec plus ou moins de méfiance, selon le mode employé et l’objet transporté. A cet égard, il convient de distinguer le transport de passagers et le transport de marchandises. La prise en compte croissante du besoin de protection du passager fait évoluer le régime auquel est soumis le transporteur. L’analyse de cette évolution est indispensable à la recherche d’un fondement commun à la responsabilité du transporteur. Considéré comme une victime, le passager devient le pivot du régime applicable au transporteur, lequel cesse d’être un régime de responsabilité. Au contraire, lorsque la responsabilité demeure, la défense exonératoire révèle le fondement rationnel de la responsabilité du transporteur : sa faute. / The carrier is under an obligation of result, the nonfulfilment of which he /she will be automatically held liable for, as soons as damage arises. Yet he can escape liablitiy if he can prove the existence of a ground for exemption. Considered as an impediment to compensation, the exemption will be assessed with more or less suspicion, depending on the transport mode and the cargo. In this respect, there should be a distinction made between the transport of passengers and goods. As the passenger’s need for protection is more and more taken into account, this causes the regime governing carriers to evolve. Analyzing these developments is essential to look for a common ground for the carrier’s liability. Considered as a victim, the passenger becomes the pivot of the regime applicable to the carrier, this regime being no longer a system of liablity. On the contrary, when liability remains, the defense based on exemption reveals the rationale behind the carrier’s liability: his fault.

本論文旨在探討近義詞的相關議題，特別是要檢視其背後的概念結構與表層的語法功能。透過「方便」與「便利」的研究，本文就這對近義詞在語意上的差異做深入並有系統地分析，並期以此解釋他們在語法層次上不同的表現。 　　以框架語意學(Frame Semantics)為理論架構，本研究發現近義詞「方便」與「便利」會引導出「方便框架」(CONVENIENCE frame)與「不方便框架」 (INCONVENIENCE frame)，而這兩個語意框架雖有相對應的框架成分(frame element)，實質上卻是引發出不同的概念型態。近一步說明這對近義詞在語意上的差別，「方便」與「便利」對於他們所涉入的複雜事件(complex event)持不同的觀點：「方便」主要是專注在結果次事件(result-subevent)並採受恩者(BENEFICIARY)的觀點；而「便利」則較專注在原因次事件(cause-subevent)並採動作者/施恩者(AGENT/BENEFACTOR)的觀點。此外，由於「方便」與「便利」具備了正面、值得嚮往的特質，這也解釋了何以「方便框架」比「不方便框架」有更高程度的目的性(intentionality)。 　　為檢視近義詞在概念上的差異是否會反映於在他們的語法表現上，本研究闡明了「方便」與「便利」的語法功能及其使用分布的情況、以及參與角色(participant role)的凸顯類型(profiling pattern)。結果顯示「方便」與「便利」主要有五種語法功能，即名詞化、修飾名詞、修飾動詞、不及物動詞謂語、及物動詞謂語，最常使用的語法功能為名詞化與動詞謂語(包含及物與不及物)。此五種語法功能皆會突顯某些參與角色，但主要都是突顯了「目的」(PURPOSE)與「手段」(MEANS)；而其他參與角色也會在不同語法功能的使用中被突顯，並且這些突顯類型皆可由「方便」與「便利」在概念上的差異來做解釋。 　　總結來說，本論文闡釋了近義詞「方便」與「便利」在概念上不同的偏好會導致他們在語法上有不同的表現；此外，「方便」與「便利」在參與角色的凸顯類型上亦不相同，這說明了，「方便」與「便利」是屬於不同的構式(construction)。最後，本論文也再次確認了詞彙背後的語意概念會決定其語法的表現。 / The purpose of this thesis is to approach the issue of near-synonyms via the examination of their respective underlying conceptual structures and surface syntactic functions. Specifically, the present study aims to furnish a fine-grained and systematic analysis of the semantic differences between the near-synonymous pair fangbian and bianli that shall better explain their differential syntactic behaviors. 　　Based on the theoretical framework of Frame Semantics, this study found that the conceptual structures of fangbian and bianli are associated with the frames of CONVENIENCE and INCONVENIENCE. While pertaining to a corresponding set of frame elements, the two frames actually prompt distinct conceptualizations. Precisely, fangbian and bianli differ in their perspectivization of the complex event involved: fangbian focuses on the result-subevent and takes the BENEFICIARY’s perspective whereas bianli on the cause-subevent and takes the AGENT/BENEFACTOR’s perspective. In addition, the fact that convenience is desirable and thus typically intended also explains the stronger intentionality involved in the CONVENIENCE frame than in the INCONVENIENCE frame. 　　To investigate whether conceptual differences between the near-synonyms would be manifested in their syntactic behaviors, this thesis further elucidated the syntactic functions and their distribution of fangbian and bianli as well as the profiling of the participant roles in each syntactic function. In particular, five main syntactic functions of fangbian and bianli were identified: nominalization, nominal modifier, verbal modifier, intransitive verbal predicate and transitive verbal predicate; each serves to profile distinct participant roles, mostly PURPOSE or MEANS. Moreover, the profiling of other participant roles can be accounted for by the perspectival distinction between the near-synonymous pair. Finally, the distribution of syntactic functions of fangbian and bianli demonstrated that the usage of the near-synonyms as verbal predicate and nominalization is the most dominant categories. 　　To conclude, this thesis has shown that the conceptual preferences of fangbian and bianli in terms of their perspectivization lead to their different syntactic behaviors. Moreover, the near-synonymous pair also differs in their profiling of the participant roles; in other words, they display distinct profiling patterns and therefore pertain to different constructions. Finally, it still holds for the present study that the semantics of a word drives its syntactic behaviors.

『智慧財產』是二十一世紀世界產業競爭的決勝關鍵。智慧財產的佈局、產出及保護固然非常重要，但是最終還是需要積極的運用，發揮智慧財產這種無形資產獨有之國際性、重複利用性及同時異地併行使用實施之特性，彰顯其最大化之價值。世界各國政府在積極建置各種政策手段提升智慧財產運用之同時，也考慮到自身國家安全及國內產業競爭力消長之影響，大多規範了一系列智慧財產輸出到國境之外的運用管制。智慧財產之積極運用與境外實施管制，是兩種截然不同，有時甚至是互相衝突之面向，需要有清晰的觀念，才能建置雙贏策略，讓國內產業在決勝關鍵所向無敵。 我國科技基本法自民國88年公佈實施以來已有十年。智慧財產的產出、保護及運用在這十年間突飛猛進。雖然如此，但是仍有許多配套措施及觀念尚未成熟的建立起來。對於彰顯及發揮智慧財產價值所面對之『境外實施管制機制』更是有相對檢視之急迫性。在『國際技術移轉制度理論與實務』（王偉霖、劉江彬 著，2010年9月初版）劉江彬教授序中，劉教授特別指出這一點，認為應該突破其限制。我國在智慧財產方面之創新管理成就，中國也在快速學習，急起直追，從中國十二五計畫之政策可以看出他們更在發揚創新商業化之投資，學習我們企業的經營哲學。台灣有相當多的創新能量，蘊含智慧財產運用之潛力，政府可以從更宏觀的角度思考，發揮台灣的『軟實力』，實現台灣的願景。 本研究針對經濟事務財團法人研究機構，於政府資助產出之專利權在中華民國管轄區域外使用實施所需要事前陳報政府主管機關核准之規定嘗試提出更有效率之管理機制。 本研究比較美國、日本、大陸及台灣之政府資助產出之成果下放、技術出口管制、技術與投資境外實施管制相關法規之規範與作法，並訪問各國極具智慧財產管理運用代表性之組織--Association of University Technology Manager (AUTM) 及Licensing Executive Society (LES) 總會之會長、美國Stanford University技轉辦公室主任、美國前University of Washington負責技術移轉之副校長、日本東京大學技轉辦公室主任、前新加坡大學之技轉辦公室主任、徐小波大律師、台灣積體電路股份有限公司負責技術移轉之法務處宿文堂處長、政治大學商學院智慧財產研究所王偉霖教授及我國技術服務業之宇東公司副執行長等在智慧財產授權領域之產官學研專家學者，彙整歸納他們之看法及筆者之意見。再綜整工業技術研究院過去十年來向經濟部提出境外實施申請之案件，以三案不同技術、授權模式及授權區域之案件為案例探討。對照經濟部投資業務處對於我國境外投資之管理規範及審核要項，對於經濟部技術處目前審核境外實施作業，分析實務操作面之問題所在，進而提出『分類分級管理』之構想。視專利權之技術內容及授權模式，將審查作業分為高度管理、低度管理及事後報備。希望未來境外實施之管制也能夠兼顧行政成本降低、多元化彈性模式及商機時效。 本研究分別對政府及申請人提出建議，並由微觀到鉅觀，對我國智慧財產落實運用之全面性結構問題提出後續可繼續研究之議題供參。 對於政府處理其出資產出之成果的境外實施管制，建議涉及國家安全之技術輸出可比照國際作法採取『高度管理』。對於不涉及國家安全之智慧財產境外實施可採『低度管理』。同時建立具體明確可預期之審理標準、流程及正面或負面表列之技術清單。專利之非專屬授權及已經經過政府相關單位審核者，建議可採『事後報備』簡化流程。進一步考量規劃逐步建立企業及研發機構境外實施『自主管理』機制。至於境外實施之對價應回歸『商業談判』之市場機制，政府不需過多干涉。最後建議加強政府承辦人員對於智慧財產管理運用理論及實務認識之訓練。 在目前政府『境外實施』機制尚未調整之前，本研究綜整過去工業技術研究院申請境外實施之經驗，對於申請人提出建議作法，希望有助於審查流程之加速。事前與政府機關承辦人多溝通有絕對必要，充分瞭解其關切之事項，並備妥相關之文件。要求境外實施之廠商直接向政府承辦機關關切不必然有助於加速審核流程，有時反而弄巧反拙，造成承辦人之困擾，相對的攪亂了審核的節奏。 『境外實施』僅為提升智慧財產運用的一個點，必須要達到數個點的突破，形成面的結構調整，後續仍然有相當多的議題需要繼續研究，提出解決方案。例如修改科技基本法以明確擴大適用之層面至政府相關研究機關及學校—如中央研究院、公立大學等。這些機關是政府單位智慧財產之重要生產者，與下放之執行機構一樣，需突破國有財產法及政府採購法以發揮智慧財產之價值，但是同時適用之政府機關應配套建立智慧財產管理及評鑑機制。本研究以經濟事務研究機構之境外實施為限，其他仍然有教育體系之學校及經濟事務以外之研究機構之境外實施制度值得一窺。 本研究參酌世界各國之作法，搭配本研究生多年在工研院之經驗，檢視目前我國之實務運作，以學術討論之立場，結合實務與理論，嘗試提出一些看法，希望能夠提供給政府宏觀的思考，構建更契合打造台灣為亞洲樞紐之願景的機制。但本研究之所有論述純屬本研究生之個人觀點，不代表工研院或其他任何機構與單位之立場。 / “Intellectual Property” is the key factor to winning the industrial competition among competitive countries in the twenty-first century. Although domestic products and well-protected intellectual property are both extremely important, intellectual property should ultimately be used actively in order to maximize its core value. While governments around the world enthusiastically harness a variety of policy instruments to actively promote the use of intellectual property, they also take into account the security and competitiveness of their nations’ own domestic industries, as well as the impact of growth and decline on their economy. With these concerns, most of the intellectual property outputs are regulated by a series of overseas licensing restrains. The active usage of intellectual property and the control over overseas licensing are issues that are usually mutually independent. However, they sometimes conflict with each other. Only a clear and thorough understanding of both topics can allow one to establish a well-rounded strategy that creates a win-win situation in reference to the relationship between overseas licensing and domestic products. The Fundamental Science and Technology Act of the Republic of China has been in effect for a decade since its original ratification. Even so, there are still a lot of support measures and concepts established by the Act that have yet to be fully developed. For example, the “Overseas Licensing” control mechanism within the Act is an important measure that has received minimal development, and is in urgent need of having its political limitations removed for it to become more effective. This study compares United States, Japan, China and Taiwan’s export controls and overseas licensing laws. By visiting leaders of those intellectual property management representative organizations - -Association of University Technology Manager (AUTM) and Licensing Executive Society (LES), Director of the United States Stanford University Technology Transfer Office, former Vice President responsible for technology transfer of University of Washington, Director of Technology Transfer Office of University of Tokyo, Ex-Director of the Office of Technology Transfer of University of Singapore, Professor Paul S. P. Hsu, Chairman & CEO of PHYCOS International Co., Ltd, Director of Legal Transactions of Taiwan Semiconductor Manufacturing Co., Ltd., National Chengchi University Institute of Intellectual Property Business School Professor Wang Weilin and Vice President of Tanspercific IP Ltd. , the study summarized views and opinions of these professionals . The author analyzed overseas licensing cases that Industrial Technology Research Institute (ITRI) applied over the last decade in their technology, business model, and licensing area. Using the analysis of the practical problems in the overseas licensing control regulations and rules under the Ministry of Economic Affairs, the author proposed a concept of “classification management” ideas. According to this concept, the technical content of patent rights and licensing models and their management will be reviewed in three different levels, including high degree management, low degree management and post-filing. In the future, the costs of administration, the diversity of business models, and the flexibility in time should be considered in all cases of overseas licensing. The overseas licensing control that is related to national security should take a “high degree of management”. The rest of which do not involve national security can be reviewed under a “low degree of management”. Non-exclusive patent license and the case which has already been reviewed by any government agencies under the overseas licensing control should be reviewed under “post-filing management” to simplify the process. Furthermore, government should consider the gradual establishment of self-management mechanism as an “Internal Control Program” in the industry and research institute. Without excessive government interference, the terms and considerations of an overseas licensing should return to” commercial market negotiations mechanism”. Government administrators who are involved in the intellectual property management affairs need to strengthen their knowledge, vision and experiences in the field of intellectual property by training courses. This study further points out several topics related to the need of follow-up studies which include extending the entity who can apply under the Fundamental Science and Technology Act to governmental natural research institutes and schools - such as Academia Sinica, public universities and so on in order to break through the National Property Act and the Government Procurement Law for getting more freedom and flexibility in Intellectual property management. Since this study focuses on Economic Affairs related overseas licensing control system, fields that are outside of this area such as educational system and other Minister which might have the same issue is worth a glimpse. This study is based on the experiences that author had when working in ITRI and the general practice in overseas licensing field, trying to raise view point from broader angle for government’s consideration. Every view point raised under this study is the observation of the author himself purely which does not represent or reflect ITRI’s thoughts whatsoever.