Global ETD Search

411	Silser See, Engadin : Gabriele Münter, Friedrich Nietzsche et le genius loci Séguin, Virginie 12 1900 (has links) Silser See, Engadin (1927) est un paysage qui fait partie des œuvres les moins connues de Gabriele Münter. La marginalisation de ce tableau dans le corpus de l’artiste s’explique d’une part par le fait que celui-ci est toujours resté à l’intérieur du cercle restreint des collections privées, et d’autre part, du fait qu’il s’inscrit dans une phase peu productive de Münter. Cette phase correspond aux années 1920-1930, soit une décennie durant laquelle la production de Münter se trouve grandement affectée par les nombreux bouleversements que la Première Guerre mondiale entraîne dans sa vie personnelle et artistique. Le but de ce mémoire est de réfléchir la signification Silser See, Engadin pour Münter et de démontrer comment ce tableau s’intègre dans le dénouement de la crise qu’elle connait en 1920-1930. Pour ce faire, j’explore d’abord les différents événements qui ont défini le développement artistique et personnel de Münter. J’approfondis ensuite l’importance du paysage dans son œuvre en étudiant son rapport à la nature et à Murnau. Puis, je m’intéresse au genius loci de Sils-Maria et à l’influence de Friedrich Nietzsche sur Münter. En tenant compte de l’ensemble de ces éléments, j’analyse finalement les différents symboles contenus dans Silser See, Engadin et démontre comment Münter s’est appropriée les composantes du paysage de Sils-Maria pour exprimer sa renaissance après une longue période de crise. Ce mémoire s’inscrit dans un désir de contribuer à la réflexion sur l’importance de la nature et des lieux dans l’épanouissement de l’être humain. / Silser See, Engadin (1927) is a landscape painting that is among the least known works of Gabriele Münter. The marginalization of this painting in her corpus can be explained on one hand by the fact that it has always remained within the restricted circle of private collections, and on the other, by the fact that Silser See, Engadin is part of a less productive phase of Münter’s work, which has so far received little interest from art historians. This phase corresponds to the years 1920-1930, a decade during which Münter’s production was greatly affected by the many upheavals that the First World War brought about in her artistic and personal life. This thesis argues for the importance of Silser See, Engadin for Münter, and demonstrates how this painting fits into the resolution of the crisis she went through during that decade. To do so, I first explore the various events that defined her artistic and personal development. I then establish the importance of landscape in Münter’s work by examining her relationship to nature and Murnau. Next, I study the genius loci of Sils-Maria and the influence of Friedrich Nietzsche on Münter. Taking all these elements into account, I finally analyze the different symbols contained in Silser See, Engadin and demonstrate how Münter transformed the components of the Sils-Maria landscape to express her rebirth after a long period of crisis. This thesis invites the reader to consider the importance of nature and places in relation to the development of the human being. Silser See Engadin Gabriele Münter Expressionnisme Peinture en plein air Paysage Genius loci Murnau Sils-Maria Friedrich Nietzsche Ainsi parlait Zarathoustra Expressionism Plein air painting Landscape Thus Spoke Zarathustra Fine arts / Beaux-arts (UMI : 0357)
412	A See-ability Metric to Improve Mini Unmanned Aerial Vehicle Operator Awareness Using Video Georegistered to Terrain Models Engh, Cameron Howard 20 November 2008 (has links) (PDF) Search and rescue operations conducted in wilderness environments can be greatly aided by the use of video filmed from mini-UAVs. While lightweight, inexpensive and easily transportable, these small aircraft suffer from wind buffeting and may produce video that is difficult to search. To aid in the video search process, we have created a system to project video frames into a 3D representation of the search region. This projection allows us to tie each frame of video to a real-world location, enabling a myriad of novel views, mosaics and metrics that can be used to guide the search including a new metric dubbed “see-ability.” The “see-ability” metric is the primary contribution of this research as it indicates what portion of the search area has been viewed and provides an estimate of the quality of that viewing. The research includes a validation of the “see-ability” metric as it correlates to objective performance in the search task by real people. BYU Brigham Young University computer vision seeability see-ability MiniUAV MUAV georegister georegistration terrain unmanned air vehicle aerial terrain model SAR search rescue search and rescue projective texture video telemetry video indexing visibility Computer Sciences
413	Improving the Single Event Effect Response of Triple Modular Redundancy on SRAM FPGAs Through Placement and Routing Cannon, Matthew Joel 01 August 2019 (has links) Triple modular redundancy (TMR) with repair is commonly used to improve the reliability of systems. TMR is often employed for circuits implemented on field programmable gate arrays (FPGAs) to mitigate the radiation effects of single event upsets (SEUs). This has proven to be an effective technique by improving a circuit's sensitive cross-section by up to 100x. However, testing has shown that the improvement offered by TMR is limited by upsets in single configuration bits that cause TMR to fail.This work proposes a variety of mitigation techniques that improve the effectiveness of TMR on FPGAs. These mitigation techniques can alter the circuit's netlist and how the circuit is placed and routed on the FPGA. TMR with repair showed a neutron cross-section improvement of 100x while the best mitigation technique proposed in this work showed an improvement of 700x.This work demonstrates both some causes behind single bit SEU failures for TMR circuits on FPGAs and mitigation techniques to address these failures. In addition to these findings, this work also shows that the majority of radiation failures in these circuits are caused by multiple cell upsets, laying the path for future work to further enhance the effectiveness of TMR on FPGAs. FPGA reliability SEE SEU radiation effects TMR MTTF fault injection radiation testing Markov chain single bit failure single point failure common mode failure common cause failure CAD incremental placement incremental routing Electrical and Computer Engineering Engineering
414	Fish assemblages in European lakes Emmrich, Matthias 28 February 2013 (has links) Fischgemeinschaften in Seen sind zunehmenden Umweltveränderungen unterworfen. Die Analyse des Einflusses abiotischer und biotischer Faktoren auf die Größenstruktur von Fischgemeinschaften ist entscheidend, um die Entwicklung von Seeökosystemen im Zuge von Umweltveränderungen vorhersagen zu können. Es ist jedoch schwierig Fische in Seen zu beproben, da Fanggeräte selektiv sind. Die Qualität und Vergleichbarkeit von Fischfängen durch Angler, Kiemennetze, Schleppnetze und Hydroakustik wurden untersucht. Anglerfänge eignen sich begrenzt für vergleichende Fischbestandsuntersuchungen. Vertikale Hydroakustik eignet sich für die Fischbiomassequantifizierung in geschichteten Seen. Der Beprobungsaufwand von Kiemennetzen kann reduziert werden, wenn zeitnah hydroakustische Untersuchungen statt finden. Schleppnetze eignen sich für die Beprobung von pelagischen Fischen in tiefen Seen. Die Größenstruktur von Fischgemeinschaften unterschied sich auf regionaler und überregionaler Ebene entlang abiotischer und biotischer Gradienten. Die regionale Studie zeigte, dass tiefe nährstoffarme Seen mit hohen Raubfischabundanzen durch mehr große Fische gekennzeichnet waren. Nährstoffreiche Flachseen mit wenigen Raubfischen zeigten höhere Anteile von mittleren Fischgrößen. Im überregionalen Vergleich führten Temperaturpräferenzen der Fischarten zu zwei Fischgemeinschaften, die sich in ihrer Größenzusammensetzung unterschieden. Ein hoher Anteil großer Salmoniden war typisch für hochgelegene Kaltwasserseen im Norden und Süden Europas. Flachlandseen mit Kühl- und Warmwasserfischen zeichneten sich durch eine Dominanz von kleinen Fischen aus. Das lässt vermuten, dass Fischgemeinschaften in Flachlandseen relativ robust gegenüber Umweltveränderungen reagieren. Kaltwasserfischgemeinschaften könnten im Zuge der Klimaerwärmung starken Änderungen unterliegen, da eine Veränderung in der Artenzusammensetzung von einer Verschiebung in der Größenstruktur hin zu mehr kleinen Fischen begleitet sein wird. / Lake fish assemblages are increasingly exposed to environmental change in their habitats. The investigation of abiotic and biotic factors and their effects on the size structure of lake fish is essential for predicting the response of fish assemblages to environmental change. However, sampling of lake fish is challenging because sampling gears are selective. The quality and correspondence of fish catches from angling, gillnetting, trawling and hydroacoustics were analysed. Non-standardised catch data from recreational angling were of limited quality for a comparison of fish stocks. Vertical hydroacoustics is an efficient method to quantify fish biomass in stratified lakes. Sampling effort of multi-mesh gillnets can be reduced when fish abundance estimates are derived from contemporarily operating hydroacoustics. Trawling is useful to sample pelagic fish assemblages in deep lakes. The size structures of fish assemblages differed on a small and a large geographical scale along gradients of abiotic and biotic lake descriptors and differences in fish assemblage composition. At a small geographical scale assemblages in deep and less nutrient-rich lakes with high predator abundances were characterised by a higher proportion of large fish. Shallow nutrient-rich lakes with few predators were characterised by more medium-sized fish. At a large geographical scale thermal optima of fish generated two types of assemblages with different size structures. A high proportion of large salmonids was observed in coldwater lakes at high elevation sites in northern and southern Europe. Lowland lakes with cool- and warmwater fish were dominated by small-sized individuals. The results suggest that lowland lake fish assemblages are relatively robust against environmental change. Coldwater fish assemblages instead may suffer dramatic consequences from global warming as expected species shifts are likely to be accompanied by shifts in the size structure towards smaller individuals. Fisch See Hydroakustik Kiemennetz Schleppnetz Freizeitangelei Körpergröße Größenstruktur lake fish hydroacoustics gillnet trawl net recreational angling body size size structure 39 Landwirtschaft, Garten WI 4740 ZD 40000 ddc:630
415	"Åtgärder som befrämja rikets försvar och överensstämma med flaggans värdighet" : En undersökning av Sveriges marinstrategi våren 1941 Strömgren Lasell, Victor January 2021 (has links) Denna uppsats undersöker Sveriges marinstrategi i händelse av krig med Tyskland respektive Sovjeteunionen våren 1941 utifrån Chefen för Marinens instruktioner för krigsfall I respektive II. / This paper explores Swedish naval strategy during the Second World War (1939-1945), an area that has not seen significant research. This paper focuses on how Swedish maritime forces were to be used in case of war with Germany (War Plan I; Krigsfall I), and with the Soviet Union (War plan II; Krigsfall II). This paper focuses on Swedish planning during the spring of 1941. The period after the fall of France (June 1940) and before the German invasion of the Soviet Union (June 1941) was a period where both Germany and the Soviet Union possessed what could be described as strategic freedom of action. This means large parts of their armed forces could have been used for operations against Sweden. The basis for each potential conflict was different: Germany occupied Norway and Denmark and could launch a ground invasion of Sweden directly; meanwhile Sweden and the Soviet Union were still separated by Finland and the Baltic Sea. Maritime forces would therefore play very different roles in the two War Plans. No official plans in case of war with the western Allies existed at the time, and hence this has not been explored here. The conclusion of this paper is that Swedish naval strategy at the time was somewhat offensive and focused on gaining sea control, at least in the Baltic Sea and Gulf of Bothnia, to maintain freedom of action to be able to conduct troop movements along the Swedish coast, to the island of Gotland, and to Finland. Sweden 1941 World War two Second world war WW2 naval strategy strategy see power naval power war planning defence planning Nazi Germany Soviet Union Finland Ruotsi 1941 Toinen maailmansota Strategia Laivasto laivaston strategia puolustuksen suunnittelu Natsi-Saksa Neuvostoliitto Suomi Schweden 1941 zweites Weltkrieg Marine Strategie Marine-Strategie See-Strategie Flotten-Strategie Verteidigungsplanung Kriegsplanung NS-Deutschland Deutschland Sowjetunion Finnland Sverige andra världskriget 1941 flottan marinstrategi strategi krigsplanering flottstrategi sjömakt försvarsplanering Nazityskland Sovjetunionen Finland History Historia Other Humanities not elsewhere specified Övrig annan humaniora
416	Admiralty jurisdiction and party autonomy in the marine insurance practice in South Africa / Regina Mshinwa Mduma Mduma, Regina Mshinwa January 2013 (has links) An increase in international trade has resulted in an increase in the carriage of goods by sea, which has also promoted the business of marine insurance on a very huge scale. Marine insurance contracts fall within both the admiralty jurisdiction where admiralty laws apply and special contract law where the rules and principles of contract law apply. In certain circumstance this has left the courts with a dilemma in deciding in particular cases which law should apply; whether maritime law, contract law or marine insurance law. There are certain principles under the law of contract that are said to be profound and cannot be ousted easily by substantive law. The principle of party autonomy is one of these principles and it has gained international recognition through a number of cases. However, to date, courts are faced with difficulties in deciding whether to uphold the choice of law on jurisdiction and governing law exercised by parties or resort to substantive law, either by virtue of admiralty law or any other statutes in a country, which provisions may be contrary to the clause on choice of law under the contract. In South Africa practice has shown that courts are always reluctant to apply the clause on choice of law if they believe such application is against the public policy and interest in South Africa. This begs the question as to the precise meaning and effect of “public policy and interest” and how this principle influences the long-standing and well-established principle of party autonomy in admiralty jurisdiction. This dissertation is aimed at providing a legal response to this problem by analysing case law and the different viewpoints of various writers. It is imperative to investigate if their decisions and views answer all the uncertainties with regard to the meaning and the effect of the concept of “public policy and interest” on the principle of party autonomy. / LLM (Import and Export Law), North-West University, Potchefstroom Campus, 2014 Admiralty Court Admiralty jurisdiction Choice of law Carriage of Goods by Sea Act (COGSA) Exclusive jurisdiction Party autonomy Public policy and interest Admiraliteitshof Admiraliteitsjurisdiksie Keuse van reg Wet op die Vervoer van Goedere ter See Ekslusiewe jurisdiksie Party-outonomie Openbare beleid en belang
417	Admiralty jurisdiction and party autonomy in the marine insurance practice in South Africa / Regina Mshinwa Mduma Mduma, Regina Mshinwa January 2013 (has links) An increase in international trade has resulted in an increase in the carriage of goods by sea, which has also promoted the business of marine insurance on a very huge scale. Marine insurance contracts fall within both the admiralty jurisdiction where admiralty laws apply and special contract law where the rules and principles of contract law apply. In certain circumstance this has left the courts with a dilemma in deciding in particular cases which law should apply; whether maritime law, contract law or marine insurance law. There are certain principles under the law of contract that are said to be profound and cannot be ousted easily by substantive law. The principle of party autonomy is one of these principles and it has gained international recognition through a number of cases. However, to date, courts are faced with difficulties in deciding whether to uphold the choice of law on jurisdiction and governing law exercised by parties or resort to substantive law, either by virtue of admiralty law or any other statutes in a country, which provisions may be contrary to the clause on choice of law under the contract. In South Africa practice has shown that courts are always reluctant to apply the clause on choice of law if they believe such application is against the public policy and interest in South Africa. This begs the question as to the precise meaning and effect of “public policy and interest” and how this principle influences the long-standing and well-established principle of party autonomy in admiralty jurisdiction. This dissertation is aimed at providing a legal response to this problem by analysing case law and the different viewpoints of various writers. It is imperative to investigate if their decisions and views answer all the uncertainties with regard to the meaning and the effect of the concept of “public policy and interest” on the principle of party autonomy. / LLM (Import and Export Law), North-West University, Potchefstroom Campus, 2014 Admiralty Court Admiralty jurisdiction Choice of law Carriage of Goods by Sea Act (COGSA) Exclusive jurisdiction Party autonomy Public policy and interest Admiraliteitshof Admiraliteitsjurisdiksie Keuse van reg Wet op die Vervoer van Goedere ter See Ekslusiewe jurisdiksie Party-outonomie Openbare beleid en belang
418	The identification & optimisation of endogenous signalling pathway modulators Gianella-Borradori, Matteo Luca January 2013 (has links) <strong>Chapter 1</strong> Provides an overview of drug discovery with particular emphasis on library selection and hit identification methods using virtual based approaches. <strong>Chapter 2</strong> Gives an outline of the bone morphogenetic protein (BMP) signalling pathway and literature BMP pathway modulators. The association between the regulation of BMP pathway and cardiomyogenesis is also described. <strong>Chapter 3</strong> Describes the use of ligand based virtual screening to discover small molecule activators of the BMP signalling pathway. A robust cell based BMP responsive gene activity reporter assay was developed to test the libraries of small molecules selected. Hit molecules from the screen were synthesised to validate activity. It was found that a group of known histone deacetylase (HDAC) inhibitors displayed most promising activity. These were evaluated in a secondary assay measuring the expression of two BMP pathway regulated genes, hepcidin and Id1, using reverse transcription polymerase chain reaction (RT-PCR). 188 was discovered to increase expression of both BMP-responsive genes. <strong>Chapter 4</strong> Provides an overview of existing cannabinoid receptor (CBR) modulating molecules and their connection to progression of atherosclerosis. <strong>Chapter 5</strong> Outlines the identification and optimisation of selective small molecule agonists acting at the cannabinoid 2 receptor (CB<sub>2</sub>R). Ligand based virtual screen was undertaken and promising hits were synthesised to allow structure activity relationship (SAR) to be developed around the hit molecule providing further information of the functional groups tolerated at the active site. Subsequent studies led to the investigation and optimisation of physicochemical properties around 236 leading to the development of a suitable compound for in vivo testing. Finally, a CB<sub>2</sub>R selective compound with favourable physicochemical properties was evaluated in vivo in a murine inflammation model and displayed reduced recruitment of monocytes to the site of inflammation. 572
419	Regulating stem cell fate within microenvironmental niches Buglass, Surahanil Katrin January 2014 (has links) Improving the repopulation potential of human umbilical cord blood (UCB) haemopoietic stem cells (HSCs) remains a paramount goal in HSC transplantation (HSCT) therapy. This implies enhancing the homing and engraftment potential of UCB-CD34+CD133+ cells to the bone marrow (BM). Although an array of molecules continues to be identified as ‘key’ homing molecules, the molecular mechanisms controlling HSC homing are still not fully understood. The regulatory implications of hypoxia in the BM, with the concomitant stabilisation of hypoxia inducible transcription factor-1α (HIF-1α), are becoming more apparent, yet at the commencement of this thesis no study had explored whether hypoxia induced signalling can be adopted to regulate the homing and engraftment of transplanted HSCs. The aim of this DPhil project was thus to investigate whether hypoxic conditions as detected in the BM influence the adhesion of UBC-CD133+ cells to osteoblasts, BM stromal cells and BM endothelial cells-60 (BMEC-60), as well as their transmigration towards chemokine SDF-1α across BMEC-60. Increasing the exposure of UCB-CD133+ cells to 1.5% O2 doubled the percentage of transmigrating cells (p<0.05), and while hypoxia stimulated UCB-CD133+ cells preferentially adhered to IL-1β stimulated BMEC-60, their adhesion to non-stimulated (BMEC-60) was significantly improved (p<0.001). To help unravel the underlying molecular mechanisms, we attempted to examine the potential involvement of hypoxia regulated scaffolding protein HEF-1/NEDD9/Cas-L (HEF-1) in the increased percentage of migrating UCB-CD133+ cells after hypoxia pre-conditioning. The role of HEF-1 in HSCs is unexplored, and its multifunctional contribution in a variety of processes including cell migration, attachment and invasion make HEF-1 a prime candidate as a contributing homing molecule. After identifying a suitable short-hairpin RNA (shRNA) sequence to knockdown HEF-1, generating lentiviral (LV)-particles in house and optimising transduction protocols, HEF-1 knockdown was achieved in haemopoietic model cell lines KG-1 and KG-1A (KG-1/KG-1A–HEF1). Significantly decreased KG-1A–HEF1 cell adhesion to non-stimulated BMEC-60 was detected. Together, these studies provide a promising platform to further explore the role of HEF-1 in hypoxia induced UCB-CD133+ cell transmigration towards the key homing molecule SDF-1α. 616.02
420	Specialised transcription factories Xu, Meng January 2008 (has links) The intimate relationship between the higher-order chromatin organisation and the regulation of gene expression is increasingly attracting attention in the scientific community. Thanks to high-resolution microscopy, genome-wide molecular biology tools (3C, ChIP-on-chip), and bioinformatics, detailed structures of chromatin loops, territories, and nuclear domains are gradually emerging. However, to fully reveal a comprehensive map of nuclear organisation, some fundamental questions remain to be answered in order to fit all the pieces of the jigsaw together. The underlying mechanisms, precisely organising the interaction of the different parts of chromatin need to be understood. Previous work in our lab hypothesised and verified the “transcription factory” model for the organisation of mammalian genomes. It is widely assumed that active polymerases track along their templates as they make RNA. However, after allowing engaged polymerases to extend their transcripts in tagged precursors (e.g., Br-U or Br-UTP), and immunolabelling the now-tagged nascent RNA, active transcription units are found to be clustered in nuclei, in small and numerous sites we call “transcription factories”. Previous work suggested the transcription machinery acts both as an enzyme as well as a molecular tie that maintains chromatin loops, and the different classes of polymerases are concentrated in their own dedicated factories. This thesis aims to further characterise transcription factories. Different genes are transcribed by different classes of RNA polymerase (i.e., I, II, or III), and the resulting transcripts are processed differently (e.g., some are capped, others spliced). Do factories specialise in transcribing particular subsets of genes? This thesis developed a method using replicating minichromosomes as probes to examine whether transcription occurs in factories, and whether factories specialise in transcribing particular sets of genes. Plasmids encoding the SV40 origin of replication are transfected into COS-7 cells, where they are assembled into minichromosomes. Using RNA fluorescence in situ hybridisation (FISH), sites where minichromosomes are transcribed are visualised as discrete foci, which specialise in transcribing different groups of genes. Polymerases I, II, and III units have their own dedicated factories, and different polymerase II promoters and the presence of an intron determine the nuclear location of transcription. Using chromosome conformation capture (3C), minichromosomes with similar promoters are found in close proximity. They are also found close to similar endogenous promoters and so are likely to share factories with them. In the second part of this thesis, I used RNA FISH to confirm results obtained by tiling microarrays. Addition of tumour necrosis factor alpha (TNF alpha) to human umbilical vein endothelial cells induces an inflammatory response and the transcription of a selected sub-set of genes. My collaborators used tiling arrays to demonstrate a wave of transcription that swept along selected long genes on stimulation. RNA FISH confirmed these results, and that long introns are co-transcriptionally spliced. Results are consistent with one polymerase being engaged on an allele at any time, and with a major checkpoint that regulates polymerase escape from the first few thousand nucleotides into the long gene. 572.8

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