Este trabalho investiga a viabilidade de se implantar no Brasil o veículo combinado de cinco eixos constituído de um cavalo mecânico mais dois semi-reboques acoplados por um dolly intermediário e chamado aqui de Duplo Semi-Reboque (DSR). Essa investigação inclui tanto aspectos econômicos (custos operacionais) quanto operacionais (densidade das cargas, rotas, demandas, veículos utilizados), tecnológicos (veículos e implementes), legais (pesos e dimensões), de segurança (estabilidade, dirigibilidade, risco de acidentes e impacto sobre o tráfego de outros veículos) e de inter-relação com a infra-estrutura rodoviária. Como a configuração analisada é largamente utilizada nos Estados Unidos, com o nome de twin trailer truck, faz-se uma ampla revisão da literatura norte-americana. O estudo apresenta as características técnicas do twin, levanta a legislação norte-americana de carga por eixo e mostra como a busca de produtividade e o aumento da carga volumosa conduziram à necessidade de veículos mais longos. Compila artigos sobre a estabilidade, a dirigibilidade e o impacto sobre o tráfego dos veículos longos combinados. Sintetiza pesquisas comparando taxas de acidentes dos veículos combinados com os caminhões convencionais. A maioria desses estudos conduz à conclusão de que, embora os twins possam degradar ligeiramente as condições de segurança de tráfego e aumentar o desgaste elos pavimentos, essa degradação é compensada pela redução do número de viagens e do custo do transporte. Conclui-se que o veículo seria economicamente viável no Brasil para substituir caminhões trucados em rotas de demanda limitada, e que poderia também economizar custos na substituição a veículos convencionais no transporte de cargas volumosas, sem provocar maiores impactos sobre a segurança operacional. Pesquisa com frotistas mostra que quase 50% das transportadoras de carga fracionada operam cargas de densidade compatível com o DSR. A introdução do veículo, no entanto, enfrenta fortes obstáculos legais e exigiria mudança profunda na legislação dos veículos combinados longos. / This paper investigates the feasibility of introducing the American twin trailer truck in the Brazilian road transport network. The twin is a five axle configuration with one tractor and two semi-trailers, coupled by an intermediate dolly. The investigation embraces not only economic questions (operational costs), but also operational aspects (freight density and volume, vehicle choice, line extension etc), technological questions (vehicles, trailers and dollies), weights and dimensions legislation, safety impacts (handling and stability, impact of traffic operations and statistic studies of accident rates) and the twin\'s interface with the highway facilities. The American and Canadian studies about twins are reviewed. The paper presents the technical characteristics of twins, the american weights and dimensions legislation and shows how the claim for more productivity in the transport industry and the low density freight growth have induced the use of longer combinations. The study compiles the main results presented in the literature about handling, stability and the twin trailer impact on the highway traffic and analyzes statistics comparing doubles with semi-trailer accident rates. The literature review leads to the conclusion that, althrough the twins could degrade slightly the vehicle traffic safety performance and accelerate the pavement wear, this degradation is overwhelmed by the reduction of the number of vehicles on the roads and direct and indirect transportation costs. The introduction of the win trailer truck in Brazil could be advantageous in order to replace tandem trucks on low demand routes. The savings in terminal times and the higher capacitiy of this configuration would cut costs as compared to the straight truck, semi-trailer and truck-and-trailer configurations, without relevant deterioration of the operational safety. The results of a large sample with brazilian LTL companies show that almost 50% of them operate with a freight density that would be ideal for twins. The twin\'s introduction, however, faces strong legal impediments in some markets, and only would be feasible if deep changes in the Brazilian weight and dimension regulations would be undertaken.

La recherche a pour objet la structuration du champ lexical des mots « chance », « fortune », « hasard » et « risque » du XVIIIe au XXIe siècle. Témoin de mutations qu’a connues la civilisation occidentale durant cette période, ce champ, qui se rattache à la notion de fortune / hasard, présente une relative homogénéité sémantique.Les mots (et leurs dérivés) sont étudiés à travers le déploiement, la régulation et la répartition des normes d’usages, non seulement en français hexagonal, mais aussi en français québécois. L’étude se fonde sur l’exploitation de deux types de corpus. D’une part, un corpus d’articles extraits d’une cinquantaine de dictionnaires sert à mettre en évidence la productivité morphosémantique et sémantique de ces unités dans une perspective historique large. D’autre part, un grand ensemble d’énoncés diversifiés permet, par la mise au jour de types de contextes, d’effectuer un suivi diachronique des usages. L’approche continuiste des différences d’usages s’appuie sur une représentation fréquentielle des changements sémantiques.La thèse apporte une contribution à la question de la variation des usages et du changement sémantique, qui ouvre sur plusieurs perspectives. Elle se veut d’abord une réflexion sur la théorie et la méthodologie descriptives, appréhendées à la lumière de l’analyse de la nature et du rôle des corpus. Elle met ensuite en évidence l’importance de la dimension intersubjective dans l’activité de signification, en particulier le rôle déterminant des structures syntagmatiques dans l’établissement de nouveaux usages sémantiques. Enfin, elle permet de mettre en relation le changement sémantique avec les conditions sociohistoriques et les représentations collectives. / The present study deals with the way in which the lexical field regrouping the words “chance”, “fortune”, “hazard” and “risqué” has been structured in the French language from the eighteenth century till the present day. Revealing major changes in western societies during this period of time, the field, which corresponds to the linguistic representation of the notion of fortune / hasard, presents a certain coherence.We have examined these words and their derived forms through the display, regulation, and distribution of norms of use, not only in Hexagonal French, but also in Quebec French. Two types of corpora have been analysed. On the one hand, a corpus of articles from around 50 dictionaries has been used to emphasize the lexical and semantic productivity of the different units on a large historical scale. On the other hand, in revealing context types, a set of texts reflecting French language varieties has allowed for carrying out a diachronic analysis of lexical uses. The continuist approach to semantic differences rests upon a frequential representation of semantic changes.The thesis brings a significant contribution to the question of usage variations and semantic change, providing new perspectives. It first deals with theory and methodology of lexical description, considered through the analysis of the nature and the role of corpora. It then evidences the central role of syntagmatic structures in the setting of new semantic uses. The study has finally put into relation semantic changes with their historical background and the collective representations of the time.

This essay deals with translation changes and problems that occur when translating collocations, i.e. sequences of words that are usually combined such as work hard, from Swedish to German. Being an essential part of our communication, collocations are common both in everyday-life and in technical terminology. This qualitative research deals with collocations in scientific texts about children’s literature and aims to increase attention on collocations in the translation process. The term collocation as used here refers to the concept of hierarchical relations between the lexemes of a collocation by the German linguist F. J. Hausmann (1984), distinguishing between bases and collocators. It proved itself useful in the translation process and showed that the translator must pay special attention to the collocator in order to find the equivalent expression in the target language. In doing so he/she is not at all obliged to translate a collocation with the respective target collocation. In fact due to stylistic reasons collocations were replaced by individual lexemes or paraphrases. Referring to Hausmann’s terminology and the studies of Baker (1992) this essay highlights the importance of considering collocations as translation units, i.e. not translating the lexemes of a collocation separately. Furthermore the assumption was disproved that translation errors, e.g. interferences and semantic deficits, are mainly caused when translating collocations to a foreign language. Even translators translating into their mother tongue have to examine collocations carefully to avoid errors that can result in doubts about the quality of the whole translation.

Glioblastoma (GBM) is the most common high-grade brain tumor diagnosed in patients who are more than 50 years of age. The standard of care treatment is surgery, followed by radiotherapy and chemotherapy. The median life expectancy of patients is only between 12 to 15 months after receiving current treatment regimes. Hence, identification of new therapeutic compounds and gene targets are highly warranted. This thesis describes four interlinked studies to attain this goal. In study 1, we explored drug combination effects in a material of 41 patient-derived GBM cell (GC) cultures. Synergies between three compounds, pterostilbene, gefitinib, and sertraline, resulted in effective killing of GC and can be predicted by biomarkers. In study 2, we performed a large-scale screening of FDA approved compounds (n=1544) in a larger panel of GCs (n=106). By combining the large-scale drug response data with GCs genomics data, we built a novel computational model to predict the sensitivity of each compound for a given GC. A notable finding was that GCs respond very differently to proteasome inhibitors in both in-vitro and in-vivo. In study 3, we explored new gene targets by RNAi (n=1112) in a panel of GC cells. We found that loss of transcription factor ZBTB16/PLZF inhibits GC cell viability, proliferation, migration, and invasion. These effects were due to downregulation of c-MYC and Cyclin B1 after the treatment. In study 4, we tested the genomic stability of three GCs upon multiple passaging. Using molecular and mathematical analyses, we showed that the GCs undergo both systematic adaptations and sequential clonal takeovers. Such changes tend to affect a broad spectrum of pathways. Therefore, a systematic analysis of cell culture stability will be essential to make use of primary cells for translational oncology. Taken together, these studies deepen our knowledge of the weak points of GBM and provide several targets and biomarkers for further investigation. The work in this thesis can potentially facilitate the development of targeted therapies and result in more accurate tools for patient diagnostics and stratification.

This thesis is concerned with mergers of companies, from the legal, accounting, and tax point of view according to applicable legislation in the Czech Republic. Part of the thesis is also devoted to the description of the merger according to IAS / IFRS. In conclusion there is a practical example of a merger of joint stock company and limited liability company

The goal is to become familiar with deferred tax concept - explain the nature and bring this accounting term near on a few selected areas. The thesis deals with two different accounting frameworks, Czech legislation and transnational concept in form of International Financial Reporting Standards with the motive to try to explain true nature of deferred tax and to conclude which of the accounting system sufficiently regulates this area so, that it could reflect all important differences with tax system and leads to fair distribution of profits among owners. In other words, not to awarded disposable earnings to those who do not belong solely because of differences between taxes and accounting. Thus, in a situation where these differences did not exist, the belonging amount of allocation of the profit would be else. The thesis is complemented with descriptive examples and illustrations created from real financial statements of two chosen companies. Representative of the Czech framework is Skanska a.s., and for a framework of IFRS the company Unipetrol a.s. The thesis concludes that a more elaborate treatment of deferred tax includes International Financial Reporting Standards, and therefore the financial statements prepared under them provide truer view of an analyzed company to user.

The master’s thesis object is to create a design of a load carrying steel structure planetarium. Its ground plan dimensions are 36,1 x 49,0 m. The planetarium hall’s roof is designed with system of trusses and purlins. The projection hall’s roof consists of ribbed cupola with radially arched ribs. The stiffness of the whole construction is ensured with bracings. The walls of the whole object are composed of columns, rails and bracings.

The subject of the master´s thesis is the design and assessment of the static load-bearing steel structure office building. It is an eight-storey building with a floor plan and dimensions 54x15m. The proposal has three variants. In one of them a steel frame with a hinge attached elements. These are the pillars, beams, trusses, joists and purlins, which are coupled with trapeze plate and thereby secure the stability of the position in the horizontal direction. The steel structure is placed between the reinforced concrete towers.

The subject of the diploma thesis is the design and static analysis of roof structure. It is prestressed roof shell (membrane) supported by a cable. The whole thesis is divided into several separated units according to task's specification. The text section describes the introduction to the issue of presstressed suspension cable constructions and displays their possible shapes, types and realizations. There is also technical report of solved shell, which was written on the base of the documents, drawn drawings and structural (static) analysis.

The subject of this thesis is the design and assessment of the supporting structure multifunctional building in the Czech Budejovice . The construction of a sphere with a maximum diameter of 30 m and a height of 19.5 meters the highest point . The supporting structure consists of curved ribs , elevator shaft and ceiling beams . The structure is designed in 4 versions . Two variants are made of steel, the third option is wooden and the latest version solves a combination of wood and steel. In the variant selected is done loading , ultimate limit state, serviceability limit state , fire resistance and compounds selected details.