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131	<b>Scanlonian Contractualism and Animals</b> Benjamin Allan Elmore (18414948) 20 April 2024 (has links) <p dir="ltr">In my dissertation, “Scanlonian Contractualism and Animals,” I take T.M. Scanlon’s ethical contractualism, convert it into a political theory, and apply it to deriving the duties of justice we owe to nonhuman animals. Here is the narrative structure of my dissertation. First, I argue in chapter 1 that nonhuman animals should be included within the scope of morality, or justice, as contractualism construes this notion. Animals are some of the “others” to whom we owe duties, particularly duties of justice. To this effect, I defend a revised version of the argument from marginal cases. </p><p dir="ltr">Second, I tell the reader how contractualism works in detail in chapters 2 and 3, making modifications and conversions into political philosophy along the way. Crucial for my discussion will be the debate between Derek Parfit and Scanlon over issues such as how to take numbers into account within contractualism. Scanlon’s considered view is that personal reasons should be added up to determine what we ought to do, but this is not the aggregation of impersonal value, for example, as in utilitarianism.</p><p dir="ltr">In chapter 4, a major step taken is the conversion of political contractualism into a form of Rawlsian political liberalism. Political liberalism takes the fact of reasonable pluralism of comprehensive doctrines on life’s important questions as a permanent feature of liberal democracy. In order to address this pluralism, political liberalism seeks to provide a political conception of justice that can be endorsed by people who differ on fundamental ethical, philosophical, and religious matters. My version of animal rights contractualism adopts this framework, but it takes work to show how animal rights and political liberalism are compatible.</p><p dir="ltr">Third, in chapter 5, a neutral metric for the harm of death will be suggested, following the requirements of political liberalism to offer a political conception of various aspects of our theories. This needs to be done because the harm of death is a complex, contested philosophical issue. The contractors need this metric to figure out what burdens are imposed by death. A neutral metric is meant to be one that can be endorsed by adherents of different comprehensive philosophical viewpoints in an overlapping consensus.</p><p dir="ltr">Fourth, and finally, some of the specific political duties we have to nonhuman animals will be stated. I survey some of the most common topics that are usually explored here, such as factory-farming, medical research, and hunting. The hope is that at the end of the work, the reader will be convinced that contractualism provides a plausible account of what we owe to each animal.</p> Ethical use of new technology Medical ethics Applied ethics not elsewhere classified Social and political philosophy Contractualism Animal Rights Animal Ethics Political Liberalism John Rawls T.M. Scanlon
132	Rinderhaltung ohne Schlachtung als Agrar-Care-System Meyer-Glitza, Patrick 04 May 2020 (has links) Sogar eine vegetarische Ernährung führt durch den Konsum von Milchprodukten zum Schlachten der nicht mehr produktiven oder ausselektierten Milchkühe sowie der männlichen Nachkommen. Eine Rinderhaltung ohne Schlachtung (ROS) wäre (für Lakto-Vegetarier) hier ein Ausweg. Es wurden narrative und semi-strukturierte Interviews mit Tierhaltern der 5 hier dargestellten Fallbeispiele mit qualitativen Methoden der interpretativen Sozialforschung (Grounded Theory, Biographieforschung und sequentielle Feinanalyse) erhoben und untersucht. Die 5 Fallbeispiele wurden anhand biographischer Entwicklungen, ihrer Ethik und ihrem Tierhaltungssystem sowie anhand ihrer Konventionen verglichen. Der Fallvergleich ergab 5 Grundsätze des Care-Systems einer ROS: 1. Universal, 2. Bedingungslos, 3. Das ganze Leben betreffend - „a lifetime of Care“, 4. Familisierend, 5. Präventiv. Das Agrar-System der Fallbeispiele wurde in drei Betriebsstile differenziert: Reine Sanctuaries (Lebens-/Gnadenhof), Landwirtschaftliche Sanctuaries und Vegetarische Rinderhaltung/Milcherzeugung. Das Care- und das Agrar-System ergeben zusammen ein Agrar-Care-System. Kernelemente des Agrar-Systems der 4 hier untersuchten europäischen Betriebe sind u.a. ein hohes durchschnittliches Abgangsalter der Kühe von 12,5 Jahren und der Ochsen von 10 Jahren, stabile Herden, insg. vielfältige Dungnutzung, eine weitgehend muttergebundene Kälberaufzucht und partielle Ochsenanspannung. Bei dem dritten Fallbeispiel beträgt die Dauer der Laktationen durchschnittlich 2,8 Jahre und es werden dabei 9.055 kg pro Laktation ermolken. Bei Kühen mit sehr langen Laktationen sinken vom ca. 4.-6. Jahr die Leistungen nicht mehr und sind persistent. Die Milchkühe sind für 3,4 Jahre (als Mittel der beiden melkenden Betriebe) „in Rente". Der kostendeckende Milcherlös liegt bei ca. 2,95 bis 3,05 EUR pro kg Milch. Eine gemolkene Kuh trägt dabei die Kosten von 0,63 Kühen „in Rente" sowie von 1,48 Ochsen. Milch und Dung wären hier Beiprodukte des Tierlebens. / Even a vegetarian nutrition, through consumption of milk products, leads to the slaughtering of dairy cows that are no longer productive or have been sorted out, and of their male offspring. A cattle husbandry without slaughtering (here ‘CWS’) could be a solution (for lacto-vegetarians). Narrative and semi-structured interviews with the heads of animal husbandry in a total of five cases have been carried out and reviewed using qualitative methods of interpretive social research (Grounded Theory, biography research and detailed sequential analysis). In a case comparison, the five cases have been compared to each other in terms of their biographical developments, their ethics and their animal husbandry systems and also in terms of their conventions. The following five principles for a care system in CWS were derived: Universality, Unconditionality, A lifetime of care, Familialisation and Prevention. The agri-system of the case studies has been differentiated into three styles of farming: Pure sanctuary, agricultural sanctuary and vegetarian cattle husbandry. The combination of the agri- and care-system becomes the agri-care-system. Core elements of the agricultural system of CWS and of the 4 European farms are: a high average dying age which is 12.5 years for cows and 10 years for oxen, novel dung products, mostly rearing calves with the dam and on some farms the use of oxen for traction. In regard to the third case study, the average duration of lactation is 2.8 years, generating about 9,055 kg milk per lactation cycle. The dairy cows "retire" for a period of 3.4 years as a mean of the two milking case studies. In cows with very long lactation cycles, the milk yield, instead of decreasing from the 4th to the 6th year, rather seems to be constant during this period. The cost-covering milk revenue would be about 2,95 up to 3,05 EUR per kg. Each milked cow carries the cost of ca. 0,63 "retired" cows and 1,48 oxen. Milk and dung are the by-product of the animal life. Tierethik Nicht-Schlachten Rinderhaltung Tierrechte Care-Ethik Vegetarismus Sanctuaries Milch Dung Betriebsstile Ökonomie der Konventionen Animal ethics non-slaughter cattle husbandry vegetarianism sanctuaries animal rights care ethic milk dung farm styles economics of convention 170 Ethik ZD 32100 ZD 15000 CC 7266 ddc:630 ddc:170
133	The Buddhist Coleridge: Creating Space for The Rime of the Ancient Mariner within Buddhist Romantic Studies Pacheco, Katie 27 June 2013 (has links) The popularization of academic spaces that combine Buddhist philosophy with the literature of the Romantic period – a discipline I refer to as Buddhist Romantic Studies – have exposed the lack of scholarly attention Samuel Taylor Coleridge and The Rime of the Ancient Mariner have received within such studies. Validating Coleridge’s right to exist within Buddhist Romantic spheres, my thesis argues that Coleridge was cognizant of Buddhism through historical and textual encounters. To create a space for The Rime within Buddhist Romantic Studies, my thesis provides an interpretation of the poem that centers on the concept of prajna, or wisdom, as a vital tool for cultivating the mind. Focusing on prajna, I argue that the Mariner’s didactic story traces his cognitive voyage from ignorance to enlightenment. By examining The Rime within the framework of Buddhism, readers will also be able to grasp the importance of cultivating the mind and transcending ignorance. Romanticism Romantic poets Buddhism Samuel Taylor Coleridge The Rime of the Ancient Mariner dualism Ecocriticism Zen meditation transcendence albatross animal rights environmental rights green anthropocentrism prajna wisdom enlightenment ignorance ethics ahimsa Buddha Buddhist Arts and Humanities Chinese Studies Christianity Comparative Methodologies and Theories English Language and Literature Ethics and Political Philosophy Ethics in Religion Literature in English, British Isles Other Arts and Humanities Other English Language and Literature Other Languages, Societies, and Cultures Other Religion Philosophy Philosophy of Mind Practical Theology Religion
134	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology
135	Development of Sensitive In Vitro Assays to Assess the Ocular Toxicity Potential of Chemicals and Ophthalmic Products McCanna, David January 2009 (has links) The utilization of in vitro tests with a tiered testing strategy for detection of mild ocular irritants can reduce the use of animals for testing, provide mechanistic data on toxic effects, and reduce the uncertainty associated with dose selection for clinical trials. The first section of this thesis describes how in vitro methods can be used to improve the prediction of the toxicity of chemicals and ophthalmic products. The proper utilization of in vitro methods can accurately predict toxic threshold levels and reduce animal use in product development. Sections two, three and four describe the development of new sensitive in vitro methods for predicting ocular toxicity. Maintaining the barrier function of the cornea is critical for the prevention of the penetration of infections microorganisms and irritating chemicals into the eye. Chapter 2 describes the development of a method for assessing the effects of chemicals on tight junctions using a human corneal epithelial and canine kidney epithelial cell line. In Chapter 3 a method that uses a primary organ culture for assessing single instillation and multiple instillation toxic effects is described. The ScanTox system was shown to be an ideal system to monitor the toxic effects over time as multiple readings can be taken of treated bovine lenses using the nondestructive method of assessing for the lens optical quality. Confirmations of toxic effects were made with the utilization of the viability dye alamarBlue. Chapter 4 describes the development of sensitive in vitro assays for detecting ocular toxicity by measuring the effects of chemicals on the mitochondrial integrity of bovine cornea, bovine lens epithelium and corneal epithelial cells, using fluorescent dyes. The goal of this research was to develop an in vitro test battery that can be used to accurately predict the ocular toxicity of new chemicals and ophthalmic formulations. By comparing the toxicity seen in vivo animals and humans with the toxicity response in these new in vitro methods, it was demonstrated that these in vitro methods can be utilized in a tiered testing strategy in the development of new chemicals and ophthalmic formulations. in vitro Alternative Methods alamarBlue rhodamine tight junctions bovine lens viability toxicity mitochondria mitochondria integrity benzalkonium chloride sodium dodecyl sulphate sodium lauryl sulfate scanning electron microscopy Draize Draize maximal average scores zonula occludens cosmetic directive PETA humane society animal league ICCVAM ECVAM JaCVAM BCOP bovine cornea ocular irritants ocular irritation ocular toxicity human corneal epithelial cells vitro confocal confocal microscopy metabolic activity optical quality reactive oxygen species contact lens contact lens care solutions barrier function microbial keratitis mulitipurpose solutions tight junction cell damage claudin ZO-1 occludin MDCK Madin Madin-Darby canine kidney cells cornea human cornea human corneal epithelium epithelial cell line human corneal epithelial cell line sodium fluorescein sodium fluorescein permeability fluorescein permeability ocular surface cell monolayer Araki-Sasaki cell physiology risk assessment safety assessment ScanTox scanning laser lens epithelium corneal cells in vitro model ophthalmic formulations multiple instillation back vertex animal testing rabbit testing alternatives to animal testing cultured bovine lens toxicity of chemicals irritation irritants laser scanner organ culture delayed toxicity toxins hydrogen peroxide cornea toxicity cornea toxicity models prediction of human toxicity no observable adverse effect level lowest observable adverse effect level NOAEL LOAEL toxicity thresholds safety factors cornea uncertainty factors preservatives disinfectants ophthalmic products preclinical preclinical testing epithelial barrier drug penetration clinical confocal microscopy animal rights rabbit cornea human cornea human clinical effects toxic animal rights activist sensitive measures toxic effect toxicity threshold agar overlay agar diffusion agar overlay method agar diffusion method cytochrome cytochrome c apoptosis necrotic apoptotic necrosis caspase rhodamine 123 resazuran resorufin cell death cell viability metabolic dye microsomal microsomal enzymes cytotoxicity cytotoxic cytotoxic effect MTT XTT WST-1 plasma membrane mitochondrial mitochondrial morphology ocular toxicity potential ocular toxicity human corneal epithelial cell line confocal analysis corneal epithelium cell fluorescence alamarBlue assay rhodamine dye animal welfare toxic injury degraded mitochondria epithelial monolayer disinfectants membrane integrity eye toxicity eye viability dye toxicity in humans human toxicity effects on the mitochondria mitochondrial toxicity in vitro battery in vitro test battery ophthalmic eye drop direct contact product safety cytotoxicity potential molecular molecular biology refine reduce replace sensitivity and relevance sensitivity relevance rabbit ocular irritation test product development cytotoxicity models cytotoxicity alternative methods replacements for animal testing three r's beagle tiered testing tiered testing strategy replacements animal testing mechanistic toxicity cornea mitochondria dose response threshold Vision Science and Biology

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