Le but principal d'un essai de phase I en oncologie est d'identifier, parmi un nombre fini de doses, la dose à recommander d'un nouveau traitement pour les évaluations ultérieures, sur un petit nombre de patients.Le critère de jugement principal est classiquement la toxicité. Bien que la toxicité soit mesurée pour différents organes sur une échelle gradée, elle est généralement réduite à un indicateur binaire appelé "toxicité dose-limitante" (DLT). Cette simplification très réductrice est problématiqu, en particulier pour les thérapies, dites "thérapies ciblées", associées à peu de DLTs.Dans ce travail, nous proposons un score de toxicité qui résume l'ensemble des toxicités observées chez un patient. Ce score, appelé TTP pour Total Toxicity Profile, est défini par la norme euclidienne des poids associés aux différents types et grades de toxicités possibles. Les poids reflètent l'importance clinique des différentes toxicités.\\ Ensuite, nous proposons la méthode de recherche de dose, QLCRM pour Quasi-Likelihood Continual Reassessment Method, modélisant la relation entre la dose et le score de toxicité TTP à l'aide d'une régression logistique dans un cadre fréquentiste.A l'aide d'une étude de simulation, nous comparons la performance de cette méthode à celle de trois autres approches utilisant un score de toxicité : i) la méthode de Yuan et al. (QCRM) basée sur un modèle empirique pour estimer, dans un cadre bayésien, la relation entre la dose et le score, ii) la méthode d'Ivanova et Kim (UA) dérivée des méthodes algorithmiques et utilisant une régression isotonique pour estimer la dose à recommander en fin d'essai, iii) la méthode de Chen et al. (EID) basée sur une régression isotonique pour l'escalade de dose et l'identification de la dose à recommander. Nous comparons ensuite ces quatre méthodes utilisant le score de toxicité aux méthodes CRM basées sur le critère binaire DLT. Nous étudions également l'impact de l'erreur de classement des grades pour les différentes méthodes, guidées par le score de toxicité ou par la DLT.Enfin, nous illustrons le processus de construction du score de toxicité ainsi que l'application de la méthode QLCRM dans un essai réel de phase I. Dans cette application, nous avons utilisé une approche Delphi pour déterminer avec les cliniciens la matrice des poids et le score de toxicité jugé acceptable.Les méthodes QLCRM, QCRM, UA et EID présentent une bonne performance en termes de capacité à identifier correctement la dose à recommander et de contrôle du surdosage. Dans un essai incluant 36 patients, le pourcentage de sélection correcte de la dose à recommander obtenu avec les méthodes QLCRM et QCRM varie de 80 à 90% en fonction des situations. Les méthodes basées sur le score TTP sont plus performantes et plus robustes aux erreurs de classement des grades que les méthodes CRM basées sur le critère binaire DLT.Dans l'application rétrospective, le processus de construction du score apparaît faisable facilement. Cette étude nous a conduits à proposer des recommandations pour guider les investigateurs et faciliter l'utilisation de cette approche dans la pratique.En conclusion, la méthode QLCRM prenant en compte l'ensemble des toxicités s'avère séduisante pour les essais de phase I évaluant des médicaments associés à peu de DLTs a priori, mais avec des toxicités multiples modérées probables.

This Diploma Thesis deals with the CRM system in the marketing concept of the multinational company Vodafone Czech Republic plc. The aim was to evaluate the system operation and implementation of sales strategies with respect to the customer. The basic hypothesis of the project was the question of whether the firm is managed by its customer, or whether the firm is in tow of its client. This work assesses theoretical approaches and marketing strategies focusing on the practical application of the strategy in the czech branch of the Vodafone plc. in relation to customers. This thesis has a proactive approach by the company to the customer - sales calls over the Customer Solution sales map, building relationships with customers through the strategy Vodafone Way, expanding the sales network through franchising and unification of new frameworks into project Filip.

Made available in DSpace on 2015-03-05T18:36:38Z (GMT). No. of bitstreams: 0 Previous issue date: 21 / Nenhuma / Competir deixou de ser somente a disputa pelo mercado para tornar-se fator de sobrevivência para a grande maioria das empresas. As organizações devem estabelecer e colocar em prática estratégias, o mais rapidamente possível, para manter-se em seu mercado. A Tecnologia da Informação e Comunicação (TIC) é ferramenta essencial para o posicionamento estratégico, pois fornece um maior detalhamento das informações disponíveis, com maior agilidade. Aliado a isso, a aplicação de uma estratégia de fidelização dos clientes rentáveis à empresa, também conhecida como estratégia de CRM (Customer Relationship Management) possibilita uma redução nos custos com captação de novos clientes, além do conhecimento mais aprofundado das preferências e costumes dos atuais clientes. Porém, mesmo com a unificação da TIC, através dos sistemas de CRM com a busca pela fidelização dos clientes, diversas empresas estão tendo dificuldades em sua utilização. Os principais fatores que impossibilitam o sucesso no uso não se referem a fatore / Competition is no longer just the fight for market share. It became critical factor for the survival of most companies. Organizations must establish strategies and put them into practice as soon as possible to survive in their markets. The Technology of Information and Communication (TIC) is an essential tool for the strategic positioning because it provides more detail regarding information available, with more agility. In addition, the implementation of a strategy to increase the loyalty of profitable costumers, known as Customer Relationship Management (CRM), makes it possible cost reductions through the acquisition of new costumers and in-depth knowledge of current costumers’ preferences and habits. However, despite the integration of the TIC, through the systems of CRM with the goal of increased costumer loyalty, many companies are finding it difficult to use it. The main factors that prevent the success of the use of such tool are not technical, as, for instance, systems or equipments, but are related t

Made available in DSpace on 2015-03-05T19:13:44Z (GMT). No. of bitstreams: 0 Previous issue date: 19 / Nenhuma / A presente pesquisa propõe a estruturação de uma Arquitetura Informacional para Gestão de Relacionamento com Alunos de Instituição de Ensino Superior (IES) privada, com base na coleta e análise dos dados do Plano de Desenvolvimento Institucional (PDI), na observação participante e nos grupos de foco com alunos e gestores da Instituiçao de Ensino Superior (IES) em estudo. Os temas que tratam de vantagem competitiva e cadeia de valor, estratégias direcionadas ao lucro e rentabilidade, Customer Relationship Management (CRM) e marketing de relacionamento apresentados no referencial teórico, orientam a identificação dos atributos e benefícios que envolvem o termo ‘relacionamento’ e que tenham representatividade para os alunos e gestores. Os temas que tratam de arquitetura informacional e Unified Modeling Language (UML) orientam a estruturação da Arquitetura Informacional. O estudo foi realizado em uma IES privada, localizada na cidade de Porto Alegre/RS, possuindo natureza aplicada com abordagem qualitativa e expl / This work proposes the structuring of Information Architecture for Relationship Management with students in a private higher education institution based on the gathering and analysis of the Institutional Development Plan data, on participative observation and on focus groups with students and management of the university being studied. The topics that deal with competitive advantage and value chain, strategies targeted at profit and profitability, Customer Relationship Management and relationship marketing presented in the theoretical content orientate the identification of the atributes and benefits entailed by the term relationship and that are meaningful to both students and management. The topics that deal with information architecture and Unified Modeling Language orientate the structuring of Information Architecture. The study was carried out in a private institution of higher education located in Porto Alegre/RS possessing an applied nature with a qualitative and exploratory approach enabling the compr

Title: French luxury companies: Challenge to do E-Commerce withoutaffecting their brand image Authors: Clément LEMAIRE and Paul LASSALLE Supervisor: Jean-Charles Languilaire Level: Bachelor Thesis in Business Administration, Marketing Key words: Marketing, E-commerce, E-merchandising, E-CRM, Louis Vuitton, Luxury market, French market, Website, Brand and Reputation Purpose: How French luxury companies, in a context of changing demand, use the e-commerce without affecting the image of their brand? Method: In the method we explain that we decide to use a descriptive method of research. We collect secondary data from our University Library and primary data from our observation of Louis Vuitton website. We also explain why we choose this company and what the limits of our study are. Theoretical framework: In a first part, we have written all the definitions and information about definitions that we have used in the empirical part. It means E-Commerce, E-Merchandising, Marketing mix and ECRM. Then, we have given some information about website elements as the first page, the graphic website, buying process, electronic payment and website security. Finally, we have defined all the information about the brand and its different powers on the market: We start by a “brand awareness” explication, then we have defined “how is build a brand” to finish by the topic “band and reputation”. Conclusions: We present the answer of our purpose. French Luxury companies use marketing tools in order to protect the image of their brand when they do e-commerce. We also bring some suggestions to Louis Vuitton and give some critics concerning our study. Finally we open our reflexion to related studies that could be interesting to do.

This diploma thesis deals with a new trend in the corporate sector -- social networks. These in fact have become a phenomenon due to its growing popularity in recent years. The aim of this thesis is to introduce the social networks in a broader context -- especially the analysis of milestones of social networks. Further comparison of selected social networks from the perspective of business alias what options the company offers a social network for your presentation with access to user data (Social CRM). The third part of the aim of this work is to analyze the critical factors in the integration of social networks into the enterprise information system. The work can be divided into the descriptive (Chapters 2-4) and the practical (Chapters 5-6) part. The first part presents the social networks, the concept of Social CRM and basic characteristics of systems integration. The practical part is focused on all those aims. Author of the work receives information primarily from the electronic information resources that are available at University of Economic in Prague and also from various sources that are on the principle of Web 2.0 (Czech and foreign). Finally, the author also receives information from social networks (social networks options). The work serves as a summary and mapping of existing communication channels on the Internet (e-mail, IRC, selected social networks) and summarizes the critical factors in the integration of social networks into the enterprise information system according to the individual project phases.

In the last decade, the ever increasing pressure of competition faced by businesses has led to the development of Customer Relationship Management (CRM). In short, CRM is the practice of integrating all aspects of business functions for dealing with customers, with the assistance of technology, and with the intention of boosting company profitability. CRM has been widely promoted as a critical contributor to business survival. However, the high failure rate of CRM projects has also attracted research attention and many factors have been discussed as contributing to the success or failure of CRM implementation. This research argues that CRM is not simply a software package or a computer program. CRM, instead, should be perceived as a strategic issue in order to realize its potential. In addition, this study also argues that CRM implementation is affected by organizational, strategic and cultural factors. In particular, this study was conducted within the context of Chinese small and medium-size enterprises (SMEs), with company size and culture as two major focuses in this study. SMEs were chosen as this segment has been overlooked in CRM study, yet it represents a great potential for growth in CRM adoption. Chinese culture was chosen as most of CRM studies have been conducted within a western cultural background. The Chinese culture has distinctive characteristics different from western culture, and this has strong influences on business operations. A quantitative method was adopted for this study and a mailed survey was used to collect data to examine the relevance of these factors within this context. Research participants were recruited using a systematic sampling technique through a comprehensive Chinese business directory. Results suggest that there are positive associations between a company's CRM implementation and its practice of organizational, strategic, and cultural issues. In particular, four organizational issues – organizational integration, executive commitment, system readiness, and resource availability; three strategic issues – vision, planning, and customer-centric culture; and one cultural issue – networking, have an impact on a company's CRM implementation.

擔保房貸憑證(CMOs)是衍生自不動產抵押證券(MBS)的證券化商品，透過分券的特殊設計，藉此降低MBS商品的提前清償風險，也增加市場投資人的選擇彈性。但特殊的設計同時也提高了評價上的困難度，由於此產品的提前清償狀況會依分券性質與標的抵押貸款借款人的償還情形而有所不同，為了準確掌握CMOs商品的現金流量，必須採用較為充分的貸款資料與提前清償模型來推估提前清償機率。本文採用競爭風險模型來做為提前清償模型，透過較多變數的選擇方式，模擬出較為精確的提前清償機率路徑。 此外，BGM利率模型是透過將利率間斷化，捕捉市場上可觀察到的利率，同時也可提供在不同時點下的即期利率，可藉此推算出不同時點下的分券價格，故採用BGM來做為本文的利率模型。

<p>Title: French luxury companies: Challenge to do E-Commerce withoutaffecting their brand image</p><p>Authors: Clément LEMAIRE and Paul LASSALLE</p><p>Supervisor: Jean-Charles Languilaire</p><p>Level: Bachelor Thesis in Business Administration, Marketing</p><p>Key words: Marketing, E-commerce, E-merchandising, E-CRM, Louis Vuitton, Luxury market, French market, Website, Brand and Reputation</p><p>Purpose: How French luxury companies, in a context of changing demand, use the e-commerce without affecting the image of their brand?</p><p>Method: In the method we explain that we decide to use a descriptive method of research. We collect secondary data from our University Library and primary data from our observation of Louis Vuitton website. We also explain why we choose this company and what the limits of our study are.</p><p>Theoretical framework: In a first part, we have written all the definitions and information about definitions that we have used in the empirical part. It means E-Commerce, E-Merchandising, Marketing mix and ECRM. Then, we have given some information about website elements as the first page, the graphic website, buying process, electronic payment and website security. Finally, we have defined all the information about the brand and its different powers on the market: We start by a “brand awareness” explication, then we have defined “how is build a brand” to finish by the topic “band and reputation”.</p><p>Conclusions: We present the answer of our purpose. French Luxury companies use marketing tools in order to protect the image of their brand when they do e-commerce. We also bring some suggestions to Louis Vuitton and give some critics concerning our study. Finally we open our reflexion to related studies that could be interesting to do.</p>

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