Masters of Science / The aim of this study was to develop a Stock Control Assessment Tool for use in the public health care sector and then to apply it to identify problems in the stock control system. This would help authorities to optimize the system. The advantages experienced with such a dynamic Assessment Tool were many: The Tool was quick and easy to apply; it was user friendly; it provided an immediate SWOT analysis of a particular facility; it is in line with the SA NDP directives and it provides an indication of which structures are in place and whether they are functioning properly. Furthermore; it could determine the increase or decrease in performance of a facility (therefore identify trends within the functional status of a system) when data is collected over a period of time; and finally, it could also be used to prioritize drug policy directives. The following steps were established in the development of the Tool: A literature review of pharmaceutical stock control and Drug Supply Management was addressed to provide the background information for the motivation of this study and to identify the various elements that could influence stock control at a facility level. Observational studies were applied at selected private and public facilities to observe the impact of these identified stock control elements. An 'ideal' stock control system was then generated from the literature review and observational assessment. A structured questionnaire was developed and surveyed at these facilities to generate key areas of concern of a stock control system. A study and adaptation of the indicator methods used by the World Health Organization (WHO) to monitor drug use in health facilities resulted in the formulation of a practical Stock Control Assessment Tool based on 11 key indicators and a number of sub-indicators, all of which were objectively defined. The Tool was then applied at selected public facilities and the results were analyzed quantitatively, qualitatively and subjectively. Each of the indicators was then applied and results examined closely with a view to possible refinements of the indicator. The refinements were made and the Tool was re-applied at two selected facilities. These two facilities were randomly selected from the original six facilities included for the testing of the Tool. Final conclusions and specific recommendations were generated to improve the stock control systems at the selected public health care facilities.

Children who experience violence is one aspect of the work of social secretaries and is a complex assignment in their work. The purpose of this essay has been to understand how social secretaries describe their work within their discretion on children who experience violence. More specifically focus has been on cases where there is a lack of consent to voluntary interventions according to the Social Services Act and when compulsory care is not possible. Previous research about this specific situation is limited which makes this study necessary. The questions of this study had a focus on how social secretaries use their discretion in these cases, which challenges they meet in their work and also their reasoning on today´s legislation regarding children who experience violence. The method of this study has been qualitative semi-structured interviews with five social secretaries in three different municipalities in Sweden. Our results have been analysed with previous research and two theoretic starting-points, discretion and caring power. This study shows that knowledge about children who experience violence is an important part in the work of social secretaries and is a crucial factor in children’s right to protection. It also shows that parental rights to refuse interventions is a major aspect that prevents the possibilities of social secretaries to protect children who experience violence which the social secretaries describe as a difficult challenge. Another difficult challenge described was when parents deny that their children are experiencing violence and there is a lack of proof in the same time. The social secretaries in this study expressed a wish to have a possibility in the law to force parents of children who experience violence to receive interventions even though there is a lack of consent.

Bakgrund   The Gugging Swallowing Screen - Intensive Care Unit (GUSS-ICU) är ett screeningtest med syfte att fånga upp indikationer på sväljsvårigheter efter långvarig intubering hos inneliggande patienter på intensivvårdsavdelningar (IVA). I dagsläget finns det inget svenskt översatt och validerat screeningtest för omvårdnadspersonalen att använda vid bedömning av sväljförmågan efter extubering på IVA. Syfte Syftet med studien var att översätta det internationella screeningtestet GUSS-ICU till svenska för användning i en svensk intensivvårdspopulation. Vidare syftade studien till att utföra en pilotstudie av den svenska versionen på extuberade patienter på IVA. Metod En framåt-bakåtöversättningsmetod användes vid översättningen av screeningtestet GUSS-ICU. Översättningsprocessen omfattade tre steg: framåtöversättning, granskning och kommentarer från en expertpanel och en bakåtöversättning. I översättningsprocessen deltog två logopedstudenter, två handledare, en expertgrupp och en översättare. Expertgruppen bestod av 10 deltagare med olika professioner inom hälso- och sjukvården. Fem inneliggande patienter från IVA planerades delta i en pilottestning av den svenska översättningsversionen. En innehållsanalys genomfördes för att kunna jämföra samtliga översättningar. Syftet med jämförelsen var att identifiera skillnader i ord och satser samt kulturella och kontextuella skillnader. Resultat       Studien resulterade i en svensk översättning (GUSS-IVA) av screeningtestet GUSS-ICU. Analysen visade på skillnader i val av ord, koncept och satser mellan de olika översättningarna. Flertalet skillnader var ej betydelseskiljande utan analyserades istället som resultat av skillnader i erfarenhet, kunskap och språkbruk. Översättningsmetoden bidrog till språklig, kontextuell och kulturell anpassning av översättningen. Slutsats Den svenska versionen av GUSS-ICU stämmer bra överens med originalversionen och enbart ett fåtal skillnader observerades mellan översättningarna. Skillnaderna mellan bakåtöversättningen och originalversionen var inte betydelseskiljande, vilket tyder på att den svenska versionen mäter det den avser att mäta. Framtida studier behöver pilottesta och validera den svenska versionen av GUSS-ICU, innan testet kan implementeras i en svensk intensivvårdspopulation. / Validering av screeningtest för sväljsvårigheter för användning inom svensk vårdkontext

This thesis focuses on harmonisation of work and family life of female university graduates at beginning of their careers and at the time when they were taking care of babies up to five years of age. I have chosen this topic not only because it is rather an actual topic but also because I'm personally attached to it. My feminist research analysis is based on the theory of power and knowledge as is it described by Foucault and Butler. I was interested in original families of my communication partners where they grew up and where they adopted their social habits and behaviour. In the light of this social process, I have analysed what powers they had to face in their original families in terms of usage of gender stereotypes based on patriarchal layout of our society and preferential existence of one gender over the other. I have also focused on current families of my communication partners and on power relationships on the basis of which the process of harmonisation of professional and family life of my communication partners takes place, both in their private and public space. I have also analysed how social habits and behaviour gained during their childhood are implemented. It was very important for the interviews and for my feminist research to approach my communication partners as subjects, and...

VOVES, Petr. Úloha Světové zdravotnické organizace v případu epidemie viru eboly na území západní Afriky v roce 2014. Praha, 2017. 95 s. Diplomová práce (Mgr.) Univerzita Karlova, Fakulta sociálních věd, Institut politologických studií. Katedra mezinárodních vztahů. Vedoucí diplomové práce PhDr. Irah Kučerová, Ph.D. Abstract The M.A. thesis deals with the World Health Organization's response to the outbreak of the ebola virus disease in Guinea, Liberia and Sierra Leone in 2014. The spread of the disease is mapped from its very beginning at the end of December 2013 until the creation of UNMEER in September 2014, which was the first international medical mission ever created by UN Security Council. The purpose of this thesis is to evaluate the particular problems, which limit WHO's role in a timely and effective response to the public health threats of international concern (PHEIC) under the reformed International Health Regulations (IHR). The response of WHO representatives to the spread of the disease is evaluated taking into account the available material and competence capacities of the organization as well as its previous practice in this field. The specific misconduct of WHO representatives is explained in the context of longstanding WHO's problems, which are mainly linked to the vertical fragmentation...

Atea är ett företag som ger sina anställda friheten att arbeta på valfri plats och detta kan leda till att ett kontor inte kanske används tillfullo. Denna studie kommer därför lägga fokus på att ta fram en lösning som kommer räkna antalet personer som är på Ateas kontor i realtid och även spara data för tidigare dagar för att ge statistik över en längre tid. Syftet med denna typ av lösning är att se hur ett kontor används, samt om detta är en lösning som kommer vara användbar och för vem. En prototyplösning har tagits fram för att testa denna typ av lösning på ett kontor. Lösningen kommer bestå av olika delar som innehåller IoT, API, Next.js och hostas på Azure. I resultatet så kan man konstaterat en rad brister och svagheter existerar i denna lösning. Mätningar visar olika data ifrån vad man personligen uppskattar gentemot vad lösningen visar. Detta beror på flera faktorer, varav den största är att lösningen endast hade tillgång till en kamera och kontoret har två in- och utgångar. Vid sammanställning av användartester så kan man se en trend av att många anser att denna typ av lösning kan vara bra i en personlig synvinkel men också ur en professionell synvinkel, och det finns ett uttryckt intresse för denna typ av lösning. / Atea is a company that gives its employees the opportunity to work from where ever they want and this can lead to the office not being used to its full potential. This study will therefore explore the option to develop a solution that can count the amount of people coming and going to an Atea office in real-time, and also save the data for previous days in order to give statistic over a longer period of time. The purpose with this type of solution is to evaluate how well an office is being used, and also to determine if the solution is useful and for who. A prototype has been created in order to test the solution at an office. The solution consists of different parts made up of IoT, API, Next.js and is hosted on Azure. The results show a lot of weaknesses and flaws in this solution. The measurements show different numbers from the ones that was estimated by personal headcount versus what the solution produced. This has to do with a couple of factors but the main one being that the solution only had access to one smart camera and the office has two entrances. When compiling the user tests, we can see a trend that most people like the solution and this type of solution would be good in a personal perspective but also in a professional one. There is also an expressed interest in a solution like this.

Philosophiae Doctor - PhD / Injuries, and head injuries in particular, are a common cause of childhood, adolescent and young adulthood morbidity and mortality. The risk factors for injuries in general have been well researched. But it remains uncertain whether these factors are similar for specific injuries, such as head injuries. The inter-relationships between individual and environmental risk factors are difficult to study. Whilst much is know of the short-term consequences of head injuries, relatively little information is available on their long-term conseque~ces. The follow-up period in most research is short (often less than 1 year) and studies are weak in terms of design. Studies generally find a variety of social, cognitive and psychological consequences in children and young adults experiencing head injuries. This study assessed in two large, nationally representative samples, a 1946 birth cohort and a 1997 cross-sectional health survey: 1) the occurrence and risk factors for childhood, adolescent and early adulthood head and other injuries, and 2) the long-term cognitive and psychiatric effects of skull injuries. The overall findings for the risk factors across the two data sets and over 5 decades of data collection were strikingly similar. Maleness was a major risk factor for the head and other injuries. Some of the behaviour and personality factors such as hyperactivity and being neurotic, even after adjusting for sex, socioeconomic status and family type, remained significantly related to injuries, particularly those affecting the head region. A clustering of demographic, socioeconomic, family and behavioural risk factors significantly increased the likelihood of injuries, particularly recurring injuries with at least one being a head injury. In the unadjusted analyses socioeconomic status and family type were less consistently related to injuries. The long-term psychiatric and cognitive consequences of skull injuries causing concussion and skull fractures in childhood and early adulthood were negligible. Other childhood factors such as educational ability, behaviour and personality, and level of education achieved were more predictive of psychiatric symptoms and cognitive problems in adulthood. This study suggests that children and adolescents with behavioural and personality problems were at greater risk of head and other injuries in childhood, adolescence and later in adulthood. Children and adolescents with behavioural and personality problems were more likely to live in manual social class families and families with a single parent or stepparent. This combination of behavioural problems and deprived socioeconomic and family circumstances may increase tendencies for violent behaviour, alcohol dependence and manual occupations later in adulthood, which all increase the risk of injuries. There is therefore a need to identify children and adolescents with behavioural and personality problems as early as possible to prevent the impact in the short- and longterm. This will not only reduce the burden of injuries but also the many other consequence of behavioural and personality problems, particularly when located within deprived socioeconomic and family circumstances.

<p>  </p> <p>A multidisciplinary study that evaluated Quality Control (QC) laboratory (lab) accreditation, and a salt screen for bedaquiline. Medicines testing facilities always seek to ensure the accuracy of data from their QC labs by attaining accreditation. This research proposed that an understanding of the cross-linkages in the requirements for implementing the 2 most widely used lab standards will facilitate testing efficiencies, and reduce the risks of accreditation failures. For the salt project, the study proposed that new salts of bedaquiline will be formed from acid-base reactions following the pKa rule. Characterizing the salts will provide specifications for the new molecular entities, and form a selection-criteria for a lead candidate.</p> <p>The research reviewed 2 lab standards: the ISO/IEC17025:2017 and the WHO Good Practices for Pharmaceutical QC labs, and identified the areas of overlap in their requirements. It then developed and tested affordable models that mitigate the 3 identified areas of high risks to lab accreditation. Additionally, it mixed<em> equimolar amounts of bedaquiline base with select counterions that have ≥ 2 pKa units in organic solvents, to yield salts</em>. ICHQ6 guidance was used to characterize the new salts.</p> <p>The highest risks to laboratory accreditation were linked to 3 quality system metrics, namely: ‘Proficiency Testing’, ‘Validation’, and ‘Measurement Traceability’. Using the identified areas of overlap in the 2 laboratory standards, this research provided tutorial videos, a competency matrix, and some instrument validation data, to optimize the requirements for lab accreditation. For the salt screen, five new candidates were synthesized as alternatives to the existing fumarate salt of bedaquiline. The results of their physicochemical properties were used for selecting a lead moiety.</p> <p>The research provided evidence that the multipronged models developed will improve efficiencies in QC labs, and increase their chances of attaining international accreditations. It also discovered the best modes for synthesizing the new salts of bedaquiline, and provided critical data to help Pharma make an informed choice for a lead candidate.</p>

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Magister Public Health - MPH / The introduction of National Health Insurance (NHI) and the Ideal Clinic Monitoring System have highlighted gaps and challenges with regard to medicine supply management (MSM) at primary health care (PHC) facilities. PHC facilities are the first point of contact communities have for their health needs, however, frequent stock-outs of medicines at PHC facilities in uMkhanyakude district, a rural district in KwaZulu-Natal, and have raised questions as to how medicine stock is managed at these facilities.