In the first part of the doctoral thesis, the capillary electrophoresis was used to test the potential chiral separation properties of monosubstituted cyclodextrin derivatives, namely PEMEDA- and PEMPDA-β-cyclodextrins for the group of selected analytes. Both selectors exhibited excellent enantioseparation properties for N-boc-D,L-tryptophan, where the enantiomers were completely separated even at 0.5 mmol·l-1 concentration of the cyclodextrin derivative in the background electrolyte. However, the differences between the enantiodiscrimination properties of individual derivatives were minimal. The second test group consisted of two cyclodextrin derivatives, namely 2-O- and 3-O- cinnamyl-α-cyclodextrins. These derivatives are able to form supramolecular polymers in aqueous solutions that disintegrate at elevated temperature. The formation of these polymers was tested by NMR and DLS experiments. None of the tested cyclodextrin derivatives showed enantiodiscrimination properties towards a group of selected analytes. In the frame of antipredatory study, HPLC-MS/MS method working in HILIC mode was used for separation of ten pterin derivatives and riboflavin, which can be present as pigments in insects, reptiles or amphibians as a part of their warning coloration. The developed methodology was applied for...

Abstract The thesis deals with the US foreign policy under Richard Nixon. More specifically, it examines the US rapprochement with Communist China (PRC) and the triangular diplomatic relations between the US, USSR, and PRC. The thesis draws from the realist theories, particularly the offensive and defensive branches of neorealism represented by John Mearsheimer and Kenneth Waltz. The thesis applies the theoretical concept of wedging strategies as power-balancing tools on the selected US foreign policy. The thesis conducts a qualitative case study using the process-tracing method. A causal mechanism derived from the concept of wedging strategies is theorized and further applied in the analysis. The analysis of the US foreign policy towards China examines the individual traces in the theorized mechanisms. The results of the study show that the US broke the Sino-Soviet alliance using a defensive wedging strategy by exploiting the Sino-Soviet split, resulting in PRC's dealignment with the USSR. The US reapproached the PRC and swayed the Chinese leadership with strategic guarantees tacitly aimed against the USSR. These guarantees were ultimately projected into the Shanghai Communique of 1972.

政府透過法律制度將原先具有非排他性及非敵對性等公共財性質之專利財產化，藉此鼓勵發明人進行研發，間接為整體社會帶來促進創新與阻礙創新等不同面向之影響，而專利之私有化使擁有專利之所有人取得排他獨佔權限，如此累積創新所帶來之結果便是形成專利叢林現象，使單一產品生產時須取得眾多專利，增加未取得專利之侵權風險，該專利叢林現象後續更促使訴訟成為新興專利聚集型態獲取利益之手段。 從專利取得之角度觀察，其取得專利之方式可系統化分為自行研發、併購等內化形式或取得專利授權等外部形式，而專利取得之動機則從單純產業利用轉變為企業策略性考量；現今專利市場中，更經常將取得之專利以授權或出售方式商品化，甚或以專利作為商業談判、利益交換之籌碼，使專利有貨幣化現象。從經濟學之角度思考，專利貨幣化或有交易、預防及投機等動機，並得從專利本質上與後續發展上之特性觀察到專利貨幣化之因素。 由於本文將專利市場分為專利聚集、專利交易平台、專利資訊提供者及一般個人、實際從事生產公司與研究機構等不同類型參與者，並將研究對象著重在專利聚集與專利交易平台二者，因此特於本文中討論專利聚集形成之階段與交易模式，且因應專利交易模式而衍生探討專利交易價金之計算。從本文可知，專利聚集得區分為攻擊型、防禦型、以授權營利型及混合型四大類，各類型專利聚集及專利交易平台皆有其創造價值之價值鏈活動安排、整體產業競爭作用力之五力分析與支援核心競爭優勢之相對應策略活動系統，並從各市場參與者之運作模式中亦得觀察可能存在之缺失。 攻擊型專利聚集表面上雖提供授權服務，然手段上具有強制性，以訴訟等手段迫使下游實際從事生產等公司支付授權金以取得專利授權，從模式上觀察，其存在未經挑選專利、擁有專利過多及組織體系過於龐雜等缺失；而防禦型專利聚集則從下游買方之迫切需求角度出發，以防禦目的之專利授權或出售為訴求，藉由廣泛涵蓋不同領域之專利組合滿足下游買方對於專利侵權風險之控管，然其現有模式可能因支付有限年費導致難以確保購買大量專利之品質，並有為符合眾多會員需求使專利相關性降低以及整體產業難以避免搭便車現象等缺失；至於以授權營利型專利聚集透過技術或產品標準定義之專利組合，包裹式將下游實際從事生產廠商需要之專利一次性授權，雖不見得有授權之急迫需求，但顯然降低下游買方取得授權之交易成本，惟其缺失為權利金分配制度之公平性與專利組合之區別標準。混合型專利聚集則涵蓋上述三種專利聚集之優勢，並以特殊之智財資本市場重新定位無形資產能夠創造之價值，對於下游買方及上游專利供應者而言，皆帶來產業結構變化之衝擊，同時以專利組合授權來滿足下游專利被授權人之需求，不過，混合型專利聚集管理複雜度高、經濟利潤有下降可能，並且長期將有價格扭曲之應變風險。 專利交易平台與專利聚集不同之處在於其不直接取得專利或專利授權，僅以專利供給方與需求方之交易中介者自居，然從廣義概念上，其亦為專利聚集之一種形態，有助於專利買賣雙方取得資訊，降低搜尋、談判或執行等交易成本，並透過其他業務互補專利交易平台業務可能之不足，惟其仍舊有所缺失，亦即價格決定機制之困難、服務範疇過大導致成本控管之不經濟與交易公開之接受程度等問題。從本文各章節之分析中，可比較各市場參與者之不同，亦得觀察彼此間之互動與缺失，從而提出未來可能之研究方向，並針對專利市場之管制與開放給予建議。 / The propertization of patents which intrinsically show the traits of public goods including non-excludable and non-rival was established to encourage inventors and therefore leads to positive and negative influence to the society indirectly. The privatization of patents protects the exclusive rights of the owners, whereas what we called the accumulated innovation set up the patent thickets that enhance the risks of infringement and promote the strategic litigations raised by new patent aggregators. The methods of acquiring patents could systematically divided into internalization which includes R&D and M&A, and externalization which includes licensing and so on. While the motivations of acquiring patents transform from industrial applications to strategic considerations, and the patents gradually become commercialized and even express its monetization. This paper classifies different players in the patent market, such as patent aggregators, patent transaction platforms, patent information providers and operating companies, while with the focus on patent aggregators and patent transaction platform. Besides, the patent aggregators could be categorized into “offensive patent aggregators”, “defensive patent aggregators”, “running by licensing patent aggregators” and “hybrid patent aggregators”. Moreover, the findings of this paper stand on what each patent aggregator and patent transaction platform has its scheduled activities of the value chain, the five forces model to the analysis of its industry and the strategic activities system for supporting its core competence, and even the demerits of its operating model. The offensive patent aggregators provide licensing services, while its services apparently contain compulsive licensing model by raising claims against the operating companies. Instead, defensive patent aggregators help the downstream buyers in need to fight against the offensive patent aggregators by licensing or selling patent portfolios which cover broad technological areas and benefit risk management. Next, the running by licensing patent aggregators package their patents by standards of technologies or products and provide “one-stop-shop licensing solutions” to the downstream buyers to save the transaction costs. Furthermore, the hybrid patent aggregators embrace the advantages of three kinds of patent aggregators mentioned above and try to create the IP capital market leading to the transformation of the industry structure. On the other hand, the patent transaction platforms are different from the patent aggregators in the ownerships of patents. The patent transaction platforms will never become the owner of the patents or acquire the rights of patent licensing, it just named themselves intermediaries of transaction that reduce the transaction cost and enhance the transparency of information. Nevertheless, the diversified operating models of different patent aggregators and patent transaction platforms exist its improvable or inevitable drawbacks. The analysis of each chapter in this paper could help to compare the players in patent market and contribute to observe the shortages and interactions between the ones. What’s more, this paper gives some suggestions for further researches in the future as the conclusion.

The relationship between international regimes regulating intellectual property, traditional knowledge and biodiversity has received much attention in recent times. Of the many complex and controversial issues in contemporary international legal discourse on this matter, the protection of traditional knowledge (TK) stands out as a significant challenge. Choices abound in the search for modalities to regulate rights to use and control TK systems and their underlying biodiversity. In recent times, the protection of geographical indications (GIs) has emerged as an option for protecting TK. Despite the considerable enthusiasm over it, there is appreciable research dearth on how far and in what context GIs can be used as a protection model. Indeed, not only is the concept of GIs itself widely misunderstood. As well, analyses as to their applicability for protecting TK often reflect underlying cultural differences in the nature, scope and the jurisprudence regarding GIs across jurisdictions. This thesis examines the relationship between GIs and TK, focusing on the responsiveness of GIs to the needs and desires of indigenous peoples and local communities (ILCs). The thesis posits that the search for a model to protect TK should involve identifying different modalities, including those based on intellectual property, to fit to the nature and uses of TK in particular contexts. The analysis conceptualizes GIs as a form of IP that are structurally and functionally suitable to protect aspects of TK in traditional knowledge-based agricultural products (TKBAPs). Substantively, the thesis draws attention to the conceptual underpinnings of GIs as encompassing cultural and economic objectives in the protection of TK. As such, it is argued that stronger protection of GIs should be achieved by integrating the negotiations and discussion concerning GIs and TK at the international level. Further, the case is made for the determination of immediate challenges and long-term opportunities in choosing a legal means for protecting GIs at the national level. In this connection, the thesis suggests that the potential of GIs to meet national and local imperatives to protect TK be assessed, inter alia, based on their instrumentality for economic, biodiversity, cultural and food security objectives in protecting TKBAPs.

現實主義的理論特色在於偏好以權力的角度理解國際政治（特別是國家的行為）並且認為在一個處處充滿衝突的無政府狀態體系中，國家是最主要的分析單元。惟類此觀點不僅是一般研究者對於現實主義的誤認，更是現實主義對自我認知的不完備。雖然現實主義將法律或規範置於權力的概念之下，認為國際法只是國家可有可無的一項工具，但事實上國際法律規範與權力卻經常彼此相互影響。 本論文之目的並非要否定現實主義，而是欲對之進行修正及反省。由國際秩序此項議題作為起點，作者處理了下列幾個問題：首先，在國家所組成的國際社中，現實主義維持秩序的策略及其效果為何？其次，若此方法不具成效或有所疏漏，吾人是否有其它的選項可供作為維持國間家往來關係穩定與和平的方法？藉由探索國家創建國際法律規範的原因以及國際法的法源等諸問題，吾人發現國際法律規範之創立往往並沒有一套如同國內法那般正式且專責的機制，但被國家承認為規範或被接受為法律者的方式（例如：國家間的共識），卻不可反駁地存在於國際社會，在這些形成法律規範的方式中，國家（或其他行為者）可以清楚的認知到規範內容中所要求的義務與責任。 因此，儘管現實主義認為國際法不具重要性，但吾人仍應探就國家為何有時願意遵守法律規範的原因。並且設法釐清在現實主義是項研究典範中不同流派的現實主義理論，對於客觀存在的國際法律規範之評價與認知。基於現實主義並非單一的理論而是為一研究典範，故本文在內容上分別從古典現實主義、結構現實主義（包括守勢與攻勢兩種現實主義）、新古典現實主義，以及較為一般人忽略的英國學派等現實主義理論的派別中去探討國際法律規範在國際政治中的地位及功能。文中指出，長期以來人們對於現實主義的理解受限於權力政治這樣的標籤，從而視現實主義與國際制度或國際法為水火而不相容！但事實上，採用現實主義理解國際關係，不意謂著就必須對國際法持以否定的態度。毋寧，在現實主義與國際法律規範之間，存在的不是一種絕對的互斥關係。非結構理論型的現實主義，如古典現實主義，對於國際法即是採取正面肯定其功能的態度。 當瞭解現實主義的秩序觀及其維持秩序策略（權力平衡）的疏漏所在之後，本文解釋了國際法律規範形成的原因以及不同流派現實主義理論對於它的評價和觀點。接著，作者就國際政治的變遷情形做了觀察和檢驗，國際政治自冷戰結束後有了鉅幅轉變，雖然體系的本質依舊如昔，即由主權國家所組成的無政府狀態體系；但是體系內部已有了不同以往的發展和變革。舉例來說，全球化現象已經從經濟領域擴展到政治和文化等其它層面，並向傳統的國家主權及其權力提出挑戰。其它諸如民族分離運動、環境生態等問題也對冷戰後的國際政治造成衝擊，這些影響主要體現在：行為體之間高度的互賴性、行為體之間差異性的擴大，以及對國際法律規範的迫切需要。上述事實使得傳統現實主義以國家作為主體的國際政治體系正朝向一個近似中世紀主義的新政治體系在形成。在此體系中，國家將喪失其原本在體系中的優勢主導性地位，而國際法律規範的發展也將相應的有所提升及調整。 事實上，並非所有行為者的行為皆忠實反映現實主義關於國際法無用論的主張。學者布爾即就國際法律規範所具有的三項政治性功能來解釋國際政治與法律規範間的關係：一、幫助國家認同與瞭解在他們彼此間所形成的「社會」事實；二、在國家和其他行為者間定訂一套基本的互動規則；三、裨益國際社會的成員達成進一步的共識與承諾。結論指出，國際法律規範是國際政治中一項不可獲缺的部分，為了克服傳統現實主義及以結構理論為核心的現實主義在解釋上的不足，「國際社會」的概念必須被深入瞭解和應用在現實主義的理論建構中。同時，吾人應投入心力展開對全球性議題的研究，例如：人權與環保，因為在這些領域中，一項現實主義最為核心的思考—國家主權的獨立與完整，將會遭遇到越來越多的挑戰並使國家藉口主權作為脫逸國際法律規範的可能性大為減低。 / The characteristic feature of Realism is its use of the power concept to explain the course of international politics (especially the behavior of state). The primary unit of analysis is the State which is regarded as operating in an anarchical system dominated by conflict. However, both notions above are misunderstood not only by general students, but the partial of Realism itself as well. Although Realism aligns norms or law with power in so far as international law is considered a tool at the disposal of the most powerful. Yet international legal norms and power also frequently do interact actually. This thesis doesn’t mean to deny the value of Realism, instead, tries to modify and introspect its viewpoints. Starting at the issue of international order, there are several tasks having been done: what is the strategy for Realism to keep order in the society of states and how does it work? Then, if the way for keeping order in Realism wasn’t constructive or in vain, do we have other choices to retain the relationship among the states stable and peaceful? By way of finding out why the states created international law and what the sources of international law are, we can think that the making process of international legal norms and norms itself don’t possess one formal mechanism responsible for law creation like the domestic law, but there are recognized and accepted methods by which legal norms or rules came into existence, for example, the consent of states. In those methods the precise content of legal norms can be identified by states (or other actors). Despite, therefore, the realist perspective deems international law to have no significance in its own right but we still have to seek to ascertain why do the States obey international law sometimes, if not always, but at least. And make it clear to know what the appraisal and perception in different schools under the Realism Paradigm. As we have known the Realism is not a single theory but a research paradigm, the author investigated respectively the different schools of Realism; they are Classical Realism, Structural Realism (including Offensive and Defensive Realism), Neoclassical Realism and Realism in English School. As the content points out, people whose stereotype of Realism has been limited to power politics are used to thinking that international institutions (and regimes) or international law is incompatible with the Realism, usually. However, it’s not absolute for us to consider that Realism turns down international law necessarily. For one instance, Realism without using structural concept, like Classical Realism, takes the positive attitude toward the role and the functions of international legal norms. After realizing the Realism’s conception of order and what the flaw of its strategy (Balance of Power) to maintain order is, this thesis then mentioned about the reasons why international law is created, and how different school under the Realism Paradigm evaluates international law. Following up, the author inspected the change in international politics. In the post Cold War era, though the nature of international system is still like what it used to be, a Anarchical system, the different and new phenomena do really happen. Globalization, for instance, is one momentous challenge to the sovereignty of States and their political power. The rest like separatist movements, environmental problems are also influential to international politics. The central issues of those influences are the interdependence among actors, the dissimilarities among actors and the yearning for international legal norms. Under the perceptions like this, the traditional state-centric international system of Realism has been being toward a Neo-Medieval system. In that system, state actors will lose their predominant and leading stand. On the other hand, the development of international legal norms will adjust itself to the new world and become more important. In fact, the behavior of international actors does not seem to bear out the realist assumption of the impotence of international law. Bull, for example, explains the international law-international politics relationship in terms of three political functions fulfilled by international law: to identify the idea of a society of sovereign States, to state the interactive basic rules of coexistence among States and international actors, and to help mobilize compliance with the rules of international society. As the conclusion in this thesis pointed out, international legal norms is one part of international politics. In order to overcome the inadequacies of the traditional and structural realist interpretation, the concept of ‘International Society’ must be dealt and applied explicitly and deeply in constructing theory of Realism. Meanwhile, people should spend more time researching the global issues, such as human rights and environmental protection, because in these sectors, the most core of realist thinking, independence and integrity of sovereignty, will get into plight and encounter more and more challenges, and the possibility for the States to get rid of international legal norms in the name of sovereignty becomes less and less.

The purpose of this study was to develop and test a measuring instrument based on the Gibb’s Defensive Communication Climate Paradigm (1961) to assess the communication climate focus of professional nurses in selected public hospitals in the Gauteng province. This focus involves the communication behaviour orientation of the professional nurses and their perceptions of the communication behaviour orientation of their operational managers. The Gibb’s model comprises six bipolar conceptual continuums, namely Evaluation-Description, Control-Problem orientation, Strategy-Spontaneity, Neutrality-Empathy, Superiority-Equality and Certainty-Provisionalism Continuums. The study consisted of a non-experimental design, including a developmental phase and a testing phase. During the developmental phase the researcher developed a measuring instrument (a Semantic Differential Scale questionnaire); used a simple, random sample method to pre-test the instrument; analysed the data by applying Cronbach’s Alpha reliability analysis and refined the instrument. Further refinement of this new instrument by future researchers is recommended. During the testing phase the researcher also used a simple, random sample, consisting of professional nurses (N = 270) from three selected public hospitals in Gauteng; tested the items against the biographical data and the three research questions and analysed the obtained data by utilising both descriptive and inferential statistics. A Delphi panel of experts were involved in both phases of the study. The results of the study indicated that although the respondents had a predominantly supportive communication behaviour orientation, they were more focused on the communication behaviour of their operational managers than on their own. Furthermore, the results indicated no significant differences in the influencing factors: age, tenure (periods in hospital), gender, language and institution (public hospital), in terms of the six conceptual continuums. Significant differences were found only in the factor: unit/ward, indicating that the supportiveness of the communication behaviour of professional nurses could be dependent on their specific work environment. Guidelines aimed at the development of a supportive climate were drawn up for the National Department of Health, Gauteng Department of Health, public hospitals, operational managers and professional nurses. It is recommended that implementation of the newly developed guidelines be pivotal for public hospitals, to refocus their communication climates towards supportive communication. / Health Studies / D. Litt. et Phil. (Health Studies)

Le château ducal de Moulins, s’il a subi diverses destructions, comporte aujourd’hui encore des éléments qui méritent d’être étudiés de près, afin de restituer son état initial. On connaît d’après les sources écrites au moins deux grandes campagnes de construction, la première fut amorcée par le troisième duc de Bourbon, Louis II, à la toute fin du XIVe siècle. La tour maîtresse « Mal-Coiffée » étant datée par dendrochronologie vers 1399/1400. Un second chantier d’agrandissement et de réaménagements débute après 1488, commandité cette fois par le duc de Bourbon Pierre de Beaujeu et son épouse Anne de France, sœur de Charles VIII. Cet agrandissement se terminera au tout début du XVIe siècle avec la construction d’un portique d’architecture renaissante, très précoce en France. Cette thèse mêle l’histoire et l’histoire de l’art mais part surtout d’une réflexion archéologique des bâtiments subsistants. C’est en cumulant et en confrontant ces diverses approches que l’étude a pu être la plus complète. / During his history, the ducal castle of Moulins has been subject to several destructions and improvements. Despite this, it still contains elements that should be studied carefully in order to restore its original state. From written sources, one knows at least two major buildings campaigns. First one was initiated by the third duke of Bourbon, Louis II, in the late fourteenth century. The remaining main tower, known as “Mal-Coiffée” ("Untidy Top"), has been dated by dendrochronology around 1399/1400. A second campaign of expansion and redevelopment begins after 1488, commissioned by the Duke of Bourbon, Pierre de Beaujeu and his wife Anne de France, Charles VIII’s sister. This expansion will be completed in the early sixteenth century with the construction of a renaissance architecture portico, very early in France. This thesis combines both History and art history, starting from an archaeological reflection of the remaining buildings. The aim of this work is to combine and compare these different approaches in order to obtain the most comprehensive and exhaustive study of this forgotten site which play a key role in History.

Central Asia has been the focal point of intense geopolitical power struggle throughout history. At the dawn of the 21st century, Central Asia has undergone major changes as the European Union and the China-led Shanghai Co-operation Organization have emerged as two normative powers, both seeking to influence the patterns of security governance in the region. This study aims to delve deep into ‘the black boxes’ of the EU’s and China’s foreign policies toward five CA republics. It starts from the premise that the bulk of research on Eurasian politics tend to concentrate mostly on realist and traditional geopolitical doctrine, which seem to have failed to properly explain the normative and ideational transformations that have taken place in the region as a result of the presence of these two emerging normative agents. By interweaving both realist and constructivist theories of International Relations (IR) into a new all-encompassing analytical framework, termed “meta-geopolitics”, the thesis seeks to trace and examine how geopolitical as well as normative components of the EU and Chinese regional strategies have affected the contemporary power dynamics in the post-Soviet space. I argue that, in contrast to the geopolitical struggle during the 19th and 20th centuries, a clash of normative powers is brewing in the region between China, under the aegis of the SCO, and the EU. The research also concludes that China has relatively been in a better position in comparison to the EU to render its policies as feasible, effective and legitimate to the Central Asian states.

The thesis: "The Causes of Iraqi War: Why the US Administration decided to invade Iraq in 2003" focuses on explanation why the administration of the USA made that step. The specification of the roots of war is based on five causes and seventeen subcauses according to the essay of Stephen Van Evera and other scholars, and the paper trough the methodology of text's analyzes investigates behavior, decision-making process and motivations of the US administration (the level of units) and some steps of the US president G. W. Bush (individual level) in the process leading to the war in Iraq. Concerning the causes of war, the paper introduces different concepts of the offense-defense balance and analyzes whether the balance was disrupted. Secondly, it examines the role of cumulative resources in Iraq like oil, territory and state structures and it shows how they influenced the decision. Third, it searches for the linkage among an emergence of a new threat and responses to it which mouthed to the acceptance of the concept of the first move advantage. Fourth, the thesis accounts for the roots of misperception, where they originate and how they operated in perception of the US administration of the Iraqi threat. Finally, the investigation of the last root of conflict explains why and how windows of...