Everyday we come up with new solutions for our existing problems. But the solutions of today are tomorrow’s problem. The products we create as designers are often bringing more complexity in our society than it is initially intended for. This thesis aims to give a new perspective on the design practice community. Instead of starting with a problem-solving scope, this thesis intent is to find what is truly meaningful for human life, meaning finding, and to propose how we can envision new ways of meaning making within interaction design. The two processes together of meaning finding and meaning making is how we can aim for concrete results that are relevant for our society. To better understand what truly matters for human life, I collected 14 stories through ethnographic research. These ethnographic stories reveal the nature of human characteristics when people face and overcome big challenges in life. Some of these ethnographic stories highlights the life of a WWII survivor, war refugee, leukaemia child-patient and a widow. Parallel, to the ethnographic work, I explored how I can evoke a deeper connection between people, by making them listen to each-other’s heartbeat.  Inevitably, by exploring the fundamental elements of human life and observing the emotions and behaviour of my interviewees and participants, the thesis find itself often on the playground between philosophy and human life. But by taking a strong interaction design perspective, these insights were manifested in the human design manifesto booklet. This booklet proposes six expressions for designers, with the intention to embrace the fundamental elements of human life when we design:  1. Design attitudes, not solutions. 2. Design the medicine of the mind. 3. Design for relationships. 4. Design for our direct senses. 5. Design for the deep human connection. 6. Design the act of kindness  Later on, for the meaning making part: one statement from the Human Design Manifesto was selected to explore in depth: Design the act of kindness. For this expression project Hidden Figures was created. Hidden Figures is a design proposal which demonstrates that a design creation can be driven by the fundamental elements of human life. In this case proposing the act of kindness as a vision on how our society could be.  In overall, this master’s thesis demonstrates how our design proposals can embody and resonate well between the three levels of design philosophy, a designer’s vision and interaction design practice: How we, as designers, can use meaning-making and meaning-finding to create more relevant impact for our society. Last, I hope this work encourages other designers to think deeply about their own creations and its impact. And help designers reflect on why they create and how they could also alternatively practice design.

Ce mémoire propose une conception narrative du système de justice criminel. Pour ce faire, l’auteure mobilise la théorie narrative suivant laquelle le procès contradictoire est appréhendé comme un concours entre différentes histoires. Le caractère général de cette théorie confère à l’auteure l’espace nécessaire pour analyser et expliquer différents aspects du traitement judiciaire des faits, que ce soit la preuve judiciaire, le processus de détermination judiciaire des faits, l’intervention judiciaire en appel ou encore le droit qui encadre chacun de ces aspects. La notion d’« histoire » favorise l’adoption d’une perspective qui sort du cadre restreint du procès dans lequel la notion de « preuve » est enfermée. La théorie narrative permet ainsi à l’auteure d’expliquer et d’organiser en un tout unifié divers aspects du processus judiciaire comme l’enquête, le dépôt des accusations, la théorie de la cause, le contre-interrogatoire ou encore la façon dont les faits sont d’abord choisis et assemblés par les parties avant d’être administrés et traités au procès sous forme de « preuve ». Appliquée au procès, cette théorie implique une approche holistique de la preuve suivant laquelle la détermination judiciaire des faits est une évaluation de la vraisemblance relative des histoires en compétition. Cela remet en question la vision traditionnelle (ou rationaliste) atomiste de la preuve où les faits sont déterminés suite à une décision sur la véracité ou la fausseté de chacun des éléments de preuve. Le nouvel éclairage qu’apporte cette vision narrative du procès et ses diverses implications mènent l’auteure à remettre en question le bien-fondé de la vision traditionnelle voulant que le procès mène à une détermination judiciaire des faits qui soit exacte. Au terme de son illustration de la valeur heuristique de la théorie narrative, l’auteure revisite sous la perspective narrative les récentes études en matière d’erreurs judiciaires. Elle en conclut que le droit commande au juge d’atteindre une vérité hybride sur les faits, à michemin entre, d’une part, ce qui est survenu dans la réalité et, d’autre part, ce qui permet de conférer un maximum de cohérence aux éléments de preuves effectivement présentés au procès. / This master’s thesis proposes a narrative conceptualization of the criminal justice system. The author employs the narrative theory framework that conceives the adversarial trial as a contest between different stories. This comprehensive theory offers a lens through which the author analyzes and explains multiple aspects of the judicial processing of facts including evidence at trial, fact-finding, appellate review and the law governing these aspects. The concept of “story” allows a broader perspective than the concept of “evidence” which is limited to the trial. This umbrella theory is therefore used to explain, organize and provide a united understanding of various aspects of the judicial system, such as the investigatory process, the laying of charges, the theory of a case, the cross-examinations, as well as how facts are chosen and organized before being presented and processed at trial as “evidence”. At trial, the global perspective of the narrative theory challenges the traditional (or rationalist) atomist approach to evidence, which explains fact-finding as a decision based on the truthfulness or the falseness of each individual piece of evidence adduced at trial. The narrative perspective, rather, suggests a holistic approach – fact-finding is a decision regarding the relative plausibility between two competing stories. Thus, these insights from the narrative theory call into question the traditional assumption that trials lead to accurate findings of fact. After her demonstration of the heuristic value of the narrative theory, the author applies the narrative framework to recent studies on miscarriages of justice. She concludes that the law enables triers of fact to reach only a hybrid truth, halfway between what happened in reality and an assessment of the consistency between the evidence adduced at trial.

Transverse myelitis (TM) is a rare auto-immune inflammatory disease in which the patient’s immune system attacks their spinal cord resulting in an unpredictable degree of neurologic disability, ranging from complete recovery to quadriplegia. TM patients often experience insufficient assistance towards understanding causes of the illness and have little to depend on in trying to deal with it. This study explores psychological strengths and coping strategies used by TM patients in coping with the illness. A theoretical framework of positive psychology with a strong focus on seven constructs, namely positive coping, searching for meaning, benefit finding, hope, sense of humour, resilience, as well as religion and spirituality is presented. The main data collection strategy for this study was the gathering of stories as a form of conversation. These were subjected to thematic analysis by interpretative phenomenological analysis (IPA) focused on identifiable themes and patterns of living and behaviour. The emerging patterns and identified fortigenic qualities were then considered, analysed and argued in relation to corresponding coping strategies. A model for the psychological coping and well-being of TM patients, based on emphasising the positive and constructive and considering existing models and strategies for the well-being of patients, was developed. The strategic and therapeutic model is presented in easily understandable language for the benefit of any care-giver (e.g. family member, friend or nurse) or the patient him/herself. / Thesis (PhD)--University of Pretoria, 2013. / lk2013 / Psychology / unrestricted

(in English): The thesis focuses on the quality of life of carers of people with dementia being cared for at home. The theoretical section describes the concept of quality of life in general terms, but also considers carers accounts of their own personal experience. This section then outlines the various stages of dementia and how they impact the quality of life of caregivers. To complete the picture, this is followed by an assessment of care burden but also the various positive aspects arising from caring for dementia patients. By conducting semi-structured interviews, this work aims to investigate how excarers assess and value their experience of caring and whether, either while they were caring or retrospectively, they were aware of any positive aspects of caring for dementia patients and if so, specify what they were and if caregivers found personal meaning in their caregiving experience. Hence, the core area of interest is whether positive aspects of caregiving, finding meaning and cognitive restructuring could form the basis of a successful intervention, which may positively impact quality of life of current caregivers of dementia patients. While excarers mentioned numerous positive aspects associated with caregiving, some also referred to the meaning that they have found through caregiving....

This diploma thesis deals with problem of design and calculation of membrane structure of stadium roof. This is a complex engineering problem, which includes many partial problems: finding of initial form of membrane, statically and architecturally suitable arrangement of catenaries, economical solution of boundary conditions (foundations). All components affect each other and cannot be dealt without mutual coordination. It always greatly depends on the experience and intuition of engineer who design such structure. Task which cannot be resolved according to the theory of the first order. Equilibrium forces on the deformed structure, which in many projected structures gives satisfactory results, did not correspond to reality. It is therefore necessary to consider equilibrium of forces on the deformed structure according to the theory of large deformations. Diploma thesis was entered with regard to the intention of the companies Ing. Software Dlubal s.r.o. and FEM consulting s.r.o., working together to develop software RFEM. These companies plan to complement this program system with a module MEMBRANE for searching of initial shapes of membrane structures. This work is a contribution to the creation of this module.

Les microARN sont de petits ARN non codants d'environ 22 nucléotides impliqués dans la régulation de l'expression des gènes. Ils ciblent les régions complémentaires des molécules d'ARN messagers que ces gènes codent et ajustent leurs niveaux de traduction en protéines en fonction des besoins de la cellule. En s'attachant à leurs cibles par complémentarité partielle de leurs séquences, ces deux groupes de molécules d'ARN compétitionnent activement pour former des interactions régulatrices. Par conséquent, prédire quantitativement les concentrations d'équilibres des duplexes formés est une tâche qui doit prendre un compte plusieurs facteurs dont l'affinité pour l'hybridation, la capacité à catalyser la cible, la coopérativité et l'accessibilité de l'ARN cible. Dans le modèle que nous proposons, miRBooking 2.0, chaque interaction possible entre un microARN et un site sur un ARN cible pour former un duplexe est caractérisée par une réaction enzymatique. Une réaction de ce type opère en deux phases : une formation réversible d'un complexe enzyme-substrat, le duplexe microARN-ARN, suivie d'une conversion irréversible du substrat en produit, un ARN cible dégradé, et de la restitution l'enzyme qui pourra participer à une nouvelle réaction. Nous montrons que l'état stationnaire de ce système, qui peut comporter jusqu'à 10 millions d'équations en pratique, est unique et son jacobien possède un très petit nombre de valeurs non-nulles, permettant sa résolution efficace à l'aide d'un solveur linéaire épars. Cette solution nous permet de caractériser précisément ce mécanisme de régulation et d'étudier le rôle des microARN dans un contexte cellulaire donné. Les prédictions obtenues sur un modèle de cellule HeLa corrèlent significativement avec un ensemble de données obtenu expérimentalement et permettent d'expliquer remarquablement les effets de seuil d'expression des gènes. En utilisant ces prédictions comme condition initiale et une méthode d'intégration numérique, nous simulons en temps réel la réponse du système aux changements de conditions expérimentales. Nous appliquons ce modèle pour cibler des éléments impliqués dans la transition épithélio-mésenchymateuse (EMT), un mécanisme biologique permettant aux cellules d'acquérir une mobilité essentielle pour proliférer. En identifiant des éléments transcrits différentiellement entre les conditions épithéliale et mésenchymateuse, nous concevons des microARN synthétiques spécifiques pour interférer avec cette transition. Pour ce faire, nous proposons une méthode basée sur une recherche gloutonne parallèle pour rechercher efficacement l'espace de la séquence du microARN et présentons des résultats préliminaires sur des marqueurs connus de l'EMT. / MicroRNAs are small non-coding RNAs of approximately 22 nucleotide long involved in the regulation of gene expression. They target complementary regions to the RNA transcripts molecules that these genes encode and adjust the concentration according to the needs of the cell. As microRNAs and their RNA targets binds each other with imperfect complementarity, these two groups actively compete to form regulatory interactions. Consequently, attempting to quantitatively predict their equilibrium concentrations is a task that must take several factors into account, including the affinity for hybridization, the ability to catalyze the target, cooperation, and RNA accessibility. In the model we propose, miRBooking 2.0, each possible interaction between a microRNA and a binding site on a target RNA is characterized by an enzymatic reaction. A reaction of this type operates in two phases: a reversible formation of an enzyme-substrate complex, the microRNA-RNA duplex, and an irreversible conversion of the substrate in an RNA degradation product that restores the enzyme which can subsequently participate to other reactions. We show that the stationary state of this system, which can include up to 10 million equations in practice, has a very shallow Jacobian, allowing its efficient resolution using a sparse linear solver. This solution allows us to characterize precisely the mechanism of regulation and to study the role of microRNAs in a given cellular context. Predictions obtained on a HeLa S3 cell model correlate significantly with a set of experimental data obtained experimentally and can remarkably explain the expression threshold effects of genes. Using this solution as an initial condition and an explicit method of numerical integration, we simulate in real time the response of the system to changes of experimental conditions. We apply this model to target elements involved in the Epithelio-Mesenchymal Transition (EMT), an important mechanism of tumours proliferation. By identifying differentially expressed elements between the two conditions, we design synthetic microRNAs to interfere with the transition. To do so, we propose a method based on a parallel greedy best-first search to efficiently crawl the sequence space of the microRNA and present preliminary results on known EMT markers.

No description available.

Die Forschung zum Informationsverhalten in Archiven hat wiederholt gezeigt, dass der Zugang zu Archivbeständen durch einen grundlegenden Wissensmangel über die Informationsbedürfnisse von Archivnutzern eingeschränkt wird. Das Ziel der vorliegenden Studie ist die Vertiefung des empirischen Verständnisses der spezifischen Informationsbedürfnisse von Archivnutzern und damit die Leistung eines grundlegenden Beitrags zur Verbesserung von archivischen Informationssystemen. Dazu untersucht die primäre Forschungsfrage die Möglichkeit der Erarbeitung einer Ontologie, die in angemessener Weise das Erkenntnisinteresse von Nutzern an Archive repräsentiert, und auf formale Anfragen, adäquate Antworten erzeugt. Zu diesem Zweck analysiert die Studie schriftliche Nutzeranfragen an das Bundesarchiv und das Nationalarchiv von Norwegen (Arkivverket). Die primären Forschungsergebnisse umfassen einen methodischen Ansatz, der eine interpretative Analyse schriftlich formulierter Fragen an Archive vertritt und, als Ergebnis seiner erfolgreichen Anwendung, das Archival Knowledge Model (AKM) erarbeitet. Das AKM ist eine ontologische Repräsentation des Gegenstandbereichs, der typischerweise als das Erkenntnisinteresse von Fragen an Archiven erscheint. Die Studie zeigt, dass derartige Anfragen dominante, grundlegende ontologische Muster aufweisen, die auf einen relativ kleinen Satz ontologischer Entitäten formalisiert werden können. Das AKM repräsentiert damit formal und explizit die Informationsbedürfnisse von Archivnutzern in Form einer Ontologie. Diese stellt ein konstitutives Modell für die Evaluierung bestehender Archivinformationssysteme und Datenschemata zur Verfügung und kann die Entwicklung neuer Katalogisierungsregeln oder musterbasierter Abfrageanwendungen unterstützen. / Research on the information behaviour of archive users has repeatedly shown that access to archival knowledge bases such as via finding aids is hindered by a certain deficiency in knowledge about users and their information needs. The objective of this study is to increase our empirical understanding of the information needs of archive users in order to facilitate access to archival information systems. The primary research question explores the possibility of creating an ontology that can reasonably represent archival inquiries and their probable interpretations as formal queries to the model of the archival target world that would generate an adequate response. For this purpose, the study analyzes archival information needs as expressed in written natural language questions submitted to the German Federal Archives (Bundesarchiv) and the National Archives of Norway (Arkivverket). The primary results point to a methodological approach that advocates an interpretative analysis of written natural language inquiries and, as the result of its practical and successful application, the Archival Knowledge Model (AKM). This constitutes an ontological representation of the subject matter typically appearing as the interest of archival inquiries. The study thus shows that written natural language questions submitted to archives exhibit dominant fundamental ontological patterns, which can be formalized to a relatively small set of entities utilizing the CIDOC CRM and compatible extensions wherever its semantics are found to be inadequate. The AKM formally and explicitly represents the information needs of archive users in the form of an ontology, thus providing a constitutive model for the evaluation of existing archive information systems and data schemas and may inform the development of new cataloguing rules or pattern-based query applications.

Part 1: ‘True Receivers': Rilke and the Contemporary Poetics of Listening In this part of this thesis I argue that a contemporary ‘poetics of listening' has emerged in the UK, and explore the writing of three of our most significant poets - John Burnside, Kathleen Jamie and Don Paterson - to find out why they have become interested in the idea of the poet as a ‘listener'. I suggest that the appeal of this listening stance accounts for their engagement with the poetry of Rainer Maria Rilke, who thought of himself as a listening ‘receiver'; it is proposed that Rilke's notion of ‘receivership' and the way his poems relate to the earthly (or the ‘non-human') also account for the general ‘intensification' of interest in his work. An exploration of the shifting status of listening provides context for this study, and I pay particular attention to the way innovations in audio and communications technology influenced Rilke's late sequences the Duino Elegies and The Sonnets to Orpheus. A connection is made between Rilke's ‘listening poetics' and the ‘listening' stance of Ted Hughes and Edward Thomas; this establishes a ‘listening lineage' for the contemporary poets considered in the thesis. I also suggest that there are intriguing similarities between the ideas of listening that are emerging in contemporary poetics and Hélène Cixous' concept of ‘écriture féminine'. Exploring these similarities helps us to understand the implications of the stance of the poet-listener, which is a counter to the idea that as a writer you must ‘find your voice'. Finally, it is proposed that ‘a poetics of listening' would benefit from an enriched taxonomy. Part 2 of the thesis is a collection of my poems entitled ‘Small Weather'.

職司審判之法院，其職權係為「認定事實」與「適用法律」。就事實之認定，我國採取「自由心證原則」，亦即事實應如何透過證據證明、推論而得，授權由法官於個案中認定，然該原則中「自由」之意義，係具有其具體之內在內涵與外在限制，並非由法官恣意判斷。過去之實務與學說並未就此為深入之闡釋，迭生審級平行與垂直判決之歧異，及人民對法院判決之非議。從而根本之道，應係完整建構自由心證原則之實質意義，由運用之主體、客體、內在內涵、外在限制及其作用等面向，並提出其運用之模組，具體化此立法者規範之不確定法律概念，使運用該原則之法官，得以有依循及參考之路徑。 而自由心證原則內涵中，最常於訴訟中運用者，即為「間接證明」，因主要事實由直接證據直接證明乃少見之情狀，而由間接證據證明間接事實，進而依間接事實之推理作用，推論主要事實存否之情形，乃訴訟中之常態。然間接證明之內涵中，「間接事實之內容與數量」、「推理作用之內涵」、「間接事實間推理作用所得證明主要事實之射程」，皆係高度個案裁量運用之認定，然現今實務之運作，卻出現審級間運用內容及結果極為歧異之現象，從而應探究其內涵，並嘗試提出運用之模組，供運用之法官思考。 自由心證與間接證明作為具有高度實務操作性格之訴訟法原則，其運用之 良窳，已實際影響具體個案事實認定之問題。為改善及斧正目前實務運作上出現之認定歧異、迭經發回之問題，亟須透過以上之研究，提出訴訟中運用之方式，以及其於事實審間、事實審與法律審間運用之審查、互動關係，使該二抽象原則具有一定法安定性，而有一定運用之軌跡可循。 / The court, to act as trial institute, has its major authority to “determine the fact” as well as “apply the law”. As for the fact-finding, our country adopts “Free Evaluation of Evidence Principle”, which authorizes the judge to determine case by case how the fact is proved and inferred through the evidences. However, the meaning of “Free” in that principle is constructed with concrete inner connotation and outer restriction, and not decided by the willfulness of the judge. In the past, courts and scholars didn’t elaborate that principle in depth, which has given a rise to the discrepant verdicts between different courts and criticisms from the people. Consequently, the fundamental solution is to build the substantial connotation of free evaluation of evidence principle, by means of the observations of its operating subject, object, inner connotation, outer restriction and function as well as its operating model, and to reify this uncertain concept of law regulated by legislator, so as to find a way to follow and refer to by the judge. The most commonly-adopted content of free evaluation of evidence principle is “Indirect Proof ”. Owing to proving the direct fact through direct evidence is rarely seen in lawsuit, the application of proving indirect fact by indirect evidence, and then inferring the existence of direct fact through the inferring function of indirect fact, is much common in each case. Nevertheless, in the meaning of Indirect Proof, the “content and amount of indirect fact”, “content of inferring function” and “scope which the direct fact could be inferred from the direct fact” are determined by large-scale discretion of the judge case by case. As a result of the discretion, the circumstances of divergent operating contents and consequences are emerged. Therefore, the connotation of that principle should be analyzed and the operating models are tried to addressed, hoping to provide for the judge to take into account. “Free Evaluation of Evidence Principle” and “Indirect Proof”, which are conducted as civil procedural principle in a highly individually case-operating nature, substantially influence the fact-finding in specific lawsuit with its odds and ends of operation. In order to improve and correct the discrepant fact-finding and constantly-verdict-reversing problems appearing in the courts at present, it is necessary to bring up the ways to operate the two principles as well as the reviewing and interacting relationships between trial courts and trial court and trial of law, and to establish specific legal certainty, legal steability and operation standards.