Les fonctionnelles de la densité couramment utilisées ont rencontrées un succès spectaculaire dans la modélisation des systèmes physiques, chimiques, et biologiques. Toutefois, elles se sont avérées inadaptées pour décrire certaines situations, comme par exemple les forces de dispersion de London ou les phénomènes de corrélation forte. Dans le cadre de cette thèse, nous nous sommes intéressés à des développements récents de la formulation de l’énergie de corrélation exprimée à partir du théorème de fluctuation-dissipation et connexion adiabatique, visant à pallier ces problèmes. En particulier, différentes implémentations des méthodes au-delà de l’approximation de la phase aléatoire, qui permettent la prise en compte de la contribution d’échange dans le calcul de l’énergie de corrélation, ont été comparées. Ensuite, afin de réduire drastiquement la complexité numérique, une procédure d’orthogonalisation des vecteurs utilisées pour représenter la matrice diélectrique a été développée. Ces méthodes ont ensuite été appliquées au calcul de l’énergie de liaison de petits complexes moléculaires. La formulation de l’énergie de corrélation de la théorie de perturbation de Møller-Plesset dans le contexte matrice diélectrique est aussi présentée et testée. En parallèle, des calculs utilisant les méthodes semi-empiriques numériquement efficaces ont été conduits sur trois ensembles de molécules afin d’en tester les performances concernant les énergies de liaisons en les comparant aux valeurs de références disponibles dans la littérature / Commonly used density functionals have encountered a spectacular success in the modelling of physical, chemical or biological systems. However, they have proven to be unsuitable to describe some situations, such as London’s dispersion forces or strong correlation behaviour. In this thesis, we have been interested in recent developments in the formulation of the correlation energy from the adiabatic connection fluctuation dissipation theorem, to overcome these problems. In particular, different implementations of methods beyond the random phase approximation, which allow to take into account the exchange contribution in the computation of the correlation energy, have been compared. Then, in order to drastically decrease the numerical complexity, an orthogonalization procedure of the vectors used to represent the dielectric matrix has been developed. Then these approaches were applied to the calculation of the binding energy of small molecular complexes. The formulation of the correlation energy of the Møller-Plesset perturbation theory within the dielectric matrix context is also presented and tested. In parallel, calculations using numerically efficient semi-empirical methods were conducted over three molecular sets in order to test their performances regarding the binding energies by comparing them to reference values available in the literature

A estabilidade genômica é condição essencial à sobrevivência e ao funcionamento dos organismos vivos. No entanto, várias situações podem provocar danos no DNA. Por exemplo, cerca de 104 lesões podem ocorrer no material genético de uma célula de mamífero a cada dia. No intuito de preservar a integridade genômica e contornar os efeitos deletérios destas modificações, uma maquinaria constituída de proteínas especializadas em reconhecer e reparar estes danos foi selecionada ao longo do curso evolutivo. Defeitos em proteínas destas maquinarias causam instabilidade genômica e pode resultar em elevada taxa de mutações e quebras do DNA que resultam em eventos de amplificação gênica, como em células cancerosas. De uma maneira aparentemente contrária ao requerimento de estabilidade genômica como condição primordial para a perpetuação da vida, Leishmania apresenta um genoma notavelmente maleável e explora a amplificação gênica como recurso de sobrevivência. Ainda que a plasticidade genômica em Leishmania seja facilmente demonstrada, nós não conhecemos os mecanismos precisos pelos quais este parasita coordena a ação da maquinaria de detecção de danos no DNA e a consumação dos eventos de amplificação gênica. No intuito de contribuir para a compreensão deste processo, nós identificamos proteínas homólogas do complexo 9-1-1 (Rad9-Hus1-Rad1) em Leishmania major. As proteínas LmHus1 e LmRad9 apresentam marcada divergência estrutural em relação aos seus homólogos em outros eucariotos e nenhuma proteína obviamente homóloga a Rad1 foi identificada neste parasita. Análises filogenéticas indicam que LmHus1 e LmRad9 são relacionadas ao complexos heterotriméricos envolvidos na detecção de danos no DNA. Em acordo com isso, nossos experimentos demonstram que alteração nos níveis destas proteínas interfere na capacidade do parasita em lidar com estresse genotóxico. LmHus1 localiza-se no núcleo, é requerida para o crescimento normal deste parasita e a diminuição de sua expressão compromete mecanismos de controle de ciclo celular e manutenção de telômeros. LmRad9 também localiza-se no núcleo e sua superexpressão causa defeito de crescimento e de resposta ao estresse genotóxico em L. major. Nós observamos que LmHus1 e LmRad9 formam um complexo responsivo ao dano no DNA in vivo, uma forte indicação de que o complexo 9-1-1 tenha sido conservado em L. major. As peculiaridades estruturais destas proteínas sugerem que o complexo 9-1-1 de L. major possua uma arquitetura distinta em comparação aos eucariotos superiores. Em adição a isto, outras proteínas, tais como a LmRpa1, também apresentam uma marcante divergência estrutural. Isso sugere que a via de sinalização de danos no DNA envolvendo o complexo 9-1-1 e Rpa1 de L. major possua mecanismos peculiares de ação. Estas observações podem permitir entender como ocorreu o processo evolutivo da sinalização mediada pelo complexo 9-1-1 nos eucariotos, além de ajudar para o entendimento das bases moleculares de como este parasito conduz os eventos de amplificação gênica. / Genome stability is a essential condition for survival and proper functioning of living organisms. However, a broad range of elements may lead to DNA damage. For instance, about 104 DNA lesions may be inflicted upon any given mammalian cell everyday. In order to maintain the genome integrity and circumvent the deleterious effects of these lesions, a molecular machinery composed of proteins specialized in detecting and repairing DNA damage has been selected in evolution. Defects of the proteins that constitute such machineries may result not only in a high mutation rate, but also in breaks in the DNA structure that can mediate gene amplification as observed in cancer cells. In an apparent opposition to such requirement for stability as an essential condition to life, the protozoan Leishmania presents a highly malleable genome and explores genome amplification as a survival and adaptation tool. Despite of the fact that the Leishmania genome plasticity can be easily demonstrated, the precise mechanisms that coordinate the molecular machineries involved in the detection and signaling of DNA damage, and in the regulation of gene amplification is still largely unknown. In order to contribute to a better understanding of these processes, we identified and studied the Leishmania major proteins that are homologues of those proteins that compose the 9-1-1 complex (Rad9-Hus1-Rad1). The proteins LmHus1 and LmRad9 present a high structural divergence when compared to its homologues from other eukaryotes and no obvious homologue of Rad1 was identified in the parasite genome. Phylogeny analysis indicated that LmHus1 and LmRad9 are closely related to heterotrimeric complexes involved in the detection of DNA damage. In accordance to that, our experiments demonstrated that altered levels of these proteins interfere with the parasite ability to deal with genotoxic stress. Moreover, LmHus1 was localized to the parasite nucleus and is a required protein for normal parasite proliferation. Besides, we showed that decreased levels of LmHus1 compromise cell cycle regulation and the maintenance of telomeres. LmRad9 was also shown to be localized to the cell nucleus and its overexpression led to growth defects and affected the L. major response to genotoxic stress. We also observed that LmHus1 and LmRad9 interact with each other to for a protein complex that is responsive to DNA damage in vivo, which strongly suggested that the 9-1-1 complex was conserved in L. major. The structural peculiarities of these proteins indicate that the possible L. major 9-1-1 complex has a different architecture when compared to the complex found in higher eukaryotes. In addition to that, other proteins, such as LmRpa1, also present a marked structural divergence. Altogether, these findings suggest that the DNA damage signaling pathway involving the 9-1-1 complex and LmRpa1 in L. major, may present a peculiar mode of action. These observations may contribute to a better understanding not only of the evolution of the signaling pathway mediated by the 9-1-1 complex in eukaryotes, but also of the molecular basis of the genome plasticity and the gene amplification phenomenon.

No description available.

No description available.

A estabilidade genômica é condição essencial à sobrevivência e ao funcionamento dos organismos vivos. No entanto, várias situações podem provocar danos no DNA. Por exemplo, cerca de 104 lesões podem ocorrer no material genético de uma célula de mamífero a cada dia. No intuito de preservar a integridade genômica e contornar os efeitos deletérios destas modificações, uma maquinaria constituída de proteínas especializadas em reconhecer e reparar estes danos foi selecionada ao longo do curso evolutivo. Defeitos em proteínas destas maquinarias causam instabilidade genômica e pode resultar em elevada taxa de mutações e quebras do DNA que resultam em eventos de amplificação gênica, como em células cancerosas. De uma maneira aparentemente contrária ao requerimento de estabilidade genômica como condição primordial para a perpetuação da vida, Leishmania apresenta um genoma notavelmente maleável e explora a amplificação gênica como recurso de sobrevivência. Ainda que a plasticidade genômica em Leishmania seja facilmente demonstrada, nós não conhecemos os mecanismos precisos pelos quais este parasita coordena a ação da maquinaria de detecção de danos no DNA e a consumação dos eventos de amplificação gênica. No intuito de contribuir para a compreensão deste processo, nós identificamos proteínas homólogas do complexo 9-1-1 (Rad9-Hus1-Rad1) em Leishmania major. As proteínas LmHus1 e LmRad9 apresentam marcada divergência estrutural em relação aos seus homólogos em outros eucariotos e nenhuma proteína obviamente homóloga a Rad1 foi identificada neste parasita. Análises filogenéticas indicam que LmHus1 e LmRad9 são relacionadas ao complexos heterotriméricos envolvidos na detecção de danos no DNA. Em acordo com isso, nossos experimentos demonstram que alteração nos níveis destas proteínas interfere na capacidade do parasita em lidar com estresse genotóxico. LmHus1 localiza-se no núcleo, é requerida para o crescimento normal deste parasita e a diminuição de sua expressão compromete mecanismos de controle de ciclo celular e manutenção de telômeros. LmRad9 também localiza-se no núcleo e sua superexpressão causa defeito de crescimento e de resposta ao estresse genotóxico em L. major. Nós observamos que LmHus1 e LmRad9 formam um complexo responsivo ao dano no DNA in vivo, uma forte indicação de que o complexo 9-1-1 tenha sido conservado em L. major. As peculiaridades estruturais destas proteínas sugerem que o complexo 9-1-1 de L. major possua uma arquitetura distinta em comparação aos eucariotos superiores. Em adição a isto, outras proteínas, tais como a LmRpa1, também apresentam uma marcante divergência estrutural. Isso sugere que a via de sinalização de danos no DNA envolvendo o complexo 9-1-1 e Rpa1 de L. major possua mecanismos peculiares de ação. Estas observações podem permitir entender como ocorreu o processo evolutivo da sinalização mediada pelo complexo 9-1-1 nos eucariotos, além de ajudar para o entendimento das bases moleculares de como este parasito conduz os eventos de amplificação gênica. / Genome stability is a essential condition for survival and proper functioning of living organisms. However, a broad range of elements may lead to DNA damage. For instance, about 104 DNA lesions may be inflicted upon any given mammalian cell everyday. In order to maintain the genome integrity and circumvent the deleterious effects of these lesions, a molecular machinery composed of proteins specialized in detecting and repairing DNA damage has been selected in evolution. Defects of the proteins that constitute such machineries may result not only in a high mutation rate, but also in breaks in the DNA structure that can mediate gene amplification as observed in cancer cells. In an apparent opposition to such requirement for stability as an essential condition to life, the protozoan Leishmania presents a highly malleable genome and explores genome amplification as a survival and adaptation tool. Despite of the fact that the Leishmania genome plasticity can be easily demonstrated, the precise mechanisms that coordinate the molecular machineries involved in the detection and signaling of DNA damage, and in the regulation of gene amplification is still largely unknown. In order to contribute to a better understanding of these processes, we identified and studied the Leishmania major proteins that are homologues of those proteins that compose the 9-1-1 complex (Rad9-Hus1-Rad1). The proteins LmHus1 and LmRad9 present a high structural divergence when compared to its homologues from other eukaryotes and no obvious homologue of Rad1 was identified in the parasite genome. Phylogeny analysis indicated that LmHus1 and LmRad9 are closely related to heterotrimeric complexes involved in the detection of DNA damage. In accordance to that, our experiments demonstrated that altered levels of these proteins interfere with the parasite ability to deal with genotoxic stress. Moreover, LmHus1 was localized to the parasite nucleus and is a required protein for normal parasite proliferation. Besides, we showed that decreased levels of LmHus1 compromise cell cycle regulation and the maintenance of telomeres. LmRad9 was also shown to be localized to the cell nucleus and its overexpression led to growth defects and affected the L. major response to genotoxic stress. We also observed that LmHus1 and LmRad9 interact with each other to for a protein complex that is responsive to DNA damage in vivo, which strongly suggested that the 9-1-1 complex was conserved in L. major. The structural peculiarities of these proteins indicate that the possible L. major 9-1-1 complex has a different architecture when compared to the complex found in higher eukaryotes. In addition to that, other proteins, such as LmRpa1, also present a marked structural divergence. Altogether, these findings suggest that the DNA damage signaling pathway involving the 9-1-1 complex and LmRpa1 in L. major, may present a peculiar mode of action. These observations may contribute to a better understanding not only of the evolution of the signaling pathway mediated by the 9-1-1 complex in eukaryotes, but also of the molecular basis of the genome plasticity and the gene amplification phenomenon.

Syfte: Den rådande digitaliseringen av samhällsbyggandet leder till möjlighet att automatisera och effektivisera processer inom samhällsbyggandet. Att automatisera delar av bygglovsprocessen med hjälp av Robotic Process Automation (RPA) är möjligt. En sådan implementering skulle kunna leda till effektivare processer, men kanske även andra effekter, negativa som positiva. Några av Sveriges kommuner har redan implementerat RPA i bygglovsprocessen och andra står i begrepp att göra det inom kort. Därför är det av hög relevans att utreda hur mycket RPA kan effektivisera bygglovsprocessen samt undersöka hur automatisering påverkar arbetet för personal på bygglovsenheter. Syftet med denna studie är, därför, att undersöka i vilken utsträckning bygglovsprocessen kan effektiviseras med hjälp av RPA. Vidare önskar studien utreda hur en sådan implementering kan påverka arbetsuppgifter och arbetstillfällen för bygglovshandläggare och administratörer på bygglovsenheter i Sverige. Metod: Denna studie utförs som en survey. För att uppnå studiens syfte och mål har två olika datainsamlingstekniker valts, där primärdata insamlas genom intervjuer och sekundärdata via en dokumentstudie. Studien är således i huvudsak av kvalitativ karaktär, men kompletteras med kvantitativ empiri för att kunna styrka slutsatser. Resultat: I rapporten framkommer det att bygglovsprocessen effektiviseras med hjälp av RPA. Genom att automatisera moment i processen, beräknas 141,5 timmar/månad sparas in på tidigare manuellt utförda arbeten. Tiden som sparas in läggs istället på uppgifter som anses relevanta och mer kunskapskrävande. Detta i sin tur leder till en förändring av arbetsuppgifter för de anställda på bygglovsenheten och lyfts som en positiv aspekt. Vidare visar studien att bygglovshandläggares arbetstillfällen inte har påverkats på grund av RPA samt ger inga anvisningar på att deras arbeten i framtiden kommer hotas. De som påverkas mest av implementeringen är administratörer, då det främst är administrativa uppgifter som kan ersättas av RPA. Studien ger en viss indikation på att administrativa tjänster och behovet av administratörer på bygglovsenheter kan komma att minska, som en följd av automatisering. Konsekvenser: Genom att implementera RPA i bygglovsprocessen uppnås inte bara en effektivisering av processen. Andra fördelar som nöjdare medarbetare och högre kvalitét på besluten är också effekter av automatisering. Nöjdare medarbetare kan, i förlängningen, leda till färre antal uppsägningar och följaktligen en förhöjd kompetensnivå på bygglovsenheten. Högre kvalitét på beslut leder till ett ökat förtroende för bygglovsenheter i Sverige. Vidare kan även RPA bidra till en mer enhetlig bygglovsprocess kommuner emellan, då uppsatta funktioner och regler, samt information kan delges mellan kommunerna. Begränsningar: Då studien utförts som ett examensarbete har begräsningar funnits i form av antal ord som studien får omfatta. Utöver det har studien undersökt tre av Sveriges kommuner som arbetat med RPA i minst ett år. Om fler kommuner undersökts, skulle studiens validitet kunnat öka. / Purpose: The current digitalization of community building leads to the opportunity to automate and streamline processes in community building. Automating parts of the building permit process using Robotic Process Automation (RPA) is possible. Such implementation could lead to more efficient processes, but perhaps also other effects, negative and positive. Some of Sweden's municipalities have already implemented RPA in the building permit process and others are about to do so shortly. Therefore, it is of high relevance to investigate how much RPA can make the building permit process more efficient and investigate how automation affects the amount of work for employees at building permit units. The purpose of this study is to investigate the extent to which the building permit process can be streamlined with the help of RPA. Furthermore, the study wishes to investigate how such an implementation can affect the tasks and jobs of caseworkers and administrators at building permit units in Sweden. Method: This study is carried out as a survey. In order to achieve the purpose and objectives of the study, two different data collection techniques have been selected, where primary data is collected through interviews and secondary data via a document study. The study is thus mainly of a qualitative nature but is supplemented with quantitative empirical evidence in order to substantiate conclusions. Findings: The report shows that the building permit process is made more efficient with the help of RPA. By automating steps in the process, it is estimated that 141.5 hours/month is saved on previously manually performed work. The time saved is instead mainly spent on tasks that are considered relevant and more knowledge-intensive. This in turn leads to a change in tasks for the employees at the building permit unit, and is highlighted as a positive aspect. Furthermore, the study shows that jobs of building permit caseworkers have not been affected due to RPA and does not provide any indications that their work will be threatened in the future. Those most affected by the implementation are administrators, as it is mainly administrative tasks that can be replaced by RPA. The study provides some indication that administrative services and the need for administrators in building permit units may decrease, as a result of automation. Implications: By implementing RPA in the building permit process, not only is the process streamlined. Other benefits such as more satisfied employees and higher quality of decisions are also effects of automation. Satisfied employees can lead to fewer redundancies and consequently an increased level of competence at the building permit unit in the long run. Higher quality of decisions leads to increased trust in building permit units in Sweden. Furthermore, RPA can also contribute to a more unitary building permit process between municipalities, as established functions and rules, as well as information can be shared between the municipalities. Limitations: Since the study was carried out as a bachelor thesis, there were restrictions of the number of words that the study may include. In addition, the study examined three of Sweden's municipalities that worked with RPA for at least one year. If more municipalities were examined, the validity of the study could increase.

Denna studie undersöker utvecklingen av digitala tjänster och integrationen av innovativ teknik hos försäkringsförmedlingsföretaget Portfolio Försäkra. Under de inledande diskussionerna med VD, Andreas Adolfsson, noterades att företaget hade vissa luckor i sitt digitala tjänsteutbud och saknade användning av innovativ teknik. Bristerna är inte unika för Portfolio Försäkra utan potentiellt förekommande inom hela försäkringssektorn, vilket innebär en stor inverkan på marknadens konkurrens.  I dagens digitala era är expertis inom teknik och innovativa metoder avgörande för försäkringssektorns framgång. Förbättrad digital tjänsteinnovation är nödvändig för att kunderna ska kunna använda information mer effektivt, vilket i slutändan leder till ökad kundlojalitet och kundnöjdhet. Därför är behovet av att förbättra de digitala tjänsterna inom försäkringssektorn absolut nödvändigt.  Syftet med denna undersökning är att fördjupa oss i de digitala möjligheter som finns tillgängliga för Portfolio Försäkra och andra försäkringsbolag som för närvarande saknar de senaste tekniska lösningarna. Vi antar rollen som forskare, genomför intervjuer och kommunicerar med anställda på Portfolio Försäkra. Vår dataanalys och våra intervjuer kommer att hjälpa oss att identifiera problemområden som kan hindra företagets utveckling och kundnöjdhet.  Resultaten tyder på att integrationen av innovation och digital teknik måste bli en integrerad del av Portfolio Försäkra företagskultur för att säkerställa en hållbar och långsiktig tillväxt. Resultaten av denna studie erbjuder värdefulla insikter för andra organisationer inom försäkringssektorn som vill förbättra sina digitaltjänsteinnovation och kundnöjdhet. / This study explores the digital service development and innovative technology integration of Portfolio Försäkra, an insurance brokerage firm. During the initial discussions with the CEO, Andreas Adolfsson, it was noted that the company faced gaps in its digital service offerings and lacked the adoption of innovative technologies. The observed shortcomings are not unique to Portfolio Försäkra but potentially prevalent across the insurance sector, signifying a major impact on market competition.  In today's digital age, expertise in technology and innovative practices is crucial to the success of the insurance sector. Improved digital service innovation is essential for the customers to utilize information more efficiently, ultimately leading to increased customer loyalty and satisfaction. Therefore, the need for digital service improvement in the insurance sector is imperative.  The aim of this research is to delve deeper into the digital opportunities available to Portfolio Försäkra and other insurance companies that currently lack the necessary technological advancements. We adopt the role of researcher, conducting interviews and communicating with Portfolio Försäkra's employees. Our data analysis and interviews will help identify problematic areas that could hinder the company's development and customer satisfaction.  The findings suggest that the integration of innovation and digital technology must become an integral part of Portfolio Försäkra's company culture to ensure sustainable and long-term growth. The results of this study offer valuable insights for other organizations in the insurance sector seeking to enhance their digital service offerings and customer satisfaction.

[pt] A Automação Robótica de Processos (RPA) surge como uma nova tecnologia advinda da indústria 4.0, focada na automação de tarefas humanas repetitivas, rotineiras e baseadas em regras. Ela promete eliminar esses processos que consomem mais tempo, sem substituir os sistemas de TI existentes. Consequentemente, reduziria custos e riscos operacionais; e melhoraria a eficiência, os processos internos e a experiência do cliente. Além disso, a RPA tem o potencial de revolucionar a auditoria tradicional, pois minimizaria as atividades tenocráticas, que apresentam baixo valor agregado, e permitiria que os auditores se concentrassem mais em atividades que exijam raciocínio analítico e julgamento profissional. Assim, levaria à ampliação da cobertura dos testes e do monitoramento de transações, aumentando a performance e a qualidade da auditoria contínua. Devido ao exposto, a RPA está sendo vista como um ativo estratégico para enfrentar os desafios da transformação digital. Por ser uma nova tendência, a literatura científica sobre o tema ainda é escassa, mas está crescendo rapidamente. E, nos últimos dois anos, foi amplamente adotada em muitas organizações e instituições financeiras com sucessos e fracassos. Portanto, considerando o modelo das três linhas de defesa, este estudo tem como objetivo propor um framework para implantação da RPA na auditoria interna de bancos brasileiros. / [en] Robotic Process Automation (RPA) emerges as a new 4.0 industry technology focused on the automation of repetitive, routine, rule-based human tasks. It promises to eliminate the most time-consuming processes without replacing existing IT systems. Consequently, reducing costs and operational risks as it improves efficiency, internal processes, and customer experience. Moreover, it has the potential to disrupt the traditional audit model as it minimizes mechanical low added value activities, enabling auditors to concentrate more on assignments that require thinking skills and professional judgment. Thus, it would lead to the expansion of testing and monitoring analytics coverage, enriching continuous audit quality and performance. Due to the above, RPA is being seen as a strategic asset to face the challenges of digital transformation. Since it is a new trend, there is limited literature on the subject, but growing fast. And, in the last couple of years, it has been widely adopted in many industries and financial organizations with successes and failures. Therefore, considering the three lines of defense model, this paper aims to propose an RPA framework for internal audit in Brazilian banks.

Bakgrund: Robotprocessautomation (RPA) är en automationsteknik som kan ersätta människors arbete i IT-system. RPA växer konstant och det finns förhoppningar om att den kan bidra med positiva effekter inom hälso- och sjukvård, bland annat genom att frigöra medarbetare till andra uppgifter och öka kvalitet i form av minskade fel. Det finns behov av fler konkreta exempel av RPA inom hälso- och sjukvården. Syfte: Studiens syfte var att undersöka effekter av RPA i en sjukhusmiljö, avseende: 1) kvalitet i form av minskade fel; 2) effektivitet i form av frigjord tid för medarbetare. Metod: En experimentell design användes med kvantitativ ansats, för att undersöka två fall på ett sjukhus: 1) RPA för att minska mänskliga fel i journalsystemets läkemedelslista. Antal och andel fel som korrigerades av RPA mättes. 2) RPA för att frigöra tid för medicinska sekreterare inom en arbetsprocess. Tidsåtgång att utföra den aktuella uppgiften mättes (14 mätningar fördelat på 4 sekreterare). Antal och andel fall som hanterades av RPA mättes. Ackumulerad besparad arbetstid för organisationen mättes, tillsammans med besparad heltidsekvivalent (HTE). Resultat: 1) RPA korrigerade mänskliga misstag i 68 % av fallen (n = 3179). 2) Den manuella processen tog 27 (24,5–30,5) sekunder att utföra (median och interkvartilavstånd). Under åtta månader hanterades 9956 fall av RPA, vilket innebar frigjord tid om 9,33 (8,47–10,54) arbetstimmar i månaden inom organisationen, motsvarande 5,3 (4,8–6,0) procent av en heltidstjänst. Slutsats: Studien visade på två fall som uppnådde önskade effekter, ett fall inom kvalitet och ett inom effektivitet. Fallen utgjorde även exempel på komplicerande faktorer, som att RPA endast är temporär lösning, samt komplexitet med att delad arbetsyta mellan människa och RPA. Resultatet kan inspirera andra organisationer samt bidra till en aggregerad kunskap för att skapa riktlinjer och standarder. / Background: Robotic Process Automation (RPA) is an automation technology that can replace human work in IT systems. RPA is a growing field, and there are hopes that it can contribute positive effects in healthcare, particularly by freeing up employees for other tasks and increasing quality by reducing errors. There is a need for more examples of RPA in healthcare. Objective: The aim of this study was to investigate the effects of RPA in a hospital environment, specifically regarding: 1) quality in terms of reduced errors, and 2) efficiency in terms of freed-up time for employees. Method: An experimental design with a quantitative approach was used to examine two cases in a hospital: 1) RPA to reduce human errors in the medication list of the electronic health record system. The number and percentage of errors corrected by RPA were measured. 2) RPA to free up time for medical secretaries in a specific workflow. The time required to complete the manual task was measured through 14 measurements involving 4 secretaries. The number and percentage of cases handled by RPA were measured. Accumulated saved working time for the organization was measured, along with the saved Full-Time Equivalent (FTE). Results: 1) RPA corrected human errors in 68% of cases (n=3179). 2) The manual process took 27 (24.5-30.5) seconds to complete (median and interquartile range). During eight months, RPA handled 9956 cases, resulting in a time savings of 9.33 (8.47-10.54) work hours per month within the organization, equivalent to 5.3 (4.8-6.0) percent of a full-time position. Conclusion: The study demonstrated two cases that achieved desired effects, one in terms of quality and one in terms of efficiency. The cases also presented complicating factors, such as RPA being a temporary solution and the complexity of shared workspace between humans and RPA. The results can inspire other organizations and contribute to aggregated knowledge for creating guidelines and standards.

Ce travail de thèse est surtout consacré à l'étude du ferromagnétisme dans les systèmes désordonnés, en particulier les semiconducteurs magnétiques dilués (DMS). Le formalisme utilisé, basé sur les fonctions de Green à température finie, est très général pour l'étude du magnétisme et du transport dans ces systèmes. Dans un premier temps, il est montré que l'approche champ moyen - RKKY (MF-RKKY) souvent utilisée n'est pas appropriée pour décrire les propriétés magnétiques des systèmes dilués. Un meilleur traitement du Hamiltonien de Heisenberg RKKY dans le cadre de la théorie RPA locale auto cohérente (SC-LRPA) a permis de montrer en particulier que l'approche MF-RKKY surestime largement les températures critiques ainsi que l'étendue de la zone de stabilité du ferromagnétisme. Dans un second temps on étudie le modèle non perturbatif « V-Jpd » par diagonalisation exacte pour chaque configuration de désordre et on calcule explicitement les échanges magnétiques. En dehors de la limite perturbative, ces échanges n'ont pas le caractère RKKY. Ensuite, le Hamiltonien de Heisenberg effectif est traité dans le cadre de la théorie SC-LRPA. Cette approche en 2 étapes montre en particulier (i) l'importance du désordre et des fluctuations thermiques et transverses et (ii) que le potentiel coulombien V joue un rôle crucial pour comprendre l'origine du ferromagnétisme dans les DMS. Ce modèle minimal tient compte de la percolation et des diffusions multiples des porteurs itinérants sur les impuretés et permet d'unifier la description des DMS. Enfin, une étude numérique des effets de taille finie et de l'importance de l'échantillonnage statistique a permis de montrer les insuffisances sévères du traitement Monté Carlo « complet » du modèle dilué « V-Jpd ». Ce modèle microscopique permet de combler le fossé entre les approches modèles trop simplistes et celles basées sur les calculs ab initio.