Cette thèse présente les travaux menés sur l’analyse et la modélisation de l’hétérogénéité tumorale lors de résistance aux traitements. Nous présentons ici un modèle EDP, dépendant de chaque patient, et prenant en compte deux types de traitements différents. Il reproduit qualitativement et quantitativement les différentes étapes de la croissance d’une tumeur soumise à ces traitements. Afin de pallier une instabilité numérique liée à ce type de modélisation, un nouveau schéma numérique est construit : le twin-WENO5.Nous développons ensuite une méthode de synthèse d’images scanners de sorte à rendre meilleure la comparaison entre les résultats numériques et les données cliniques. Enfin un critère robuste permettant de quantifier l’hétérogénéité à la fois des images cliniques et des images de synthèse, est construit. / This thesis deals with tumor heterogeneity analysis and modeling during treatments resistances. A patient-dependent PDEs model, that takes into account two kinds of treatments, is presented. It qualitatively and quantitatively reproduces the different stage during the tumor growth undergoing treatments. In order to overcome a numerical instability linked to the type of modeling, a new numerical scheme is built : the twin-WENO5. Then,an image synthesis method is developed to enable a better comparison between the numerical results and the clinical data. Finally, a robust criteria that quantifies the tumor heterogeneity from the clinical data and from the synthesis images, is built.

Cette recherche s’intéresse aux mouvements de contestation à l’égard du système marchand et de ses dispositifs, ayant pour mobile les préoccupations sociales et environnementales. Ce travail vise à rendre compte de l’existence du phénomène de la résistance socialement responsable (RSR) à la consommation et de son intérêt, compte tenu de sa singularité et des enjeux managériaux qu’il implique. A travers une approche netnographique non participante mobilisant une méthode interprétativiste d’analyse des données, la recherche repose sur l’étude de trois communautés distinctes et représentatives du phénomène étudié, débouchant sur deux résultats majeurs. D’une part, la recherche aboutit à l’élaboration d’une conceptualisation compréhensive du phénomène, explicitant les facteurs déclencheurs, les caractéristiques, ainsi que le répertoire des manifestations de la RSR. D’une autre part, le travail de recherche met en exergue les perspectives d’évolution et de réforme des pratiques, méthodes et stratégies du marketing. / This research focuses on protest movements towards market system and its devices, having for main motive the social and environmental concerns. This work aims at underlining the existence of the socially responsible resistance (SRR) and therefore its interest, considering its uniqueness and the managerial challenges that it implies. Through an observational netnography approach using an interpretativist method for data analysis, the research is based on a study of three virtual different communities’representative of the investigated phenomenon and leads to two major results. On the first hand, the research end in an understanding conceptualization of the phenomenon, stressing its initiator factors, caracteristics, but also the SRR wide range of expression forms. On the other hand, this work emphasizes evolution and reform perspectives of marketing practices, methods and strategies.

L’injonction à la "participation" des populations n’est pas propre aux démocraties. Dans des situations autoritaires comme en Tunisie, des politiques de développement affichent aussi la "participation de la société civile". Cette thèse analyse ces dispositifs participatifs et leurs appropriations à partir d’un matériau ethnographique et proposopographique recueilli dans la région minière de Gafsa entre 2006 et 2010, via une démarche inductive et une "description dense" des rapports ordinaires au politique. Les politiques "participatives" contribuent à la construction des figures symétriques des "bons pauvres" et des "bons experts", rôles auxquels les acteurs tendent à se conformer. Ici, la "participation" n'est pas tant l’objet de la recherche qu’un analyseur des effets de la domination du régime et des capacités des acteurs à la contourner (ou pas). Sortir des référentiels cognitifs de la "participation démocratique" – implique alors d'analyser les (contre-)conduites des acteurs et organisations concernés autant au sein qu'en dehors de ces dispositifs : le choix d'un nombre relativement réduit d'enquêtés permet une étude longitudinale des variations de ces rapports au politique. L'oxymore d'autoritarisme participatif désigne ici à la fois le type de domination autoritaire analysé et les formes des différents registres de participations politiques que cette domination tend à encourager, cadrer et canaliser, ou au contraire à interdire et à réprimer. Nous contournons par cette démarche deux oppositions par trop naturalisées : d'une part, la dichotomie entre consentement et révolte ; d'autre part, une opposition d'échelle entre individus (ou petits groupes) et structures / Injunction to “participation” isn’t specific to democratic regimes. In authoritarian situations, such as in Tunisia, development policies also claim “civil society’s participation”. This dissertation analyses the participatory devices and their appropriations from an ethnographical and prosopographic material collected in the Gafsa mining region between 2006 and 2010, through an inductive approach and thick descriptions of ordinary relations to politics. “Participatory” policies contribute to the building of the symmetric figures of the “good poors” and the “good experts” – roles to which actors tend to conform to. Here, “participation” isn’t so much the object of an investigation than an analyzer of the effects of the regime’s domination and of the capacities actors have (or haven’t) to bypass it. Breaking with the cognitive frameworks of “democratic participation” implies to analyze actor’s and organization’s (counter)behaviors within as well as outside of those devices: the choice of a relative small number of actors opens way for a longitudinal study of the variation of theirs relations to politics. The “participatory authoritarianism” oxymoron describes here both the type of the analyzed authoritarian domination and the forms of the diverse types of political participations that this domination tends to support, frame and channel; or to forbid and suppress. This enables us to avoid two oppositions which have been too much naturalized : on the one hand, the dichotomy between consent and rebellion, and, on the other, the opposition of scales between individuals (or small groups) and structures.

The work is divided into two parts – theoretical and practical. The first, theoretical part is focused on introduction with the problematics, describing the concept of translation motion and brake physics, defining terms adhesion and friction, skid, driving resistances, calculation formulas etc. After the mechanics chapter follows the chapter about tire and its composition and properties, and a brake system chapter, describing Anti-lock brake system (ABS) and some other important brake-support systems. Second part of this thesis is focused on practical side, which contains acceleration measuring and skid marks creation, followed by evaluation of measured data in form of calculations and graphs.

This thesis seeks to understand the formation and representation of local, national and international identities of nations and their societies by critically analysing a big public international art event, the Kochi-Muziris Biennale. It will thus address two complex historical and theoretical problems: first, the role such biennales have had in the nation building process for several Third World countries; second, the established hierarchies in theorizations of contemporary art from the global south. By addressing these problems, it aims to illustrate the issue at the heart of this thesis: to find the praxis which can break the model of binaries and representations established in the concept of modernity.

La lutte contre le cancer est certainement l’un des défis majeurs de ce 21ème siècle. Les résistances qui émergent contre les agents de thérapie ciblée présentent un aspect particulièrement épineux de cette problématique. La thèse présentée ici s’inscrit dans ce cadre. Elle vise à développer des molécules bioactives pouvant circonvenir les résistances apparues contre les traitements de certaines hémopathies malignes : la leucémie myéloïde chronique (LMC) et le syndrome myélodysplasique (SMD). Après avoir mis au point une méthodologie de synthèse monotope permettant de transformer un azoture en un 5-alcynyl-1,2,3-triazole, nous avons synthétisé deux séries de produits : nucléosidique et non nucléosidique. Pour chacune de ces séries, des relations structure-activité ont été établies. Après plusieurs cycles d’optimisation, trois composés lead très efficaces contre des lignées cellulaires résistantes de LMC et SMD, ont été sélectionnés. De surcroît, leur mode d’action s’est révélé très intéressant : il repose (partiellement ou entièrement, suivant le composé) sur un processus cellulaire qui connaît un véritable regain d’intérêt, à savoir l’autophagie. Une évaluation in vivo a été réalisée et a permis de valider l’activité prometteuse de notre composé lead nucléosidique. Par ailleurs, des études visant à déterminer la localisation intracellulaire et les cibles moléculaires de nos produits sont actuellement en cours / The fight against cancer is certainly one of the biggest challenges of the 21st century. Resistance that comes up against targeted therapy agents presents a particularly important aspect of this issue. The thesis presented here takes part within that framework. It aims at developing bioactive molecules able to circumvent resistance that have emerged against the treatment of certain hematological malignancies: chronic myeloid leukemia (CML) and myelodysplastic syndrome (MDS). Having developed a one-pot synthesis methodology that converts azides into 5-alkynyl-1,2,3-triazole, we synthesized two series of products: nucleosidic and non-nucleosidic. For each of these series, structure-activity relationships have been established. After running several cycles of optimization, three lead compounds particularly active on resistant cell lines of CML and MDS were selected. Further, their mode of action proved to be very interesting. It is based (partially or fully, depending on the compound) on a cellular process, which is experiencing a real renewed interest, the autophagy. An in vivo evaluation confirmed the promising activity of our nucleosidic lead compound. Moreover, studies aiming at determining the intracellular localization and molecular targets of our products are currently in progress

<p dir="ltr">Non-Newtonian fluid models such as the Bingham and Herschel-Bulkley models are used to characterize the flow behavior of many complex fluids and soft solids. The three parameter Herschel-Bulkley model captures the yield stress behavior and the nonlinear power law behavior. In this thesis, the semi-analytical solution of Herschel-Bulkley fluids provided by Covey and Stanmore is used to experimentally characterize the squeeze flow behavior. A ‘Squeeze Flow and Thermal Resistance Tester’ was custom designed to perform velocity controlled squeeze flow experiments. The tester has an additional capability of performing thermal resistance characterization adhering to the ASTM-D5470 standard. A novel framework is described for characterizing the three Herschel-Bulkley parameters (τy, n and ηHB) using the developed tester. </p><p dir="ltr">Thermal Interface Materials (TIMs) are used to efficiently dissipate heat from a heat generating component to a heat sink in an electronic package. Thermal grease is a type of TIM comprising of a base material (e.g. polymer) loaded with highly conducting filler particles (e.g, boron nitride, alumina or sometimes conducting metals such as aluminum or silver). These greases are expected to exhibit Herschel-Bulkley flow behavior. Hence, thermal greases are used as candidate materials for squeeze flow characterization. In addition to the flow characterization, the thermal resistance across these thermal greases are also characterized using the custom designed tester. Characterization of mechanical and thermal behavior of TIMs is crucial to predicting their long-term reliability. </p><p dir="ltr">The effect of in-situ isothermal baking duration and test temperature on flow behavior is studied. The increase in duration of isothermal baking at test temperature of 55◦C showed that the material tends to stiffen with baking duration. The increase in test temperature from 5◦C to 100◦C resulted in a decrease in the power law index n and viscosity ηHB. </p><p dir="ltr">Finally, a numerical simulation strategy for performing squeeze flow simulations is described. The characterized flow parameters from the squeeze flow experiments were used as input material parameters for a dynamic mesh-based numerical simulation of squeeze flow between parallel surfaces. The results of the experimental force response and numerical simulation results were compared and found to be in close agreement. In order to simulate flow of thermal greases in a package undergoing deformation, a non-flat test setup was fabricated and squeeze experiments were performed. Numerical simulations were subsequently performed for the non-flat surface using material parameters extracted from previous experiments and the results were compared. The results from both experiments and numerical simulations showed that the force response of thermal greases under non-flat surfaces was significantly higher than the planar case.</p>

An operating vehicle requires energy to oppose the subjected driving resistances. This energy is supplied via the fuel combustion in the engine. Decreasing the opposing driving resistances for an operating vehicle increases its fuel efficiency: an effect which is highly valued in today’s industry, both from an environmental and economical point of view. Therefore a lot of progress has been made during recent years in the area of fuel efficient vehicles, even though some driving resistances still rises perplexity. These resistances are the air drag Fd generated by the viscous air opposing the vehicles propulsion and the rolling resistance Frr generated mainly by the hysteresis caused by the deformation cycle of the viscoelastic pneumatic tires. The energy losses associated with the air drag and rolling resistance account for the majority of the driving resistances facing an operating vehicle, and depends on numerous stochastic and ambient parameters, some of which are highly correlated both within and between the two resistances. To increase the understanding of the driving mechanics behind the energy losses associated with the complexity that is rolling resistance, a set of complete vehicle tests has been carried out. These tests were carried out on the test track Malmby Fairground, using a Scania CV AB developed R440 truck equipped with various sensors connected in one measurement system. Under certain conditions, these parameters can allow for an investigation of the rolling resistance, and a separation of the rolling resistance and air drag via explicit subtraction of the air drag from the measured traction force. This method is possible since the aerodynamic property AHDVCd(β) to some extent can be generated from wind tunnel tests and CFD simulations. Two measurement series that enable the above formulated method of separation were designed and carried out, using two separate measurement methods. One which enables the investigation of the transient nature of rolling resistance as it strives for stationarity, where the vehicle is operated under constant velocities i.e. no acceleration, and one using the well established method of coastdown, where no driving torque is applied. The drive cycles spanned a range of velocities, which allowed for dynamic and stationary analyses of both the tire temperature- and the velocity dependence of rolling resistance. When analysing the results of the transient analysis, a strong dependence upon tire temperature for given constant low velocity i.e. v ≤ 60 kmh−1 was clearly visible. The indicated dependency showed that the rolling resistance decreased as the tire temperature increased over time at a given velocity, and vice versa, towards a stationary temperature and thereby rolling resistance. The tire temperature evolution from one constant velocity to another, took place well within 50 min to a somewhat stationary value. However, even though the tire temperature had reached stationarity, rolling resistance did not; there seemed to be a delay between stationary tire temperature, and rolling resistance. The results did not indicate any clear trends for v ≥ 60 kmh−1, where the results at v = 80 kmh−1 were chaotic. This suggests that some additional forces were uncompensated for, or that the compensation for air drag was somehow wrongly treated at higher velocities. Several factors ruled out any attempts at proposing a new rolling resistance model. These included: the chaotic results for v = 80 kmh−1, the delayed rolling resistance response upon tire temperature stabilization, and the lack of literature support for the observed tendency. The results from the coastdown series on the other hand, showed good agreement with a dynamical model suggested in literature. The stationary temperature behaviour for the considered velocity range at assumed constant condition is also supported in literature. Finally, an investigation of the aerodynamic property AHDVCd inspired by ongoing work in ACEA (European Automobile Manufacturers’ Association), was carried out assuming both zero and non-zero air drag at low velocities. The results indicated surprisingly good agreement with wind tunnel measurements, especially when neglecting air drag at low velocities: as suggested by ACEA. / För att övervinna de motstånd som ett fordon utsätts för under drift krävs energi, vilket levereras genom förbränningen av bränsle. Genom att minska de körmotstånd som ett fordon utsätts för under drift, kan man öka dess energieffektivitet. Denna potential är idag högt värderad i fordonsindustrin, både ur ett miljömässigt och ekonomiskt perspektiv. På senare år har stora framsteg gjorts inom området energieffektiva fordon, men fortfarande råder det förvirring kring de energiförluster som förknippas med luftmotstånd Fd och rullmotstånd Frr, där luftmotståndet skapas av den omkringliggande viskösa luften, medan rullmotståndet genereras av hysteresen som uppstår när fordonets viskoelastiska pneumatiska däck utsätts för deformation. De energiförluster som förknippas med luft- och rullmotstånd motsvarar den största delen av de motstånd som ett fordon påverkas av, och beror på en mängd stokastiska och yttre parametrar, varav vissa är starkt korrelerade både inom och mellan nämnda motstånd. För att förbättra förståelsen kring dessa energiförluster, med fokus på förståelsen av rullmotstånd, har ett antal helfordonstest genomförts. Dessa genomfördes på provbanan Malmby Fairground med en R440 lastbil från Scania CV AB, utrustad med en mängd sensorer sammankopplade i ett mätsystem. Det uppbyggda mätsystemet möjliggjorde samtida mätningar av bl.a. drivande moment, motorvarv, fordonshastighet, däcktemperatur, omkringliggande lufts hastighet och dess riktning. Under specifika förhållanden kunde dessa parametrar möjliggöra analys av rullmotstånd genom en explicit subtraktion av luftmotstånd från den uppmätta drivande kraften. Denna metod är möjlig tack vare en förhållandevis bra modell av ekipagets aerodynamiska egenskap AHDVCd(β), som generats från vindtunneltest och CFD simuleringar. Två körcykler som möjliggjorde ovan formulerade separation designades och genomfördes. Dessa använder två skilda mätmetoder, varav den ena möjliggör analys av rullmotståndets övergående förlopp från dynamiskt till stationärt genom att hålla konstant hastighet. Den andra studerade det dynamiska förloppet genom den väletablerade metoden utrullning, dvs. utan något drivande moment. Dessa körcyklar genomfördes, för ett antal hastigheter, vilket möjliggjorde analys av både hastighets- och däcktemperaturberoendet hos rullmotstånd, under dynamiska såväl som stationära förlopp. Analysen av rullmotståndets dynamik i strävan mot stationära förhållanden visade på ett starkt temperaturberoende vid låga hastigheter dvs. v ≤ 60 kmh−1. Beroendet visade på att rullmotståndet avtog med ökande däcktemperatur och vice versa, tills dess att en någorlunda stationär temperatur för given hastighet uppnåtts. Däcktemperaturen stabiliserades till ett nytt stationärt värde inom 50 min från att hastigheten ändrats. Resultaten tyder dock på att även om stationär däcktemperatur uppnåtts finns det en fördröjning i rullmotståndets tidsspann innan rullmotståndet stabiliserat sig. För högre hastigheter, dvs. v ≥ 60 kmh-1, var dock inga klara trender synliga, varken i hastighet eller temperatur och resultaten vid v = 80 kmh-1 var kaotiska. Detta antyder att man missat att kompensera för någon kraft vid höga hastigheter, alternativt att man på något sätt kompenserar fel för luftmotståndet vid högre hastigheter. Flera faktorer hindrade försök att föreslå någon ny rullmotståndsmodell. Dessa faktorer inkluderar det kaotiska resultatet vid v = 80 kmh-1, tidsfördröjningen mellan stationärt rullmotstånd och däcktemperatur samt att resultatet för antagna stationära värden inte finner stöd i litteraturen. Resultatet från utrullningsprovet överstämmer dock bra med tidigare föreslagen dynamisk modell, samt att resultaten av beteendet hos stationär temperatur för olika hastigheter även de överensstämmer med och finner stöd i litteraturen. Slutligen har en studie kring den aerodynamiska egenskapen AHDVCd, inspirerad av pågående arbete inom ACEA (European Automobile Manufacturers’ Association) utförts både med antagandet av ett noll- skilt och med ett försumbart luftmotstånd vid låga hastigheter. Resultatet visar på en överraskande god överensstämmelse med vindtunnelmätningar, framför allt under antagandet av försumbart luftmotstånd vid låga hastigheter i enlighet med förslagen metod från ACEA.

L'inspiration de ce mémoire provient du point trois de la règle 50 de la Charte olympique : « Aucune sorte de démonstration ou de propagande politique, religieuse ou raciale n’est autorisée dans un lieu, site ou autre emplacement olympique. » (CIO 2013 : 96) Cette règle s'avère non seulement contraignante pour les athlètes portant le hijab, mais elle est aussi mobilisée pour les discréditer. Pourquoi cette contrainte? Le sport ne devrait-il pas être accessible pour toutes étant donné tous les aspects positifs qu'il apporte? En prenant pour base conceptuelle les concepts d'islamophobie genrée (Zine 2006), d'intersectionnalité incorporée (Mirza 2012) et de nationalisme (Balibar 1997 [1988]), et pour base analytique le régime des représentations racialisées (Hall 1997), ce mémoire propose une lecture croisée de trois types de discours : le discours des médias sur le hijab dans les sports et sur les femmes qui le portent ; le discours tenu par les athlètes hijabis elles-mêmes ; et le discours du public, dont les fans. À travers l'étude de la « personnalité publique » de quatre athlètes hijabis telle que construite sur leur page Facebook, toutes des sportives de haut niveau, et des échanges que celles-ci ont eu sur cette plateforme avec leur public, ce mémoire porte un éclairage sur un discours alternatif à ceux des médias dominants qui voient largement le hijab dans les sports comme un problème. On y découvre entre autres le rôle positif que ces athlètes jouent dans la promotion des sports et de l'activité physique chez les femmes musulmanes, notamment celles portant le hijab. / The inspiration for this master's thesis comes from the third item of the rule 50 in the Olympic Charter : No kind of demonstration or political, religious or racial propaganda is permitted in any Olympic sites, venues or other Olympic areas. (CIO 2013: 96) This rule is not only restrictive for athletes wearing the hijab, but it is also used to discredit them. Why this constraint? Should not sport be accessible for all, given all the benefits it offers? Taking the conceptual basis of gendered islamophobia concepts (Zine 2006), embodied intersectionality (Mirza 2012) and nationalism (Balibar 1997 [1988]) as well as the racialized regime of representation (Hall 1997) as analytical basis, this master's thesis offers a cross-reading of three types of discourses : the media discourses on the hijab in sports and on the women who wear it ; the discourses held by the hijabis athletes themselves ; and public discourses, including fans. Through the study of the "public personality" of four hijabis athletes as built on their Facebook page, all of the top athletes, and the exchanges that these have had on this platform with their audience, this study shows alternative discourses to those of the dominant medias who widely see the hijab in sports as a problem. These include the positive role that these athletes play in promoting sports and physical activity among Muslim women, especially those wearing the hijab.

Os personagens analisados nessa tese são os escravizados negros, indígenas e homens livres no Mato Grosso e suas circulações na fronteira com Bolívia e Paraguai na segunda metade do século XVIII e primeira metade do XIX. Defendemos nessa tese o protagonismo desses escravizados negros e indígenas no processo de colonização portuguesa e espanhola na região. Afirmamos que nenhum desses personagens responderam passivos às submissões de senhores, nem mesmo às instituições coloniais administrativas e religiosas. Durante o século XVIII foram travados vários embates entre indígenas e colonizadores nessa tríplice fronteira e os indígenas responderam a essa colonização desenvolvendo estratégias diversas como enfrentamento ou alianças com aquele que mais lhe convinha, ora com portugueses, ora com espanhóis. E mesmo depois de estabelecida a colonização, com construções de fortalezas e vilas nessa fronteira luso-espanhola e também estabelecidas as reduções jesuíticas em território fronteiriço de domínios hispânicos, os indígenas continuaram fazendo alianças e sendo personagens importantes comercializando seus produtos tanto com portugueses quanto com espanhóis tentando manter seu território conquistado sempre. Os escravizados negros começaram a chegar no Mato Grosso na segunda metade do século XVIII depois de uma longa e penosa viagem desde outras regiões do Brasil e também da África. Percebemos que, por ser uma região de fronteira, os escravizados fugiam para os domínios hispânicos, mas, para isso deveriam atravessar os caudalosos rios Paraguai, Guaporé ou Mamoré que dividiam os domínios das duas coroas ibéricas (Portugal e Espanha) na fronteira oeste do Mato Grosso. Mais do que uma fronteira política que limitava essas duas coroas ibéricas, a fronteira luso-espanhola foi um espaço no qual diferentes grupos sociais inventavam práticas diversas procurando melhores condições de vida e sobrevivência. Esse espaço de convívio de diferentes identidades na fronteira oeste da capitania, assim como as fugas de escravizados negro para os domínios hispânicos e formação de quilombos foram constantes durante todo o período colonial, e não cessaram durante o período imperial. Para avalizar essa tese pesquisamos documentação em três países. No Brasil recorremos ao Arquivo Público do Estado de Mato Grosso (APMT), localizado em Cuiabá. Na Bolívia, pesquisamos dois arquivos: o primeiro foi o Archivo y Biblioteca Nacionales de Bolivia (ABNB), localizado em Sucre; e o segundo foi o Museo de Historia y Archivo Histórico de Santa Cruz (MHAHSC), localizado em Santa Cruz de la Sierra. O último arquivo pesquisado foi no Paraguai, em Assunção, o Archivo Nacional de Asunción (ANA). Por fim, no diz respeito à fronteira oeste do Mato Grosso, para os lusitanos, tratava-se de manter o território conquistado; para os espanhóis, impedir o avanço; e, para ambos era conter a força indígena. Já os escravizados negros viam nos países vizinhos uma oportunidade para conquistar a liberdade e de melhores condições de sobrevivência e trabalho, com menos vigilância institucional, enquanto os proprietários de escravizados deveriam exercer mais vigilância para que não houvesse marginalidades. No caso dos indígenas, essa fronteira também era uma oportunidade de fuga institucional das coroas ibéricas (Portugal e Espanha) e das missões jesuíticas, mas também lutando para manter seu território em situação de conquista, essa fronteira possibilitava negociação, tanto com portugueses quanto com espanhóis. Quanto aos homens livres, essa fronteira facilitava as fugas de soldados desertores dos fortes construídos nesse limite institucional imposto pelas metrópoles, mas também maior possibilidade de comércio, contrabando e negociações entre nações fronteiriças vizinhas. / The characters analyzed during this thesis are black enslaved men, Indians and free men in Mato Grosso and their circulations on the border with Bolivia and Paraguay in the second half of the eighteenth century and the first half of the nineteenth. We defend the protagonism of these enslaved black and indigenous people at the process of the Portuguese and Spanish colonization in the region. We affirm none of those responded passively to the submissions of owners, colonial administration and religious institutions. At the eighteenth century, several clashes between Indians and colonizers, at the triple frontier, were fought, and the indigenous population responded to the colonization by developing diverse strategies such as confrontation or even alliances with the ones who suited them the most, sometimes with the Portuguese others with Spaniards. Even after the colonization was established, with fortress and villages constructed at the Portuguese-Spanish border, and the launch of Jesuitical reductions at borderland territory of the Hispanic domains, the Indians continued to form alliances. They were important figures commercializing their products for both Portuguese and Spanish, always trying to keep their conquered territory. Black enslaved began arriving in Mato Gross in the second half of the eighteenth century after a long and painful journey from other regions of Brazil and also Africa. We realized, because it was a borderland region, the enslaved fled to the Hispanic dominions. However, they had to cross the Paraguay, Guaporé or Mamoré rivers that divided the domain of the two Iberian crowns (Portugal and Spain) on the western border of Mato Grosso. Even more than a political borderland limiting these two Iberian crowns, the Portuguese-Spanish frontier was a space in which different social groups created diverse practices seeking better living conditions and survival. This coexistence space of different identities on the western border of the captaincy, as well as the escapes of black enslaved to Hispanic dominions and the formation of quilombos were constant throughout the colonial period, and did not cease during the imperial period. To support the thesis we researched documentation in three countries. In Brazil we used the Public Archive of the State of Mato Grosso (APMT), located in Cuiaba. In Bolivia, we researched two archives: the first was the National Archive and Library of Bolivia (ABNB), located in Sucre; and the second was the Historical History and Archive Museum of Santa Cruz (MHAHSC), located in Santa Cruz de la Sierra. The last searched one was in Paraguay, in Asuncion, National Archive of Asuncion (ANA). Lastly, concerning the western border of Mato Grosso, for the Portuguese it was a matter of maintaining the conquered territory; for the Spaniards stop the advancements; and for both contain the indigenous people force. Black enslaved, however, saw in neighboring countries an opportunity for freedom and better survival and work conditions with less institutional vigilance. The enslaved owners should exercise more vigilance so there would be no marginalities. Regarding the Indians case, this frontier was also an opportunity for an institutional escape of the Iberian crowns (Portugal and Spain) and the Jesuitical missions, but also the struggle to keep their territory in a conquering situation. Such border allowed the negotiation with both Portuguese and Spanish. Concerning the free men, the frontier facilitated the escape of deserted soldiers from the fortress built in the institutional limit imposed by the metropolises, but also greater possibility of trade, smuggling and negotiations between borderland neighboring nations.