Made available in DSpace on 2014-12-17T14:13:26Z (GMT). No. of bitstreams: 1 EduardoJGS.pdf: 119973 bytes, checksum: dbdb322fee12ba3edd9d72e5446d9c91 (MD5) Previous issue date: 2009-09-23 / The science of Dentistry wishes obtains the ideal solution for the dental plaque chemical control. This research evaluated antimicrobial action capacity in calcium hydroxide and tergentol various solutions starting for the CHD 20, a root canals irrigating solution with a reason of 80% calcium hydroxide saturated solution and 20% tergentol detergent with the aim of evaluate this drug mouth rinse indication with prevention or combat objective for dental caries and periodontal diseases. Antibiogram disks and biofilm tests were accomplished for the microorganisms: Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus and Lactobacillus casei. Different reasons of detergent for the calcium hydroxide saturated solution, tergentol and distillated water solution, 0,12% clorhexydine digluconate solution was positive control and distillated water was negative control. The results showed better performance of clorhexydine in relation to calcium hydroxide directing to not accept this (CHD20) as mouth rinse solution / Na busca pela ci?ncia odontol?gica de se chegar ao composto que possa ser considerado o agente ideal para o controle qu?mico do biofilme dental foi idealizado este estudo. Avaliou-se a capacidade antimicrobiana in vitro de diferentes solu??es a base de hidr?xido de c?lcio e tergentol partindo em princ?pio do HCT 20, solu??o irrigadora dos canais radiculares composta por 80% da solu??o saturada de hidr?xido de c?lcio (?gua de cal) e 20% do detergente tergentol buscando verificar sua poss?vel indica??o como solu??o para bochechos, visando preven??o ou combate a doen?as como c?rie dent?ria e doen?a periodontal. No laborat?rio de microbiologia do Departamento de Odontologia da UFRN, foram realizados testes em discos de antibiograma para os microrganismos: Streptococcus mutans, Streptococcus sanguis, Streptococcus sobrinus e Lactobacillus casei. Bem como em bact?rias formadoras de biofilme para os mesmos, ? exce??o do L. casei. Estipulou-se diferentes concentra??es de tergentol para a ?gua de cal, al?m do tergentol em ?gua destilada, usou-se digluconato de clorexidina a 0,12% como controle positivo e ?gua destilada como controle negativo. Os resultados mostraram desempenho inferior das solu??es a base de Ca(OH)2 em rela??o ? clorexidina frente a estes microrganismos e ? metodologia empregada, direcionando pois, para a n?o indica??o do uso do HCT 20 como colut?rio bucal

<i>Cryptosporidium parvum</i> is a protozoan parasite historically associated with waterborne and more recently foodborne outbreaks of diarrheal illness. Contamination of certain foods, such as unpasteurized apple cider, with infective oocysts may occur as oocysts are shed in the feces of common ruminants like cattle and deer that graze in and around orchards. Cryptosporidiosis can result in a severe illness for previously healthy individuals and a life-threatening illness in immunocompromised individuals. Disease occurs after the ingestion of small infective oocysts (4 to 5 mm in size). The relatively thick membrane of the oocysts allows them to be resistant to chlorine and many other environmental pressures, making oocysts difficult to inactivate. In this study, alternative treatments to pasteurization were evaluated for their ability to inhibit <i>C. parvum</i> oocyst viability in fruit juices. Oocyst viability was analyzed with a cell culture infectivity assay, using a human illeocecal cell line (HCT-8) that is most similar to human infection. The percent inhibition of infection by each treatment was determined along with the corresponding log reduction for the treatments found to be most effective. Infection by treated oocysts was compared to that of control untreated oocysts. Cell monolayers were infected with 10⁶ treated oocysts or a series of 10-fold dilutions. Parasitic life stages were visualized using an immunohistochemistry system and 100 microscope fields counted per monolayer. Organic acids and H₂O₂ were added on a wt/vol basis to apple cider, orange juice, and grape juices. Malic, citric, and tartaric acids at concentrations from 1%-5% inhibited <i>C. parvum</i> infectivity of HCT-8 cells by up to 88%. Concentrations ranging from 0.025%-3% H₂O₂ were evaluated where addition of 0.025% H₂O₂ to each juice resulted in a >5 log reduction of C. parvum infectivity as determined with an MPN-based cell culture infectivity assay. Treating apple cider, orange juice, and grape juice with ozone for a time period of 30 seconds up to 15 minutes at 6° and 22°C (0.9 g/L flow rate) inhibited C. parvum viability to > 90% as monitored in the cell culture assay. It is hypothesized that oocyst wall proteins that are necessary for infection are oxidized by the reactive oxygen species generated from the decomposition of the ozone and hydrogen peroxide treatments. These treatments or combinations thereof may offer potential alternatives to traditional pasteurization for fruit juices to successfully inhibit <i>C. parvum</i> viability. / Ph. D.

Syfte – Studiens syfte är att öka kunskapen om hur fordonstillverkares affärsmodeller påverkas vid förändring av statliga regelverk genom att studera ett framtida införande av HCT i Sverige. HCT, High Capacity Transports, är ett samlingsnamn för lastbilar som är tyngre och/eller längre än vad gällande lagstiftning tillåter. Regelförändringen övervägs för att sänka kostnader och miljöpåverkan.  Metod – Arbetet har genomförts i form av en case-studie. För att studera påverkan på både fordonstillverkares och åkeriers affärsmodeller har intervjuer genomförts med varuägare, åkerier och förare inom fjärrtransporter av styckegods. Detta har kompletterats med löpande kontakt med uppdragsgivande fordonstillverkare samt deltagande i konferenser inom ramen för det nationella HCT-arbetet.  Resultat – Inget större modalskifte mellan järnvägs- och landsvägstransporter förväntas eftersom järnvägens infrastruktur styr transportvalet och inte påverkas av ett HCT-tillåtande. Vidare riskerar fordonstillverkare att sälja färre lastbilar vid ett tillåtande av HCT men genom anpassning av affärsmodellen kan de öka värdet per fordon. Detta värde kan ökas genom att sänka kundernas driftkostnad, maximera fordonens drifttid och föra kundens talan mot myndigheter.  Praktiskt bidrag – Studien har resulterat i ett nytt affärsmodellsramverk för fordonstillverkare vid införande av HCT. Ramverket visar att samtliga nuvarande värdeområden bör inkluderas i kommande affärsmodell och att flertalet får ökad betydelse. På grund av nya förutsättningar blir vissa av dessa områden dessutom svårare att uppnå samtidigt som nya områden kan läggas till.  Vetenskapligt bidrag – Genom att öka kunskapen om affärsmodellspåverkan vid förändring av statliga regelverk utvidgar studien befintlig teori om förändringar av affärsmodeller. Studien belyser även vikten av att studera hela leverantörskedjan vid sådana förändringar. Detta eftersom statliga regelverk styr förutsättningarna för flera aktörer med starka inbördes relationer. Därmed sprider sig effekterna av en regelverksförändring till övriga aktörer i kedjan. / Purpose – The purpose of this study is to increase the knowledge about how legislative changes affect the business model of vehicle manufactures by studying a future allowance of HCT in Sweden. HCT, High Capacity Transports, is a generic term for trucks exceeding today’s weight and/or length regulations. Reasons for implementing HCT include reducing costs and environmental consequences. Method – Effects of legislative changes have been studied through a case-study of how HCT would affect the Swedish transport system. In order to study business model implications for both vehicle manufactures and hauliers, interviews have been held with transport buyers, hauliers and drivers within long distance haulage of break bulk cargo. This has been complemented by continuous contact with the commissioning vehicle manufacturer and participation in HCT conferences. Findings – Findings indicate that there will be no major modal shift between railway and road since the railway infrastructure determines the modal choice and is unaffected by HCT. Furthermore findings show that vehicle manufactures risk to sell fewer vehicles in case of HCT allowance but a business model adaption can increase the value per vehicle. This can be achieved by reducing customer operating costs, increasing vehicle uptime and being the voice of the customer against authorities. Practical implications – The study has resulted in a HCT business model framework for vehicle manufactures. The framework shows that all present value areas should be included in a future business model and that several areas will increase in importance. In the effect of new conditions several areas will become more difficult to fulfill. Furthermore new areas will be added. Theoretical implications – This study expands current theories within business model changes by increasing knowledge about how legislative changes affect business models. Furthermore this study highlights the importance of studying the whole supply chain in the event of these changes. The reason for this is that legislations affect the conditions for several players with strong peer relationships. Thereby effects due to changed legislations will spread to other players in the chain.

Magister Public Health - MPH / The study had an observational, descriptive, cross sectional design. The sample consisted of 205 participants selected through convenience sampling. All students who presented for HIV testing during the colleges’ HIV Counselling and Testing campaign in December 2011 were asked to complete a self-administered closed-ended questionnaire voluntarily. The data was analysed with EPI Info versions 3.5.1. A frequency analysis was conducted for all the variables such as demographics, risk perception to HIV, knowledge of HIV, HIV testing behaviour. The association between HIV knowledge, risk perception and risk behaviours were assessed for gender differences. Chi-square analysis was conducted to determine the association between the main variable of interest HIV risk behaviour and each other explanatory variable (demographics, HIV knowledge, risk perception etc). Results were discussed using the theory of planned behaviour.

I dagens samhälle spelar miljön en viktig roll, både för hur miljön skall bevaras och hur miljöproblem kan undvikas. Med detta uppmanas allt fler människor ha en större miljömedvetenhet. Miljöproblemet är ytterst märkbart i infrastrukturen och främst transporter av dess olika slag. Större fordon, såsom lastbilar, färdas långa sträckor för att transportera gods som i sin tur ökar bränsleförbrukning och gör att utsläppen blir allt mer. Genom att öka lasten, per transporterad enhet, på de tyngre fordonen så kan bränsleförbrukningen minskas. Företaget Parator Industri AB som tillverkar lastbilstrailers är med i ett HCT-projekt (High Capacity Transport) där de tillsammans med andra involverade företag ska ta fram en ny konstruktion av tyngre fordon med ett hållbarhetstänk.Syftet med detta examensarbete är att är att ta fram en lösning för kombination av en lastbil med kopplat släp vilket senare kommer utgöra produktionsunderlaget till företaget Parator. Detta genom att hjälpa företaget konstruera en ny DUO-trailern som kommer bestå av två chassin som ska sammanfogas och som kommer transportera containrar med gods i. Genom aktionsforskning med fokus på intervjuer och observationer, har vetenskapliga källor samlats in. Detta kombineras med modellering på dataprogrammet SolidWorks där 3D-modellering av den nya konstruktionen utförs. Med överslagsberäkning beräknas hållfastheten fram på den nya trailerns infästningar. Även ett nytt produktionsunderlag, med tillhörande materiallista och ritningar har tagits fram i rapporten. Studien har vidare analyserat huruvida de tillämpade tillverkningsmetoderna samt monteringar kan vara hållbara ur ett produktionsperspektiv. / Today the environment is a common question and how to reduce emissions into nature. With this more people are encouraged to have an environmental mindset. Mostly the environmental damage comes from the transport with different kinds of vehicles and their exhaust gas. Larger vehicles, such as trucks, travel long distances to deliver goods which increases fuel consumption and increases emissions. By increasing the load, per transported unit on the heavier vehicles, fuel consumption can be reduced. The company Parator Industry AB that designs truck-trailers is involved in an HCT-project (High Capacity Transport) together with other companies where the goal for the company is to achieve a more sustainable production material and have less impact on nature.The purpose of this study is to find a solution for a combination of the truck connected with a trailer which will later form the production basis for the company Parator. This by helping the company design a new DUO-trailer which will consist of two chassis to be joined and will transport containers with goods. Through action research with a focus on interviews and observations, scientific sources can be collected. This will be combined with modeling on the computer program SolidWorks where 3Dmodeling of the new design is performed.Estimated value of the design is done for the new attachments. The study also contains a production base with produced drawings and material list. The study also analyzes the relevance of the calculated values and if they will be sustainable in the future.

This study investigated the factors influencing the utilisation of PMTCT of HIV services and proposed measures to promote service utilisation by HIV positive pregnant women in the FCT, Abuja, Nigeria. Effective interventions exist that can reduce the transmission of HIV infection to the baby. The study is a quantitative descriptive one, with 190 HIV positive pregnant women from 20 health Centres in three area councils in Abuja, who were interviewed using structured questionnaire to get their opinion. The findings revealed that the majority (90.4%) of the respondents were aware of PMTCT and how HIV can be transmitted from mother-to-child. The respondents (95.9%) were of the opinion that all pregnant women should be tested. Notably, PMTCT services will be hindered by the following: permission from spouse before being tested, couple counselling not done, group post test counselling, non-incorporation of family planning and low support group enrolment. Recommendations made include emphasis on couple counselling, confidentiality and friendly environment / Health Studies / M.A. (Public Health)

This study investigated the factors influencing the utilisation of PMTCT of HIV services and proposed measures to promote service utilisation by HIV positive pregnant women in the FCT, Abuja, Nigeria. Effective interventions exist that can reduce the transmission of HIV infection to the baby. The study is a quantitative descriptive one, with 190 HIV positive pregnant women from 20 health Centres in three area councils in Abuja, who were interviewed using structured questionnaire to get their opinion. The findings revealed that the majority (90.4%) of the respondents were aware of PMTCT and how HIV can be transmitted from mother-to-child. The respondents (95.9%) were of the opinion that all pregnant women should be tested. Notably, PMTCT services will be hindered by the following: permission from spouse before being tested, couple counselling not done, group post test counselling, non-incorporation of family planning and low support group enrolment. Recommendations made include emphasis on couple counselling, confidentiality and friendly environment / Health Studies / M.A. (Public Health)

No description available.

Le génie tissulaire est un domaine interdisciplinaire qui applique les principes du génie et des sciences de la vie (notamment la science des cellules souches) dans le but de régénérer et réparer les tissus et organes lésés. En d'autres mots, plutôt que de remplacer les tissus et les organes, on les répare. La recherche en génie tissulaire est considérable et les ambitions sont grandes, notamment celle de mettre fm aux listes d'attente de dons d'organes. Le génie tissulaire a déjà commencé à livrer des produits thérapeutiques pour des applications simples, notamment la peau et le cartilage. Les questions sur la façon de réglementer les produits thérapeutiques qui sont issus du génie tissulaire sont soulevées à chaque nouveau produit. À ce jour, ces questions ont reçu peu d'attention comparativement aux questions éthiques associées aux recherches avec les cellules souches et les risques qu'engendrent les produits biologiques. Il est donc important d'examiner si le cadre normatif qui entoure la mise en marché des produits issus du génie tissulaire est approprié puisque de tels produits sont déjà disponibles sur le marché et plusieurs autres sont en voie de l'être. Notre analyse révèle que le cadre canadien actuel n'est pas approprié et le moment d'une reforme est arrivé. Les États-Unis et l'Union européenne ont chacun des approches particulières qui sont instructives. Nous avons entrepris une revue des textes réglementaires qui encadrent la mise en marché des produits issus du génie tissulaire au Canada, aux États-Unis et dans l'Union européenne et formulons quelques suggestions de réforme. / Tissue engineering is an interdisciplinary field that applies the principles of engineering and the life sciences (including the science of stem cells) toward the development of biological substitutes that restore, maintain or improve tissue function. In other words, rather than being replaced, tissues and organs are repaired. Research in tissue engineering is important and ambitions are high, such as ending the waiting list for organ transplant. Tissue engineering has already started delivering therapeutic products for simple applications such as skin and cartilage. Questions on the way tissue engineered therapeutic products are regulated are raised with each new product. Until now, these questions have been given little attention compared to the ethical issues related to stem cell research and to the risks generated by biologics. It is therefore important to examine whether the regulatory framework is suitable since some tissue engineered products are already available on the market and others are soon to be marketed. Our analysis reveals that the Canadian regulatory framework is not suitable and the time is ripe for reform. The United States and the European Union have their own approaches that are instructive. We have undertaken a study of the regulatory premarket approval frameworks in Canada, United States and the European Union, and formulated suggestions for reform.

Le génie tissulaire est un domaine interdisciplinaire qui applique les principes du génie et des sciences de la vie (notamment la science des cellules souches) dans le but de régénérer et réparer les tissus et organes lésés. En d'autres mots, plutôt que de remplacer les tissus et les organes, on les répare. La recherche en génie tissulaire est considérable et les ambitions sont grandes, notamment celle de mettre fm aux listes d'attente de dons d'organes. Le génie tissulaire a déjà commencé à livrer des produits thérapeutiques pour des applications simples, notamment la peau et le cartilage. Les questions sur la façon de réglementer les produits thérapeutiques qui sont issus du génie tissulaire sont soulevées à chaque nouveau produit. À ce jour, ces questions ont reçu peu d'attention comparativement aux questions éthiques associées aux recherches avec les cellules souches et les risques qu'engendrent les produits biologiques. Il est donc important d'examiner si le cadre normatif qui entoure la mise en marché des produits issus du génie tissulaire est approprié puisque de tels produits sont déjà disponibles sur le marché et plusieurs autres sont en voie de l'être. Notre analyse révèle que le cadre canadien actuel n'est pas approprié et le moment d'une reforme est arrivé. Les États-Unis et l'Union européenne ont chacun des approches particulières qui sont instructives. Nous avons entrepris une revue des textes réglementaires qui encadrent la mise en marché des produits issus du génie tissulaire au Canada, aux États-Unis et dans l'Union européenne et formulons quelques suggestions de réforme. / Tissue engineering is an interdisciplinary field that applies the principles of engineering and the life sciences (including the science of stem cells) toward the development of biological substitutes that restore, maintain or improve tissue function. In other words, rather than being replaced, tissues and organs are repaired. Research in tissue engineering is important and ambitions are high, such as ending the waiting list for organ transplant. Tissue engineering has already started delivering therapeutic products for simple applications such as skin and cartilage. Questions on the way tissue engineered therapeutic products are regulated are raised with each new product. Until now, these questions have been given little attention compared to the ethical issues related to stem cell research and to the risks generated by biologics. It is therefore important to examine whether the regulatory framework is suitable since some tissue engineered products are already available on the market and others are soon to be marketed. Our analysis reveals that the Canadian regulatory framework is not suitable and the time is ripe for reform. The United States and the European Union have their own approaches that are instructive. We have undertaken a study of the regulatory premarket approval frameworks in Canada, United States and the European Union, and formulated suggestions for reform.