Global ETD Search

31	Creating and Utilizing Online Assignments in a Calculus Class Jungic, Veselin, Kent, Deborah, Menz, Petra 17 April 2012 (has links) The aims of this paper are to present some of the findings about the creation and utilization of online assignments and choice of support software for several calculus classes at Simon Fraser University (SFU) by considering the needs and perspectives of the instructors, students, and administrators. The term online assignment is used for a set of problems that are posted, submitted, graded, and recorded electronically through a course learning management system (LMS) of choice. The purpose of this note is to contribute to the discussion about a common question detected among research papers on the theme of online assignments; how can technology be used in teaching so that students benefit the most? Questions are provided to guide an instructor in choosing online assignment problems, and a list of necessary skills is supplied for an instructor to be able to deal effectively with this pedagogical tool. info:eu-repo/classification/ddc/510 ddc:510
32	Mitochondrial modulators of hypoxia-related pathways in tumours Snell, Cameron Edward January 2013 (has links) The Lon protease is a mitochondrial matrix quality-control protease belonging to the family of AAA+ proteins (ATPases associated with many cellular activities). We had previously found Lon to be upregulated in lung tumours with a non-angiogenic phenotype in a microarray study comparing these to conventional angiogenic tumours. In this project I set out to investigate whether Lon had any role in modulating the hypoxic response of tumour cells. Using a novel monoclonal antibody against Lon, I found that upregulation of Lon was present in breast and lung tumours and that higher levels of Lon are correlated with shorter overall survival in breast cancer patients. Targeting Lon with siRNA and shRNA in tumour cell lines reduced the normoxic and hypoxic stabilisation of HIF-α subunits. This is mediated through a mechanism independent of the activity of HIF-prolyl hydroxylases and independent of any changes in mitochondrial transcription. I found that the pre-imported form of Lon could bind and chaperone VHL in the cytoplasm potentially modulating VHL activity. In cell lines and human tumours, I observed that the proline-hydroxylated form of HIF-1α is induced by hypoxia and the hydroxylated form of HIF-1α is associated with shorter overall survival in breast cancer patients. This observation supports the notion that higher levels of Lon is associated with poor survival by downregulating VHL leading to higher levels of hydroxylated HIF. Finally I show that targeting Lon in cell lines is able to inhibit growth in a cell-line dependent fashion and partially reverses the Warburg effect, increasing oxygen consumption and reducing lactate production. In conclusion, I have demonstrated the broad therapeutic potential of targeting the Lon protease in tumours and highlighted a mechanism of post-hydroxylation HIF-regulation that has not been previously recognised in VHL competent tumours. 616.99
33	Novos sistemas de libera??o de f?rmacos ? base de xilana Oliveira, Elquio Eleamen 07 June 2010 (has links) Made available in DSpace on 2014-12-17T14:13:33Z (GMT). No. of bitstreams: 1 ElquioEO_TESE.pdf: 1649953 bytes, checksum: 1098cd34b1d3e6c9a180949d25fa8185 (MD5) Previous issue date: 2010-06-07 / Universidade Federal do Rio Grande do Norte / The aim of this work was to perform the extraction and characterization of xylan from corn cobs and prepare xylan-based microcapsules. For that purpose, an alkaline extraction of xylan was carried out followed by the polymer characterization regarding its technological properties, such as angle of repose, Hausner factor, density, compressibility and compactability. Also, a low-cost and rapid analytical procedure to identify xylan by means of infrared spectroscopy was studied. Xylan was characterized as a yellowish fine powder with low density and poor flow properties. After the extraction and characterization of the polymer, xylan-based microcapsules were prepared by means of interfacial crosslinking polymerization and their characterization was performed in order to obtain gastroresistant multiparticulate systems. This work involved the most suitable parameters of the preparation of microcapsules as well as the study of the process, scale-up methodology and biological analysis. Magnetic nanoparticles were used as a model system to be encapsulated by the xylan microcapsules. According to the results, xylan-based microcapsules were shown to be resistant to several conditions found along the gastrointestinal tract and they were able to avoid the early degradation of the magnetic nanoparticles / O presente trabalho teve como objetivo a extra??o e caracteriza??o do pol?mero de xilana a partir de res?duos de sabugo de milho e a produ??o de microc?psulas a partir deste pol?mero. O primeiro passo foi a extra??o da xilana em meio alcalino e caracteriza??o deste pol?mero quanto as suas propriedades tecnol?gicas (?ngulo de repouso, fator de Hausner, densidade, compressibilidade e compactabilidade), bem como a elabora??o de uma procedimento r?pido e barato para a identifica??o deste pol?mero atrav?s de espectroscopia de absor??o na regi?o do infravermelho. O pol?mero de xilana foi caracterizado como sendo um p? de cor amarelada de baixa densidade e com propriedades de escoamento pouco favor?veis. Ap?s a obten??o e caracteriza??o do pol?mero, microc?psulas de xilana foram preparadas atrav?s da reticula??o polim?rica interfacial e caracterizadas a fim de se obter sistemas multiparticulados gastroresistentes. O trabalho foi delineado buscando-se os melhores fatores na t?cnica de prepara??o das microc?psulas, assim como o estudo do processo, aumento de escala e avalia??o biol?gica. Nanopart?culas magn?ticas foram utilizadas como sistema modelo a ser encapsulado pelas microc?psulas ? base de xilana. Os resultados obtidos demonstraram que as microc?psulas de xilana s?o resistentes ?s diversas condi??es encontradas ao longo do trato gastrintestinal e foram capazes de evitar a degrada??o pr?via das nanopart?culas magn?ticas in vitro Xilana Microc?psulas Libera??o c?lon-espec?fica Reticula??o polim?rica interfacial Xylan infrared spectroscopy microcapsules colon-specific delivery interfacial cross-linking polymerization CNPQ::CIENCIAS DA SAUDE
34	El derecho como forma de alcanzar la justicia Abarzúa Navarrete, Sebastián Andrés, Valenzuela Vargas, Marcelo Hernán January 2014 (has links) Memoria (licenciado en ciencias jurídicas y sociales) / Nuestra memoria intenta mostrar que es posible pensar un más allá del derecho positivo en la conexión que creemos necesaria con la moral y que el ideal de justicia es posible si se parte desde esta perspectiva. Para llegar hasta allí comenzaremos por esbozar lo que entenderemos por Positivismo Jurídico, mostrando sus cimientos y analizando a sus principales exponentes para posteriormente explicar la existencia de una moral interna en el derecho y como puede ser ésta el camino para conectarse con la justicia apreciando la relación de alteridad que debe haber entre ambos conceptos si se quiere hacer frente a la urgente amenaza que significa la irrupción del estado de excepción. Positivismo jurídico
35	Klasická versus inteligentní elektroinstalace / Classical versus intelligent electrical installation Haluza, Miroslav January 2010 (has links) This work topic is development and history of intelligent wiring systems in Czech Republic as well as abroad. The firs paragraphs describe following: intelligent wiring systems, the differences between classic and intelligent wiring systems and consequently is described the intelligent wiring system itself (types, principles, advantages, disadvantages etc.). Detailed description of system Inels follows in the next chapters. This system is supposed to be the fundamental matter of this work and is used in consequent suggestions for intelligent wiring system that is defined at the end of the theoretical part of this work. At the conclusion the economic evaluation of various wiring options and assessment by the multicriteria analysis (MCA) will be provided.
36	Tolerated illegality and intolerable legality: from legal philosophy to critique Plyley, Kathryn 26 April 2018 (has links) This project uses Michel Foucault’s underdeveloped notion of “tolerated illegality” as a departure point for two converging inquiries. The first analyzes, and then critiques, dominant legal logics and values. This part argues that traditional legal philosophers exhibit a “disagreement without difference,” generally concurring that legal certainty and predictability enhance agency. Subsequently, this section critiques “formal legal” logic by linking it to science envy (specifically the desire for certainty and predictability), and highlighting its agency- limiting effects (e.g. the violence of law en-force-ment). The second part examines multiple dimensions of tolerated illegality, exploring the permutations of this complex socio-legal phenomenon. Here the implications of tolerated illegality are mapped across different domains, ranging from the dispossession of Indigenous peoples of their lands, to the latent ideologies embedded in superhero shows. This section also examines the idea of liberal “tolerance,” as well as the themes of power, domination, politics, bureaucracy, and authority. Ultimately, this project demonstrates that it is illuminating to study legality and (tolerated) illegality in tandem because although analyses of “formal legality” provide helpful analytical texture, the polymorphous and entangled nature of tolerated illegality makes clear just how restricted and artificial strict analyses of legality can be. / Graduate tolerated illegality legality rule of law socio-legal critique Indigenous resurgence power relations toleration superheroes law and film law and television critical legal thought Michel Foucault Lon Fuller Wendy Brown tolerance legal philosophy Antigone The Wire gap studies scientism in law Indigenous dispossession law and order neoliberalism legal certainty and predictability bureaucracy Daredevil
37	A Pragmatic Standard of Legal Validity Tyler, John 2012 May 1900 (has links) American jurisprudence currently applies two incompatible validity standards to determine which laws are enforceable. The natural law tradition evaluates validity by an uncertain standard of divine law, and its methodology relies on contradictory views of human reason. Legal positivism, on the other hand, relies on a methodology that commits the analytic fallacy, separates law from its application, and produces an incomplete model of law. These incompatible standards have created a schism in American jurisprudence that impairs the delivery of justice. This dissertation therefore formulates a new standard for legal validity. This new standard rejects the uncertainties and inconsistencies inherent in natural law theory. It also rejects the narrow linguistic methodology of legal positivism. In their stead, this dissertation adopts a pragmatic methodology that develops a standard for legal validity based on actual legal experience. This approach focuses on the operations of law and its effects upon ongoing human activities, and it evaluates legal principles by applying the experimental method to the social consequences they produce. Because legal history provides a long record of past experimentation with legal principles, legal history is an essential feature of this method. This new validity standard contains three principles. The principle of reason requires legal systems to respect every subject as a rational creature with a free will. The principle of reason also requires procedural due process to protect against the punishment of the innocent and the tyranny of the majority. Legal systems that respect their subjects' status as rational creatures with free wills permit their subjects to orient their own behavior. The principle of reason therefore requires substantive due process to ensure that laws provide dependable guideposts to individuals in orienting their behavior. The principle of consent recognizes that the legitimacy of law derives from the consent of those subject to its power. Common law custom, the doctrine of stare decisis, and legislation sanctioned by the subjects' legitimate representatives all evidence consent. The principle of autonomy establishes the authority of law. Laws must wield supremacy over political rulers, and political rulers must be subject to the same laws as other citizens. Political rulers may not arbitrarily alter the law to accord to their will. Legal history demonstrates that, in the absence of a validity standard based on these principles, legal systems will not treat their subjects as ends in themselves. They will inevitably treat their subjects as mere means to other ends. Once laws do this, men have no rest from evil. natural law theory legal positivism HLA Hart William Blackstone John Locke Jeremy Bentham John Austin Galileo Socrates Trotsky Athens Soviet law Stuart dynasty John Dewey Dewey Commission Sidney Hook Congregation of the Holy Office Galileo Affair trial of Socrates Moscow Trials trial of Galileo heresy trial of Trotsky reason autonomy consent philosophy of law pragmatism Kant Inquisition ostracism Anaxagoras Protagoras Alcibiades Arginusae Pericles Peloponnesian War Solon Ephialtes Apology Plato Herodotus Xenophon Plutarch Roscoe Pound common law Oliver Wendell Holmes, Jr. The Common Law The Path of the Law Learned Hand Christopher Columbus Langdell Ronald Dworkin Lon Fuller Lenin Stalin King Rex Sergei Kirov Permanent Revolution Socialism in One Country Great Terror Dekulakization Holomodor Terror Famine Italian positivist school Harold J. Berman Gustav Radbruch Ramon Mercader Trotsky assassination Marteman Ryutin Old Bolsheviks Genrikh Yagoda Pope Urban VIII Walter Duranty Harold Denny New York Times Joseph E. Davies Mission to Moscow New Republic John F. Finerty Lev Sedov Military Collegium Vasili Ulrikh Gaspare Borgia Cardinal Robert Bellarmine Pericles Father Commissary Michelangelo Segizzi Cardinal Francesco Barberini Cardinal Maffeo Barberini Siderius Nuncius Starry Messenger Accademia dei Lincei Letters on Sunspots Friar Tommaso Caccini Niccolo Lorini Commentaries on the Laws of England Second Treatise on Civil Government Henry de Bracton Sir Edward Coke Sir John Fortescue Matthew Hale Ranulf de Glanvil James I Charles I James II Charles II ship money forest fines distraint of knighthood impositions dispensing power royal prerogative Duke of Buckingham Oliver Cromwell Bishops Wars William Prynne Great Migration Declaration of Indulgence Settlement Act Test Act Protectorate Clarendon Code Quaker Act William and Mary English Civil War Puritan Revolution Glorious Revolution Thirty Years' War Earl of Shaftesbuty William Laud Historiomatrix Long Parliament Rump Parliament Barebones Parliament sociological jurisprudence Red Terror war communism New Economic Policy 1926 Criminal Code Kirov Amendments judicial discretion semantic sting The Concept of Law Fragments on Government The Province of Jurisprudence Determined A Fragment on Government Anarchical Fallacies primary rules secondary rules rule of recognition legal validity internal point of view external point of view law as prediction the bad man perspective on law life of the law page of history Basilikon Doron Trew Law of Free Monarchies

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