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221	SEDAÇÃO EM ODONTOPEDIATRIA: PERCEPÇÕES DE ACOMPANHANTES E EQUIPE PROFISSIONAL / Pediatric dental sedation: perceptions of children s accompanying adults and a sedation team LIMA, Alessandra Rodrigues de Almeida 16 October 2008 (has links) Made available in DSpace on 2014-07-29T15:25:23Z (GMT). No. of bitstreams: 1 Tese_Alessandra_Lima.pdf: 1481884 bytes, checksum: 96048bc1655b1b5cda7bb927be1dfd55 (MD5) Previous issue date: 2008-10-16 / The management of a child s behavior in a dental setting is routinely accomplished by a good communicative technique known as basic methods. Advanced me thods (protective stabilization, sedation, and general anesthesia) have been indicated for resistant children. When the basics methods are not enough to provide a safe and effective treatment, Brazilian dentists seem to prefer the protective stabilization to restrain a child. After the establishment of rules for nitrous oxide sedation in Brazil, a change in practice can be expected. In minimal and moderate sedation, patient can respond to every dental treatment s stimulus with cry and struggle. The purpose of this study was to known the perceptions of sedation by accompanying adults and a sedation team. This was a qualitative research, based on three in-depth interviews with two groups of accompanying adults groups and one group of a dental sedation team. Interviews were transcribed verbatim and independently analyzed by three investigators through the thematic content method. The first analysis explored the ACCOMPANYING ADULTS SATISFACTION; two categories emerged: the good side (conscious, safety, satisfaction, behavior management) and the bad side (suffering, adverse effects) of pediatric dental sedation. The second analysis regarding the MEANINGS OF SEDATIONFOR ACCOMPANYING ADULTS generated FOUR categories: Protective stabilization (to bind, to protect on sedation), sedation (positive and negative side) , general anesthesia (positive point of a view) and mothers feelings (aversion peace, fair, security, motivation). Three categories emerged from the third interview about DENTAL TEAM PERCEPTIONS: knowledge (technique, indication, aim, amnesia, unexpected), disappointment (hopes, disappointment, depreciation), and difficulties (expense, accompanying adults and care team s opposition, tendency to be better). Accompanying adults did not accept physical restraint, but were satisfied with dental sedation despite its limitations and saw general anesthesia as an alternative method. The dental sedation team was aware of the sedation s advantages and flaws, but was pessimist about the method / A utilização de métodos de controle de comportamento da criança, quer sejam básicos (comunicativos) ou avançados (estabilização protetora, sedação e anestesia geral), é uma constante nos consultórios de odontopediatria. A sedação realizada em ambulatório, mantem o paciente responsivo e com isso o mesmo sente os estímulos inerentes à prática odontológica, podendo reagir a eles com choro e movimento. Tal procedimento já tem sua eficácia e segurança cientificamente comprovadas, todavia não se conhece as percepções que acompanhantes e profissionais envolvidos formulam sobre a sedação. Objetivou-se conhecer as percepções sobre sedação segundo um grupo de acompanhantes de crianças préescolares e equipe profissional vinculada ao atendimento sob sedação . Trata-se de trabalho de pesquisa qualitativa e realizou-se três entrevistas abertas, com enfoques distintos, com três grupos de indivíduos envolvidos no atendimento de crianças sob sedação no Núcleo de Estudos em Sedação Odontológica (NESO), sendo dois grupos de acompanhantes e um grupo com os membros da equipe profissional. O s dados foram transcritos, lidos exaust ivamente e analisados a partir da análise de conteúdo, modalidade temática. A análise dos dados e a apresentação dos resultados foram feitos de forma independente para cada grupo de dados coletados a saber: SATISFAÇÃO DOS RESPONSÁVEIS da análise das entrevistas como primeiro grupo de acompanhantes emergiram duas categorias temáticas, o Lado Bom (consciência, segurança, satisfação, condicionamento) e Lado Ruim da Sedação (sofrimento e efeito paradoxal) ; SIGNIFICADOS ATRIBUIDOS PELOS ACOMANHANTES AOS MÉTODOS AVANÇADOS DE CONTROLE COMPORTAMENTAL da análise do segundo grupo de entrevistas emergiram quatro categorias temáticas, Estabilização Protetora (amarrar, segurar na sedação) , Sedação (aspectos positivos e negativos) , Anestesia Geral (aspectos positivos), Sentimento dos Acompanhantes (revolta, tranqüilidade, medo, segurança, motivação); PERCEPÇÕES DA EQUIPE PROFISSIONAL da análise das entrevistas realizadas com os profissionais da equipe NESO emergiram as seguintes categorias temáticas o Conhecimento (técnica, indicação, objetivo, amnésia e imprevisibilidade), Frustração (expectativa, frustração e desvalorização) e Problemas (custo, resistência de pais e profissionais e tendência a melhorar) . Considerou-se que os acompanhantes entrevistados não aceitam a estabilização protetora para o atendimento de suas crianças, ponderam as l imitações da técnica de sedação e sentem-se satisfeitos apesar das limitações da mesma. E ainda, aceitam a anestesia geral como uma alternativa à técnica de sedação . Os profissionais do NESO, por outro lado, percebem a sedação de forma negativa e pessimista contrapondo -se à aceitação dos acompanhantes. odontopediatria restrição física sedação consciente percepção cuidadores equipe de assistência ao paciente pediatric dentistry physical restraint conscious sedation perception caregivers patient care team
222	Characteristics associated with unplanned extubation in an intensive care unit Nairobi, Kenya Ahamed, Parin Hanif 11 1900 (has links) Unplanned extubation is premature removal of endotracheal tube, is an adverse event; which can either, be accidental during a nursing procedure or self deliberate by the patient. The AACN Synergy Model for Patient Care was used as conceptual model for this study. A retrospective descriptive design revealed that over a period of two years, 327 patients admitted to the intensive care unit require intubation of which 40.4% were self-deliberate extubation and 59.4% accidental extubation. Of the accidental extubated patients, 29.8% had physical restrains, 57.6% received sedation, 43.9% had analgesic infusion and 38.9% were on neuromuscular blockade. A means Glasco Coma Scale was 9.4 and 56% of the patients were reported as being. Most patients (89.9%) required re-intubation. The findings also revealed that 49.1% of the nurses who cared for the patients when the extubation occured had one patient at the time. Also, 84.2% of nurses had 0-6 years of nursing experience and 74% of nurses had less than five years of ICU experience. / Health Studies / M.A. (Health Studies) Unplanned extubation Accidental extubation Self-deliberate extubation Sedation Physical restraints Intensive Care Unit AACN Synergy model of patient care 616.0280967625
223	Avaliação do eugenol e de óleos essenciais na redução do estresse em aquicultura / Evaluation of the stress-reducing effect of eugenol and essential oils on aquaculture Parodi, Thaylise Vey 07 January 2014 (has links) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior / This study evaluated the anesthetic efficacy of eugenol and essential oils (EOs) of Aloysia triphylla and Lippia alba on aquaculture, as well as their stress-reducing effect during transport of shrimp and fish. The effectiveness of eugenol on blocking noxious stimulis was also tested. Sub-adult and post-larvae of white shrimp (Litopenaeus vannamei), albine and grey silver catfish (Rhamdia quelen) and fat snook (Centropomus paralellus) were evaluated for anesthetic induction time and recovery during short and long exposure to the EOs and eugenol. Oxidative stress parameters were also evaluated in sub-adult shrimps. Both silver catfish strains and fat snook were transported in water containing EO of A. triphylla at different concentrations and the reduction of stress was evaluated. An experimental model was elaborated to test the analgesic activity of eugenol in zebrafish (Danio rerio). The concentrations of eugenol, EO of A. triphylla and L. alba recommended for anesthesia in shrimps were respectively 200, 300 and 750 μL L-1 for sub-adults and 175, 300 and 500 μL L-1 for post-larvae. The concentrations indicated for transport are between 20-50, 20-30 and 50 μL-1 for sub adults and for post-larvae only eugenol and EO of A. triphylla at 20 and 20-50 μL L-1. A better antioxidant capacity in the hemolymph was obtained with 30 μL L-1 EOs of A. triphylla and L. alba and 20 μL L-1 eugenol. Albine silver catfish juveniles induced and recovered form anesthesia in longer time than grey ones and 200 μL L-1 was considered the most suitable concentration for both strains. In the transport the OE de A. triphylla increased whole body cortisol but did not promote ion loss. The increase of the concentration of OE A. triphylla proportionately decreased and increased the time of induction and recovery from anesthesia in fat snooks. The concentration of 20 μL L-1 reduced blood glucose levels after 24 h and plasma cortisol and lactate levels after 6h. Eugenol itself did not presented analgesic activity, but after the injection of acetic acid in the anterior portion eugenol blocked the noxious reflex. / O trabalho objetivou avaliar a eficácia anestésica do eugenol e óleos essenciais (OEs) de Aloysia triphylla e Lippia alba em aquicultura, bem como a eficácia dos mesmos como redutores de estresse durante o transporte de camarões e peixes e verificar efeito bloqueador de estímulos nocivos do eugenol. Camarões (sub-adultos e pós larvas), ambas variedades de jundiá e robalos-peva foram transportados em água contendo óleo essencial de A. triphylla em diferentes concentrações e avaliada a redução do estresse. Para eugenol foi traçado modelo experimental de avaliação da atividade analgésica em peixe-zebra (Danio rerio). As concentrações de eugenol e OE de A. triphylla e L. alba recomendadas para anestesia em camarões foram, respectivamente de 200, 300,750 μL L-1 para sub-adultos e para pós-larvas 175, 300 e 500 μL L-1. Para transporte concentrações entre 20-50; 20-30 e 50 μL L-1 são apropriadas para sub-adultos e para pós-larvas somente eugenol e OE de A. triphylla 20 e 20-50 μL L-1. Uma melhor capacidade antioxidante na hemolinfa de camarões foi obtida com 30 μL L-1 OEs de A. triphylla e L. alba e 20 μL L-1 para eugenol. Juvenis albinos de jundiá induziram e recuperaram da anestesia em maior tempo que os cinzas e considerou-se 200 μL L-1 a concentração mais adequada. No transporte, embora o OE de A. triphylla tenha causado aumento de cortisol corporal em jundiás, houve redução da perda de íons. Em robalospeva o aumento da concentração do OE de A. triphylla proporcionalmente diminuiu e aumentou o tempo de indução e recuperação anestésica, respectivamente. A concentração de 20 μL L-1 reduziu os níveis de glicose sanguínea após 24h e de cortisol e lactato após 6h. O eugenol por si só não apresentou atividade analgésica, porém quando injetado ácido acético na porção anterior de zebrafish a resposta ao efeito nocivo foi bloqueada. Aloysia triphylla Aquicultura Anestesia Estimulo Nocivo Parâmetros sanguíneos Transporte Sedação Óleos essenciais Estresse oxidativo Aloysia triphylla Aquaculture Anesthesia Noxious stimulis Blood parameters Transportation Sedation Essential Oils Oxidative stress CNPQ::CIENCIAS BIOLOGICAS::FARMACOLOGIA
224	Activité électrique diaphragmatique au cours du sevrage ventilatoire après insuffisance respiratoire aigue / Diaphragm electrical activation during weaning from mechanical ventilation after acute respiratory failure Rozé, Hadrien 12 December 2014 (has links) Le contrôle de la ventilation procède d’une interaction complexe entre des efférences centrales à destination des groupes musculaires ventilatoires et des afférences ventilatoires provenant de mécano et de chémorécepteurs. Cette commande de la ventilation s’adapte en permanence aux besoins ventilatoires. L’activation électrique du diaphragme (EAdi) informe sur la commande ventilatoire, la charge des muscles respiratoires, la synchronie patient-ventilateur et l’efficacité de la ventilation des patients de réanimation. L’utilisation inadaptée d’un mode deventilation spontanée avec une sur ou sous-assistance peut entrainer des dysfonctions diaphragmatiques, des lésions alvéolaires et des asynchronies. La première étude a permis de cibler l’assistance du mode NAVA en fonction de l’EAdi enregistrée lors d’un échec de test de sevrage. Nous avons observé une augmentation quotidienne de cette EAdi au cours du sevrage jusqu’à l’extubation. La deuxième étude a montré que cette augmentation n’est pas associée à une modification de l’efficacité neuro-ventilatoire lors du test de sevrage, possiblement en rapport avec l’inhibition d’une sédation résiduelle. La troisième étude a montré l’importance de l’inhibition de cette sédation résiduelle par midazolam sur l’EAdi et le volume courant au début du sevrage ainsi que la corrélation qui existe entre les deux. Une dernière étude a montré l’absence d’augmentation du volume courant sous NAVA chez des patients transplantés pulmonaires aux poumons dénervés sans réflexe de Herring Breuer par rapport à un groupe contrôle. Par ailleurs le volume courant sous NAVA était corrélé à la capacité pulmonaire totale. Ces études ont montré l’intérêt du monitorage l’EAdi dans le sevrage. / The control of breathing results from a complex interaction involving differentrespiratory centers, which feed signals to a central control mechanism that, in turn, provides outputto the effector muscles. Afferent inputs arising from chemo- and mechanoreceptors, related to thephysical status of the respiratory system and to the activation of the respiratory muscles, modulatepermanently the respiratory command to adapt ventilation to the needs. Diaphragm electricalactivation provides information about respiratory drive, respiratory muscle loading, patientventilatorsynchrony and efficiency of breathing in critically ill patients. The use of inappropriatelevel of assist during spontaneous breathing with over or under assist might be harmful withdiaphragmatic dysfunction, alveolar injury and asynchrony. The first study settled NAVA modeaccording to the EAdi recorded during a failed spontaneous breathing trial (SBT). An unexpecteddaily increase of EAdi has been found during SBT until extubation. The second study did not findany increase of the neuroventilatory efficiency during weaning, possibly because of residualsedation. A third study described the inhibition of residual sedation on EAdi and tidal volume at thebeginning of the weaning, and the correlation between them. The last study did not find anyincrease of tidal volume under NAVA after lung transplantation, with denervated lung withoutHerring Breuer reflex, compared to a control group. Moreover tidal volume under NAVA wascorrelated to total lung capacity. These studies highlight the interest of EAdi monitoring duringweaning. Activité électrique diaphragmatique Ventilation mécanique Neurally Adjusted Ventilatory Assist Insuffisance respiratoire aiguë Sevrage Commande diaphragmatique Sédation Transplantation pulmonaire Diaphragm electrical activity Mechanical ventilation Neurally Adjusted Ventilatory Assist Acute Respiratory Failure Weaning Diaphragmatic command Sedation Lung transplantation
225	Att förändra ett mikrosystem med hjälp av patientkontrollerad sedering : Studie angående medarbetares erfarenheter av systematiskt förbättringsarbete / Transforming a microsystem with patient-controlled sedation : A study of co-worker`s experience with systematic quality improvement Karlsson, Linda, Trofast, Ann-Helene January 2021 (has links) I dagens samhälle vill människor bli delaktiga och få medbestämmande. Personcentrerad vård medför att sjukvårdens strävar efter att patienten involveras och vården anpassas efter dennes behov och förutsättningar. På så sätt blir vården mer jämlik och kan utföras på ett kostnadseffektivt sätt. Vid utgångsläget på studerat sjukhus utfördes mindre gynekologiska interventioner på operationsavdelningen. Processen var resurskrävande och hade låg patientdelaktighet. Patientkontrollerad sedering (PCS) betyder att patienten styr sederingen själv. På så sätt kan både patientens delaktighet och värdet i mikrosystemet öka. Förbättringsarbetet innebar att utbilda sjuksköterskor från kvinnoklinikens mottagning att erbjuda PCS självständigt utan att anestesisjuksköterskan deltar. Då skapas möjlighet att utföra vissa interventioner på mottagningen istället för på operation. Syftet med förbättringsarbetet var att öka patientens delaktighet genom att införa patientkontrollerad sedering vid gynekologiska interventioner på kvinnoklinikens mottagning, Värnamo sjukhus. Eftersom detta arbetssätt inte är vedertaget var studiens syfte var att undersöka medarbetarnas erfarenheter av att erbjuda patientkontrollerad sedering. Förbättringsarbetet utgick från Nolans förbättringsmodell och strukturen i förbättringsrampen. Värdekompassens perspektiv och mätetal användes för att belysa effekten av förändringen, både för patienten, medarbetarna och verksamheten. Studien genomfördes med kvalitativ metod med hjälp av semistrukturerad fokusgruppintervju av medarbetare på kvinnoklinikens mottagning, Värnamo Sjukhus. Förbättringsarbetet resulterade i en funktionell sederingsmetod och ett förändrat mikrosystem för kvinnor som ska genomgå gynekologiska interventioner. Förbättringsarbetet stärkte patientens delaktighet och ökade möjligheten att bli en aktiv medspelare i sin egen vård. Samtliga värdekompassens balanserade mått påvisade att arbetssättet var välfungerande, patientsäkert och uppskattat både av patienter och medarbetare. Ytterligare effekt var att medarbetarnas kompetens ökade och att samverkan mellan klinikerna förbättrades. Studien påvisade att medarbetarna upplevde att det nya arbetssättet stärkte den personcentrerade vården. Införandet av PCS upplevdes både relationsskapande, engagerande och resurskrävande. / In modern society people prefer participation and co-determination. Person-centred care leads health care to involve the patient and the care adapts to the patient´s needs and conditions. This way the care will be more equal and can be performed in a more cost-effective way. Originally gynaecological interventions were costly performed in the operating room (OR) with lack of participation. Patient- controlled sedation (PCS) means that the patient controls the sedation itself. With this the patient's participation grows and increases value in the microsystem. The Quality improvement (QI) involved to teach nurses at the out-patient clinic (OPC) to handle PCS by themselves, without an anaesthetic nurse attending. In this way some interventions could be performed in the OPC instead of in the OR. The purpose of QI was to increase patient-participation by introducing PCS during interventions at the gynaecological OPC at Värnamo hospital. The study aimed at determining the co-worker's experiences when introducing PCS. The QI started from Nolans improvement model and the structure in the improvement ramp. The value-compass and measurements were used to evaluate the effects of the changes. The study was performed in a qualitative method with inductive approach using focus-group interview with co-workers at the gynaecological OPC. By introducing PCS in the QI women became participants in the gynaecological OPC. The QI resulted in that more interventions could safely be performed in the OPC. The new procedure makes the patient an active co-player, the competence of the co-workers rises, the collaboration between the clinics grows and the care is performed at the right level of care. The study showed that the co-workers experienced increased patient-centered care. The QI built relationships, was engaging and demanding resources. gynaecological interventions interprofessional collaboration person-centered care sedation systematic quality improvement gynekologiska interventioner interprofessionellt samarbete personcentrerad vård sedering systematiskt förbättringsarbete
226	Mechanisms of benzyl alcohol tolerance in Drosophila melanogaster Alhasan, Yazan Mahmoud 19 August 2010 (has links) Proper neuronal function requires the preservation of appropriate neural excitability. An adaptive increase in neural excitability after exposure to agents that depress neuronal signaling blunts the sedative drug effects upon subsequent drug exposure. This adaptive response to drug exposure leads to changes in drug induced behaviors such as tolerance, withdrawal and addiction. Here I use Drosophila melanogaster to study the cellular and neuronal components which mediate behavioral tolerance to the anesthetic benzyl alcohol. I demonstrate that rapid tolerance to benzyl alcohol is a pharmacodynamic mechanism independent of drug metabolism. Furthermore, tolerance is a cell autonomous response which occurs in the absence of neural signaling. Using genetic and pharmacological manipulations I find the synapse to play an important role in the development of tolerance. In addition, the neural circuits that regulate arousal and sleep also alter benzyl alcohol sensitivity. Beyond previously described transcriptional mechanisms I find a post-translational role of the Ca2+-activated K+-channel, slowpoke in the development of tolerance. Finally, I explore a form of juvenile onset tolerance, which may have origins that differ from rapid tolerance. The implications of this study go beyond tolerance in Drosophila melanogaster to benzyl alcohol and can shed light on human drug tolerance, withdrawal and addiction. / text Anesthetic Anesthesia Tolerance Sedation Arousal Alcohol Benzyl alcohol Mushroom bodies Ellipsoid body Gal4 Ion channel Slowpoke BK Shibire Shi Syx Syntaxin Comatose Comt Para Paralytic Larva Drosophila melanogaster Homeostasis NEM N-ethylmaleimide Temperature sensitive Conditional mutants Cell autonomous Neuronal excitability Resistance Sensitization Vesicle fusion Vesicle recycling Heat shock
227	Validação da medida da pressão crítica de fechamento da faringe durante o sono induzido / Validation of the pharyngeal critical closing pressure during induced sleep Genta, Pedro Rodrigues 31 March 2011 (has links) Introdução: A pressão crítica de fechamento da faringe (PCrit) é a pressão nasal em que há colapso da faringe. Conceitualmente a Pcrit reflete a contribuição anatômica na gênese da apnéia obstrutiva do sono (AOS). No entanto, a relação entre a PCrit e a anatomia das vias aéreas superiores (VAS) tem sido pouco estudada. A PCrit determinada durante o sono requer pesquisadores experientes durante a noite. A indução do sono com midazolam é usada na prática clínica para a realização de procedimentos ambulatoriais e poderia ser uma alternativa mais conveniente para se determinar a Pcrit. Porém, o midazolam pode provocar sedação além de simples indução do sono, reduzir a atividade muscular das VAS e aumentar a colapsabilidade quando comparado com o sono normal. Objetivos: 1. validar a determinação da PCrit durante o dia após a indução do sono com midazolam; 2. comparar a arquitetura do sono induzido com baixa dose de midazolam com o sono natural; 3. correlacionar a PCrit com a anatomia das VAS. Métodos: Homens com graus variados de sintomas sugestivos de AOS foram submetidos a polissonografia completa noturna, determinação da PCrit durante o sono natural e após a indução do sono com midazolam bem como tomografia computadorizada de cabeça e pescoço para avaliação das VAS. Resultados: Foram estudados 15 sujeitos com idade (média±DP) de 54 ± 10 anos, índice de massa corporal de 29,9 ± 3,9 kg/m2 e índice de apnéiahipopnéia (IAH) de 38 ± 22 (variação: 8-66 eventos/h). A indução do sono foi obtida em todos os sujeitos, utilizando doses mínimas de midazolam (mediana [intervalo interquartil]) (2,4 [2,0-4,4] mg). A PCrit durante o sono natural e induzido foram semelhantes (-0,82 ± 3,44 e -0,97 ± 3,21 cmH2O, P = 0,663) e se associaram (coeficiente de correlação intraclasse=0,92 (IC 95% 0,78-0,97 P<0,001). A distribuição das fases do sono durante sono natural e induzido foi similar, com excessão da fase 1 (10,5 ± 5,1% vs. 20,6 ± 8,1, respectivamente; P=0,001). A Pcrit determinada durante o sono natural e induzido se correlacionaram com o IAH (r=0,592, P=0,020 e r=0,576, P=0,025, respectivamente). Além disso tanto a Pcrit determinada por sono natural e induzido se correlacionaram com diversas variáveis tomográficas de VAS, incluindo a posição do osso hióide, ângulo da base do crânio e as áreas seccionais da velofaringe e hipofaringe (r variando de 0,577 a 0,686, P<0,05). A regressão linear múltipla revelou que o IAH foi independentemente associado com a Pcrit durante sono induzido, circunferência da cintura e idade (r2 = 0,785, P = 0,001). Conclusão: A PCrit determinada durante o dia com indução do sono é semelhante à determinada durante o sono natural e é um método alternativo promissor para determinar a PCrit. O sono induzido por doses baixas de midazolan promove um sono similar ao sono natural. A Pcrit determinada tanto durante o sono natural e induzido correlaciona-se com várias características anatômicas das VAS / Introduction: The pharyngeal critical closing pressure (Pcrit) is the nasal pressure at which the airway collapses. Pcrit is thought to reflect the anatomical contribution to the genesis of obstructive sleep apnea (OSA). However, the relationship between Pcrit and upper airway anatomy has been poorly investigated. Pcrit determined during sleep requires experienced investigators at night. Sleep induction with midazolam is frequently used in clinical practice during ambulatory procedure and could be a more convenient alternative to assess Pcrit. On the other hand, midazolam could induce sedation rather than sleep, decrease upper airway muscle activity and increase collapsibility compared with natural sleep. Objectives: 1. validate Pcrit determination during the day after sleep induction with midazolam; 2. compare the sleep architecture of induced sleep after low doses of midazolam with natural sleep; 3.correlate Pcrit with upper airway anatomy. Methods: Men with different severity of OSA symptoms underwent baseline full polysomnography, Pcrit determination during natural sleep and after sleep induction with midazolam and head and neck computed tomography. RESULTS: Fifteen men aged (mean±SD) 54±10ys, body mass index=29.9 ± 3.9 Kg/m2 and apnea hypopnea index=38±22, range: 8-66 events/h were studied. Sleep induction was obtained with minimum doses of midazolam (median[interquartile range] (2.4 [2.0-4.4] mg). Sleep phase distribution during natural and induced sleep was similar, except for stage 1 (10.5 ± 5.1% vs. 20.6 ± 8.1, respectively; P=0.001). Natural and induced sleep Pcrit were similar (-0.82 ± 3.44 and -0.97 ± 3.21 cmH2O, P=0.663) and closely associated (intraclass correlation coefficient=0.92 (95%CI 0.78-0.97, P<0.001). Natural and sleep induced Pcrit correlated with AHI (r=0.592, P=0.020; r=0.576, P=0.025, respectively). Pcrit determined both during natural and induced sleep were significantly associated with several tomographic variables, including hyoid position, cranial base angle and cross sectional areas of the velopharynx and hypopharynx (r range: 0.577 to 0.686, P<0.05). Multiple linear regression revealed that AHI was independently associated with induced sleep Pcrit, waist circumference and age (r2=0.785, P=0.001). Conclusion: Pcrit determined during the day with sleep induction is similar to natural sleep and is a promising alternative method to determine Pcrit. Sleep induction with small doses of midazolam promoted sleep similar to natural sleep. Pcrit determined both during natural and induced sleep correlates with several anatomical characteristics of the upper airway Conscious sedation Faringe/anatomia & histologia Faringe/efeitos de drogas Faringe/fisiopatologia Midazolam Midazolam Pharyngeal critical closing pressure Pharynx/anatomy & histology Pharynx/drug effects Pharynx/physiopatology Sedação consciente Sleep apnea obstructive/physiopathology Tomografia computadorizada por raios X X-ray computed tomography
228	Validação da medida da pressão crítica de fechamento da faringe durante o sono induzido / Validation of the pharyngeal critical closing pressure during induced sleep Pedro Rodrigues Genta 31 March 2011 (has links) Introdução: A pressão crítica de fechamento da faringe (PCrit) é a pressão nasal em que há colapso da faringe. Conceitualmente a Pcrit reflete a contribuição anatômica na gênese da apnéia obstrutiva do sono (AOS). No entanto, a relação entre a PCrit e a anatomia das vias aéreas superiores (VAS) tem sido pouco estudada. A PCrit determinada durante o sono requer pesquisadores experientes durante a noite. A indução do sono com midazolam é usada na prática clínica para a realização de procedimentos ambulatoriais e poderia ser uma alternativa mais conveniente para se determinar a Pcrit. Porém, o midazolam pode provocar sedação além de simples indução do sono, reduzir a atividade muscular das VAS e aumentar a colapsabilidade quando comparado com o sono normal. Objetivos: 1. validar a determinação da PCrit durante o dia após a indução do sono com midazolam; 2. comparar a arquitetura do sono induzido com baixa dose de midazolam com o sono natural; 3. correlacionar a PCrit com a anatomia das VAS. Métodos: Homens com graus variados de sintomas sugestivos de AOS foram submetidos a polissonografia completa noturna, determinação da PCrit durante o sono natural e após a indução do sono com midazolam bem como tomografia computadorizada de cabeça e pescoço para avaliação das VAS. Resultados: Foram estudados 15 sujeitos com idade (média±DP) de 54 ± 10 anos, índice de massa corporal de 29,9 ± 3,9 kg/m2 e índice de apnéiahipopnéia (IAH) de 38 ± 22 (variação: 8-66 eventos/h). A indução do sono foi obtida em todos os sujeitos, utilizando doses mínimas de midazolam (mediana [intervalo interquartil]) (2,4 [2,0-4,4] mg). A PCrit durante o sono natural e induzido foram semelhantes (-0,82 ± 3,44 e -0,97 ± 3,21 cmH2O, P = 0,663) e se associaram (coeficiente de correlação intraclasse=0,92 (IC 95% 0,78-0,97 P<0,001). A distribuição das fases do sono durante sono natural e induzido foi similar, com excessão da fase 1 (10,5 ± 5,1% vs. 20,6 ± 8,1, respectivamente; P=0,001). A Pcrit determinada durante o sono natural e induzido se correlacionaram com o IAH (r=0,592, P=0,020 e r=0,576, P=0,025, respectivamente). Além disso tanto a Pcrit determinada por sono natural e induzido se correlacionaram com diversas variáveis tomográficas de VAS, incluindo a posição do osso hióide, ângulo da base do crânio e as áreas seccionais da velofaringe e hipofaringe (r variando de 0,577 a 0,686, P<0,05). A regressão linear múltipla revelou que o IAH foi independentemente associado com a Pcrit durante sono induzido, circunferência da cintura e idade (r2 = 0,785, P = 0,001). Conclusão: A PCrit determinada durante o dia com indução do sono é semelhante à determinada durante o sono natural e é um método alternativo promissor para determinar a PCrit. O sono induzido por doses baixas de midazolan promove um sono similar ao sono natural. A Pcrit determinada tanto durante o sono natural e induzido correlaciona-se com várias características anatômicas das VAS / Introduction: The pharyngeal critical closing pressure (Pcrit) is the nasal pressure at which the airway collapses. Pcrit is thought to reflect the anatomical contribution to the genesis of obstructive sleep apnea (OSA). However, the relationship between Pcrit and upper airway anatomy has been poorly investigated. Pcrit determined during sleep requires experienced investigators at night. Sleep induction with midazolam is frequently used in clinical practice during ambulatory procedure and could be a more convenient alternative to assess Pcrit. On the other hand, midazolam could induce sedation rather than sleep, decrease upper airway muscle activity and increase collapsibility compared with natural sleep. Objectives: 1. validate Pcrit determination during the day after sleep induction with midazolam; 2. compare the sleep architecture of induced sleep after low doses of midazolam with natural sleep; 3.correlate Pcrit with upper airway anatomy. Methods: Men with different severity of OSA symptoms underwent baseline full polysomnography, Pcrit determination during natural sleep and after sleep induction with midazolam and head and neck computed tomography. RESULTS: Fifteen men aged (mean±SD) 54±10ys, body mass index=29.9 ± 3.9 Kg/m2 and apnea hypopnea index=38±22, range: 8-66 events/h were studied. Sleep induction was obtained with minimum doses of midazolam (median[interquartile range] (2.4 [2.0-4.4] mg). Sleep phase distribution during natural and induced sleep was similar, except for stage 1 (10.5 ± 5.1% vs. 20.6 ± 8.1, respectively; P=0.001). Natural and induced sleep Pcrit were similar (-0.82 ± 3.44 and -0.97 ± 3.21 cmH2O, P=0.663) and closely associated (intraclass correlation coefficient=0.92 (95%CI 0.78-0.97, P<0.001). Natural and sleep induced Pcrit correlated with AHI (r=0.592, P=0.020; r=0.576, P=0.025, respectively). Pcrit determined both during natural and induced sleep were significantly associated with several tomographic variables, including hyoid position, cranial base angle and cross sectional areas of the velopharynx and hypopharynx (r range: 0.577 to 0.686, P<0.05). Multiple linear regression revealed that AHI was independently associated with induced sleep Pcrit, waist circumference and age (r2=0.785, P=0.001). Conclusion: Pcrit determined during the day with sleep induction is similar to natural sleep and is a promising alternative method to determine Pcrit. Sleep induction with small doses of midazolam promoted sleep similar to natural sleep. Pcrit determined both during natural and induced sleep correlates with several anatomical characteristics of the upper airway Faringe/anatomia & histologia Faringe/efeitos de drogas Faringe/fisiopatologia Midazolam Sedação consciente Tomografia computadorizada por raios X Conscious sedation Midazolam Pharyngeal critical closing pressure Pharynx/anatomy & histology Pharynx/drug effects Pharynx/physiopatology Sleep apnea obstructive/physiopathology X-ray computed tomography
229	De l'invention du mourant à la figure de l'agonie. Recherche sur l'ultime épiphanie de la personne incarnée / From the invention of the dying, to the figure of agony : research on the final epiphany of the incarnated person Tranchant, Blandine 11 January 2017 (has links) A l’heure où la prise en charge médicale s’avère de plus en plus nécessaire pour accompagner la fin de vie, il nous apparait que sa place est de plus en plus importante et de moins en moins questionnée. Or, réduire la fin de vie à la question du mourant et de sa prise en charge est pour le moins problématique. L’arrêt d’hydratation et d’alimentation, les différentes formes de sédation, l’euthanasie, le suicide assisté, les soins palliatifs résument-ils à eux seuls ce que l’on peut dire de la fin de vie ? Peut-elle se résumer uniquement à une question d’ordre médical ? N’est-elle pas avant tout une question d’ordre existentiel où, à l’heure de notre déclin, nous sommes confrontés à l’agonie ? Souffrance et finitude se trouvent au cœur de notre interrogation et nous poussent à nous confronter au pâtir de la vie, nous dévoilant ainsi comme être de chair. Grâce à la philosophie henryenne, l’agonie va peu à peu se dévoiler comme une occasion ultime de révélation de soi à soi en tant que soi. Face à l’aporie du mal qui frappe, nous découvrons les hommes capables toujours d’y faire face par un effort de repersonnalisation. C’est cet effort nécessaire qui va se dévoiler tant dans le champ métaphysique, que dans le champ éthique, et que dans le champ politique. C’est ce même effort qui amène l’homme à prendre ses responsabilités et à répondre aux questions existentielles. La subjectivité de chacun se doit alors de devenir le centre de l’institution soignante. L’agonie devient possibilité de repenser la place de la personne au sein du système hospitalier : place de la personne soignante, de la personne soignée, de ceux qui accompagnent, tout en développant une éthique de l’accompagnement qui doit ensuite se décliner dans une politique. Car si, métaphysiquement, vivre son agonie ne peut se justifier que par l’Amour, éthiquement, il nous faut construire une nouvelle poétique de l’action faisant place à la fraternité issue de la chair, à l’imagination de l’homme pour répondre à l’appel d’autrui et de la vie, et à la subsidiarité, afin que chacun soit respecté dans son agir et sa conscience. Politiquement, cela nous ouvre alors à un système hospitalier respectueux de chaque « Je Peux » qui se déploie en son sein. Le respect du consentement du patient reste ainsi la pierre angulaire du système hospitalier ; mais il ne peut se construire que dans une alliance avec les soignants. / In the context of today’s world, medical care is becoming increasingly necessary to assist patients at the end of life. It appears that this care is taking on more and more importance and is subject to fewer and fewer questions. is less and less questioned. However, confining the end of life to the state of dying and its medical support is problematic. Can the end of life be resumed as stopping hydration and artificial feeding, sedation in its different forms, euthanasia, assisted suicide, and palliative care? Can it be summed up as a simple medical question? Isn’t the end of life, first and foremost, linked to an existential question in which, at the time of our decline, we come face to face with agony? Finiteness and suffering are at the heart of our questioning as we confront life’s hardships, revealing the mystery of the flesh. With the help of Michel Henry’s philosophy, agony will gradually reveal itself as an ultimate opportunity for self-revelation. Faced with the paradox of evil, we find Man capable of coping with an effort of re-personification. This necessary effort will unfold in the metaphysical, ethical and political fields. This same effort allows Man to take responsibility for himself and to contemplate existential questions. The subjectivity of each person must become the center of the healthcare institution. Agony becomes the possibility to rethink the place of the individual person within the hospital system: the care giver, the care receiver and those supporting them, all while developing an ethical personal assistance which must then translated into policies. Because even if metaphysically, living out agony cannot be otherwise justified but by Love, ethically we must build a new way of operating. We must leave room for fraternity as a consequence of being of the flesh, to imagination in order to respond to our fellow man and our life’s calling, and to subsidiarity so that everyone is respected in his actions and consciousness. Politically, it opens up the possibility of a hospital system respectful of each "I Can" which is echoed within its walls. Respect for the patient's consent remains the cornerstone of the hospital system but can only be built with an alliance with caregivers. Agonie Chair Pâtir Jouir Douleur Souffrance Fin de vie Consentement Sédation Euthanasie Suicide assisté Mourant Hôpital Institution Imagination Subsidiairité Fraternité Épiphanie Incarnation Liberté Éthique Politique Loi Agir Subjectivité Exception Angoisse Mal Amour Accompagnement Soulager Éthique médicale Médecine Soignants Proches Soigné Agony Flesch Suffer from Enjoy Suffering Pain End of life Consent Sedation Euthanasia Assisted suicide Dying Hospital Institution Imagination Subsidiarity Brotherhood Epiphany Incarnation Freedom Ethic Politic Law To act Subjectivity Exception Anguish Bad Love Individual support To relieve Medical ethics Medicine Care giver Close relatives Care receiver 100

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