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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
171

Opvoedkundige sielkundige riglyne vir die hantering van die agterblywende gesinslede van die selfmoordslagoffer / Educational psychological guidelines for intervention with families of the suicide victim

Barnard, Ilonka 11 1900 (has links)
Text in Afrikaans / Selfmoord is 'n kontroversiele aangeleentheid wat beide omstanders en agterblywendes met onsekerheid vervul. 'n Belangrike rede hiervoor is dat dit 'n onnatuurlike afsterwe is wat teen baie mense se norme en waardes indruis. ldiografiese navorsing is onderneem om die belewenisse van agterblywende gesinslede te ondersoek aangesien hulle die eintlike slagoffers van 'n selfmoord is wat met 'n komplekse realiteit gelaat word. Die doel van die navorsing was om riglyne daar te stel vir die hantering en ondersteuning van hierdie mense. Vanuit 'n in-diepte literatuurstudie, het dit geblyk dat die grootste probleme waarmee agterblywendes gekonfronteer word, wentel random problematiese emosies, veroordeling deur omstanders en belewings van persoonlike onvermoe om te midde van intense rousmart selfaktualisering optimaal te volvoer. 'n Vraelys wat aspekte (socs dit uit die literatuurstudie geblyk het) inkorporeer, is opgestel en aan agterblywendes gegee om te beantwoord. Van die belangrikste elemente wat na vore gekom het, is dat intense verhoudingskomplikasies na 'n selfmoord figureer, dat agterblywendes 'n behoefte het om rouverwerking teen hul eie tempo te doen, dat agterblywendes verkies dat omstanders nie voortdurend die gebeure sal ontleed en soek na oorsake in die teenwoordigheid van agterblywendes nie en dat elke agterblywende persoon se roubelewing persoonlik en uniek is. 'n Hoofstuk is gewy aan 'n wye verskeidenheid terapeutiese tegnieke wat geimplementeer kan word tydens hulpverlening aan agterblywendes. Die studie beskryf ook 'n gevallestudie en die verloop van sestien individuele terapeutiese sessies. In die terapeutiese insette is daar hoofsaaklik gebruik gemaak van hipnoterapie as 'n vorm van ontspanningsterapie waartydens daar gelokus word op problematiese emosies en persepsies wat voortgesette kwalitatiewe selfaktualisering belemmer. In die studie word Opvoedkundige Sielkundige riglyne vir hulpverlening aan agterblywendes, wat benut kan word deur hulpverleners (soos sielkundiges, onderwysers en ander ondersteuningsisteme). verskaf. Die studie bevestig dat die agterblywendes as die werklike slagoffers na 'n selfmoord agtergelaat word, maar dat sinvolle intervensie hierdie persone in staat kan stel om ten spyte van die gebeure weer optimaal te selfaktualiseer. / Suicide is a controversial topic. It causes both bystanders and survivors to feel insecure. An important reason for this is that it is an unnatural death which directly opposes the norms and values of the majority of people. ldiografic research has been undertaken to closely examine the experiences of suicide survivors as they are the real victims who are left to cope with a complex reality after a suicide. The objective of this study was to provide guidelines to effectively manage and render assistance to survivors. From an in depth review of available literature it appeared that troubled emotions, being denounced by bystanders and the inability to proceed with continued qualitative self-actualization are some of the most important problems survivors have to cope with. A questionnaire, incorporating significant aspects reported in literature, was compiled and given to survivors to complete. From their responses certain facets seemed to be problematic. Among the more problematic aspects were complicated interpersonal relations, the basic need to grieve at their own pace, the preference that bystanders avoid analysing the suicide and possible contributing factors (especially in the presence of survivors) and the recognition that each survivor's grief is personal and unique. A chapter has been devoted to a wide range of therapeutic techniques that can be implemented to facilitate the support given to survivors. The study also describes a case study as well as the progression of sixteen individual therapy sessions. Therapeutic intervention was mainly based on hypnotherapy as a form of relaxation therapy during which the focus is placed on problematic emotions and perceptions which prevent continued qualitative self-actualization. Educational Psychological guidelines along which assistance can be rendered by psychologists, teachers as well as other support services are given. This study not only confirms that the survivors are the actual victims of a suicide, but also that it is possible to assist these people to achieve optimal self-actualization through meaningful intervention. / Psychology of Education / D. Ed. (Sielkundige Opvoedkunde)
172

Yellow Stars and Trouser Inspections : Jewish Testimonies from Hungary, 1920–1945

Palosuo, Laura January 2008 (has links)
This study analyzes narratives of individual Jewish experiences of discrimination and genocidal violence in Hungary during the period of 1920–1945. The aim is to increase our knowledge and understanding of the events through an investigation of survivor testimonies concerning anti-Jewish laws and the Holocaust. The main focus is on how survivors perceived the treatment to which they and their fellow Jews were exposed, and how they responded to the persecution they faced. Perceptions and responses are analyzed through multiple factors such as gender, age, social class, and geographical place. The period under investigation stretches from 1920, when the law of Numerus Clausus (a quota system influencing admission to universities) was introduced, until the end of the Second World War in early 1945. Focus is placed on the war years, especially on 1944, the year of German occupation and the fascist Arrow Cross rule. Experiences from the labour service system, the Jewish houses in Budapest, and the ghettos, as well as of hiding and resistance, are some of the recurring themes which are examined here. Extensive interviews, along with eyewitness reports and memoirs, form the empirical basis of the study. The results demonstrate the complexity of individual experiences during times of upheaval, and the importance of the above factors is evident within the testimonies. The survivors’ experiences greatly depended on gender, age, social class, geographical place, civil status, religious orientation, as well as “race”. However, the importance of the different factors changed over time. For instance, in the beginning of this period, discrimination had a direct impact on adult males, while children, women, and the elderly were indirectly affected. Furthermore, persons belonging to the upper classes could circumvent the anti-Jewish laws in various ways. Ultimately, differences in treatment decreased, according to the testimonies. Women, children, and the elderly also became victims, as did individuals from all social classes.
173

省營事業機構人員精簡方案對留任員工組織行為影響之研究 / The Study of Impact of the Personnel Downsizing Program of the Provincial Government Enterprises on the Organizational Behavior of those Employees Kept Afterwards

葉雅倩, Yeh, Yah Chein Unknown Date (has links)
近年來由於世界性的經濟持續低迷,再加以各項自然資源的日益稀少與枯竭,以及面臨外在環境快速變遷與科技不斷推陳出新的衝擊,無論企業組織或政府部門莫不積極尋求降低人事費用、控制成本支出以及維繫組織目標發展的可行策略,而在各種策略當中,「精簡」(downsizing)常被認為是一項能促使組織重建、更新,降低成本費用、提高收益、增加競爭優勢及增進顧客滿意度的有效管理工具、故廣被國內外公私組織採用。在此同時,有關組織精簡對留任人員所造成的影響, 以及留任人員對於精簡方案的感受、反應與留任人員的感受、反應對精簡後組織運作績效之間的關聯性等方面的問題也逐漸受到討論重視。本研究乃以訂有人員精簡計畫,並已裁減部分人員的台汔、台鐵、中興、高硫、農工等五家省營事業機構為對象,探討其所實施的人員精簡方案與留任員工之組織行為的關係。本研究經由問卷調查分析後獲致下列結果:1.雖然受測的留任員工認為實施精簡使其工作職責加重,不安全感增加,對於精簡方案的規劃內容及實施過程方面也不甚滿意,但是他們對於人員精簡方案的整體評價仍較趨於正面;2.在實施人員精簡方案之後,受測的留任員工其組織承諾並未降低,在工作壓力及工作滿足方面也無明顯變化,而工作績效表現則較精簡前更為良好;3.受測者對人員精簡方案的認知與其精簡前後的組織承諾、工作壓力、工作滿足及工作績效變化情形之間存有顯著相關;4.不同年齡、婚姻狀況、教育程度、服務機關、服務年資、職務性質、職務等級的留任員工對人員精簡方案的認知有顯著差異;不同性別、年齡、婚姻狀況、教育程度、服務機關、服務年資、職務等級的留任員工在精簡後之組織行為變化上有顯著差異。
174

我國公務人員新退休撫卹制度之研究 / The Studing of New Retirement and Survivor Payment System of the Civil Service in the Republic of China

曾德宜, Tseng, Te-Yi Unknown Date (has links)
人口高齡化之現象係現代各國所面臨的重要社會問題之一,及政府與民間共同關切之人口發展趨勢,其所引發的社會性、政治性、經濟性、文化性議題,已逐漸成為現代工業化國家公共政策之焦點。由於醫療保健技術進步及生活水準提高,使得人類平均壽命延長,導致老年人口佔總人口的比例逐年遞增,而形成人口老化現象,在世界各國人口逐漸老化之際,我國也面臨相同的問題,據統計資料顯示,臺灣地區在民國82年底已邁入了聯合國所謂的「老人國」(即65歲以上人口占率超過7%)之社會發展階段,且人口老化之現象正不斷地在持續之中,未來人口結構高齡化之現象將直接並持續衝擊我國現有之政經結構,且此在一衝擊下之影響,將會日益擴散至公共事務各層面,形成各種對政府與社會之危機與挑戰。此一人口老化以及平均餘命增加之高齡化社會現象,對我國公共人事行政影響最著者,首推公務人員退休撫卹制度。公共人事行政管理系統,始於公務人員甄選之考試任用,終於退休撫卹之辦理,因此退休撫卹制度自是人事行政的重要環節。本研究擬針對現代社會高齡化之趨勢,就有關退撫制度之理論與公務人員退撫制度相關文獻進行探討,進而檢視我國歷代文官之退撫體制,並比較研究各國退撫制度之內容與實施情形,做為本研究之參考架構,復就我國原退撫制度之內容進行敘述和說明,藉以做為瞭解新制之基礎,另針對新制之建制背景及制度內容進行分析,並論及有關退撫基金管理營收以及制度規畫之議題,最後並檢視我國退撫制度的政策內涵及其相關措施,並提出改進建議,俾以規畫一符合現代社會安全需求與發揮公共人力資源管理效能之公務人員退休撫卹制度,做為發展國家與建立安定和諧之社會的基礎。
175

Estimação do tamanho ótimo das empresas na indústria manufatureira brasileira

Friche, Simone Castella 30 June 2010 (has links)
Submitted by Roberta Lorenzon (roberta.lorenzon@fgv.br) on 2011-05-23T12:40:03Z No. of bitstreams: 1 63080100001.pdf: 1298963 bytes, checksum: 2aa3f5c6602ec74daf85a303ab1d1fc8 (MD5) / Approved for entry into archive by Suzinei Teles Garcia Garcia(suzinei.garcia@fgv.br) on 2011-05-23T12:50:36Z (GMT) No. of bitstreams: 1 63080100001.pdf: 1298963 bytes, checksum: 2aa3f5c6602ec74daf85a303ab1d1fc8 (MD5) / Approved for entry into archive by Suzinei Teles Garcia Garcia(suzinei.garcia@fgv.br) on 2011-05-23T12:51:35Z (GMT) No. of bitstreams: 1 63080100001.pdf: 1298963 bytes, checksum: 2aa3f5c6602ec74daf85a303ab1d1fc8 (MD5) / Made available in DSpace on 2011-05-23T12:54:43Z (GMT). No. of bitstreams: 1 63080100001.pdf: 1298963 bytes, checksum: 2aa3f5c6602ec74daf85a303ab1d1fc8 (MD5) Previous issue date: 2010-06-30 / O tamanho ótimo de uma empresa exerce papel importante na determinação da estrutura de mercado, nas decisões de planejamento de empresas, e em políticas de regulação e antitruste. Assim, um dos principais objetivos deste trabalho foi estimar o tamanho ótimo (ou EME) das empresas para 106 setores da indústria manufatureira brasileira, num contexto de informação limitada. Outro objetivo foi analisar a mudança do tamanho ótimo das empresas devido ao processo de abertura comercial brasileiro. Para isso foram empregados dois procedimentos em sequência: Máxima Entropia (GOLAN, JUDGE & PERLOFF, 1996) e Survivor Technique (STIGLER, 1958). Primeiramente aplicamos a Máxima Entropia, para estimar as distribuições de market shares em cada setor utilizando somente medidas de concentração. Os dados se referem aos anos de 1978, 1995 e 1997. O próximo procedimento consistiu na aplicação da survivor technique a estas distribuições para encontrarmos o tamanho ótimo da empresa nos períodos pré e pós abertura comercial. Os resultados indicam que o processo de abertura comercial contribuiu para uma elevação do tamanho ótimo das empresas em mais de 60% dos setores. Este aumento ocorreu principalmente em setores capital intensivo e que apresentavam elevadas taxas de participação de empresas estrangeiras. Esses resultados corroboram os argumentos da literatura de organização industrial e comércio internacional que afirmam que o elevado protecionismo estimulou a proliferação de empresas pequenas e ineficientes que operam com escalas reduzidas e pouco competitivas. / The optimal firm size plays an important role in determining market structure, planning business decisions, and for antitrust and regulation. Thus, one goal of this study was to estimate the optimal firm size (or EME) for 106 sectors of Brazilian manufacturing industry in a context of limited information. Another goal was to analyze the change of the optimal firm size due to trade liberalization in Brazil. For this purpose two procedures were used in sequence: Maximum Entropy (GOLAN, JUDGE & PERLOFF, 1996) and Survivor Technique (STIGLER, 1958). First we applied the Maximum Entropy to estimate the distribution of market shares in each sector using only measures of concentration. Data refer to the years 1978, 1995 and 1997. The next procedure was the application of the survivor technique to these distributions to find the optimal firm size during the periods before and after trade liberalization. The results indicate that the trade liberalization process has contributed to an increase in the optimal firm size in over 60% of the sectors. This increase occurred mainly in capital intensive sectors that had high foreign firms’ ownership rates. These results support the arguments of industrial organization and international trade literature which claim that the high protectionism stimulated the proliferation of small and inefficient firms producing on small and not competitive scales.
176

Opvoedkundige sielkundige riglyne vir die hantering van die agterblywende gesinslede van die selfmoordslagoffer / Educational psychological guidelines for intervention with families of the suicide victim

Barnard, Ilonka 11 1900 (has links)
Text in Afrikaans / Selfmoord is 'n kontroversiele aangeleentheid wat beide omstanders en agterblywendes met onsekerheid vervul. 'n Belangrike rede hiervoor is dat dit 'n onnatuurlike afsterwe is wat teen baie mense se norme en waardes indruis. ldiografiese navorsing is onderneem om die belewenisse van agterblywende gesinslede te ondersoek aangesien hulle die eintlike slagoffers van 'n selfmoord is wat met 'n komplekse realiteit gelaat word. Die doel van die navorsing was om riglyne daar te stel vir die hantering en ondersteuning van hierdie mense. Vanuit 'n in-diepte literatuurstudie, het dit geblyk dat die grootste probleme waarmee agterblywendes gekonfronteer word, wentel random problematiese emosies, veroordeling deur omstanders en belewings van persoonlike onvermoe om te midde van intense rousmart selfaktualisering optimaal te volvoer. 'n Vraelys wat aspekte (socs dit uit die literatuurstudie geblyk het) inkorporeer, is opgestel en aan agterblywendes gegee om te beantwoord. Van die belangrikste elemente wat na vore gekom het, is dat intense verhoudingskomplikasies na 'n selfmoord figureer, dat agterblywendes 'n behoefte het om rouverwerking teen hul eie tempo te doen, dat agterblywendes verkies dat omstanders nie voortdurend die gebeure sal ontleed en soek na oorsake in die teenwoordigheid van agterblywendes nie en dat elke agterblywende persoon se roubelewing persoonlik en uniek is. 'n Hoofstuk is gewy aan 'n wye verskeidenheid terapeutiese tegnieke wat geimplementeer kan word tydens hulpverlening aan agterblywendes. Die studie beskryf ook 'n gevallestudie en die verloop van sestien individuele terapeutiese sessies. In die terapeutiese insette is daar hoofsaaklik gebruik gemaak van hipnoterapie as 'n vorm van ontspanningsterapie waartydens daar gelokus word op problematiese emosies en persepsies wat voortgesette kwalitatiewe selfaktualisering belemmer. In die studie word Opvoedkundige Sielkundige riglyne vir hulpverlening aan agterblywendes, wat benut kan word deur hulpverleners (soos sielkundiges, onderwysers en ander ondersteuningsisteme). verskaf. Die studie bevestig dat die agterblywendes as die werklike slagoffers na 'n selfmoord agtergelaat word, maar dat sinvolle intervensie hierdie persone in staat kan stel om ten spyte van die gebeure weer optimaal te selfaktualiseer. / Suicide is a controversial topic. It causes both bystanders and survivors to feel insecure. An important reason for this is that it is an unnatural death which directly opposes the norms and values of the majority of people. ldiografic research has been undertaken to closely examine the experiences of suicide survivors as they are the real victims who are left to cope with a complex reality after a suicide. The objective of this study was to provide guidelines to effectively manage and render assistance to survivors. From an in depth review of available literature it appeared that troubled emotions, being denounced by bystanders and the inability to proceed with continued qualitative self-actualization are some of the most important problems survivors have to cope with. A questionnaire, incorporating significant aspects reported in literature, was compiled and given to survivors to complete. From their responses certain facets seemed to be problematic. Among the more problematic aspects were complicated interpersonal relations, the basic need to grieve at their own pace, the preference that bystanders avoid analysing the suicide and possible contributing factors (especially in the presence of survivors) and the recognition that each survivor's grief is personal and unique. A chapter has been devoted to a wide range of therapeutic techniques that can be implemented to facilitate the support given to survivors. The study also describes a case study as well as the progression of sixteen individual therapy sessions. Therapeutic intervention was mainly based on hypnotherapy as a form of relaxation therapy during which the focus is placed on problematic emotions and perceptions which prevent continued qualitative self-actualization. Educational Psychological guidelines along which assistance can be rendered by psychologists, teachers as well as other support services are given. This study not only confirms that the survivors are the actual victims of a suicide, but also that it is possible to assist these people to achieve optimal self-actualization through meaningful intervention. / Psychology of Education / D. Ed. (Sielkundige Opvoedkunde)
177

Úmrtnost ve vysokých věcích / Mortality in high ages

Malá, Kateřina January 2018 (has links)
In this thesis, we study modelling of mortality in high ages by several approaches. Some of mentioned models take into account the phenomenon of mortality deceleration. Further, we present several ways of estimating of exposed to risk in (almost) extinct cohorts. We focus especially on the survivor ratio method but we also mention the MD method and the DG method. Finally, we perform a numerical study.
178

”Men tydligast minns jag den hand som räddade mig” : En studie om journalistikens Estoniahjältar / “Most clearly I remember the hand that saved me” : A study of journalisms heroes of the M/S Estonia.

Granberg, Hannes, Johansson, Linn January 2017 (has links)
This thesis examines how the Swedish newspapers Aftonbladet and Expressen portrays heroes in the aftermath of the sinking of the M/S Estonia in September of 1994. Our research questions are 1) How is heroism portrayed in the news reports about the Estonia disaster in the newspapers Expressen and Aftonbladet? 2) Are there similarities and distinctions between female and male heroes?   We have approached our material from a qualitative perspective analyzing 12 articles using critical discourse analysis.   Upon completion of our research we found that both men and women can be heroes, but regardless of gender heroes are all portrayed with traditionally male attributes, such as being aggressive, rational and courageous. To find and understand the hero in news context, the victim plays a periphery but important role. Our result also shows that the victim is needed in order for the hero to perform his or her actions. The victim can be both male or female, but are all described with female attributes as being weak, dependent and fragile.   The results of our study may be of use to understand how the journalistic practice actively uses stories about heroes to 1. personify a disaster, 2. summarize a fragmented chain of events and 3. project a distinction between the contemporary aspect of male and female.
179

Strategiatyöhön osallistuminen:strategistit ja strategiaselviytyjät

Pietilä, H. (Heli) 18 November 2015 (has links)
Abstract The purpose of this study is to increase understanding of participating in strategy practice when examined as membership in organizational hierarchy and as subjectivities in strategy discourse. The study approaches subjectivity in strategy practice from the viewpoint of organizational research within the strategy-as-practice (SasP) field, but has chosen a critical perspective to the assumption that strategy work belongs only to senior management. The study is based on interviews relating experiences of strategy participation in a public sector organization. It was found that when strategic planning and decision-making take place fairly far from practical everyday work, two separate strategy worlds would emerge within the organization: the conceptual and the practical world. The well-intended decisions made in the conceptual strategy world set demands for the subjects in the practical strategy world, who had to resort to coping mechanisms and survival strategies to deal with the practical consequences of the decisions. Furthermore, the traditional view of strategy as a senior management's top-down plan seemed to result in a division between strategy subjects and strategy objects. The division of subjectivities was not this dichotomic, however, as individuals moved more dynamically between the subjectivities identified in the strategy discourse. These positionings and subjectivities were products of the strategy practice and strategy discourse and they were studied using discourse analysis and positioning analysis. This study also opens a discussion on how a strategist's subjectivity could be defined within the strategy practices instead of being determined by hierarchical status. It proposes organizational citizenship as a basis for participating in strategy and views strategy as a combination of performing everyday work in a continuum, awakening and reacting to discontinuities and making necessary changes. / Tiivistelmä Tämän tutkimuksen tavoitteena on lisätä ymmärrystä siitä, millaiseksi strategiatyöhön osallistuminen määrittyy, kun sitä tarkastellaan toisaalta organisaation hierarkian jäsenyytenä ja toisaalta organisaation strategiadiskurssin subjektiviteetteina. Tutkimus kiinnittyy organisaatiotutkimuksen näkökulmasta strategy-as-practice (SasP) -kenttään tarkastellessaan strategiatoimijuutta osallistumisena strategiakäytäntöön, mutta valitsee kuitenkin kriittisen tarkastelukulman siihen, että strategiatyö kuuluisi vain johdolle. Tämä tutkimus perustuu haastatteluihin, joissa kartoitettiin strategiatyöhön osallistumisen kokemuksia kuntaorganisaatiossa. Yksi tutkimuksen havainnoista oli, että strategisen suunnittelun ja päätöksenteon tapahtuessa suhteellisen kaukana työn arjesta organisaatiossa näytti muodostuvan kaksi erilaista strategiamaailmaa: konseptuaalinen ja käytännöllinen. Konseptuaalisen strategiamaailman hyvässä tarkoituksessa tekemät strategiset linjaukset edellyttivät usein käytännöllisen strategiamaailman toimijoilta erilaisia selviytymismekanismeja ja selviytymisstrategioita. Lisäksi strategiatradition näkemys strategiasta johdon suunnitelmana näytti johtavan jakoon strategiasubjekteihin ja strategiaobjekteihin sekä osallistujiin ja osallistettaviin. Subjektiviteettien osalta jako ei kuitenkaan ollut näin dikotominen, vaan yksilöt liikkuivat dynaamisemmin strategiadiskurssissa tunnistettujen subjektiviteettien välillä. Näitä strategiakäytännössä ja strategiadiskurssissa muotoutuvia asemointeja ja subjektiviteetteja tutkittiin diskurssi- ja positiointianalyysia hyödyntämällä. Tutkimuksessa avataan keskustelua myös siitä, kuinka strategistin toimijuus voitaisiin nähdä strategiakäytännöissä määrittyvänä sen sijaan, että se määrittyy hierarkkisen aseman myötä tulevana oletuksena. Tällöin strategiaan osallistumista tarkastellaan organisaatiokansalaisuuteen liittyvänä toimijuutena ja strategia nähdään jatkumosta, epäjatkuvuuskohtiin havahtumisesta ja epäjatkuvuuskohtiin liittyvistä muutoksista muodostuvana kokonaisuutena.
180

Health-related quality of life in survivors of childhood acute lymphoblastic leukaemia

Harila, M. (Marika) 07 June 2011 (has links)
Abstract Leukemia treatment has been implicated to be responsible for a diversity of long-term adverse effects (Pui 2008), which can occur even years after diagnosis and can seriously impair survivors’ performance status and quality of life (Campbell et al. 2007, Zeltzer et al. 2008). The aim of the present work was to assess health-related quality of life in long-term survivors of acute lymphoblastic leukemia (ALL), and to find out whether vocational rehabilitation can promote the coping at work of young people who take part in a training intervention or help them find employment. Neuropsychological testing was performed on 64 survivors. Cranial irradiation had been administered to 44 of the survivors, while 20 survivors had been treated solely with chemotherapy. A control group consisted of 45 healthy young adults. We found that young adult survivors of childhood ALL treated with cranial irradiation had clear progressive deficits in their neurocognitive functioning at a mean of 20 years after diagnosis compared with healthy controls. Non-irradiated ALL survivors performed significantly better, but even they had statistically significant impairments in some of the neuropsychological test scores compared with the controls. Rand-36-Item health Survey (RAND-36) was used to assess subjective HRQoL, depressive symptoms were assessed with Beck Depression Inventory (BDI-21), and mental distress with General Health Questionnaire (GHQ-12) in 74 survivors of ALL. The control group consisted of 146 healthy young adults selected from local population registry. ALL survivors showed good HRQoL scores in comparison to the control group. Patients who had been treated for an ALL relapse and had received the most intensive chemo- and radiotherapy had significantly higher scores on mental health and vitality than the controls. Survivors of ALL report fewer depressive symptoms and equal mental well-being compared to healthy controls. Nine out of 63 survivors were selected for rehabilitation based on their occupation and psychosocial difficulties. The occupational rehabilitation course improved physical fitness and decreased overweight in long-term survivors of ALL, but impaired their HRQoL. Our findings support the idea that ALL survivors’ subjective experience of well-being is possibly affected by a repressive adaptive style. / Tiivistelmä Leukemiahoidoilla on todettu olevan pitkäaikaisvaikutuksia (Pui 2008), jotka voivat ilmetä jopa vuosia diagnoosin jälkeen heikentäen sairaudesta selvinneiden toimintakykyä ja elämänlaatua (Campbell et al. 2007, Zeltzer et al. 2008). Tämän tutkimuksen tavoitteena oli arvioida akuutista lymfaattisesta (ALL) leukemiasta selvinneiden terveyteen liittyvää elämänlaatua pitkällä aikavälillä sekä selvittää, voidaanko ammatillisen kuntoutuksen avulla edistää interventioon osallistuneiden työssä selviytymistä tai työllistymistä. Neuropsykologiseen tutkimukseen osallistui 64 ALL pitkäaikaisselviytyjää. Heistä 44 oli saanut pään alueen sädehoitoa ja 20 pelkästään solunsalpaajahoitoa. Verrokkiryhmässä oli 45 tervettä nuorta aikuista. Havaitsimme, että lapsuudessa pään alueen sädehoitoa saaneilla ALL-selviytyjillä oli verrokkeihin verrattuna selkeitä progressiivisia muutoksia neurokognitiivisessa toimintakyvyssä keskimäärin 20 vuotta diagnoosista. Ne, jotka eivät olleet saaneet sädehoitoa suoriutuivat huomattavasti paremmin, mutta heilläkin havaittiin tilastollisesti merkittäviä puutoksia joillakin neuropsykologisten testien osa-alueilla verrokkeihin verrattuna. 74 entisen ALL-potilaan terveyteen liittyvää elämänlaatua (HRQoL) mitattiin Rand-36 -mittarilla, masennusoireita Beckin masennustestillä (BDI-21) ja henkistä hyvinvointia General Health Questionnaire -mittarilla (GHQ-12). Verrokkiryhmäksi valittiin väestörekisteristä 146 tervettä nuorta aikuista. ALL-ryhmässä tutkittavien terveyteen liittyvää elämänlaatua mittaavat pisteet olivat hyvät verrokkiryhmään verrattuna. Ne potilaat, joita oli hoidettu leukemian uusiutumisen takia ja jotka olivat saaneet intensiivisintä solunsalpaaja- ja sädehoitoa saivat huomattavasti paremmat pisteet psyykkisen hyvinvoinnin ja vitaalisuuden osa-alueilla kuin verrokit. ALL -selviytyjät raportoivat vähemmän masennusoireita, ja he arvioivat psyykkinen hyvinvointinsa yhtä hyväksi kuin verrokit. Yhdeksän ALL pitkäaikaisselviytyjää osallistui heille suunnattuun ammatilliseen kuntoutusinterventioon. Ammatillinen kuntoutuskurssi paransi ALL -selviytyjien fyysistä suorituskykyä ja vähensi ylipainoa, mutta heikensi terveyteen liittyvää elämänlaatua. Tutkimustulokset tukevat ajatusta, että repressiivinen adaptaatio voi vaikuttaa lapsuusiän leukemiasta selvinneiden subjektiiviseen hyvinvoinnin kokemukseen.

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