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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Utvärdering av tre olika metoder för Van Gieson Elastin färgning på Kolorektalcancer i syfte att identifiera venös invasion / Evaluation of three different methods for Van Gieson Elastin staining on Colorectal Cancer in order to identify venous invasion

Moradi, Behrouz January 2021 (has links)
Kolorektalcancer är den tredje vanligaste cancerformen hos både män och kvinnor i Sverige där storkärls invasion, venös invasion (VI), är en viktig prognostisk indikator. Noggrann bedömning av VI är särskilt viktigt för patienter med kolorektal cancer i stadium II eftersom det kan påverka beslutet att erbjuda adjuvant behandling. Histologisk bedömning av VI kan vara utmanande på rutinmässig Hematoxylin och Eosin färgning (H&E). Elastinfärgning med syfte att identifiera elastinfibrer i kärlväggen kan underlätta bedömning av VI. I dagsläget finns inte någon bra elastinfärgning som kan användas rutinmässigt hos klinisk patologi i Värmland, Centralsjukhuset Karlstad, prover måste skickas till annat laboratorium vilket är tidskrävande. Denna studie ska finna den optimala färgningsmetoden för elastin genom att utvärdera tre olika färgningsmetoder för elastin fibrer. Färgningens resultat bedömdes rent histokemiskt av överläkare enlig kriterierna, frånvaro av avsedda kärl (skala 0–1), specifik infärgning (skala 0–1), specifik infärgnings intensitet (skala 1–3) och ospecifik infärgning (skala 0–1) och data samlades för respektive metod. Resultatet tyder på att rent histokemiskt är den manuella elastinfärgning metoden från Region Jönköpings län konsekvent och visade signifikant skillnad. Därför metoden är potentiellt användbar för den större frågeställningen om storkärlsinväxt i kolorektal cancer samt rekommenderas starkt som en rutinmässig elastinfärgning till klinisk patologi i Värmland, Centralsjukhuset Karlstad. / The third most common form of cancer in both men and women in Sweden is Colorectal cancer. Prognostic indicators of colorectal cancer include Large vessel invasion and venous invasion (VI). Careful assessment of VI is of particular interest especially with patients having stage II colorectal cancer. This is because it may influence decisions to offer adjuvant therapy. Accurate histological assessment of VI can be challenging on routine hematoxylin and eosin staining. But staining that can identify the elastin fibers in the vessel can enhance the assessment of VI. Currently, there is not any good Elastin staining that can be routinely used in clinical pathology in Värmland, Karlstad Central Hospital. Therefore, samples are required to be sent to other laboratories which in effect is time consuming. This study is aimed at finding an optimal elastin staining method through evaluations of three different staining methods for elastin fibers. Staining results were assessed histochemically by the chief physician according to the following criteria, absence of intended vessels (scale 0–1), specific staining (scale 0–1), specific staining intensity (scale 1–3) and nonspecific staining (scale 0–1), while different data were collected for each method. The results indicate that purely histochemically, elastin staining-manual method Region Jönköping County is consistent and significant. Therefore, the method is potentially useful for the detection of colorectal cancer and is strongly recommended as a routine elastin staining for clinical pathology in Värmland, Karlstad Central Hospital.
2

A computer assisted study of science education in Australian primary schools

Allen, L. R., n/a January 1982 (has links)
It is a well documented fact that primary teachers as a group are quite lacking in their enthusiasm for science, a subject of constant concern for those committed to its role as a component of the primary school curriculum. In order to test the effects of various treatments on groups of teachers and pre-service trainees, a 21 item questionnaire was developed to measure attitudes towards science in the primary school curriculum, towards improving expertise in the area, and in the traditional &quotescientific attitudes and values&quote. A new group of pre-service students provided one group and the pilot population, students in their final semester of a Diploma in Teaching programme another group, and teachers attending residential schools for UG2 conversion and PGl teacher education courses provided several other groups based on teaching location. Items were selected from the pilot instrument on their ability to discriminate between high scoring and low scoring groups measured with the Mann-Whitney U test. Analyses in the main survey between groups, were carried out using Mann-Whitney U test and Kruskal-Wallis one way analysis of variance, and between items, using Wilcoxon matched-pairs signed-ranks test. All manipulation and analysis of data was carried out with the assistance of two computer programs, written in PASCAL by the author specifically for this study � one for item analysis, the other, a statistical package for analysing the main survey data. Findings include 'support for prediction in the literature that change in education is a slow process, demanding ongoing support by the system and teacher education institutions, for teachers committed to the change. Also, the value of computer support, and advantages of tailoring a statistical package to the study, rather than the study to analyses readily accessible, are clearly demonstrated.
3

Detection of Honey Bee Viruses in Apis mellifera and Apis cerana

Lindström, Malin January 2011 (has links)
Two species of bees in the genus Apis, real honey bees, has long been of interest for man. These two are the European honey bee, Apis mellifera, and the Asian honey bee, Apis cerana. In Vietnam, beekeeping is of great importance, both with A.cerana and A.mellifera. The aim of this project was to investigate if the introduction of the European honey bee in Asia has affected the Asian honey bee, and whether different pathogens from A.mellifera have been transferred to A.cerana. Totally 40 samples, 20 from every species, were analysed for 8 different viruses. RNA was extracted and analysed with qRT-PCR. The results showed that 5 different viruses were present in the samples, DWV, CBPV, BQCV, SPV and SBV. SPV and SBV were only found occasionally while DWV, CBPV and BQCV were present in the majority of the samples. Differences in virus titres between the two bee species were significant for CBPV and BQCV, however the result for DWV titres was not considered significant. DWV therefore seem to be a ubiquitous virus in Vietnamese beekeeping irrespective of species. Further, the results cannot describe the influence or origin of the viruses but only confirm their presence. Additional investigations are needed in order to answer this question.
4

Jämförelser av styrkefunktioner för t-testet och Mann-Whitneys U-test en simuleringsstudie /

Widjeskog, Östen. January 1982 (has links)
Thesis--Åbo akademi, 1982. / Added t.p. with thesis statement inserted. Includes bibliographical references (p. 95-102).
5

Výzkum řečových příznaků hodnotících diadochokinetické (DDK) úlohy / Research of speech features quantifying diadochokinetic (DDK) tasks

Kukučka, Peter January 2014 (has links)
Speech processing methods were studied to calculate parameters of pacient with Parkinon's disease. Main focus of this work is to examine diadochokinetic (DDK) tests. Algorithm for parameters extraction was proposed. It works in more parts. DC is removed from speech signal, preemphasis aplicated. Envelope of input signal is calculated, peaks of syllables are detected. Parameters and statistical results of Mann-Whitney U~test are calculated from detected peaks. Proposed algorithm is implemented in Matlab.
6

Developing a new transformatory cultural tourism experience model / Milena Ivanovic

Ivanovic, Milena January 2014 (has links)
The research question addressed by this thesis is: To what degree the results of the statistical analysis will corroborate the main theoretical assumptions of the proposed theoretical model of new authentic transformatory cultural tourism experience as transmodern phenomenon of equality of two Cartesian levels of reality, material (objective authenticity) and experiential (constructive authenticity) in informing the intrapersonal existential authenticity as outcome transformatory tourist experience. The main reason for undertaking this study is to resolve the evident crisis of postmodern authenticity discourse arising from a failure of postmodern theoretical framework to integrate three social authenticity theories into a coherent authenticity discourse. The research design adopted in the study is theory-testing theory-building paradigm which incorporates both deductive and inductive logic and was applied in three successive phases. In the first phase the new theoretical model of transformatory cultural tourism experience was proposed, underpinned by transmodern flat ontology and philosophy of the Speculative Realism. In the second phase the main theoretical assumptions of equal contribution of objective and constructive authenticity as independent variables in informing the transformatory experience as dependent variable were empirically tested by standard multiple regression analysis. In the last deductive phase the results of all empirical tests were inferred onto initial theoretical assumptions of the original model and new modified model of transformatory cultural tourism experience has been proposed with an addition of two newly identified transmodern experiential constructs, epistemological and ontological authenticity. For a primary data collection the instrument was a self-administered questionnaire and the sampling strategy was a non-probability sampling. The data was collected during the period 01st and 18 April 2011 at two sites, Constitution Hill and Hector Peterson Memorial in Johannesburg. The sample size from two sites was N=406. The scales of measurements were already developed in the earlier questionnaire and the confirmatory factor analysis was used to confirm the variables contained in each factor, namely objective and constructive authenticity as independent variables and transformatory experience as the dependent variable. The results of a standard multiple regression analysis confirmed the importance of the model as independent variables explained 30.7% of the variances (R2=.307) in the model. An unexpected result was that objective authenticity explained 34.5% of the variance in the model (β = .345) which is significantly higher than 30.5% of variance explained by constructive authenticity (β = .305). The results of standard multiple regression analysis confirmed the main theoretical assumption of the model of equality of material and experiential levels of Cartesian duality in informing the new transformatory experience regarded as a transmodern phenomenon. The standard, stepwise and hierarchical multiple regression tests were further conducted to establish if any moderating variables should be added into the original model containing two independent variables. The tests included five demographic variables (gender, place of residence, connection with culture, and two items of education (pre-tertiary education and Bachelors degree) and none of the variables explained a level of variability which warranted their inclusion into the model. Consequently, the results of the retests of the model did not change its initial conceptualisation. Finally, the t-test and Mann-Whitney U tests identified a significant difference between the two groups in the level of authenticity of their experience derived from two sites. A group having stronger inclination for authenticity is identified as Cultural Creatives, who are known as the forerunners of transmodernism. Based on the results of all statistical tests the final model was modified to reflect the important theoretical findings pertaining to two new types of transmodern authenticity. Epistemological authenticity denotes combined effects of objective and constructive authenticity in feeding the ontological authenticity of transformatory experience. The ontological authenticity is further identified as a confirmation of authentic-self which is required by Cultural Creatives. With proposition of new modified model the theory-testing theory-building research design came to its conclusion. The importance of research findings presented in this study lies not only in resolving the current crises of authenticity discourse in tourism but in the proposed New theoretical and conceptual model of transformatory cultural tourism experience underpinned by objective ·and constructive authenticity which will open a whole new field in tourism research arising from new transmodern experiential paradigm. / PhD (Tourism Management), North-West University, Potchefstroom Campus, 2014
7

Developing a new transformatory cultural tourism experience model / Milena Ivanovic

Ivanovic, Milena January 2014 (has links)
The research question addressed by this thesis is: To what degree the results of the statistical analysis will corroborate the main theoretical assumptions of the proposed theoretical model of new authentic transformatory cultural tourism experience as transmodern phenomenon of equality of two Cartesian levels of reality, material (objective authenticity) and experiential (constructive authenticity) in informing the intrapersonal existential authenticity as outcome transformatory tourist experience. The main reason for undertaking this study is to resolve the evident crisis of postmodern authenticity discourse arising from a failure of postmodern theoretical framework to integrate three social authenticity theories into a coherent authenticity discourse. The research design adopted in the study is theory-testing theory-building paradigm which incorporates both deductive and inductive logic and was applied in three successive phases. In the first phase the new theoretical model of transformatory cultural tourism experience was proposed, underpinned by transmodern flat ontology and philosophy of the Speculative Realism. In the second phase the main theoretical assumptions of equal contribution of objective and constructive authenticity as independent variables in informing the transformatory experience as dependent variable were empirically tested by standard multiple regression analysis. In the last deductive phase the results of all empirical tests were inferred onto initial theoretical assumptions of the original model and new modified model of transformatory cultural tourism experience has been proposed with an addition of two newly identified transmodern experiential constructs, epistemological and ontological authenticity. For a primary data collection the instrument was a self-administered questionnaire and the sampling strategy was a non-probability sampling. The data was collected during the period 01st and 18 April 2011 at two sites, Constitution Hill and Hector Peterson Memorial in Johannesburg. The sample size from two sites was N=406. The scales of measurements were already developed in the earlier questionnaire and the confirmatory factor analysis was used to confirm the variables contained in each factor, namely objective and constructive authenticity as independent variables and transformatory experience as the dependent variable. The results of a standard multiple regression analysis confirmed the importance of the model as independent variables explained 30.7% of the variances (R2=.307) in the model. An unexpected result was that objective authenticity explained 34.5% of the variance in the model (β = .345) which is significantly higher than 30.5% of variance explained by constructive authenticity (β = .305). The results of standard multiple regression analysis confirmed the main theoretical assumption of the model of equality of material and experiential levels of Cartesian duality in informing the new transformatory experience regarded as a transmodern phenomenon. The standard, stepwise and hierarchical multiple regression tests were further conducted to establish if any moderating variables should be added into the original model containing two independent variables. The tests included five demographic variables (gender, place of residence, connection with culture, and two items of education (pre-tertiary education and Bachelors degree) and none of the variables explained a level of variability which warranted their inclusion into the model. Consequently, the results of the retests of the model did not change its initial conceptualisation. Finally, the t-test and Mann-Whitney U tests identified a significant difference between the two groups in the level of authenticity of their experience derived from two sites. A group having stronger inclination for authenticity is identified as Cultural Creatives, who are known as the forerunners of transmodernism. Based on the results of all statistical tests the final model was modified to reflect the important theoretical findings pertaining to two new types of transmodern authenticity. Epistemological authenticity denotes combined effects of objective and constructive authenticity in feeding the ontological authenticity of transformatory experience. The ontological authenticity is further identified as a confirmation of authentic-self which is required by Cultural Creatives. With proposition of new modified model the theory-testing theory-building research design came to its conclusion. The importance of research findings presented in this study lies not only in resolving the current crises of authenticity discourse in tourism but in the proposed New theoretical and conceptual model of transformatory cultural tourism experience underpinned by objective ·and constructive authenticity which will open a whole new field in tourism research arising from new transmodern experiential paradigm. / PhD (Tourism Management), North-West University, Potchefstroom Campus, 2014
8

Aplikace statistické analýzy řeči pacientů s Parkinsonovou nemocí / Application of statistical analysis of speech in patients with Parkinson's disease

Bijota, Jan January 2016 (has links)
This thesis deals with speech analysis of people who suffer from Parkinson’s disease. Purpose of this thesis is to obtain statistical sample of speech parameters which helps to determine if examined person is suffering from Parkinson’s disease. Statistical sample is based on hypokinetic dysarthria detection. For speech signal pre-processing DC-offset removal and pre-emphasis are used. The next step is to divide signal into frames. Phonation parameters, MFCC and PLP coefficients are used for characterization of framed speech signal. After parametrization the speech signal can be analyzed by statistical methods. For statistical analysis in this thesis Spearman’s and Pearson’s correlation coefficients, mutual information, Mann-Whitney U test and Student’s t-test are used. The thesis results are the groups of speech parameters for individual long czech vowels which are the best indicator of the difference between healthy person and patient suffering from Parkinson’s disease. These result can be helpful in medical diagnosis of a patient.
9

Atrial Fibrillation Detection Algorithm Evaluation and Implementation in Java / Utvärdering av algoritmer för detektion av förmaksflimmer samt implementation i Java

Dizon, Lucas, Johansson, Martin January 2014 (has links)
Atrial fibrillation is a common heart arrhythmia which is characterized by a missing or irregular contraction of the atria. The disease is a risk factor for other more serious diseases and the total medical costs in society are extensive. Therefore it would be beneficial to improve and optimize the prevention and detection of the disease.   Pulse palpation and heart auscultation can facilitate the detection of atrial fibrillation clinically, but the diagnosis is generally confirmed by an ECG examination. Today there are several algorithms that detect atrial fibrillation by analysing an ECG. A common method is to study the heart rate variability (HRV) and by different types of statistical calculations find episodes of atrial fibrillation which deviates from normal sinus rhythm.   Two algorithms for detection of atrial fibrillation have been evaluated in Matlab. One is based on the coefficient of variation and the other uses a logistic regression model. Training and testing of the algorithms were done with data from the Physionet MIT database. Several steps of signal processing were used to remove different types of noise and artefacts before the data could be used.   When testing the algorithms, the CV algorithm performed with a sensitivity of 91,38%, a specificity of 93,93% and accuracy of 92,92%, and the results of the logistic regression algorithm was a sensitivity of 97,23%, specificity of 93,79% and accuracy of 95,39%. The logistic regression algorithm performed better and was chosen for implementation in Java, where it achieved a sensitivity of 97,31%, specificity of 93,47% and accuracy of 95,25%. / Förmaksflimmer är en vanlig hjärtrytmrubbning som kännetecknas av en avsaknad eller oregelbunden kontraktion av förmaken. Sjukdomen är en riskfaktor för andra allvarligare sjukdomar och de totala kostnaderna för samhället är betydande. Det skulle därför vara fördelaktigt att effektivisera och förbättra prevention samt diagnostisering av förmaksflimmer.   Kliniskt diagnostiseras förmaksflimmer med hjälp av till exempel pulspalpation och auskultation av hjärtat, men diagnosen brukar fastställas med en EKG-undersökning. Det finns idag flertalet algoritmer för att detektera arytmin genom att analysera ett EKG. En av de vanligaste metoderna är att undersöka variabiliteten av hjärtrytmen (HRV) och utföra olika sorters statistiska beräkningar som kan upptäcka episoder av förmaksflimmer som avviker från en normal sinusrytm.   I detta projekt har två metoder för att detektera förmaksflimmer utvärderats i Matlab, en baseras på beräkningar av variationskoefficienten och den andra använder sig av logistisk regression. EKG som kommer från databasen Physionet MIT används för att träna och testa modeller av algoritmerna. Innan EKG-signalen kan användas måste den behandlas för att ta bort olika typer av brus och artefakter.   Vid test av algoritmen med variationskoefficienten blev resultatet en sensitivitet på 91,38%, en specificitet på 93,93% och en noggrannhet på 92,92%. För logistisk regression blev sensitiviteten 97,23%, specificiteten 93,79% och noggrannheten 95,39%. Algoritmen med logistisk regression presterade bättre och valdes därför för att implementeras i Java, där uppnåddes en sensitivitet på 91,31%, en specificitet på 93,47% och en noggrannhet på 95,25%.
10

GRAVIDA KVINNORS INTAG AV KOSTTILLSKOTT : En kvantitativ studie med fokus på järn och probiotika / PREGNANT WOMEN´S INTAKE OF DIETARY SUPPLEMENT : A quantitative study focusing on iron and probiotics

Lange Bålman, Miriam January 2019 (has links)
Sammanfattning  Bakgrund Vitamin- och mineralbrister hos gravida kvinnor kan leda till missfall och allvarliga störningar i barnets utveckling. Moderns tarmflora överförs med stor sannolikhet till barnet under förlossningen och kan därför innebära ett viktigt steg i utvecklingen av barnets tarmflora. En tänkbar lösning för att säkra ett adekvat intag kan vara konsumtion av kosttillskott och probiotika. I dagsläget finns osäkra uppgifter om hur många gravida kvinnor som intar tillskott.  Syfte Att undersöka hur många gravida kvinnor i Västerbottens län som valde att inta kosttillskott, främst järn och probiotika, samt om det fanns en skillnad mellan olika faktorer och intag.  Metod En kvantitativ tvärsnittsstudie där gravida kvinnor (n=1473) från Northpop-studien i Västerbottens län svarade på ett frågeformulär gällande intag av kosttillskott och faktorer som ålder, utbildning, kostregim etc. De statistiska tester som användes var Chi-2-test, oberoende t-test och Mann Whitney U-test. Materialet analyserades i SPSS. Signifikansnivån sattes till p<0,05.  Resultat Majoriteten av deltagarna svarade att de intog kosttillskott. Faktorer som ökade intaget av kosttillskott hos gravida kvinnor var högre ålder (p=0,030) jämfört med lägre ålder, högre utbildningsnivå (p=0,006) jämfört med lägre utbildningsnivå och vegetarisk/vegansk kost (p=0,021) jämfört med blandkost. Femtiofem procent uppgav att de intog järntillskott. De faktorer som ökade intaget av järntillskott hos gravida kvinnor var vegetarisk/vegansk kost (p=0,001) jämfört med blandkost. Probiotika intogs av 2 procent. Ett högre intag av probiotika sågs hos personer boende i stadsområde (p=0,024) jämfört med övriga boenderegioner samt de som åt vegetarisk/vegansk kost (p=0,001) jämfört med blandkost.  Slutsats Majoriteten av deltagarna intog någon typ av kosttillskott, hälften intog järntillskott och en liten andel intog probiotika. Lågutbildade, yngre, de som äter blandkost och bor utanför stadsområde verkar vara i riskgruppen för att inte inta kosttillskott. / Abstract  Background Vitamin and mineral deficiencies in pregnant women can lead to miscarriage and serious disturbances in children’s development. The intestinal flora of the mother is most likely transmitted to the child during childbirth and may lay the foundation for the child's health. One possible solution to ensure an adequate intake may be the consumption of dietary supplements and probiotics. At present, there is insufficient data on supplement consumption among pregnant women.  Objective The purpose of the study was to examine how many pregnant women in Västerbotten County chose to consume dietary supplements, mainly iron and probiotics, and whether there was a difference between different factors and intake.  Method A quantitative cross-sectional study where pregnant women (n=1473) from the Northpop-study in Västerbotten County responded to a questionnaire regarding consumption of dietary supplements and factors such as age, education, diet etc. The material was analyzed in SPSS with Chi-2-test, independent T-Test and Mann-Whitney U-Test. Using significance level <0.05.  Results The majority of participants, 90 percent, responded that they consumed dietary supplements. The factors that increased the intake of dietary supplements in pregnant women were higher age (p=0.030), higher education (p=0.006) and vegetarian/vegan diet (p=0.021). Iron was reported to be consumed by 804 people, 55 percent. The factors that increased the intake of iron supplement in pregnant women were vegetarian/vegan diet (p=0.001). Probiotics were consumed by 25 people, 2 percent. Living in urban areas (p=0.024) and eating vegetarian/vegan diet (p=0.002) increased consumption of probiotics.  Conclusion The majority of participants chose to consume some type of dietary supplement, half of the participants consumed iron supplements and a small part consumed probiotics. It appears that pregnant women who are low educated, younger, eating an omnivorous diet and living outside urban areas are in the risk zone for not consuming dietary supplements. / Northpop

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