Inscrite dans le champ de l’analyse du discours en interaction, notre thèse propose une étude des formes et des fonctions des discours rapportés (DR) dans le cadre des six débats télévisés de l’entre-deux-tours des présidentielles ayant eu lieu en France entre 1974 et 2012. Il y est question de déterminer avec précision à quoi sert le DR — dont on pourrait penser qu’il n’est pas véritablement constitutif du genre — dans ces interactions où chacun des candidats poursuit les objectifs particuliers de s’autopromouvoir et de délégitimer son adversaire.L’analyse détaillée des quelques quatre cents extraits recensés dans le corpus montre que les DR répondent, selon leur lieu d’apparition dans l’échange en cours, la nature de leur source (l’adversaire, un tiers extérieur au débat ou le locuteur lui-même) et leur teneur propositionnelle, à trois différentes visées qualifiables d’autopromotionnelle, de défensive et de polémique — visées auxquelles contribuent en outre parfois leur mode de mise en scène para- et non verbale (mouvements de la voix, mais aussi mimiques, postures, regards et gestuelles déployés par le locuteur conjointement au DR).Répondant ainsi à une intuition de départ, ce travail met à jour le fait que non seulement les discours rapportés sont mis au service des objectifs spécifiques des candidats lors des débats, mais encore qu’ils occupent, selon la nature de leur source, des fonctions différentes mais complémentaires (fonctions relatives à la dynamique des échanges et à l’élaboration d’un discours en confrontation, fonctions strictement argumentatives ou encore fonctions relatives à la finalité des débats en eux-mêmes). / Grounded in the framework of the discourse-in-interaction analysis, this work analyses the forms and functions of reported speech within the six second-round debates of the French presidential election taking place in France between 1974 and 2012. Its object is to precisely determine the purpose of reported speech (which one might think that it is not truly constitutive of the genre) within these interactions in which candidates’main aims are self-promotion and the opponent depreciation.By analysing in details the almost four hundreds extracts recorded in the corpus, our work shows that reported speeches aim, depending on their place within the exchanges, their source (the opponent, a third party or the speaker) and their propositional content, three different purposes we can consider as self-promotion, defence and argument — these purposes can be furthermore supported by some para- and non-verbal elements (voice movements, facial expression, posture, eye expression and gesture deployed at the same time).Following an initial intuition, this study reveals that not only reported speeches serve the candidates’ main goals during debates, but also, depending on their source, they assure different and complementary functions (functions serving the dynamic within the exchanges and the construction of a speech in confrontation, functions exclusively argumentative, or also functions relating to the debates global purpose).

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Les expositions psychosociales au travail restent un problème de santé publique important en Europe. Il est nécessaire d'étudier le rôle de ces expositions dans l'association avec la santé en explorant les différences selon le genre, la position sociale et le pays. Le rôle de ces expositions dans l'explication des inégalités sociales du bien-être est presque inexploré. À ce jour, les concepts émergents d'expositions psychosociales au travail ont été souvent négligés.À l’aide des enquêtes européennes sur la qualité de vie 2007 (17 005 travailleurs) et sur les conditions de travail 2010 (33 443 salariés), les résultats ont montré que les inégalités sociales de santé perçue et du bien-être persistent en Europe. L'ampleur de ces inégalités diffère selon le genre et est plus élevé dans les pays qui ne sont pas dans l'Union européenne. Une forte demande psychologique, des faibles récompenses et une mauvaise conciliation travail-famille sont des facteurs de risque pour la santé perçue dans le modèle ajusté complet. Un certain nombre des facteurs psychosociaux au travail ont montré des associations significatives avec un faible bien-être. Presque aucune différence selon le genre, la profession et le pays n’a été trouvée dans ces associations pour les deux marqueurs de la santé. Les facteurs psychosociaux au travail contribuent à réduire les inégalités sociales de bien-être de 97% et plus selon le genre et la profession. Parmi eux, les facteurs liés à l’influence et au développement des compétences jouent un rôle important.Le genre, la position sociale et une grande variété de facteurs psychosociaux au travail doivent être considérés de manière plus complète dans les futures recherches et politiques de prévention. Les résultats de cette thèse pourraient être utilisés comme un élément fondamental pour mettre en œuvre des politiques de prévention au niveau européen. / Psychosocial work exposures remain a public health issue in Europe. There is a need of studying the role of these exposures in the association with health outcomes exploring differences according to gender, social position and country at the same time. The role of these exposures in the explanation of social inequalities in well-being is almost unexplored. To date emergent concepts of psychosocial work exposures have been often neglected. Using European data coming from the European Quality of Life Survey 2007 (17005 workers) and the European Working Conditions Survey 2010 (33443 employees), the results showed that social inequalities in self-reported health (SRH) and well-being remain in Europe. The magnitude of these inequalities differed according to gender and was higher in countries that are not in the European Union. High psychological demands, low reward and work-life imbalance were risk factors for poor SRH in the full-adjusted model. A number and variety of psychosocial work factors showed significant associations with poor well-being. Almost no differences according to gender, occupation and country were found in the associations with both health outcomes. Psychosocial work factors reduced social inequalities in well-being by 97% and more according to gender and occupation studied. Factors related to influence and development at work played a substantial role.Gender, social position and a variety of psychosocial work factors should be considered more comprehensively in future research and policies. Findings of this thesis could be used as a fundamental element in implementing health prevention policies at a European level.

Contexte : Les neuroleptiques sont souvent prescrits chez les sujets âgés et les patients souffrant de schizophrénie qui sont des personnes vulnérables. Notre objectif était d’étudier l’impact des NLP en situation réelle de prescription, dans ces deux populations. Etude 1. Consommation de neuroleptiques et décès en période de canicule chez les sujets âgés. A partir de données de l’Assurance Maladie, nous avons comparé les prescriptions de NLP chez des sujets âgés décédés pendant la canicule d’août 2003 (n=11624) aux prescriptions de témoins non décédés. Nous avons mis en évidence une association entre risque de décès et consommation de neuroleptiques, que ce soit juste avant ou pendant le pic de canicule et indépendamment d’autres médicaments, d’une démence ou d’une pathologie cardiaque. Etude 2. Efficacité réelle des NLP chez les patients souffrant de schizophrénie. A partir de données d’une cohorte observationnelle ayant inclus en France entière des schizophrènes adultes, nous avons montré que chez les patients déjà traités par NLP (n=5500), il y avait une association entre traitement par antipsychotique atypique (vs. NLP classique) et une meilleure satisfaction avec les soins et ce, pour tous les AA pris en compte et indépendamment du niveau de symptomatologie. Par ailleurs, chez les patients naïfs vis-à-vis de tout NLP et pour qui un traitement était introduit pour la première fois (n=467), un tiers des patients ne s’améliorait pas. Les facteurs prédictifs d’une meilleure réponse clinique étaient une moindre sévérité initiale globale des symptômes et des symptômes négatifs de schizophrénie. Au total, il existait cinq types de trajectoires d’évolution clinique. / Context : Antipsychotic drugs (AD) are often prescribed to elderly people and patients with schizophrenia and both populations are fragile. The aim of the present thesis was to investigate the impact of AD in these patients, in a real-life setting. Study 1. Antipsychotic drug use during a heatwave and risk of death, in older people. Using data from the French Social Security, prescriptions of older people who died during the heatwave in August 2003 (n=11624) were compared to these of controls who survived. An association was evidenced between a prescription of AD and death, in the periods just preceding and during the heatwave, independently of other psychotropic drugs, dementia or cardiac disease. Study 2. Effectiveness of AD in schizophrenia patients. Using data from a French nationwide observational study, we found that in patients treated for schizophrenia (n=5500), a higher level of satisfaction was independently associated with being on second-generation AD as compared to first-generation AD. Also, in drug-naive patients (n=467) followed up during 6 months after a first AD initiation, one third of the patients did not experience any improvement of symptoms. The factors predictive of a better clinical response were lower levels of baseline negative symptoms and overall severity of symptoms. A total of 5 trajectories of clinical evolution were identified.

Ce travail présente une étude linguistique des expressions d'opinions issues de différentes sources dans des textes en espagnol. Le travail comprend la définition d'un modèle pour les prédicats d'opinion et leurs arguments (la source, le sujet et le message), la création d'un lexique de prédicats d'opinions auxquels sont associées des informations provenant du modèle et la réalisation de trois systèmes informatiques.Le premier système, basé sur des règles contextuelles, obtient de bons résultats pour le score de F-mesure partielle: prédicat, 92%; source, 81%; sujet, 75%; message, 89%, opinion, 85%. En outre, l'identification de la source donne une valeur de 79% de F-mesure exacte. Le deuxième système, basé sur le modèle Conditional Random Fields (CRF), a été développé uniquement pour l'identification des sources, donnant une valeur de 76% de F-mesure exacte. Le troisième système, qui combine les deux techniques (règles et CRF), donne une valeur de 83% de F-mesure exacte, montrant ainsi que la combinaison permet d'obtenir des résultats intéressants.En ce qui concerne l'identification des sources, notre système, comparé à des travaux réalisés sur des corpus d'autres langues que l'espagnol, donne des résultats très satisfaisants. En effet ces différents travaux obtiennent des scores qui se situent entre 63% et 89,5%.Par ailleurs, en sus des systèmes réalisés pour l'identification de l'opinion, notre travail a débouché sur la construction de plusieurs ressources pour l'espagnol : un lexique de prédicats d'opinions, un corpus de 13000 mots avec des annotations sur les opinions et un corpus de 40000 mots avec des annotations sur les prédicats d'opinion et les sources. / This work presents a study of linguistic expressions of opinion from different sources in Spanish texts. The work includes the definition of a model for opinion predicates and their arguments (source, topic and message), the creation of a lexicon of opinion predicates which have information from the model associated, and the implementation of three systems.The first system, based on contextual rules, gets good results for the F-measure score (partial match): predicate, 92%; source, 81%; topic, 75%; message, 89%; full opinion, 85%. In addition, for source identification the F-measure for exact match is 79%. The second system, based on Conditional Random Fields (CRF), was developed only for the identification of sources, giving 76% of F-measure (exact match). The third system, which combines the two techniques (rules and CRF), gives a value of 83% of F-measure (exact match), showing that the combination yields interesting results.As regards the identification of sources, our system compared to other work developed for languages ​other than Spanish, gives very satisfactory results. Indeed these works had scores that fall between 63% and 89.5%.Moreover, in addition to the systems made for the identification of opinions, our work has led to the construction of several resources for Spanish: a lexicon of opinion predicates, a 13,000 words corpus with opinions annotated and a 40,000 words corpus with opinion predicates end sources annotated.

Black American women have the highest screening rates for cervical cancer among all the ethnic groups in the United States. Even though evidence from the literature suggests that the number of deaths from cervical cancer in the United States could be reduced by preventive screening, this particular minority population still suffers disproportionately higher mortality from the disease than the other minority and majority populations in the United States. This study was proposed to investigate cancer screening disparities among different subpopulations of women residing in the United States during 1999, and to recommend public health interventions that could potentially increase cervical cancer screening rates, thereby decreasing differential mortality rates for cervical cancer among these subpopulations. The Preventive Health Model in conjunction with data from the 1999 Behavioral Risk Factor Surveillance System was used to identify the covariates of cervical cancer screening behavior in an ethnically diverse population of American women residing in the United States during the specified timeframe. Univariate, bivariate and multivariable logistic regression procedures were used to evaluate the association between each one of the independent variables and the dependent variable (compliance with the 1999 cervical screening guidelines of the American Cancer Society). One of the major findings of this study was that Black, White and Hispanic American women were more similar in their screening behavior than dissimilar. The study also showed that the disparity in cervical cancer screening behavior in this population is in age, rather than in ethnic origin. Black, White and Hispanic American women of child-bearing age (18-44 years) were more likely to be compliant with the 1999 cervical cancer screening guidelines of the American Cancer Society, than Black, White and Hispanic American women who were not of child-bearing age (45 to 64 years). Implications for public health intervention studies are discussed, and recommendations made for future research in this area of cervical cancer screening behavior.

<p>Inferno constitutes a turning point in Strindberg's literary production in that scriptural quotations appear more frequently and a new style emerges. This thesis presents the characteristics of the scriptural quotations appearing in Inferno (1897) and Jacob Wrestles (a fragment following Légendes, written in French and in Swedish in 1898). Comparative, discourse, textual and intertextual approaches are used to define the place and role of scriptural quotations in this literary corpus.</p><p>From a historical point of view, both novels are part of the religious history of late 19th century France, where religion played a more important role than during the scientific, rationalist era characterizing the preceding decades. Strindberg adopts a new style corresponding to the spirit of his time. The art of "quoting the Bible at random" is a rhapsodic style, which appears mainly in Strindberg’s correspondence, in his Occult Diary (writings contemporary with Inferno) and in the work of some French 19th century writers. This style originates, above all, in the occult tradition, but it is also a means of imitating the Bible and identifying with a prophetic figure.</p><p>The research discussed in this dissertation has made it possible to determine, for the first time, what Bible translations are used in the two novels by Strindberg (translations by Ostervald and Martin / Roques). Five different types of rewritings of quotations were found: omissions, cutting of verses, substitutions, typographical changes and inversions. These variations were aimed at harmonising the Biblical text and the Strindbergian text, while removing contextual and theological elements that bothered the writer. The discourse analysis has concentrated on the quotations viewed as reported speech, distinguishing different ways of introducing Biblical verses in the novel. It was found that the narrator's subjectivity is present in the comments leading up to the quotations. The polyphonic character of some quotations has stressed the importance of identification play between the narrator and certain quotations characters such as Christ, Job and the psalmist.</p><p>The intertextual analysis has revealed a large number of similarities in the scriptural quotations in the literary production of Strindberg, Swedenborg and French 19th century literature. It is shown that Inferno contains various quotations that appear in Occult Diary and in other writers’ works, such as those of Swedenborg, Péladan, Zola, Huysmans and Chateaubriand. Jacob Wrestles, on the other hand, does not include as many intertextual elements but instead reassembles many scriptural quotations that were underlined in the Bible translation used for this novel: La Sainte Bible, Ostervald's translation from 1890, which can be found in Blå Tornet (The Strindberg Museum in Stockholm). Strindberg is consequently recycling Biblical material when he writes Inferno, while resorting to the French Bible of Ostervald from 1890 to write Jacob Wrestles.</p><p>The quotations strewn in Inferno constitute a crescendo and reveal the narrator’s unsuccessful attempt at conversion, at the same time forming the structure of a complaint psalm in which the narrator cries out his suffering and awaits liberation. In the French text of Jacob Wrestles, the writer offers a package of scriptural quotations in order to identify the narrator as "a religious man", imploring God's mercy like Moses and Job. In the Swedish text of Jacob Wrestles, a new perspective is introduced as a result of the change in language, the change from Old to New Testament, the new spiritual disposition of the narrator and the sudden intrusion of the writer in the narrator’s space. The role of scriptural quotations in the entire fragment of Jacob Wrestles is a true linguistic, thematic and theological revolution, which accounts for the narrator's extraordinary religious evolution. The misery of the narrator in Inferno allows a ray of Christian hope, which will persist in Strindbergs’s literary production post-Inferno.</p>

Inferno constitutes a turning point in Strindberg's literary production in that scriptural quotations appear more frequently and a new style emerges. This thesis presents the characteristics of the scriptural quotations appearing in Inferno (1897) and Jacob Wrestles (a fragment following Légendes, written in French and in Swedish in 1898). Comparative, discourse, textual and intertextual approaches are used to define the place and role of scriptural quotations in this literary corpus. From a historical point of view, both novels are part of the religious history of late 19th century France, where religion played a more important role than during the scientific, rationalist era characterizing the preceding decades. Strindberg adopts a new style corresponding to the spirit of his time. The art of "quoting the Bible at random" is a rhapsodic style, which appears mainly in Strindberg’s correspondence, in his Occult Diary (writings contemporary with Inferno) and in the work of some French 19th century writers. This style originates, above all, in the occult tradition, but it is also a means of imitating the Bible and identifying with a prophetic figure. The research discussed in this dissertation has made it possible to determine, for the first time, what Bible translations are used in the two novels by Strindberg (translations by Ostervald and Martin / Roques). Five different types of rewritings of quotations were found: omissions, cutting of verses, substitutions, typographical changes and inversions. These variations were aimed at harmonising the Biblical text and the Strindbergian text, while removing contextual and theological elements that bothered the writer. The discourse analysis has concentrated on the quotations viewed as reported speech, distinguishing different ways of introducing Biblical verses in the novel. It was found that the narrator's subjectivity is present in the comments leading up to the quotations. The polyphonic character of some quotations has stressed the importance of identification play between the narrator and certain quotations characters such as Christ, Job and the psalmist. The intertextual analysis has revealed a large number of similarities in the scriptural quotations in the literary production of Strindberg, Swedenborg and French 19th century literature. It is shown that Inferno contains various quotations that appear in Occult Diary and in other writers’ works, such as those of Swedenborg, Péladan, Zola, Huysmans and Chateaubriand. Jacob Wrestles, on the other hand, does not include as many intertextual elements but instead reassembles many scriptural quotations that were underlined in the Bible translation used for this novel: La Sainte Bible, Ostervald's translation from 1890, which can be found in Blå Tornet (The Strindberg Museum in Stockholm). Strindberg is consequently recycling Biblical material when he writes Inferno, while resorting to the French Bible of Ostervald from 1890 to write Jacob Wrestles. The quotations strewn in Inferno constitute a crescendo and reveal the narrator’s unsuccessful attempt at conversion, at the same time forming the structure of a complaint psalm in which the narrator cries out his suffering and awaits liberation. In the French text of Jacob Wrestles, the writer offers a package of scriptural quotations in order to identify the narrator as "a religious man", imploring God's mercy like Moses and Job. In the Swedish text of Jacob Wrestles, a new perspective is introduced as a result of the change in language, the change from Old to New Testament, the new spiritual disposition of the narrator and the sudden intrusion of the writer in the narrator’s space. The role of scriptural quotations in the entire fragment of Jacob Wrestles is a true linguistic, thematic and theological revolution, which accounts for the narrator's extraordinary religious evolution. The misery of the narrator in Inferno allows a ray of Christian hope, which will persist in Strindbergs’s literary production post-Inferno.

Amalgam has been used as a dental restorative material for centuries, but its potential health effects and biopersistance has lead to a decreased use especially in the Nordic countries. New materials have been introduced, partly to replace the mercury containing amalgam and partly because of esthetical reasons. The possible health effects of amalgam have been studied extensively and the material has been replaced with other less well-examined materials during the last few decades. The prevalence of side effects of dental materials is considered to be low in relation to the vast number of dental treatments undertaken. With the introduction of new and more complex materials, side effects related to dental treatment may increase. Epidemiological data suggest that the side effects of dental resins that have almost completely replaced amalgam fillings in Scandinavia, possess a risk for adverse reactions; however, the causal relation has not been fully established. Therefore, the type and extent of side effects caused by resin-based materials are of great interest. The aims of the study were: - to describe the change in health over time for patients with problems related to their dental materials. The hypothesis was that the patients could be divided into subgroups based on their symptoms and that the ability to recover differs between these groups [Paper I]. Furthermore, to determine whether factors such as the replacement of dental restorative materials and follow-up time had any impact on the perceived health. - to assess the long-term development of symptoms and their social consequences among patients referred for diagnosis and treatment of symptoms related to dental materials [Paper II] - to investigate the possible risks with dental restorative materials other than amalgam [Paper III]. - to describe side effects assessed to be caused by resin-based materials that occurred in a group of patients as well as treatment and long-term consequences of the reactions [Paper IV]. A questionnaire was sent to 614 patients [Paper I and II] that had been referred to the School of Dentistry, Umeå, Sweden, with symptoms allegedly caused by dental materials. The questionnaire contained questions on, among others; civil status, present health, medical and dental treatment and other measures and precautions taken because of psychosocial problems related to current employment situation, feelings, self-image and coping behavior. Moreover, information was collected [Paper III] from the Swedish Dental Materials Register 2003 (DentMr), a compilation of MSDS for 487 materials, and information from the user guide of the materials. The Material Safety Data Sheets (MSDS) included in the DentMR were examined regarding the given composition of the products, the occurrence of CAS-numbers and the risk- and safety phrases of the substances. Information was collected [Paper IV] on 36 patients with reactions to resin-based restorative materials from the Swedish National Register of Side-Effects of Dental Materials. Patients with complex symptoms had a more unfavorable long-term prognosis concerning persistent complaints than those with local symptoms only. Furthermore, the results indicate that the patients might experience health improvements after removal of their dental restorative materials. However, the reason for this improvement was unclear. Replacement of dental restorative materials had no significant impact on the ability to recover completely. Our results also indicate a relationship between patients’ self-related health and social consequences in daily life. Those with remaining complex symptoms had more often stopped working or had decreased their work hours because of their symptoms The information about hazards with dental materials seems insufficiently described in MSDS and there might be materials with side effects unknown to both patients and dental professionals. A literature search indicated that some of the listed substances had possible hazards, e.g. substances with embryotoxic and neurotoxic potential. The patients were very heterogeneous; a few with only local symptom free reactions while other had more complex symptoms. The latter group would gain from a multidisciplinary approach, i.e. dental, medical, as well as social and psychological factors have to be considered when developing care management programs for this group of patients. Furthermore, there is a need for stronger regulations of dental materials, such as those applied to pharmaceutical drugs. Finally, it was found that the majority of symptoms suspected to be caused by resin-based materials were local or a combination of local and extra-oral symptoms that appeared within the first 24 hours after treatment. The most frequent adverse effect reported was skin problems/dermatitis. It appears as though immediate reactions to resin based materials are not uncommon and more prevalent than allergic reactions. Still, we have had, difficulties in verifying associations between the dental restorative materials and adverse reactions and also to identify the offending component.

The overall aim of this thesis was to develop, deploy and evaluate new IT-based methods for supporting treatment and assessment of treatment of advanced Parkinson’s disease. In this condition a number of different motor and non-motor symptoms occur in episodes of varying frequency, duration and severity. In order to determine outcome of treatment changes, repeated assessments are necessary. Hospitalization for observation is expensive and may not be representative for the situation at home. Paper home diaries have questionable reliability and storage and retrieval of results are problematic. Approaches for monitoring using wearable sensors are unable to address important non-motor symptoms. A test battery system consisting of both self-assessments of symptoms and motor function tests was constructed for a touch screen mobile phone. Tests are performed on several occasions per day during test periods of one week. Data is transmitted over the mobile net to a central server where summaries in different symptom dimensions and an overall test score per patient and test period are calculated. There is a web application that graphically presents the results to treating clinical staff. As part of this work, a novel method for assessment of spiral drawing impairment useful during event-driven sampling was developed. To date, the system has been used by over 100 patients in 10 clinics in Sweden and Italy. Evidence is growing that the test battery is useful, reliable and valid for assessment of symptoms during advanced Parkinson’s disease. Infusion of a levodopa/carbidopa gel into the small intestine has been shown to reduce variation in plasma drug levels and improve clinical response in this patient category. A pharmacokinetic-pharmacodynamic model of this intestinal gel infusion was constructed. Possibly this model can assist the process of individualization of dosage for this treatment through in numero simulations. Results from an exploratory data analysis indicate that severity measures during oral levodopa treatment may be factors to consider when deciding candidates for infusion treatment.