Face à l’apparition grandissante de souches bactériennes multi-résistantes à l’arsenal d’antibiotiques actuels, les thiopeptides antibiotiques, bien que connus depuis plus de 60 ans, suscitent actuellement un fort regain d’intérêt. En effet, cette classe de molécules présente une forte activité antibiotique contre des souches bactériennes résistantes et multirésistantes, et met en œuvre deux modes d’inhibition originaux de la synthèse protéique encore inexploités en thérapie antibiotique humaine. Leur développement pharmacologique est en particulier freiné par la difficulté de préparation de ces molécules très complexes. L'élaboration d'une stratégie innovante de synthèse de la partie la plus complexe de ces molécules, le cœur hétérocyclique est étudiée dans ce travail. Cette approche repose sur l'étude et la valorisation de nouvelles méthodologies de fonctionnalisation directe des liaisons C-H et C-X de mono- et bis-thiazoles avec une large gamme d’hétéroaromatiques. Sa viabilité est démontrée par la préparation du cœur hétérocyclique commun aux amythiamicines. / Due to the emergence of multiresistant bacterial strains to standard antibacterial treatments, thiopeptides antibiotics are actually highly considered, though they are known for 60 years. They show an excellent antibiotic activity against multiresistant bacterial strains, and implement two originals inhibition mechanisms of protein synthesis, still unemployed in human therapy. However, the difficulty to prepare these complex macromolecules limits their pharmacological development. The development of a new strategy to synthetize the most complicated part of these macromolecules, their heterocyclic core, is studied here in. This approach is based on the study and the exploitation of novel direct C-H and C-X transition-metal-catalyzed couplings of mono- and bithiazoles units with a broad panel of heteroaromatics. Its viability is here demonstrated trough the multi-step synthesis of the common heterocyclic core of amythiamicins.

PhD (AGR) (Animal Science) / Department of Animal Science / Horticultural by-products such as seed and nut oil residues have the potential to replace conventional protein and energy sources in diets for ruminants. The objective of the study was to evaluate the nutritive value of Macadamia oil cake and Baobab seed cake as nutrient supplements for feedlot animals. Several experiments were carried-out to evaluate the nutritive value of Macadamia oil cake and Baobab seed cake as feed for ruminants. The nutrient composition of the cakes were determined using both proximate and modern methods of analysis of feeds and a t-test was used to compare the means of Macadamia oil cake and Baobab seed cake. The in sacco technique was used to determine the rumen degradability parameters of dry matter, crude protein and Amino acids of the cakes. This experiment was conducted using a completely randomized design. A three step-in vitro technique was used to conduct a post ruminal digestibility trial and the study was arranged in a completely randomized design. An apparent digestibility trial was conducted using metabolism cages and fecal bags to avoid the mixing of urine and faeces and the experiment was carried out as a completely randomized design arranged in a 2 x 2 factorial. A growth trial was conducted using a completely randomized block design arranged in a 2x2 factorial with two protein supplements and two inclusion levels as factors and blocked by sex of the lambs. The two cakes had similar (P>0.05) dry matter, fat, hemicellulose and gross energy contents. Baobab seed cake had significantly (P<0.05) higher ash, crude protein, acid detergent lignin and nitrogen free extract than macadamia oil cake. Macadamia oil cake had significantly (P<0.05) higher crude fiber, acid detergent fiber, neutral detergent fiber and cellulose concentrations. Baobab seed cake had significantly (P<0.05) higher calcium, magnesium, potassium, phosphorus (macroelements), zinc, and copper than macadamia oil cake. Macadamia oil cake was significantly (P<0.05) higher in manganese and iron contents than Baobab seed cake. Sodium content was not significantly (P>0.05) different between the two cakes. Baobab seed cake had more (Tryptophan, Cysteine, Arginine, Aspartic acid, Glutamic acid, Valine, Phenylalanine, Isoleucine, Leucine) Amino acids which were significantly (P<0.05) higher in quantity than macadamia oil cake with the two cakes having similar (P>0.05) remaining Amino acids contents. Generally Macadamia oil cake had more (P<0.05) saturated and mono-unsaturated fatty acids than Baobab seed cake whereas Baobab seed cake had more (P<0.05) poly-unsaturated fatty acids. v The in sacco rumen degradability characteristics of baobab seed cake and macadamia oil cake were estimated for dry matter and crude protein of the cakes. Macadamia oil cake had significantly (P<0.01) higher a value for dry matter than boabab seed cake. Baoaba seed cake had significantly (P<0.01) higher a value for crude protein than macadamia oil cake. the b, c, and a+b values for dry matter of both Baobab seed cake and Macadamia oil cake were not significantly (P>0.05) different form each other. However, the potential degradability (a+b) value for crude protein of baobab seed cake was significantly (P<0.01) higher than that of macadamia oil cake. The b and c constants of the two cakes for crude protein were not significantly (P>0.05) different from each other. The ED (Effective degradability) values calculated at three outflow rates (0.02, 0.05, 0.08) were estimated for dry matter and crude protein of Baobab seed cake and macadamia oil cake. The ED of the two cakes calculated at 0.02 outflow rate did not significantly (P>0.05) differ from each other. However, baobab seed cake had significantly (P<0.05) higher ED value at outflow rate of 0.05 whereas macadamia oil cake had significantly (P<0.05) higher ED value calculated at outflow rate of 0.08. The ED values of baobab seed cake for crude protein calculated at the three outflow rate were significantly (P<0.01) higher than those of macadamia oil cake. The two cakes did not significantly (P>0.05) differ in dry matter ruminal degradability but baobab seed cake had significantly (P<0.05) higher ruminal crude protein disappearance from 16 to 72 hours of incubation than macadamia oil cake. The in situ Amino acid degradation was determined on 0, 12, 16, 24, and 48 hour of ruminal incubation of the cakes’ samples and generally they were significant (P<0.05) differences for both cakes according to different incubation periods. The 3-step in vitro digestibility trial revealed that baobab seed cake had significantly (P<0.05) higher dry matter, crude protein and Amino acids digestibility values than macadamia oil cake. Apparent digestibility study revealed that nutrient intake, faecal and urine outputs, and digestibility of nutrients were not significantly (P>0.05) different between baobab seed cake and macadamia oil cake. However, lambs on 10% macadamia cake having retained significantly (P<0.05) more nitrogen than the lambs on 15% macadamia oil cake, 10% and 15% baobab seed cakes diets. However, the inclusion of either baobab seed cake or macadamia oil cake at 10% or 15% in the diets of lambs did not significantly (P>0.05) affect the DOMR, microbial protein yield and purine derivates output. For the growth trial the lambs were offered four diets formulated to contain 10% MOC (control), 15% MOC, 10 BSC and 15% BSC. The inclusion of 15% MOC and 10% BSC in the diets of lambs did not significantly (P>0.05) affect their final body weight, total weight gain, average daily feed intake, average daily weight gain, warm and cold carcass masses between these two vi groups. The inclusion of 10% MOC and 15% BSC in the diets of lambs did not significantly affect average daily feed intake and animal performance between these two groups. However, lambs on 10% MOC and 15% BSC had significantly (P<0.05) higher average daily feed intake and animal performance compared to lambs on 15% MOC diet. The feed conversion efficiency and of the lambs in the four diets were not significantly (P>0.05) different. The dressing percentage, carcass length, neck weight, fat thickness, body weight thickness and rib eye area of the carcasses of lambs in this trial did not differ significantly (P>0.05) except for spleen and skin with lambs on 10% BSC diets having the least skin weight and lambs on 10% MOC diet having heaver spleens. Generally BSC had higher (P<0.05) nutrient content than MOC. BSC and MOC were highly degradable in the rumen whereas BSC was higly digestible post-ruminally compared to MOC. The diets of fattening lambs formulated to include 10% or 15% of BSC or MOC as protein supplements did not affect the apparent digestibility of the diets. Macadamia oil cake can be incomporated in the diet of finishing lambs as a protein supplement at 10% inclusion level without compromising the growth and carcass characteristics of the lambs. Baobab seed cake as a protein supplement can be included in the diet of finishing lambs at up to 15% inclusion level without deleteriously compromising on the growth and carcass characteristics of the animals. ______________________________________ / NRF

Die vorliegende Bachelorarbeit erläutert die Entwicklung eines File Managers für das Hadoop Distributed Filesystem (HDFS) im Zusammenhang mit der Entwicklung des Dedoop Prototyps. Der File Manager deckt die Anwendungsfälle refresh, rename, move und delete ab. Darüber hinaus erlaubt er Uploads vom und Downloads zum lokalen Dateisystem des Anwenders. Besonders beachtet werden mussten hierbei die speziellen Anforderungen des Mehrbenutzerbetriebs. Darüber hinaus beschreibt die Bachelorarbeit die Entwicklung einer MapReduce Workflow Submission-Komponente für Dedoop, welche für die Übertragung und Ausführung der vom Anwender erzeugten Worflows verantworklich ist. Auch hierbei mussten die Anforderungen des Mehrbenutzer- und Multi-Cluster-Betriebs beachtet werden.

This project aims to contribute to the discussion regarding reproducibility of machinelearning research. This is done through utilizing the methods specified in the report ImprovingReproducibility in Machine Learning Research [30] to select an appropriateobject detection machine learning research paper for reproduction. Furthermore, this reportwill explain fundamental concepts of object detection. The chosen machine learningresearch paper, You Only Look Once (YOLO) [40] is then explained, implemented andtrained with various hyperparameters and pre-processing steps.While the reproduction did not achieve the results presented by the original machinelearning paper, some key insights were established. Firstly, the results of the projectdemonstrates the importance of pretraining. Secondly, the checklist provided by the NeurIPS[30] should be adjusted such that it is applicable in more situations.

Yes / Risk Management is one of the most relevant approaches and systematic applications of strategies, procedures and practices management that have been introduced in literatures for identifying and analysing risks which exist through the whole life of a product ,a process or services. Therefore, the aim of this paper is to propose a risk assessment model that will be implemented to the energy sector, particularly to power plants. This model combines the Analytic Hierarchy Process (AHP) technique with a new enhanced Balance Score Card (BSC). AHP is constructed to determine the weights and the priorities for all perspectives and risk indicators that involved in the BSC. The novelty in this paper is not only in using the BSC for risk assessment, but also, in developing a new BSC with six perspectives, which are sustainability perspective; economic; learning and growth; internal and operational business process; supply chain and customer/demand perspective. Another three contributions of this paper are firstly, including the sustainability dimension in BSC, and covering nine risk categories, which comprise 84 risk indicators that have been distributed across the six risk BSC perspectives. Secondly, assessing the non-technical risks in power plants and finally, this research will concentrate on the strategic level instead of the operational level where the majority of researches focus on latter but the former is far less researched. The created model will provide an effective measurement for the risks particularly, in the power plants sector. The results of this study demonstrate that the supply chain risks perspective is the keystone for the decision making process. Furthermore, these risk indicators with the new structure of BSC with six perspectives, help in achieving the organisation mission and vision in addition to affording a robust risk assessment model. The inputs of this model are composed from a previous stage using a modified Failure Mode and Effect Analysis (FMEA) (which has been used the Exponential Weighted Geometric Mean (EWGM)) to understand and analyse all risks, after which, the results of the developed FMEA which are the Risk Priority Numbers (RPN’s), have been used to build the AHP-BSC risk model. These risks are collected with difficulty from various literatures. This study will be validated in the next stage in power plants in the Middle East. / Hashemite University, Jordan

Submitted by JOSIANE SANTOS DE OLIVEIRA (josianeso) on 2017-09-22T13:25:26Z No. of bitstreams: 1 Fabricio Colvero Avini_.pdf: 3377321 bytes, checksum: b18160c29f04c7b1de74a9b4ccdf5f40 (MD5) / Made available in DSpace on 2017-09-22T13:25:26Z (GMT). No. of bitstreams: 1 Fabricio Colvero Avini_.pdf: 3377321 bytes, checksum: b18160c29f04c7b1de74a9b4ccdf5f40 (MD5) Previous issue date: 2017-06-01 / Nenhuma / A saúde apresenta enorme desafio de conciliar qualidade com viabilidade financeira. Como premissa, é uma área que demanda fazer mais, com menos recursos e com resultados que podem impactar na vida das pessoas. No Brasil, hospitais de excelência têm iniciativas muito próximas as internacionais de destaque, visando atender requisitos de qualidade elevada, medindo sua performance, como os hospitais da ANAHP (Associação Nacional de Hospitais Privados), mas a principal questão desta pesquisa é em relação a quais indicadores representam melhor a área de atenção hospitalar e poderia ser aplicada para todos perfis de hospitais do país. Os indicadores avaliados neste estudo foram agrupados nas dimensões do BSC (Balanced Scorecard), onde foram considerados processos de gestão e assistenciais, além de aspectos financeiros, recursos humanos e percepção de qualidade pelo cliente. O trabalho propõe, a partir de 7 referências nacionais e internacionais, um conjunto de 30 indicadores, com preocupação de cobrir não apenas processos estratégicos de gestão, mas também assistenciais, menos avaliado em hospitais fora do grupo de excelência. Este conjunto de indicadores foi validado por especialistas em gestão e assistência, não apenas ligados a hospitais de excelência, mas também ao perfil de hospitais identificados como futuros “adopters”, mais prevalente no brasil, como os filantrópicos, na tentativa de explorar a percepção de viabilidade futura de adoção de uma plataforma nacional de bencharming hospitalar. Após validado o conjunto de indicadores, foi apresentado um protótipo não-funcional em uma plataforma tecnológica em ambiente web, disponível no domínio benchealth.com.br e realizada a avaliação sobre a viabilidade de importar estas informações a partir dos Sistemas de Informação Hospitalar (SIH) presentes no mercado e de acordo com o nível de sistematização, com intuito de avaliar a viabilidade de extração destes indicadores. O resultado deste estudo demonstrou aderência aos indicadores propostos, porém ficou evidente as dificuldades de obtenção de alguns indicadores, principalmente relacionados a processos assistenciais, menos sistematizados nos hospitais. Também entende-se como necessidade futura, avaliar viabilidade de outros indicadores que possuem representatividade em ambientes de excelência e ainda não fizeram parte deste estudo inicial. / The health area presents huge challenge of reconciling quality with financial viability. As a premise is an area that demands to do more, with fewer resources and with results that can impact lives of people. In Brazil, hospitals of excellence have initiatives that are very close to the most important international ones, aiming to meet high quality requirements, measuring their performance, such as hospitals members of ANAHP (National Association of Private Hospitals), which has a collection of indicators and comparison between participants, but the main question of this research is in relation to which Indicators better represent the area of hospital care and could be applied to all profiles of hospitals in the country. The indicators evaluated in this study were grouped into the BSC (Balanced Scorecard) dimensions, mainly related within management and assistance process, besides financial aspects, human resources and customer perception of quality. The work proposes, from 7 national and international references, a set of 30 indicators, with concern to cover not only strategic processes of management, but also assistance, less evaluated in hospitals outside the group of excellence. This set of indicators was validated by a group of management and healthcare specialists, not only linked to hospitals of excellence, but also to the widespread profile of hospitals, identified as future adopters, more prevalent in Brazil, such as non-profit, in an attempt to exploring the perception of future feasibility of adopting a national hospital benchmarking platform. After validating the set of indicators, a non-functional prototype was presented in a web-based technology platform, available in the benchealth.com domain, and an assessment was made to visualize the feasibility of importing this information from the Hospital Information Systems (HIS) most used in market, considering systematization level within HIT, in order to evaluate the viability of extracting these indicators. The result of this study showed adherence to the proposed indicators, but also signaled difficulties in obtaining some indicators, mainly related to care processes, less systematized in hospitals. It is also clear the need to assess the viability of other indicators that have representativeness in environments of excellence and have not yet been part of this initial study.

Text in Afrikaans / Die doel van die onderhawige studie is onder meer om loopbaanorientering aan die tersiere student (BSc Agric) teoreties te fundeer. 'n Uitgebreide Europese studiereis is ondemeem met die doel om bestaande loopbaanorienteringsprogramme aan tersiere instansies, veral universiteite, te ondersoek en die effektiwiteit daarvan te evalueer ten einde voortreflikhede te implementeer. In hierdie studie word die loopbaanorienteringsprogram vir BSc (Agric)studente aan die Universiteit van Pretoria wat reeds in 1994 ontwerp en ge'implementeer is, beskryf sowel as die behoeftepeiling wat onder BSc (Agric)-studente (voor en na die implementering van die program), en vennote in die landboubedryf gedoen is. 'n Verdere doel met die studie is om 'n wetenskaplik verantwoorde loopbaanorienteringsverrykingsprogram vir BSc (Agric)-studente aan die Universiteit van Pretoria te begrond, te ontwerp, die implementering daarvan te beskryf en die resultate daarvan te evalueer. Daar is gepoog om beide loopbaanontwikkelings- en studente-ontwikkelingsteoriee te beskryf en uit te le as fundering vir 'n verantwoorde loopbaanorienteringsverrykingsprogram vir tersiere studente. 'n Oorsig en perspektief is gebied op bestaande loopbaanorienteringsprogramme en -inisiatiewe in 'n intemasionale, nasionale en plaaslike konteks. Die verskynsel van die snelveranderende wereld-van-werk is literatuurmatig gepresiseer en die implikasies uitgewys vir die opleiding van en loopbaanorientering aan die student in die Landbouwetenskap. 'n Behoeftepeiling van loopbaan (en lewens-)kundighedeen vaardighede waaroor graduandi moet beskik is gedoen onder BSc (Agric)-studente (v66r en mi programimplementering) en onder vennote in die landboubedryf. Die ontwikkeling, beslaggewing en ,evaluering van 'n loopbaanorienteringsverrykingsprogram vir BSc (Agric)-studente is beskryf en toegelig. 'n Samevatting van die studie is gegee met enkele gemotiveerde aanbevelings wat uit die navorsing voortvloei. Voorstelle is gemaak vir die inisiering van 'n loopbaansentrum vir studente van die Universiteit van Pretoria. / The aim of this study is amongst others to lay the theoretical foundation of career orientation for BSc (Agric)-students. An extensive European study tour was undertaken with the aim of investigating and evaluating existing career orientation programmes and/or student enrichment endeavours at the various tertiary institutions especially universities. The effectiveness of these programmes was evaluated with the aim of utilizing and implementing aspects of them. In this study the career orientation enrichment programme for BSc (Agric)-students that was already designed and implemented at the University of Pretoria in 1994, is described. The needs of the BSc (Agric)-students before and after the implementation of this programme were determined as well as those of the partners in the agricultural industry. Another aim of this study is to describe the foundation, design and implementation of a scientific, accountable career orientation enrichment programme for BSc (Agric)-students at the University of Pretoria and to evaluate the outcome thereof. The various career development and student development theories are elucidated and described as a foundation for an accountable career orientation enrichment programme for tertiary students. An overview is given of career orientation programmes and initiatives in an international, national and local context. The phenomenon of the fast changing world-ofwork is described and defined more precisely through a literature study with reference to the implications for the training of and career orientation regarding the student in the Science of Agriculture. An investigation was done of the career (and life-) skills that graduates have to attain. The needs and views of BSc (Agric)-students (before and after the programme implementation) and partners in the agricultural industry were extracted. A summary is given of the arguments put forward in this thesis together with some recommendations that have emerged from this research. Proposals are made for the initiation of a career centre for students at the University of Pretoria. / Psychology of Education / D. Ed. (Sielkundige Opvoedkunde)

Syfte: Syftet med denna studie är att skapa förståelse för hur styrkortsanvändning hos svenska kommuner upplevs av involverade chefer, särskilt sett till användbarhet och användarvänlighet. Metod: Denna studie antar ett kvalitativt och tolkningsinriktat synsätt och har en abduktiv ansats. Tillvägagångssättet omfattar en litteraturstudie samt empiri-insamling medelst semistrukturerade intervjuer, vilka sedan växelvis har ställts mot varandra genom en tematiserad analys. Slutsats: Vår slutsats är att styrkortsanvändning hos svenska kommuner uppvisar avsevärd variation, men att styrkorten överlag upplevs som användbara för organisationen; något mindre användbara för den enskilde chefen samt att bristfällig användarvänlighet är vanligt förekommande. Förslag till fortsatt forskning: Se stycke 6.4. Studiens bidrag: Vår studie bidrar med empirisk bekräftelse av att balanserat styrkort upplevs vara ett användbart koncept för kommunal styrning. Vidare påvisar studien att styrkortet främst är praktiskt användbart för organisationen som helhet; sett till den enskilde chefen är användbarheten och användarvänligheten mer begränsad, och förbättringspotentialen upplevs vara stor sett till båda perspektiv. / Aim: The purpose of this study is to create an understanding for how scorecard usage in Swedish local government is perceived by the involved managers, especially in terms of usefulness and ease of use. Method: This study adopts a qualitative and interpretative stance and has an abductive approach. The mode of procedure includes a literature study and collection of empiric material through semistructured interviews, which have then iteratively been positioned versus each other in a thematised analysis. Conclusions: Our conclusions are that scorecard usage in Swedish local government organisations encompasses considerable variation, but that the scorecards in general are perceived as useful for the organisation; somewhat less useful for the individual manager and that inadequate ease of use is commonly occurring. Suggested future research: See paragraph 6.4 below. Contribution of the thesis: Our study contributes with empiric confirmation that the balanced scorecard is perceived to be a suitable concept for Swedish local government management. The study also shows that the scorecard is useful primarily for the organisation as a whole; the usefulness and ease of use seen to the individual manager is more limited, and the potential for improvement is perceived to be considerable seen to both perspectives.

平衡計分卡( Balanced Scorecard, BSC)是一項可以協助描述、並推動組織策略付諸實行的利器，關於描述組織之價值創造的四個構面模式，可以當成高階管理團隊彼此間討論企業發展方向與策略議題優先性的共同語言。至於有關策略性衡量指標，除了是四大構面的績效指標之外，也應被視為BSC內四個構面具有因果關係連結的目標、項目；Robert S. Kaplan和David P. Norton共同創造出一個關於此連結的通用表達方式，用來協助高階主管進行討論，並稱之為策略地圖。他們同時也證明了BSC所寄託的一個基本原則，那就是「如果您能夠衡量，就可以管理」 從實務經驗中大多數人都會認為管理資訊系統不僅協助企業管理工作，也是產出各種衡量數據的利器，因此本研」究希望透過分析已導入過BSC之個案公司，探討該公司由策略地圖所引導出來的各項策略性衡量指標的資訊需求，是否能夠在其管理資訊系統中獲得滿足？管理資訊系統的建置是否應該優先支援公司策略性目標？實際上探訪各行業導入BSC之狀況，發現普遍存在著「數據落差」。 本研究旨在建構一套能夠彌補「數據落差的資訊需求規劃模式，利用商業智慧(BI)工具擷取ERP、CRM、SCM、Workflow、KM、e-Learning等管理資訊系統之有效數據，進行資訊加工後，提供給BSC資訊系統，在數位儀表板上顯示，以協助隨時管控策略性衡量指標之達成狀況。本研究也將BSC導入程序及資訊系統整合作業加以制式化，整理成BSC導入專案進度表，供其它有意導入BSC之企業參考，本論文最後延伸說明BSC在協助組織變革管理、協助智慧資本之衡量、及審視資訊資本齊備程度等方面，都很有助益。 / Balanced Scorecard (BSC) is a powerful tool for describing and implementing an organization’s strategy. The four-perspective model of describing a value-creating organization can be regards as a language for executive teams to discuss the direction and priority of their strategic agenda. In terms of strategy measures, they do not only represent as the key performance indicators (KPIs) of four independent perspectives, but also regard as the cause-effect linkage of goals and items among the four perspectives of BSC. Robert S. Kaplan and David P. Norton created the expression model of the cause-effect linkage to assist the discussion process of executive teams. It is so called a strategy map. They both also demonstrated a fundamental principle underling the BSC; i.e. “If you can measure, you can manage it.” From an empirical perspective, people believe that management information systems (MISs) can help the efficiency and effectiveness of business administration as well as be the powerful tool of generating data for various performance measures. Therefore, by analyzing a case of a BSC roll-out enterprise, this research would like to address whether the data requirements of strategic measures generating from strategy maps are fulfilled by the data output from the MISs or not. Is it a necessity to support the strategic goals of an enterprise first in case of building MISs for an enterprise? After studying the status of roll-out BSC enterprises in different industries, it shows that there is a “KPI-data accuracy” issue between actual KPIs needed and the data resources from. The purpose of this research is to build a data requirement planning model to find out the “accurate data” by using a business intelligence (BI) tool to access the effective information from ERP, CRM, SCM, Workflow, KM, e-Learning; etc., and then to manipulate those data in order to output the BSC indicators for executive teams for monitoring the status achieved of BSC from the dashboard anytime. Moreover, the study also standardizes the BSC roll-out processes and the integration processes of MISs by summarizing into time tables of project management which can be regarded as a reference kit for enterprises intending to implement BSC in the future. Finally, the study also demonstrates the benefits of BSC in assisting change management of an organization, in evaluating the intellectual capital, and in measuring information capital readiness of an enterprise, etc.

Made available in DSpace on 2016-04-25T18:39:37Z (GMT). No. of bitstreams: 1 Paulo Dias Raposo Filho.pdf: 1209264 bytes, checksum: 639d7c16d8c1d854ff3bbc07573abd0e (MD5) Previous issue date: 2011-02-24 / The objective of this work consists of developing an appraisal system based on the premises developed by BSC, through a case study, with opinion polls and quality approach. It was proposed a generic model to set up the performance indicators in a small sized drugstore which produces tailored made and prescribed chemical formulas. In order to compose the system design, a theoretical revision was carried out, broaching some proposals commonly developed in big companies. The work developed a revision of the strategic positioning, the formulation of SWOT analysis and the obtaining of strategic map for the company.Counting on a defined profile, it was set up on this basis in an appraisal system which substantiated BSC and from it indicators for entrepreneurial performance appraisal were set up. The development of this proposed work was centralized in the company Pharmakon Farmácia de Manipulação e Homeopatia ( Pharmakon Drugstore which produces tailored made and prescribed chemical formulas and Homeopathies), which has a structure classified as a small sized company. This work developed the review of strategic positioning, formulation of SWOT analysis and the obtaining of strategic map for the company. The consequences of implementation related to the work shown, considering the limitations of generalization of study case, can be adapted to other researches, besides being a useful subside for BSC implementation in other companies classified as small or medium ones / O objetivo deste trabalho consiste em desenvolver um sistema de avaliação de desempenho a partir das premissas desenvolvidas pelo BSC, por meio de um estudo de caso com pesquisa participante e abordagem qualitativa. Foi proposto um modelo genérico para a configuração dos indicadores de desempenho em uma farmácia de manipulação de pequeno porte. Para compor o desenho do sistema foi feita uma revisão teórica, abordando algumas propostas comumente desenvolvidas em empresas de grande porte. Com o perfil definido, foi configurado nessa base um sistema de avaliação fundamentado no BSC, e a partir dele foram estabelecidos os indicadores para a avaliação da performance empresarial. O desenvolvimento do trabalho foi centrado na empresa Pharmakon Farmácia de Manipulação e Homeopatia, que apresenta uma estrutura classificada como de pequeno porte. O trabalho desenvolveu a revisão do posicionamento estratégico, a formulação da análise SWOT e a obtenção do mapa estratégico para a empresa. Os reflexos da implementação do trabalho apresentado, considerando as limitações da generalização do estudo de caso, podem ser adaptados a outras pesquisas, além de servir de subsídio para implementação do BSC a outras empresas classificadas como de médio e pequeno porte