Global ETD Search

1	Modely s racionálním očekáváním. / Models with rational expectation. Bechyňák, Petr January 2007 (has links) Práce popisuje vývoj konceptu mekonomického očekávání od extrapolativního, přes adaptivní až po racionální, včetně modelů, v nichž byla tato očekávání použita. V druhé části je odvozen a popsán model, využívající právě racionální očekávání. Tento agregovaný makroekonomický model je pak aplikován na prostředí ČR. Je zde testován i samotný předpoklad racionálního očekávání, což je myšlenka novější, než samotný model.
2	Generierung und Charakterisierung von Proteinderivaten zur gezielten Mineralisierung von DNA-Konstrukten Gehlhar, Maria 14 June 2021 (has links) Die Besonderheit der DNA-Nanotechnologie liegt in der Verwendung von DNA als Konstruktionsmaterial für die Herstellung von artifiziellen Strukturen im Nanometermaßstab (Seeman, 1982; Winfree et al., 1998). Diese DNA-Nanoobjekte, wie beispielsweise DNA-Nanoröhren, offerieren innovative und vielversprechende Anwendungsmöglichkeiten in verschiedenen Bereichen wie der Elektronik oder Medizin. Eine Herausforderung für die dauerhafte Verwendung von DNA-Nanoröhren stellt deren Stabilität dar. Einflussfaktoren wie die DNA-Nukleaseaktivitäten, die Ionenstärke und hohe Temperaturen können dabei eine langfristige Anwendung limitieren. Als ein Lösungsansatz für die Erhöhung der Beständigkeit wird eine gezielte Mineralisierung der DNA-Nanoröhren durch spezifische Fusionsproteine angestrebt. Ziel dieser Arbeit ist die dafür notwendige Herstellung und Charakterisierung der DNA-bindenden Fusionsproteine mit Mineralisierungsdomänen vorzustellen. Das umfasst das Auswählen geeigneter DNA-Bindungsproteine als Bestandteil der Fusionsproteine. In dieser Arbeit wurden die DNA-Bindungsproteine MutH und SBB aus Escherichia coli (E. coli) sowie Yku70p aus Saccharomyces cerevisiae (S. cerevisiae) aufgrund ihrer spezifischen Bindungseigenschaften dafür identifiziert. Damit können die Fusionsproteine sequenzspezifische oder -unspezifische Bindungen mit doppelsträngiger (engl. double stranded DNA, dsDNA) oder einzelsträngiger DNA (engl. single stranded DNA, ssDNA) eingehen. Es ist mittels Klonierung gelungen, verschiedene Fusionskonstrukte mit den genannten DNA-Bindungsproteinen zu generieren. Diese beinhalten ebenfalls das enhanced green fluorescent protein sowie den His6-Tag für den Expressionsnachweis und die Proteinreinigung. Weitere Varianten der Fusionskonstrukte bestehen zusätzlich aus der tobacco etch virus-Protease-Erkennungssequenz zur Entfernung des His6-Tags und der Domänen R5-Peptid (R5P) oder Poly-L-Arginin (PLR) für die Mineralisierung. Bestandteil dieser Arbeit sind Western-Blot-Analysen und mikroskopische Aufnahmen, welche die erfolgreiche heterologe Expression aller Fusionskonstrukte nachweisen. Aus den Ergebnissen der Expressions- und Löslichkeitsanalysen lässt sich schlussfolgern, dass insbesondere das Expressionslevel und die Synthese löslicher Proteine mit den Mineralisierungsdomänen eine Herausforderung darstellen. Ebenfalls in dieser Arbeit sind Versuche zur Optimierung mit verschiedenen Expressionsstämmen (E. coli und S. cerevisiae) und Expressionsparametern (Temperatur und Induktor-Konzentration) enthalten. Den Ergebnissen nach eignen sich besonders die Fusionsproteine MutH-EGFP-His6 und SSB-EGFP-His6 für die weiteren Experimente. Die Untersuchungen der DNA-Bindungseigenschaften erfolgten mittels Electrophoretic mobility shift assay (EMSA) und Rasterkraftmikroskopie (engl. atomic force microscopy, AFM). Diese Methoden mussten für jedes Fusionsprotein zuvor etabliert und optimiert werden. Zu Beginn stand das MutH-Fusionsprotein im Focus, wobei die durchgeführten EMSA-Untersuchungen die Spezifität zur GATC-Erkennungssequenz sowie zur dsDNA betrachteten. Die Charakterisierung mittels AFM diente als weitere Möglichkeit zur Analyse der DNA-Bindungseigenschaften. Zusätzlich kam in dieser Arbeit eine Variante des CRISPR/Cas9-Systems als Fusionsprotein für eine sequenzspezifische Adressierung von dsDNA zum Einsatz. Die EMSA- und AFM-Analysen deuteten dabei auf eine Interaktion von dem dCas9-Fusionsproteins und dsDNA hin. Weiterhin war das SSB-Fusionsprotein Bestandteil der Untersuchungen. Die Bindungsanalysen mittels EMSA zeigten, dass es bevorzugt mit ssDNA interagiert und nur eine geringe Affinität zu dsDNA vorliegt. Die Bindung zu ssDNA konnte ebenfalls erfolgreich anhand von AFM-Untersuchungen gezeigt werden. Zusammenfassend bestätigen die Ergebnisse die Funktionalität des MutH- und SSB-Fusionsproteins. Es konnten zudem erste Hinweise erbracht werden, die eine spezifische Bindung der Fusionsproteine an dsDNA oder ssDNA belegen. Mit dieser Arbeit ist es gelungen, Proteinderivate zu generieren und charakterisieren, wodurch eine entscheidende Grundlage für die gezielte Mineralisierung von DNA-Konstrukten geschaffen wurde. info:eu-repo/classification/ddc/570 ddc:570
3	DNA Mismatch Repair In Haemophilus Influenzae : Characterization Of MutH, L, S And Their Interaction Joseph, Nimesh 12 1900 (has links) (PDF) No description available. Influenzae DNA DNA Interaction Haemophilus Influenzae DNA Mlsmatch Repair MutH MutL MutS Biochemistry
4	Mutational Analysis of the MutH from Escherichia Coli: a Dissertation Loh, Tamalette 29 September 2000 (has links) DNA mismatch repair is one process in the preservation of genomic integrity. It has been found in Archeae, bacteria, plants, yeast and mammals. The mismatch repair system is highly conserved among species and allows the strand-specific elimination of base-base mispairs, chemical base modifications, as well as short insertion/deletion loops following DNA replication. The repair system also has important effects on homeologous recombination, contributing to the frequency of reciprocal exchanges. In humans, defects in the repair system have been found to be associated with tumorigenesis. In Escherichia coli, this pathway was originally called long patch repair before being renamed the methyl-directed mismatch repair system. It is unique in that it utilizes a DNA methylation pattern to discriminate between the parental DNA strand and the newly synthesized daughter DNA strand. The current model for the initiation of methyl-directed mismatch repair is that the mispaired bases are recognized and bound by the MutS protein with MutL as a helper protein for binding. MutL also assists the MutH protein to bind, thereby forming the completed initiation complex of MutS, MutL and MutH. In the presence of ATP, there is evidence for translocation ofthe complex along the DNA forming alpha loops. At a d(GATC) site the MutH protein binds and nicks the unmethylated daughter DNA strand 5' to the d(G) (by recognizing the N6-d(A) methylation of the parental DNA strand which it is unable to cut). This completes the initiation of the repair system and allows the hydrolysis and resynthesis of the daughter DNA strand. MutH is a monomer of 25.5 kD in solution and contains a latent Mg2+-dependent endonuclease activity. Unmethylated DNA is nicked without any discrimination on one of the two strands and fully methylated DNA is resistant to cleavage by MutH even though the protein is able to bind the d(GATC) site. The structure of MutH was recently solved and compared to a group of restriction endonucleases that share a structural common core domain with similarly placed catalytic residues. The MutH protein is comprised of two major domains that are able to pivot and rotate with respect to one another. The cleft between the two domains is large enough for double-strand DNA to bind. This research started with the determination of the MutH structure before it was known. After crystallizing the protein and collecting several heavy atom data sets, it was found that the electron density maps were too discontinuous to trace the structure of the protein. Following that work, site-directed mutagenesis was performed on several areas of MutH based on the similarity of MutH and PvuII structural models. The aims were to identify DNA binding residues (in two flexible loop regions), to determine if MutH has the same mechanism for DNA binding and catalysis as PvuII (MutH histidines 112 and 115), and to localize the residues responsible for MutH stimulation by MutL (MutH C-terminal tail region). An in-vivoscreen based on the mutator phenotype was used to select for functionally defective MutH mutants. These bacteria accumulate mutations at a greater frequency than wild-type and this was monitored by selection on plates with rifampicin. Three MutH mutants were identified from this screen (K48A, G49A, and Δ214). They were purified and assayed for total activity and binding ability. Four other mutants with wild-type phenotypic screen results were also chosen to confirm they were not involved in any MutH function (D47A, H112A, H115A, and Δ224). No DNA binding residues (such as D47A) were identified in the two flexible loop regions of MutH, although similar loops in PvuII are involved in DNA binding. The purified D47A MutH protein showed wild-type biochemical activity. Instead, the lysine residue (K48) in the first flexible loop was found to function in catalysis together with the three presumed catalytic amino acids (Asp70, Glu77, and Lys79). This purified MutH protein (K48A) had wild-type binding ability but no endonuclease activity without MutL. In the presence of MutL, the K48A protein had only a three-fold reduction in endonuclease activity. This research has shown that MutL stimulates the wild-type MutH activity by 1000-fold. The wild-type MutH stimulation by MutL for binding was only shown to be 16-fold. The G49A MutH mutant interferes with the proper functioning of the protein but is not informative about the mechanism of action. The binding ability of this mutant was the same as wild-type and the endonuclease activity was down 30-fold with a 10-fold stimulation by MutL. The extra methyl group of the alanine may cause slight structural changes in the lysine 48 side chain that slows catalysis. The two histidines (H112 and H115) in MutH that are in a similar position as the two histidines (H84 and H85) in PvuII (that signal for DNA binding and catalysis) were changed to alanines, but had wild-type activity both in-vivo and in-vitro. These results indicate that the MutH signal for DNA binding and catalysis remains unknown. The two deletion mutations (MutHΔ224 and MutHΔ214) in the C-terminal end of the protein, localized the MutL stimulation region to five amino acids (Ala220, Leu221, Leu222, Ala223, and Arg224). Mutant MutHΔ224 had wild-type MutL stimulation activity, while MutHΔ214 showed no MutL stimulation. Another deletion mutant, MutHΔ119, from another laboratory was shown to have wild-type MutL stimulation also. This leaves one (or more) of the remaining five residues as important for MutL stimulation. Escherichia coli DNA Repair MutH gene product Amino Acids, Peptides, and Proteins Bacteria Genetic Processes
5	Studies On DNA Mismatch Repair Nicking Endonucleases Of Haemophilus Influenzae And Neisseria Gonorrhoeae Duppatla, Viswanadham 01 1900 (has links) DNA mismatch repair ensures faithful transmission of genetic material from parents to progeny, which is required for the survival of the organism. The studies on E. coli MMR proteins have formed the basis for the study of the MMR system in eukaryotic organisms, because the functions of MMR proteins believed to be been conserved. In organisms that harbor MutH protein, it is known that MutH acts as a monomer which nicks the unmethylated daughter strand and is activated in a MutS-MutL- dependent manner. The cleavage specificity of MutH is very stringent. Till recently, it was not clear as to how MutH distinguishes hemimethylated DNA from fully or unmethylated DNA. The co-crystal structures of MutH-DNA complexes revealed that Y212, R184 and P185 were in close proximity to the methyl-adenine. Clustal-W sequence alignment of MutH with Sau3AI showed that Sau3AI has PCT residues instead of L183, R184, and P185. A triple mutant MutH-L183P-R184C-P185T was found to cleave both unmethylated and methylated DNA. The nicking endonuclease activity of the LRP→ PCT triple mutant was enhanced in the presence of Haemophilus influenzae MutL. The mutL gene of Neisseria gonorrhoeae was cloned and the gene product purified. It was shown that the homodimeric Neisseria gonorrhoeae MutL (NgoL) protein displays an endonuclease activity that incises covalently closed circular DNA in the presence of manganese or magnesium or calcium ions unlike human MutLα which shows endonuclease activity only in the presence of manganese. Further more the C-terminal domain of Neisseria gonorrhoeae MutL (NgoL-CTD) consisting of amino acids 460 to 658 also exhibits Mn2+ dependent endonuclease activity. Sedimentation velocity, sedimentation equilibrium and dynamic light scattering experiments show NgoL-CTD to be a dimer. By in vitro comparison of wild-type and a mutant NgoL-CTD protein, it was shown that the latter protein exhibits highly reduced endonuclease activity. Surface plasmon resonance spectroscopy was used to determine the kinetics of DNA binding by NgoL. The DNA binding was carried out in absence of metal ions. Interaction studies with NgoL with ssDNA in SPR spectroscopy revealed a KD value of 4.7 × 10–8 M. While the human MutLα endonuclease activity was shown to be stimulated by ATP, ATP inhibits NgoL endonuclease activity. By in vitro comparison of wild-type and a mutant NgoL-CTD protein, it was shown that the latter protein exhibits highly reduced endonuclease activity. NgoL ATPase activity was enhanced in the presence of DNA. The fact that NgoL ATPase activity is stimulated ~ 2.5-fold by dsDNA and ~ 2-fold by ssDNA is a further evidence for the interaction between NgoL and DNA. The results presented above show that NgoL harbors a nicking endonuclease activity which is present in the C-terminal domain. NgoL and NgoL-CTD are dimers in solution and DMHA(X)2E(X)4E motif present in the CTD is required for the nicking endonuclease activity. These results suggest that DNA mismatch repair mechanism in N. gonorrhoeae is different from that in E. coli. In the absence of MutH homolog, N. gonorrhoeae is able to repair the DNA by virtue of MutL nicking endonuclease activity. DNA Haemophilus Influenzae Neisseria Gonorrhoeae Endonucleases DNA Mismatch Repair DNA Repair MutL Proteins MutH Proteins Biochemical Genetics
6	Quantitative Modeling of DNA Systems Crocker, Kyle A. January 2021 (has links) No description available. Biophysics Nanotechnology Physics Polymers Theoretical Physics DNA quantitative modeling computational biology thermodynamics DNA mismatch repair statistical physics DNA origami DNA nanotechnology nucleosome MutS MutL MutH
7	DESIGN AND SYNTHESIS OF POTENT HIV-1 PROTEASE INHIBITORS AND ENANTIOSELECTIVE SYNTHESIS OF ANTIDIABETIC AGENT, CARAMBOLAFLAVONE William L. Robinson (12211523) 17 May 2024 (has links) HIV-1 protease inhibitor drugs are important components of current antiretroviral therapy (cART). The cART treatment regimens dramatically improved life expectancy and mortality of patients with HIV-1 infection and AIDS. However, new and improved protease inhibitor drugs are essential for future treatment options. To this end, syntheses of optically active (3a<i>S</i>,4<i>S</i>,7a<i>R</i>)-hexahydro-4<i>H</i>-furo[2,3-<i>b</i>]pyran-4-ol, (3a<i>R</i>,4<i>R</i>,7a<i>S</i>)-hexahydro-4<i>H</i>-furo[2,3-b]pyran-4-ol, and (3<i>R</i>,3a<i>S</i>,6a<i>R</i>)-hexahydrofuro[2,3-6]furan-3-ol have been accomplished. These stereochemically defined heterocyclic derivatives are important high-affinity P2 ligands for a variety of highly potent HIV-1 protease inhibitors. The key steps for the synthesis hexehydrofuropyranol involve an efficient Paternò-Büchi [2+2] photocycloaddition, catalytic hydrogenation, acid-catalyzed cyclization to form the racemic ligand alcohol, and enzymatic resolution with immobilized Amano Lipase PS-30. Optically active ligand alcohols were obtained with high enantiomeric purity. Enantiomer (-)-ligand alcohol has been converted to potent HIV-1 protease inhibitors. <div><br></div><div>(3<i>R</i>,3a<i>S</i>,6a<i>R</i>)-Hexahydrofuro[2,3-<i>b</i>]furan-3-ol(<i>bis</i>-tetrahydrofuran) is a key subunit of darunavir, an FDA approved HIV-1 protease inhibitor drug which is widely used for the treatment of HIV/AIDS patients. This stereochemically defined bicyclic heterocycle is also embedded in a variety of highly potent HIV-1 protease inhibitors. The synthesis of optically active <i>bis</i>-tetrahydrofuran was achieved in optically pure form utilizing commercially available and inexpensive 1,2-<i>O</i>-isopropylidene-α-D-xylofuranose or 1,2-O-isopropylidene-α-D-glucofuranose as the starting material. The key steps involve a highly stereoselective substrate-controlled hydrogenation of ethyl 2-(dihydrofuran-3(2H)-ylidene)acetate, a Lewis acid-catalyzed anomeric reduction of a 1,2-<i>O</i>-isopropylidene-protected glycofuranoside, and a Baeyer-Villiger oxidation of a tetrahydrofuranyl-2-aldehyde derivative. Optically active (3<i>R</i>,3a<i>S</i>,6a<i>R</i>)-hexahydrofuro[2,3-<i>b</i>]furan-3-ol ligand was converted to darunavir efficiently. Furthermore, both furopyranol and bis-tetrahydrofuran ligand alcohols have been converted into a variety of potent HIV-1 protease inhibitors including inhibitors containing P2'-boronic acid ligands.<br></div><div><br></div><div>Diabetes mellitus is a chronic, progressive metabolic disorder that seriously threatens human health worldwide, particularly in developing countries. The prevalence of diabetes has been increasing steadily, especially in developing countries. Carambolaflavone A is a natural flavonoid isolated from the leaves of starfruit tree, <i>Averrhoacarambola</i>, in 2005. Carambolaflavone A possesses a <i>C</i>-aryl glycosidic linkage. Carambolaflavone A exhibited significant antihyperglycemic properties. More detailed biological studies reveal that it can lower acute blood glucose. The biology and chemistry of carambolaflavone A attracted our interest in synthesis and further design of interesting structural variants. A convergent total synthesis of carambolaflavone A has been accomplished. The synthesis highlights a bismuth triflate-catalyzed stereoselective C-aryl glycosylation of flavan and an appropriately protected D-fucose derivative as the key step. The glycosylation partners were synthesized from commercially available (±)-naringenin and D-(+)-galactose, respectively. An oxidative bromination and elimination reaction sequence was utilized to construct the flavone. The natural product is obtained in 10 steps (longest linear sequence) from D-(+)-galactose.<br></div> Natural products and bioactive compounds carambolaflavone HIV/AIDS synthesis darunavir glycosylation bis-muth salt catalysis Natural Products Chemistry
8	The Social Construction of Economic Man: The Genesis, Spread, Impact and Institutionalisation of Economic Ideas Mackinnon, Lauchlan A. K. Unknown Date (has links) The present thesis is concerned with the genesis, diffusion, impact and institutionalisation of economic ideas. Despite Keynes's oft-cited comments to the effect that 'the ideas of economists and political philosophers, both when they are right and when they are wrong, are more powerful than is commonly understood'(Keynes 1936: 383), and the highly visible impact of economic ideas (for example Keynesian economics, Monetarism, or economic ideas regarding deregulation and antitrust issues) on the economic system, economists have done little to systematically explore the spread and impact of economic ideas. In fact, with only a few notable exceptions, the majority of scholarly work concerning the spread and impact of economic ideas has been developed outside of the economics literature, for example in the political institutionalist literature in the social sciences. The present thesis addresses the current lack of attention to the spread and impact of economic ideas by economists by drawing on the political institutionalist, sociological, and psychology of creativity literatures to develop a framework in which the genesis, spread, impact and institutionalisation of economic ideas may be understood. To articulate the dissemination and impact of economic ideas within economics, I consider as a case study the evolution of economists' conception of the economic agent - "homo oeconomicus." I argue that the intellectual milieu or paradigm of economics is 'socially constructed' in a specific sense, namely: (i) economic ideas are created or modified by particular individuals; (ii) economic ideas are disseminated (iii) certain economic ideas are accepted by economists and (iv) economic ideas become institutionalised into the paradigm or milieu of economics. Economic ideas are, of course, disseminated not only within economics to fellow economists, but are also disseminated externally to economic policy makers and business leaders who can - and often do - take economic ideas into account when formulating policy and building economic institutions. Important economic institutions are thereby socially constructed, in the general sense proposed by Berger and Luckmann (1966). But how exactly do economic ideas enter into this process of social construction of economic institutions? Drawing from and building on structure/agency theory (e.g. Berger and Luckmann 1966; Bourdieu 1977; Bhaskar 1979/1998, 1989; Bourdieu 1990; Lawson 1997, 2003) in the wider social sciences, I provide a framework for understanding how economic ideas enter into the process of social construction of economic institutions. Finally, I take up a methodological question: if economic ideas are disseminated, and if economic ideas have a real and constitutive impact on the economic system being modelled, does 'economic science' then accurately and objectively model an independently existing economic reality, unchanged by economic theory, or does economic theory have an interdependent and 'reflexive' relationship with economic reality, as economic reality co-exists with, is shaped by, and also shapes economic theory? I argue the latter, and consider the implications for evaluating in what sense economic science is, in fact, a science in the classical sense. The thesis makes original contributions to understanding the genesis of economic ideas in the psychological creative work processes of economists; understanding the ontological location of economic ideas in the economic system; articulating the social construction of economic ideas; and highlighting the importance of the spread of economic ideas to economic practice and economic methodology. 410401 Design Theory 349901 Political Economy 370000 Studies in Human Society 340302 History of Economic Thought 349900 Other Economics 410402 Design Innovation 360201 Public Policy 360000 Policy and Political Science 380100 Psychology 360100 Political Science 360200 Policy and Administration 370101 Social Theory 370102 Social Policy and Planning 340100 Economic Theory genesis spread diffusion impact institutionalisation economic ideas idea ideation psychology of creativity Wallas Wertheimer stage model productive thinking creative creativity process economic economics sociology social methodology methodological self-altering self-fulfilling self-denying prophecy belief reflexive reflexivity institution institutionalise institutionalised social construction Berger Luckmann Bhaskar critical realism Lawson Bordieu habitus field spread impact ideation ideational structure social structure action creativity creative economists sociology philosophy of science homo economicus homo oeconomicus economic man economic agent rational economic man man lucas critique Goodhart's law Keynes Marx Mill Hayek Hicks Samuelson Walras Jevons Arrow Debreu Samuelson Merton sociology of economics sociology of scientific knowledge SSK Holton prediction control reflexive prediction reflexivity Whitley Mackie canonization Henshel Grunberg Modigliani Morgenstern Lucas Muth Simon Blyth Hall Sikkink Hira Hood institutionalize institutionalized socialise socialisation internalise internalisation internalization socialization behaviour behavior Thomas theorem expectations stage model productive thinking evolution
9	Johann Friedrich von Uffenbach. Sammler – Stifter – Wissenschaftler / Johann Friedrich von Uffenbach. Collector - Donor - Scientist Meyerhöfer, Dietrich 28 January 2020 (has links) No description available. 700 Sammeln Uffenbach Frankfurt am Main Wissenschaftliche Gesellschaft Zeichnung Optische Geräte Instrumente zur Gnomonik Astronomische Instrumente 18. Jahrhundert Druckgraphik Sammlungsgeschichte Privatgelehrter Kavaliersreise Bildungsreise Tagebücher Reisetagebücher Auktionswesen Auktionen Auktion Florsheim Geschichte des Sammelns Inventare von Druckgraphik Auktionskatalog Auktionskataloge Gegenschreiberbuch Monogrammistenlexikon Künstlermonogramme Stiftung Göttingen Georg-August-Universität Göttingen Kupferstich Holzschnitt Radierung Sammler Kunstmarkt im 18. Jahrhundert Grand Tour Frankfurter Patrizier Malerakademie Akademie der Wissenschaften Alte Mainbrücke Architekt Architektur Astronomie Bibliothek Bibliotheken Bibliothekswesen Buchhandel Buchhändler Diarien Diarium Direktdruck Drechseln Drechsler Drehbank Druckzustand Enkaustik Fehldruck Fernrohr Fernrohre Festungsbau Feuerwerk Feuerwerkerei Findbuch Findbücher Firnis Firniß Fontäne Fortifikation Geografie Geographie Geometrie Goethehaus Hobelbank Kartographie Klebeband Korrespondenz Kunsthandel Kunsthändler Kunstsammlung Landkarte Landkarten Ludwig XIV. Materialist Mikroskop Mikroskope Mineralienkabinett Naturdruck Oper Optik Prinzmetall Protokoll Pumpenanlage Reisebericht Sammelmappe Schildpatt Sonnenuhr Sonnenuhren Teleskop Teleskope Topographie Vakuumpumpe Vergantung Wassermaschine Wasserspiele Repertorium Protokollband Protokollbände Protokolle Georgia-Augusta Atzenheim Friedrich Philipp von Behaghel Philipp Jacob Benson William Bérain Jean Bernstorff Johann Hartwig Ernst Graf von Bignon Jean–Paul Böhm Johann Christian Breitkopf Bernhard Christoph Buttieri Carlo Antonio Campani Giuseppe Chiarelli Antonio Christ Johann Friedrich Heumann Christoph August Culpeper Edward d’Osangis Jean Pigeon Daimant Le Maire Pierre Dathan Johann Georg Dietzsch Johann Israel Diesterweg Albert Adolf Eberhard Conrad Hieronymus, gen. Schwind Egell Paul Ettling Johann Friedrich Fasch Johann Friedrich Fer Nicolas de Geysel Johann Daniel Goethe Johann Caspar Gottsched Johann Christoph Graupner Christoph Grünewald Gottfried Häckel Heinrich Jakob von Leth Hendrick de Heß Peter Heyne Christian Gottlob Hotteterre Jacques-Martin Hugo Friedrich Ludolph von Marshall John Kaller Johann Christian Kinet Johann Melchior Kniphof Johann Hieronymus Kißner Johann Georg Largillière Nicolas Leth Andries de Mariette Pierre Jean Marolles Michel de Mascow Gottfried Metz Conrad Michu Benoit Moritz Johann Friedrich Münchhausen Gerlach Adolf von Muth Heinrich Ludwig Musschenbroeck Pieter van Pütter Johann Stephan Richter Georg Gottlob Rigaud Hyacinthe Schelhorn Johann Georg Schürmann Georg Caspar Schütz d.Ä. Christian Georg Scotin Gerard Senckenberg Heinrich Christian von Stanislaus I. Leszynski Telemann Georg Philipp Ucheln Heinrich von Uffenbach Johann Friedrich von Uffenbach Wilhelm von Uffenbach Zacharias Conrad von Visscher Nicolaes Wagner Joseph Wolf Johann Christoph Zeller Franz Frauenstein Patriziergesellschaft Collecting Uffenbach Frankfurt am Main Scientific society Drawing optical devices gnomonic instruments Astronomical instruments 18. century Prints history of collection private scholar grand tour diary travel diaries Auctioning Auctions auction Florsheim History of collecting Print graphic inventories Auction catalog Auction catalogs Counter-writing book Monogrammist encyclopedia Artist monograms donation Goettingen Georg-August-University of Goettingen engraving woodcut etching collector Art market in the 18th century Frankfurt patrician Academy of painters Academy of Science Old Main Bridge architect architecture astronomy Library Libraries Librarianship Book trade Bookseller Diaries Diarium Direct printing Turning Turner Lathe Print condition Encaustic Misprint Telescope Telescopes Fortress construction Fireworks pyrotechnics repertory repertories varnish fountain fortification geography geometry Goethe House carpenter’s bench cartography Correspondence Art trade Art dealer Art collection map maps Louis XIV microscope microscopes Mineral cabinet Natural print Opera Optics minutes Pump system Account of a journey file Tortoiseshell sundial sundials topography Vacuum pump waterworks Atzenheim Friedrich Philipp von Behaghel Philipp Jacob Benson William Bérain Jean Bernstorff Johann Hartwig Ernst Graf von Bignon Jean–Paul Böhm Johann Christian Breitkopf Bernhard Christoph Buttieri Carlo Antonio Campani Giuseppe Chiarelli Antonio Christ Johann Friedrich Heumann Christoph August Culpeper Edward d’Osangis Jean Pigeon Daimant Le Maire Pierre Dathan Johann Georg Diesterweg Albert Adolf Dietzsch Johann Israel Eberhard Conrad Hieronymus, gen. Schwind Egell Paul Ettling Johann Friedrich Fasch Johann Friedrich Fer Nicolas de Geysel Johann Daniel Goethe Johann Caspar Gottsched Johann Christoph Graupner Christoph Grünewald Gottfried Häckel Heinrich Jakob von Leth Hendrick de Heß Peter Heyne Christian Gottlob Hotteterre Jacques-Martin Hugo Friedrich Ludolph von Marshall John Kaller Johann Christian Kinet Johann Melchior Kißner Johann Georg Kniphof Johann Hieronymus Largillière Nicolas Leth Andries de Mariette Pierre Jean Marolles Michel de Mascow Gottfried Metz Conrad Michu Benoit Moritz Johann Friedrich Münchhausen Gerlach Adolf von Muth Heinrich Ludwig Musschenbroeck Pieter van Pütter Johann Stephan Richter Georg Gottlob Rigaud Hyacinthe Schelhorn Johann Georg Schürmann Georg Caspar Schütz d.Ä. Christian Georg Scotin Gerard Senckenberg Heinrich Christian von Stanislaus I. Leszynski Telemann Georg Philipp Ucheln Heinrich von Uffenbach Johann Friedrich von Uffenbach Wilhelm von Uffenbach Zacharias Conrad von Visscher Nicolaes Wagner Joseph Wolf Johann Christoph Zeller Franz Georgia-Augusta Frauenstein Kunst (PPN613163508)

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