Global ETD Search

21	Child-centred technologies as learning tools within the primary classroom : exploring the role of tablets and the potential of digital pens in schools Mann, Anne-Marie January 2017 (has links) This thesis provides insights into how technology can be and is used as child-centric learning tools within primary school classrooms. The conducted studies look closely at how tablet technology is integrated into the modern classroom, and considers how existing digital writing technologies could support handwriting-based learning exercises in future. This is achieved by conducting three in-the-wild studies, using different approaches, with a total of seventy-four children in school classrooms. In the first study, focus is placed on how tablets integrate into and with existing classroom practices, documenting when and how children use tablets in class. Relevant and complementary to this, the use of traditional writing tools is questioned and two further studies explore the potential and suitability of digital pens to support children's handwriting-based learning. One looks in detail at how children's handwriting is effected by different existing digital pen technologies. The other study, conducted through a creative, participatory design session, asks children to provide their opinions regarding desirable features for digital writing technology. The findings from this research classify and exemplify the role of tablets in the classroom, and explore potential design directions of digital writing tools which could be used by children in the future. This work may be useful and of interest to others who conduct research with children within the fields of Human Computer Interaction, Child Computer Interaction or education. 004.01
22	Pol?tica da literatura e suas faces na palavra muda de Manoel de Barros / Pol?tica da literatura e suas faces na palavra muda de Manoel de Barros Gon?alves, Marta Aparecida Garcia 09 December 2011 (has links) Made available in DSpace on 2015-02-24T19:36:58Z (GMT). No. of bitstreams: 1 MartaAGG_TESE.pdf: 1435067 bytes, checksum: 90f7ddcfd2a216ca3831f34237754072 (MD5) Previous issue date: 2011-12-09 / Ce travail de th?se ici propos? a comme but de recherche la production lit?raire du po?te br?silien Manoel Wenceslau Leite Barros, Manoel de Barros, (1916 Cuiab?-MT) en l articulant avec la reflexion sur le concept de politique de l ?crite propos? par le philosophe alg?rien-fran?ais Jacques Ranci?re (1940 Algiers Alg?rie). L hypoth?se qui se presente est celle sur l ?crite po?tique de Manoel de Barros dont les ?marques du sensible? dans les exp?riences d?mocratiques sont perceptibles. Sa production inclue ce que se peut denominer d une micrologie po?tique, une reconfiguration du ?partager?, dans le sense de l ?laboration pratiques de l ?galit?, des pratiques de redistribution et de circulation des voix, instauratrices de la constitution esth?tiques des communaut?s diff?renci?es, consid?r?es comme alternatives, face au mod?le de syst?me canonique de la lit?rature. Au moment que sa fonctionnent comme des formes de subvertions, elles produisent des espaces ou marge d ?mancipation de l ?tre : lecteur et ?crivain, en d?clanchant des nouvelles perspectives ?thiques et esth?tiques. De cette mani?re, l objectif qui se dessine est ce qui comprend comment se configure la proposition d une politique de l ?crite de Manoel de Barros et la fa?on qu elle se place par rapport ? une politique des arts. Pour cela, nous utiliseront comme base la pens?e de Jacques Ranci?re qui se fait remarquer, les derni?res ann?es, pour entreprendre une refl?xion syst?matique et lucide par rapport aux relations ?xistantes entre esth?tique et politique dans la soci?t? pr?sente, ali? ? ce que se d?fine comme des mani?res et des formes de penser ?labor?es par le texte po?tique (lui m?me) de Manoel de Barros et de mani?re incontinu? dans ses entretiens-critiques, plubli?es dans des journaux et revues, pr?sent?es en vid?os, et nous n oublierons pas non plus des contributions th?oriques et des refl?xions parvenues de la pens?e contemporaine / O trabalho de tese aqui proposto possui como foco de investiga??o a produ??o liter?ria do poeta brasileiro Manoel Wenceslau Leite de Barros, Manoel de Barros, (1916 - Cuiab?-MT) articulando-a com a reflex?o sobre o conceito de pol?tica da escrita proposto pelo fil?sofo argelino-franc?s Jacques Ranci?re (1940 Algiers - Arg?lia). A hip?tese que se apresenta ? a de que na escrita po?tica de Manoel de Barros s?o percept?veis as ?marcas do sens?vel? nas experi?ncias democr?ticas. Sua produ??o engloba aquilo que se pode denominar de uma micrologia po?tica, uma reconfigura??o da partilha, no sentido de que elabora pr?ticas de igualdade, pr?ticas de redistribui??o e circula??o de vozes, instauradoras da constitui??o est?tica de comunidades diferenciadas, consideradas alternativas, em face ao modelo can?nico da literatura enquanto sistema. Ao funcionar como formas de subvers?o, estas produzem espa?os ou margens de emancipa??o do ente: leitor e escritor, desencadeando novas perspectivas ?ticas e est?ticas. Dessa forma, o objetivo que se traceja ? o de compreender como se configura a proposta de uma pol?tica da escrita na obra de Manoel de Barros e o modo como essa escrita se posiciona em rela??o a uma pol?tica das artes. Para tanto, utilizaremos como aporte basilar o pensamento de Jacques Ranci?re que se notabilizou, nos ?ltimos anos, por empreender uma reflex?o sistem?tica e l?cida a respeito das rela??es existentes entre est?tica e pol?tica na sociedade presente, aliado ao que se circunscreve como modos e formas de pensar elaboradas pelo pr?prio texto po?tico de Manoel de Barros e de maneira descont?nua em suas entrevistas-cr?ticas, publicadas em jornais e revistas e apresentadas em v?deos, assim como n?o descuraremos das contribui??es te?ricas e reflex?es advindas do pensamento contempor?neo Literatura e pol?tica Partilha do sens?vel Manoel de Barros Jacques Ranci?re Pensamento contempor?neo Est?tica ?tica Lit?rature et politique Le partager du sensible Manoel de Barros Jacques Ranci?re Pens?e contemporaine Esth?tique ?thique
23	Protein-DNA Graphs And Interaction Energy Based Protein Structure Networks Vijayabaskar, M S 01 1900 (has links) (PDF) Proteins orchestrate a number of cellular processes either alone or in concert with other biomolecules like nucleic acids, carbohydrates, and lipids. They exhibit an intrinsic ability to fold de novo to their functional states. The three–dimensional structure of a protein, dependent on its amino acid sequence, is important for its function. Understanding this sequence– structure–function relationship has become one of the primary goals in biophysics. Various experimental techniques like X–ray crystallography, Nuclear Magnetic Resonance (NMR), and site–directed mutagenesis have been used extensively towards this goal. Computational studies include mainly sequence based, and structure based approaches. The sequence based approaches such as sequence alignments, phylogenetic analysis, domain identification, statistical coupling analysis etc., aim at deriving meaningful information from the primary sequence of the protein. The structure based approaches, on the other hand, use structures of folded proteins. Recent advances in structure determination and efforts by various structural consortia have resulted in an enormous amount of structures available for analysis. Innumerable observations such as the allowed and disallowed regions in the conformations of a peptide unit, hydrophobic core in globular proteins, existence of regular secondary structures like helices, sheets, and turns and a limited fold space have been landmarks in understanding the characteristics of protein structures. The uniqueness of protein structure is attained through non–covalent interactions among the constituent amino acids. Analyses of protein structures show that different types of non–covalent interactions like hydrophobic interactions, hydrogen bonding, salt bridges, aromatic stacking, cation–π interactions, and solvent interactions hold protein structures together. Although such structure analyses have provided a wealth of information, they have largely been performed at a pair–wise level and an investigation involving such pair–wise interactions alone is not sufficient to capture all the determinants of protein structures, since they happen at a global level. This consideration has led to the development of graphs/networks for proteins. Graphs or Networks are a collection of nodes connected by edges. Protein Structure Networks (PSNs) can be constructed using various definitions of nodes and edges. Nodes may vary from atoms to secondary structures in Synopsis proteins, and the edges can range from simple atom–atom distances to distance between secondary structures. To study the interplay of amino acids in structure formation, the most commonly used PSNs consider amino acids as nodes. The criterion for edge definition, however, varies. PSNs can be constructed at a course grain level by considering the distances between Cα/Cβ atoms, any side–chain atoms, or the centroids of the amino acids. At a finer level, PSNs can be constructed using atomic details by considering the interaction types or by computing the extent of interaction between amino acids. Representation of proteins as networks and their analyses has given us a unique perspective on various aspects such as protein structure organization, stability, folding, function, oligomerization and so on. A variety of network properties like the degree distribution, clustering coefficient, characteristic path lengths, clusters, and hubs have been investigated. Most of these studies are carried out on protein structures alone. However, the interaction of proteins with other biopolymers like nucleic acids is vital for many crucial biological processes like transcription and translation. In this thesis, we have attempted to address this problem by constructing and analyzing combined graphs of the structures of protein and DNA. Also, in almost all of the PSN studies, the connections have been made solely on the basis of geometric criteria. In the later part of the thesis, we have taken PSN a step further by defining the non–covalent connections based on chemical considerations in the form of the energies of interactions. The thesis contains two sections. The first part mainly involves the construction and application of PSNs to study DNA binding proteins. The DNA binding proteins are involved in several high fidelity processes like DNA recombination, DNA replication, and transcription. Although the protein– DNA interfaces have been extensively analyzed using pair–wise interactions, we gain additional global perspective from network approach. Furthermore, most of the earlier investigations have been carried out from the protein point of view (protein centric) and the present network approach aims to combine both the protein centric and the DNA centric view points by construction and analyses of protein–DNA graphs. These studies are described in Chapters 3 and 4. The second part of the thesis discusses the development, characterization, and application of protein structure networks based on non– covalent interaction energies. The investigations are presented in chapters 5 and 6. Chapter 3 discusses the development of Protein–DNA Graphs (PDGs) where the protein–DNA interfaces are represented as networks. PDG is a bipartite network in which amino acids form a set of nodes and the nucleotides form the other set. The extent of interaction between the two diverse types of biopolymers is normalized to define the strength of interaction. Edges are then constructed based on the interaction strength between amino acids and nucleotides. Such a representation, reported here for the first time, provides a holistic view of the interacting surface. The developed PDGs are further analyzed in terms of clusters of interacting residues and identification of highly connected residues, known as hubs, along the protein–DNA interface and discussed in terms of their interacting motifs. Important clusters have been identified in a set of protein–DNA complexes, where the amino acids interact with different chemical components of DNA such as phosphate, deoxyribose and base with varying degrees of connectivity. An analysis of such fragment based PDGs provided insights into the nature of protein–DNA interaction, which could not have been obtained by conventional pair–wise analysis. The predominance of deoxyribose–amino acid clusters in beta–sheet proteins, distinction of the interface clusters in helix–turn–helix and the zipper type proteins are some of the new findings from the analysis of PDGs. Additionally, a potential classification scheme has been proposed for protein–DNA complexes on the basis of their interface clusters. This classification scheme gives a general idea of how the proteins interact with different components of DNA in various complexes. The present graph–based method has provided a deeper insight into the analysis of the protein–DNA recognition mechanisms from both protein and DNA view points, thus throwing more light on the nature and specificity of these interactions (Sathyapriya, Vijayabaskar et al. 2008). Chapter 4 delineates the application of PSN to an important problem in molecular biology. An analysis of interface clusters from multimeric proteins provides a clue to the important residues contributing to the stability of the oligomers. One such prediction was made on the DNA binding protein under starvation from Mycobacterium smegmatis (Ms–Dps) using PSNs. Two types of trimers, Trimer A (tA) and Trimer B (tB) can be derived from the dodecamer because of the inherent three fold symmetry of the spherical crystal structure. The irreversible dodecamerization of these native Ms--Dps trimers, in vitro, is known to be directly associated with the bimodal function (DNA binding and iron storage) of this protein. Interface clusters which were Synopsis identified from the PSNs of the derived trimers, allowed us to convincingly predict the residues E146 and F47 for mutation studies. The prediction was followed up by our experimental collaborators (Rakhi PC and Dipankar Chatterji), which led to the elucidation of the molecular mechanism behind the in vitro oligomerization of Ms--Dps. The F47E mutant was impaired in dodecamerization, and the double mutant (E146AF47E) was a native monomer in solution. These two observations suggested that the two trimers are important for dodecamerization and that the residues selected are important for the structural stability of the protein in vitro. From the structural and functional characterizations of the mutants, we have proposed an oligomerization pathway of Ms–Dps (Chowdhury, Vijayabaskar et al. 2008). The second part of the thesis involves the development, characterization (Chapter 5) and application (Chapter 6) of Protein Energy Networks (PENs). As mentioned above, the PSNs constructed on the geometric basis efficiently capture the topology and associated properties at the level of atom–atom contact. The chemistry, however, is not completely captured by these network representations, and a wealth of information can be extracted by incorporating the details of chemical interactions. This study is an advancement over the existing PSNs, in terms of edges being defined on the basis of interaction energies among the amino acids. This interaction energy is the resultant of various types of interactions within a protein. Use of such realistic interaction energies in a weighted network captures all the essential features responsible for maintaining the protein structure. The methodology involved in representing proteins as interaction energy weighted networks, with realistic edge weights obtained from standard force fields is described in Chapter 5. The interaction energies were derived from equilibrium ensembles (obtained using molecular dynamics simulations) to account for the structural plasticity, which is essential for function elucidation. The suitability of this method to study single static structures was validated by obtaining interaction energies on minimized crystal structures of proteins. The PENs were then characterized using network parameters like edge weight distributions, clusters, hubs, and shortest paths. The PENs exhibited three distinct behaviors in terms of the size of the largest connected cluster as a function of interaction energy; namely, the pre–transition, transition, and post transition regions, irrespective of the topology of the proteins. The pre– transition region (energies<–20 kJ/mol) comprises smaller clusters with mainly charged and polar residues as hubs. Crucial topological changes take place in the transition region (–10 to –20 kJ/mol), where the smaller clusters aggregate, through low energy van der Waals interactions, to form a single large cluster in the post–transition region (energies>–10 kJ/mol). These behaviors reinforce the concept that hydrophobic interactions hold together local clusters of highly interacting residues, keeping the protein topology intact (Vijayabaskar and Vishveshwara 2010). The applications of PENs in studying protein organization, allosteric communication, thermophilic stability and the structural relation of remote homologues of TIM barrel families have been outlined in Chapter 6. In the first case, the weighted networks were used to identify stabilization regions in protein structures and hierarchical organization in the folded proteins, which may provide some insights into the general mechanism of protein folding and stabilization (Vijayabaskar and Vishveshwara 2010). In the second case the features of communication paths in proteins were elucidated from PENs, and specific paths have been extensively discussed in the case of PDZ domain, which is known to bring together protein partners, mediating various cellular processes. Changes in PEN upon ligand binding, resulting in alterations of the shortest paths (energetically most favorable paths) for a small fraction of residues, indicated that allosteric communication is anisotropic in PDZ. The observations also establish that the shortest paths between functionally important sites traverse through key residues in PDZ2 domain. Furthermore, shortest paths in PENs provide us the exact pathways of communication between residues. Although the communication in PDZ has been extensively investigated, detailed information of pathways at the energy level has emerged for the first time from the present study from PEN analysis (Vijayabaskar and Vishveshwara 2010). In the third case, a set of thermophilic and mesophilic proteins were compared to determine the factors responsible for their thermal stability from a network perspective using PENs. The sub– graph parameters such as cluster population, hubs and cliques were the prominent contributing factors for thermal stability. Also, the thermophilic proteins have a better–packed hydrophobic core. The property of thermophilic protein to increase stability by increasing the connectivity but retain conformational flexibility is discussed from a cliques and communities (higher order inter–connection of residues) perspective (Vijayabaskar and Vishveshwara 2010). Finally, the remote homologues from the TIM barrel fold have been analyzed using PENs to identify the interactions responsible for the maintenance of the fold despite low sequence similarity. A study of conserved Synopsis interactions in family specific PENs reveals that the formation of the central beta barrel is vital for the TIM barrel formation. The beta barrel is being formed by either conserved long range electrostatic interactions or by tandem arrangement of low energy hydrophobic interactions. The contributions of helix–sheet and helix–helix interactions are not conserved in the families. This study suggests that the sequentially near residues forming the helix–sheet interactions are common in many folds and hence formed despite non– conservation, whereas formation of beta barrel requires long range interactions, thus more conserved within the families. The thesis also consists of an appendix in which a web–tool, developed to express proteins as networks and analyze these networks using different network parameters is discussed. The web based program–GraProStr allows us to represent proteins as structure graphs/networks by considering the amino acid residues as nodes and representing non–covalent interactions among them as edges. The different networks (classified based on edge definition) which can be obtained using GraProStr are Protein Side–chain Networks (PScNs), Cα/Cβ distance based networks (PcNs) and Protein– Ligand Networks (PLNs). The parameters which can be generated include clusters, hubs, cliques (rigid regions in proteins) and communities (group of cliques). It is also possible to differentiate the above mentioned parameters for monomers and interfaces in multimeric proteins. The well tested tool is now made available to the scientific community for the first time. GraProStr is available online and can be accessed from http://vishgraph.mbu.iisc.ernet.in/GraProStr/index.html. With a variety of structure networks, and a set of easily interpretable network parameters GraProStr can be useful is analyzing protein structures from a global paradigm (Vijayabaskar, Vidya et al. 2010). In summary, we have extensively studied DNA binding proteins using side– chain based protein structure networks and by integrating the DNA molecule into the network. Also, we have upgraded the existing methodology of generating structure networks, by representing both the geometry and the chemistry of residues as interaction energies among them. Using this energy based network we have studied diverse problems like protein structure formation, stabilization, and allosteric communication in detail. The above mentioned methodologies are a considerable advancement over existing structure network representations and have been shown in this thesis to shed more light on the structural features of proteins. Proteins-DNA Graphs (PDGs) Protein Structures Protein Side–chain Networks (PScNs) Protein–DNA Graphs (PDGs) Protein Energy Networks (PENs) Dps Mycobacterium smegmatis Structure Network Analysis Protein Structure Networks GraProStr Structure Networks Biochemistry
24	Psí útulek s veterinárním zázemím / Dog Shelter with Veterinary Facilities Hulenková, Barbora January 2015 (has links) The aim of this diploma thesis is the design of this closed area of the shelter dogs with veterinary facilities and administration shelter in a specific location in the outskirts of Bystřice pod Hostýnem, street Meziříčská. It is a building amenities. In addition to the project itself is part of the job specialization - health and technical installations and connections. The work was developed in response to a bachelor thesis. The intention is to create a functional device with everyday hour, which will be provided by 7 employees. Given that the region is not represented such a device, its implementation will meet the requirements and demands of citizens of the town but also surrounding communities. The capacity of the shelter is designed based on the client's requirements with the possibility of placing domestic animals in max. Of 50 dogs, 50 cats and 16 small animals. Unless capacity is full, the device can be used as an animal hotel. In its own proposal, the emphasis was on the overall architectural character and design solutions. Structures in the area are designed from the structural system KM BETA with a contact system.The aim of this diploma thesis is the design of this closed area of the shelter dogs with veterinary facilities and administration shelter in a specific location in the outskirts of Bystřice pod Hostýnem, street Meziříčská. It is a building amenities. In addition to the project itself is part of the job specialization - health and technical installations and connections. The work was developed in response to a bachelor thesis. The intention is to create a functional device with everyday hour, which will be provided by 7 employees. Given that the region is not represented such a device, its implementation will meet the requirements and demands of citizens of the town but also surrounding communities. The capacity of the shelter is designed based on the client's requirements with the possibility of placing domestic animals in max.
25	Dr. Eleine Mad Jacobsson, Madeleine January 2021 (has links) Dr. Eleine Mad är Madeleine Jacobsssons talesperson för dom vetenskapliga och paranormala upptäckter som uppstår i hennes världar. Hon beskriver innehåll, teknik och estetik utifrån ett kategoriseringssytem där konsten delas upp som olika typer av komponenter och därefter avkodas dessa allteftersom. För att förstå intuitionens inblandning i arbetsprocessen omförvandlas den till tre separata roller av en Sökare, Samlare och Myntare. Med rollerna försöker jag beskriva på vilka sätt som intuitionen är till gagn eller av förödelse för det konstnärliga arbetet. Sagan om M handlar om en grodlik karaktär, Delop, som lämnar sin hemplanet för att uppsöka andra världar. I sitt sökande hittar Delop ett folkslag vars syn och levnadssätt skiljer sig från hennes erfarenheter av “verkligheten” såsom hon lärt sig att överleva i den. / Dr. Eleine Mad is Madeleine Jacobsson's spokesperson for the scientific and paranormal discoveries that arise in her worlds. She describes content, tecniques and aesthetics based on a categorization system where art is divided into different types of components and then decoded as they go. To understand the intuition's involvement in the work process, it is transformed into three separate roles by a Seeker, Collector and a Myntare(In swedish language the one who is a "myntare" -is verbally declaring a concept or term). With these roles I try to describe in what ways intuition is beneficial or devastating to the artistic work. The story of M is about a frog-like character, Delop, who leaves the home planet to seek out other worlds. In her search, Delop finds a world whose views and lifestyles differ from her experiences of "reality" as she learned to survive in it. / <p>Recorded sound and image material of the presentation is available for private use.</p> mjjgkjacb longing desire pang aj worlds shark genital symbol female sexuality worlds content the tale of M Doctor M mad life artifact animals figures emotional states red existentialism epicenter dog mythology folk beer whistle closeness aversions seeker collector myntare stagnation hibernation intuition sausage soup majdalakdemlsmikopa Delop Cow Lice snake hare sheep ödel oktor threat antipathy empathy fear performance function allow belief clitoral heroes monsters pink components situation dual nature euphoria bic-pens reality violence desert sea AQB brain holistics social codes self fairy tale space blue horse hell gotland dizzying flourish anthropomorphic jewels death plaster spiders commit survive frog whale bear purpose communication wild fascination animal incomparable monster ugly disturbed perspective marauder green symbolism who suffer anger reverence gods recast transformation yellow pry entrance interest alternative insignificant rigid position of power as disease real added disgusting wake up doubt mourn pray images horror plants rock stop mjjgkjacb längtan åtrå pang aj världar haj världsallt könssymbol kvinnlig sexualitet världarnas innehåll sagan om M Doktor M mad livet artefakt djur figurer känslomässiga tillstånd röd existentialism epicentrum hund mytologi folköl vissla närhet aversioner sökare samlare myntare stagnation dvala intuition korvsoppa majdalakdemlsmikopa Delop Ko Löss orm hare får Ödel Oktor hot antipati empati rädsla föreställning funktion tillåta tro klitorala hjältar monster rosa världar komponenter situation dubbla natur eufori bic-pennor verkligheten våld öken hav A.Q.B hjärna holistisk sociala koder självet sagorymd blå häst helvete Gotland vimmelkantig florera antropomorf juveler döden plåsterspindlar vägvisare begå överleva groda val björn syfte kommunicering vild fascination djurisk makalös vidunder ful störd perspektiv marodör grön symbolism vem genomlida ilska vördnad gudar omstöpt sammandrabbningar transformation gul bända ingång intresserar alternativ oväsentlig stel maktposition som sjukdom verkligt tillsatt äcklig vakna tvivla sörja be urbilder skräck växter rock stopp Arts Konst

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